Mammalian Development & Cell Biology (MACE Lab)
ions | Bruxelles Woluwe, Louvain-la-Neuve
Research
The mammalian cerebral cortex plays key roles in learning and memory, the control of sensory and motor functions or of our emotions. The proper execution of these tasks depends on a long process of embryonic and postnatal development which relies on the production by neural stem cells of the appropriate number of neurons with proper identities that migrate to their specific location and make connections with each other. Defective signaling pathways during development are the causes of human brain disorders such as lissencephalies and heterotopias, mental retardation, dyslexia, schizophrenia, autism, epilepsy and many others. The goal of our laboratory is to better define the mechanisms of neural cell proliferation, migration, differentiation and synaptogenesis.
A better understanding of how the brain develops in normal conditions and in disease will provide new concepts for therapeutic approaches to improve diagnosis and to treat and prevent neurodevelopmental disorders.
video MACE
Publications
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Article de journalKon, E., Calvo Jimenez, E., Cossard, A., Na, Y., Cooper, J. A., & Jossin, Y. (2019). N-cadherin-regulated FGFR ubiquitination and degradation control mammalian neocortical projection neuron migration. eLife, 8. https://doi.org/10.7554/eLife.47673 (Original work published 2019)
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Article de journalKon, E., Cossard, A., & Jossin, Y. (2017). Neuronal Polarity in the Embryonic Mammalian Cerebral Cortex. Frontiers in Cellular Neuroscience, 11. https://doi.org/10.3389/fncel.2017.00163 (Original work published 2017)
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Article de journalJossin, Y. (2011). Polarization of migrating cortical neurons by Rap1 and N-cadherin: Revisiting the model for the Reelin signaling pathway. Small GTPases, 2(6), 322-328. https://doi.org/10.4161/sgtp.18283 (Original work published 2011)
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Jossin, Y., & Cooper, J. A. (2011). Reelin, Rap1 and N-cadherin orient the migration of multipolar neurons in the developing neocortex. Nature Neuroscience, 14(6), 697-703 (2011 juin). https://doi.org/10.1038/nn.2816 (Original work published 2011)
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Article de journalBock, H. H., Jossin, Y., Liu, P., Förster, E., May, P., Goffinet, A., & Herz, J. (2003). Phosphatidylinositol 3-kinase interacts with the adaptor protein Dab1 in response to Reelin signaling and is required for normal cortical lamination. Journal of Biological Chemistry, 278(40), 38772-38779. https://doi.org/10.1074/jbc.M306416200 (Original work published 2003)
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Article de journal
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