ISBA
Voie du Roman Pays 20/L1.04.01
1348 Louvain-la-Neuve
- Accueil
- Répertoire
- Catherine Legrand
Catherine Legrand
Professeure ordinaire
SST/SC -- Faculté des sciences
SST/SC/LSBA -- Louvain School of Statistics, Biostatistics and Actuarial Sciences
SSH/IDAM -- Louvain Institute of Data Analysis and Modeling in economics and statistics (IDAM)
SSH/IDAM/ISBA -- Institut de Statistique, Biostatistique et Sciences Actuarielles
Présidente (IDAM)
Catherine Legrand obtained a Master Degree in Mathematics from the Université Libre de Bruxelles (ULB) in 1998. Before embracing an academic career, she worked for 7 years at the European Organization for Research and Treatment of Cancer (EORTC, Brussels) as the primary statistician of the EORTC Lung Cancer Group. She was also a member of the Treatment Outcome Research Group, the Elderly Task Force, and coordinator of the EORTC Independent Data Monitoring Committee (IDMC). She was involved in the design, monitoring, and analysis of numerous clinical trials. In parallel, she completed a PhD in 2005 at the Center for Statistics, UHasselt, developing new methods based on the frailty model to investigate heterogeneity in cancer multi-center clinical trials. Early 2006, she started working as biometrician at Merck Sharp & Dohme (MSD, Brussels) where she was involved in the design and analysis of clinical trials in respiratory diseases and HIV. Since September 2007, she is full time Professor at the Institute of Statistics, Biostatistics and Actuarial Sciences (ISBA) of the Université catholique de Louvain (UcL), teaching statistics and biostatistics to bachelor and master students.
- Diplômes
Année Label Institution 1998 Licence en mathématique, orientation statistique Université Libre de Bruxelles 2006 Doctorat en sciences mathématiques, orientation biostatistique Universiteit Hasselt
- Les cours
Nom ID Éléments de mathématiques pour la statistique LSTAT2011 Modèles linéaires mixtes LSTAT2210 Advanced survival models LSTAT2230 Statistique des essais cliniques LSTAT2330 Biostatistiques et analyse critique de l'information LVETE1262 Epidémiologie génomique WESP2232 Eléments de statistiques médicales WMDS1114
Main area of research includes survival data (more particularly frailty models and cure models) and design and analysis of multicenter clinical trials (in particular in oncology and vaccine), with an emphasis on treatment effect heterogeneity and central statistical monitoring.
PhD Thesis promotor:
- Marco Munda. “Beyond the shared frailty model. Goodness-of-fit, decreasing heterogeneity, and spatial dependence”. Promotor : Catherine Legrand (UCL)
- Anne Benoit. “Estimation of the efficacy of seasonal influenza vaccines: Vaccine development, statistical modelling and trial design”. Promotor : Catherine Legrand (UCL)
- Federico Rotolo. “Frailty multi-state models for the analysis of survival data from multicenter clinical trials”. Promotors: Monica Chiogna (Universita degli Studi di Padova) and Catherine Legrand (UCL)
- Sylvie Scolas. “Modelling interval-censored event times in the presence of a cure fraction: From building to refining”. Promotors: Anouar El Ghouch (UCL) and Catherine Legrand (UCL)
- Aurélie Bertrand. “Survival models with a cured fraction and mismeasured covariates”. Promotors: Ingrid Van Keilegom (UCL/KUL) and Catherine Legrand (UCL)
- Mailis Amico. “Semi-parametric mixture cure models”. Promoters: Ingrid Van Keilegom (UCL/KUL) and Catherine Legrand (UCL)
- Anne-Sophie Lambert. “Quelles méthodes utiliser pour réaliser une analyse d’efficacité d’interventions complexes, à partir de base de données de routine, en tenant compte des caractéristiques des bénéficiaires et du contexte ? ”. Promotors: Jean Macq (UCL) and Catherine Legrand (UCL)
2024
Lambert, Anne-Sophie ; Legrand, Catherine ; Scholtes, Béatrice ; Samadoulougou, Sékou ; Deconinck, Hedwig ; Alvarez Irusta, Lucia ; Macq, Jean. Population stratification based on healthcare trajectories: A method for encouraging adaptive learning at meso level. In: Health Policy, Vol. 148, p. 105137 (2024). doi:10.1016/j.healthpol.2024.105137.
2024
Soetewey, Antoine ; Legrand, Catherine ; Denuit, Michel ; Silversmit, Geert. Right to be forgotten for mortgage insurance issued to cancer survivors: critical assessment and new proposal. In: European Actuarial Journal, (2024). doi:10.1007/s13385-024-00403-6 (Accepté/Sous presse).
2023
Harkemanne, Evelyne ; Legrand, Catherine ; Sawadogo, Kiswendsida Clovis ; van Maanen, Aline ; Vossaert, Katrien ; Argenziano, Giuseppe ; Braun, Ralph ; Thomas, Luc ; Baeck, Marie ; Tromme, Isabelle. Evaluation of primary care physicians' competence in selective skin tumour triage after short versus long dermoscopy training: a randomized non-inferiority trial.. In: Journal of the European Academy of Dermatology and Venereology, Vol. 37, no.8, p. 1595-1605 (2023). doi:10.1111/jdv.19087.
2023
Seront, Emmanuel ; Van Damme, An ; Legrand, Catherine ; Bisdorff-Bresson, Annouk ; Orcel, Philippe ; Funck-Brentano, Thomas ; Sevestre, Marie-Antoinette ; Dompmartin, Anne ; Quere, Isabelle ; Brouillard, Pascal ; Revencu, Nicole ; De Bortoli, Martina ; Hammer, Frank ; Clapuyt, Philippe ; Dumitriu, Dana Ioana ; Vikkula, Miikka ; Boon, Laurence M.. Preliminary results of the European multicentric phase III trial regarding sirolimus in slow-flow vascular malformations. In: JCI Insight, Vol. 8, no.21 (2023). doi:10.1172/jci.insight.173095.
2022
Legrand, Catherine ; Tubeuf, Sandy. Le développement des vaccins anti-Covid-19 est-il allé trop vite ?. In: Regards économiques, Vol. Focus, no. 29 (2022).
2022
Soetewey, Antoine ; Legrand, Catherine ; Denuit, Michel ; Silversmit, Geert. Semi-markov modeling for cancer insurance. In: European Actuarial Journal, Vol. 12, p. 813–837 (2022). doi:10.1007/s13385-022-00308-2.
2021
Declercq, Jozefien ; Van Damme, Karel F A ; De Leeuw, Elisabeth ; Maes, Bastiaan ; Bosteels, Cedric ; Tavernier, Simon J ; De Buyser, Stefanie ; Colman, Roos ; Hites, Maya ; Verschelden, Gil ; Fivez, Tom ; Moerman, Filip ; Demedts, Ingel K ; Dauby, Nicolas ; De Schryver, Nicolas ; Govaerts, Elke ; Vandecasteele, Stefaan J ; Van Laethem, Johan ; Anguille, Sebastien ; van der Hilst, Jeroen ; Misset, Benoit ; Slabbynck, Hans ; Wittebole, Xavier ; Liénart, Fabienne ; Legrand, Catherine ; Buyse, Marc ; Stevens, Dieter ; Bauters, Fre ; Seys, Leen J M ; Aegerter, Helena ; Smole, Ursula ; Bosteels, Victor ; Hoste, Levi ; Naesens, Leslie ; Haerynck, Filomeen ; Vandekerckhove, Linos ; Depuydt, Pieter ; van Braeckel, Eva ; Rottey, Sylvie ; Peene, Isabelle ; Van Der Straeten, Catherine ; Hulstaert, Frank ; Lambrecht, Bart N. Effect of anti-interleukin drugs in patients with COVID-19 and signs of cytokine release syndrome (COV-AID): a factorial, randomised, controlled trial.. In: The Lancet. Respiratory medicine, Vol. 9, no.12, p. 1427-1438 (2021). doi:10.1016/S2213-2600(21)00377-5.
2021
Soetewey, Antoine ; Legrand, Catherine ; Denuit, Michel ; Silversmit, Geert. Waiting period from diagnosis for mortgage insurance issued to cancer survivors. In: European Actuarial Journal, Vol. 11, p. 135-160 (2021). doi:10.1007/s13385-020-00254-x.
2020
Cantagallo, Eva ; De Backer, Mickaël ; Kicinski, Michal ; Ozenne, Brice ; Collette, Laurence ; Legrand, Catherine ; Buyse, Marc ; Péron, Julien. A new measure of treatment effect in clinical trials involving competing risks based on generalized pairwise comparisons. In: Biometrical Journal, Vol. 63, no. 2, p. 272-288 (2020). doi:10.1002/bimj.201900354.
2020
Molenberghs, Geert ; Buyse, Marc ; Abrams, Steven ; Hens, Niel ; Beutels, Philippe ; Faes, Christel ; Verbeke, Geert ; Van Damme, Pierre ; Goossens, Herman ; Neyens, Thomas ; Herzog, Sereina ; Theeten, Heidi ; Pepermans, Koen ; Abad, Ariel Alonso ; Van Keilegom, Ingrid ; Speybroeck, Niko ; Legrand, Catherine ; De Buyser, Stefanie ; Hulstaert, Frank. Infectious diseases epidemiology, quantitative methodology, and clinical research in the midst of the COVID-19 pandemic: Perspective from a European country. In: Contemporary Clinical Trials, Vol. 99, p. 106189 (2020). doi:10.1016/j.cct.2020.106189.
2020
Speybroeck, Niko ; Legrand, Catherine. Les experts de l'UCLouvain vous répondent: "Plusieurs indicateurs nécessaires pour une épidémie". In: Le Vif - L'Express, (2020).
2019
Callegaro, Andrea ; Ndour, Cheikh ; Aris, Emmanuel ; Legrand, Catherine. A note on tests for relevant differences with extremely large sample sizes. In: Biometrical Journal, Vol. 61, no.1, p. 162-165 (2019). doi:10.1002/bimj.201800195.
2019
Narasimhaiah, Deepti ; Legrand, Catherine ; Damotte, Diane ; Remark, Romain ; Munda, Marco ; De Potter, Patrick ; Coulie, Pierre G. ; Vikkula, Miikka ; Godfraind, Catherine. DNA alteration-based classification of uveal melanoma gives better prognostic stratification than immune infiltration, which has a neutral effect in high-risk group.. In: Cancer medicine, Vol. 8, no. 6, p. 3036-3046 (2019). doi:10.1002/cam4.2122.
2019
Lambert, Anne-Sophie ; Legrand, Catherine ; Cès, Sophie ; Van Durme, Thérèse ; Macq, Jean. Evaluating case management as a complex intervention: Lessons for the future. In: PLoS One, Vol. 14, no.10, p. e0224286 (2019). doi:10.1371/journal.pone.0224286.
2019
Bertrand, Aurélie ; Van Keilegom, Ingrid ; Legrand, Catherine. Flexible parametric approach to classical measurement error variance estimation without auxiliary data : Classical Measurement Error Variance Estimation. In: Biometrics, Vol. 75, no. 1, p. 297-307 (2019). doi:10.1111/biom.12960.
2019
Najafi, Nadia ; Veyckemans, Francis ; Vanhonacker, Domien ; Legrand, Catherine ; Van de Velde, Anne ; Vandenplas, Yvan ; Poelaert, Jan. Incidence and risk factors for adverse events during monitored anaesthesia care for gastrointestinal endoscopy in children: A prospective observational study.. In: European journal of anaesthesiology, Vol. 36, no.6, p. 390-399 (2019). doi:10.1097/EJA.0000000000000995.
2019
Burny, Wivine ; Marchant, Arnaud ; Hervé, Caroline ; Callegaro, Andrea ; Caubet, Magalie ; Fissette, Laurence ; Gheyle, Lien ; Legrand, Catherine ; Ndour, Cheikh ; Tavares Da Silva, Fernanda ; van der Most, Robbert ; Willems, Fabienne ; Didierlaurent, Arnaud M. ; Yarzabal, Juan. Inflammatory parameters associated with systemic reactogenicity following vaccination with adjuvanted hepatitis B vaccines in humans. In: Vaccine, Vol. 37, no.14, p. 2004-2015 (2019). doi:10.1016/j.vaccine.2019.02.015.
2019
Barbieri, Antoine ; Legrand, Catherine. Joint longitudinal and time-to-event cure models for the assessment of being cured.. In: Statistical methods in medical research, Vol. 29, no. 4, p. 1256-1270 (2020). doi:10.1177/0962280219853599.
2019
Amico, Maïlis ; Van Keilegom, Ingrid ; Legrand, Catherine. The Single-Index/Cox Mixture Cure Model. In: Biometrics, Vol. 75, p. 452-462 (2019). doi:10.1111/biom.12999.
2019
Nicolaie, Mioara Alina ; Taylor, Jeremy M. G. ; Legrand, Catherine. Vertical modeling: analysis of competing risks data with a cure fraction. In: Lifetime Data Analysis, Vol. 25, no.1, p. 1-25 (2019). doi:10.1007/s10985-018-9417-8.
2018
Scolas, Sylvie ; Legrand, Catherine ; Oulhaj, Abderrahim ; El Ghouch, Anouar. Diagnostic checks in mixture cure models with interval-censoring. In: Statistical Methods in Medical Research, Vol. 27, no. 7, p. 2114-2131 (2018). doi:10.1177/0962280216676502.
2018
Denuit, Michel ; Legrand, Catherine. Risk classification in life and health insurance: extension to continuous covariates. In: European Actuarial Journal, Vol. 8, no.1, p. 245-255 (2018). doi:10.1007/s13385-018-0171-9.
2017
Tromme, Isabelle ; Legrand, Catherine ; Devleesschauwer, Brecht ; Leiter, Ulrike ; Suciu, Stefan ; Eggermont, Alexander ; Sacré, Laurine ; Baurain, Jean-François ; Thomas, Luc ; Beutels, Philippe ; Speybroeck, Niko. Corrigendum to "Cost-effectiveness analysis in melanoma detection: A transition model applied to dermoscopy" [Eur J Cancer 67 (2016) 38-45].. In: European Journal of Cancer, Vol. 82, p. 247 (2017). doi:10.1016/j.ejca.2017.06.001.
2017
Bertrand, Aurélie ; Legrand, Catherine ; Carroll, Raymond J. ; de Meester de Ravenstein, Christophe ; Van Keilegom, Ingrid. Inference in a survival cure model with mismeasured covariates using a simulation-extrapolation approach. In: Biometrika, Vol. 104, no. 1, p. 31-50 (2017). doi:10.1093/biomet/asw054.
2017
Bertrand, Aurélie ; Legrand, Catherine ; Léonard, Daniel ; Van Keilegom, Ingrid. Robustness of estimation methods in a survival cure model with mismeasured covariates. In: Computational Statistics & Data Analysis, Vol. 113, p. 3-18 (2017). doi:10.1016/j.csda.2016.11.013.
2017
Desmet, Lieven ; Venet, David ; Doffagne, Erik ; Timmermans, Catherine ; Legrand, Catherine ; Burzykowski, Tomasz ; Buyse, Marc. Use of the beta-binomial model for central statistical monitoring of multicenter clinical trials. In: Statistics in Biopharmaceutical Research, Vol. 9, no. 1, p. 1-11 (2017). doi:10.1080/19466315.2016.1164751.
2016
Tromme, Isabelle ; Legrand, Catherine ; Devleesschauwer, Brecht ; Leiter, Ulrike ; Suciu, Stefan ; Eggermont, Alexander ; Sacré, Laurine ; Baurain, Jean-François ; Thomas, Luc ; Beutels, Philippe ; Speybroeck, Niko. Cost-effectiveness analysis in melanoma detection: A transition model applied to dermoscopy. In: European Journal of Cancer, Vol. 67, p. 38-45 (2016). doi:10.1016/j.ejca.2016.07.020.
2016
Rotolo, Federico ; Rondeau, Virginie ; Legrand, Catherine. Incorporation of nested frailties into semiparametric multi-state models. In: Statistics in Medicine, Vol. 35, no.4, p. 609-621 (2016). doi:10.1002/sim.6734.
2016
Tromme, Isabelle ; Legrand, Catherine ; Devleesschauwer, Brecht ; Leiter, Ulrike ; Suciu, Stefan ; Eggermont, Alexander ; Francart, Julie ; Calay, Frederic ; Haagsma, Juanita A. ; Baurain, Jean-François ; Thomas, Luc ; Beutels, Philippe ; Speybroeck, Niko. Melanoma burden by melanoma stage: Assessment through a disease transition model. In: European Journal of Cancer, Vol. 53, p. 33-41 (2016). doi:10.1016/j.ejca.2015.09.016.
2016
Timmermans, Catherine ; Doffagne, Erik ; Venet, David ; Desmet, Lieven ; Legrand, Catherine ; Burzykowski, Tomasz ; Buyse, Marc. Statistical monitoring of data quality and consistency in the Stomach Cancer Adjuvant Multi-institutional Trial Group Trial. In: Gastric Cancer, Vol. 19, no. 1, p. 24-30 (2016). doi:10.1007/s10120-015-0533-9.
2016
Scolas, Sylvie ; El Ghouch, Anouar ; Legrand, Catherine ; Oulhaj, Abderrahim. Variable selection in a flexible parametric mixture cure model with interval-censored data. In: Statistics in Medicine, Vol. 35, no.7, p. 1210-1225 (2016). doi:10.1002/sim.6767.
2015
Benoit, Anne ; Beran, J. ; Devaster, J.-M. ; Esen, M. ; Launay, O. ; Leroux-Roels, G. ; McElhaney, J. E. ; Oostvogels, L. ; van Essen, G. A. ; Gaglani, M. ; Jackson, L. A. ; Vesikari, T. ; Legrand, Catherine ; Tibaldi, F. ; Innis, B. L. ; Dewe, W.. Hemagglutination Inhibition Antibody Titers as a Correlate of Protection Against Seasonal A/H3N2 Influenza Disease. In: Open Forum Infectious Diseases, Vol. 2, no. 2, p. ofv067-ofv067 (2015). doi:10.1093/ofid/ofv067.
2015
Benoit, Anne ; Legrand, Catherine ; Dewé, Walthère. Influenza vaccine efficacy trials: a simulation approach to understand failures from the past. In: Pharmaceutical Statistics : the journal of applied statistics in the pharmaceutical industry, Vol. 14, no.4, p. 294-301 (2015). doi:10.1002/pst.1685.
2015
Boscolo, Elisa ; Limaye, Nisha ; Huang, Lan ; Kang, Kyu-Tae ; Soblet, Julie ; Uebelhoer, Mélanie ; Mendola, Antonella ; Natynki, Marjut ; Seront, Emmanuel ; Dupont, Sophie ; Hammer, Jennifer ; Legrand, Catherine ; Brugnara, Carlo ; Eklund, Lauri ; Vikkula, Miikka ; Bischoff, Joyce ; Boon, Laurence M.. Rapamycin improves TIE2-mutated venous malformation in murine model and human subjects. In: Journal of Clinical Investigation, Vol. 125, no. 9, p. 3491-3504 (2015). doi:10.1172/JCI76004.
2015
Munda, Marco ; Legrand, Catherine ; Duchateau, Luc ; Janssen, Paul. Testing for decreasing heterogeneity in a new time-varying frailty model. In: Test, Vol. 25, no.4, p. 591-606 (2015). doi:10.1007/s11749-015-0468-9.
2014
Munda, Marco ; Legrand, Catherine. Adjusting for centre heterogeneity in multicentre clinical trials with a time-to-event outcome. In: Pharmaceutical Statistics : the journal of applied statistics in the pharmaceutical industry, Vol. 13, no.2, p. 145-152 (2014). doi:10.1002/pst.1612.
2014
Tromme, Isabelle ; Devleesschauwer, Brecht ; Beutels, Philippe ; Richez, Pauline ; LEROY, Laurence ; Baurain, Jean-François ; Cornelis, Frank ; BERTRAND, Claude ; Legrand, N ; Degueldre, Jérôme ; Thomas, Luc ; Legrand, Catherine ; LAMBERT, Julien ; Haagsma, J ; Speybroeck, Niko. Health-related quality of life in patients with melanoma expressed as utilities and disability weights. In: British Journal of Dermatology, Vol. 171, no.6, p. 1443-1450 (2014). doi:10.1111/bjd.13262.
2014
Heuchenne, Cédric ; Laurent, Stéphane ; Legrand, Catherine ; Van Keilegom, Ingrid. Likelihood-Based Inference for Semi-Competing Risks. In: Communications in Statistics - Simulation and Computation, Vol. 43, no. 5, p. 1112-1132 (2014). doi:10.1080/03610918.2012.725495.
2014
Desmet, Lieven ; Venet, D ; Doffagne, E ; Timmermans, Catherine ; Burzykowski, T ; Legrand, Catherine ; Buyse, M. Linear mixed-effects models for central statistical monitoring of multicenter clinical trials.. In: Statistics in Medicine, Vol. 33, no. 30, p. 5265-5279 (2014). doi:10.1002/sim.6294.
2014
Tromme, Isabelle ; Devleesschauwer, Brecht ; Beutels, Philippe ; Richez, Pauline ; Praet, Nicolas ; Sacré, Laurine ; Marot, Liliane ; Van Eeckhout, Pascal ; Theate, Ivan ; Baurain, Jean-François ; Lambert, Julien ; Legrand, Catherine ; Thomas, Luc ; Speybroeck, Niko. Selective use of sequential digital dermoscopy imaging allows a cost reduction in the melanoma detection process: a belgian study of patients with a single or a small number of atypical nevi.. In: PLoS One, Vol. 9, no. 10, p. e109339 (2014). doi:10.1371/journal.pone.0109339.
2014
Loeys, Tom ; Legrand, Catherine ; Schettino, Antonio ; Pourtois, Gilles. Semi-parametric proportional hazards models with crossed random effects for psychometric response times. In: British Journal of Mathematical and Statistical Psychology, Vol. 67, no.2, p. 304-327 (2014). doi:10.1111/bmsp.12020.
2013
Rotolo, Federico ; Legrand, Catherine ; Van Keilegom, Ingrid. A simulation procedure based on copulas to generate clustered multi-state survival data. In: Computer methods and programs in biomedicine, Vol. 109, no. 3, p. 305-312 (2013). doi:10.1016/j.cmpb.2012.09.003.
2013
Dewe, Walthere ; Benoît, Anne ; Legrand, Catherine. Assessing vaccine efficacy in influenza clinical trials: challenges and difficulties. In: Expert Review of Clinical Pharmacology, Vol. 6, no.4, p. 403-411 (2013). doi:10.1586/17512433.2013.811817.
2013
Forget, Patrice ; Machiels, Jean-Pascal ; Coulie, Pierre G. ; Berlière, Martine ; Poncelet, Alain ; Tombal, Bertrand ; Stainier, Annabelle ; Legrand, Catherine ; Canon, Jean-Luc ; Kremer, Yann ; De Kock, Marc. Neutrophil:Lymphocyte Ratio and Intraoperative Use of Ketorolac or Diclofenac are Prognostic Factors in Different Cohorts of Patients Undergoing Breast, Lung, and Kidney Cancer Surgery. In: Annals of Surgical Oncology, Vol. 20, no. Suppl 3, p. S650-660 (2013). doi:10.1245/s10434-013-3136-x.
2012
Laurent, Stéphane ; Legrand, Catherine. A bayesian framework for the ratio of two poisson rates in the context of vaccine efficacy trials Journal. In: ESAIM: Probability & Statistics, Vol. 16, p. 375-378 (2012). doi:10.1051/ps/2010018.
2012
Venet, David ; Doffagne, Erik ; Burzykowski, Tomasz ; Beckers, François ; Tellier, Yves ; Genevois-Marlin, Eric ; Becker, Ursula ; Bee, Valerie ; Wilson, Veronique ; Legrand, Catherine ; Buyse, Marc. A statistical approach to central monitoring of data quality in clinical trials. In: Clinical trials (London, England), Vol. 9, no. 6, p. 705-713 (2012). doi:10.1177/1740774512447898.
2012
Tromme, Isabelle ; Sacré, L ; Hammouch, Fatima ; Legrand, Catherine ; Marot, Liliane ; Vereecken, Pierre ; Théate, Ivan ; van Eeckhout, Pascal ; Richez, Pauline ; Baurain, Jean-François ; Thomas, L ; Speybroeck, Niko ; DEPIMELA study group. Availability of digital dermoscopy in daily practice dramatically reduces the number of excised melanocytic lesions: results from an observational study. In: British Journal of Dermatology, Vol. 167, no. 4, p. 778-786 (2012). doi:10.1111/j.1365-2133.2012.11042.x.
2012
Hollevoet, Kevin ; Nackaerts, Kristiaan ; Thas, Olivier ; Thimpont, Joël ; Germonpré, Paul ; De Vuyst, Paul ; Bosquée, Lionel ; Legrand, Catherine ; Kellen, Eliane ; Kishi, Yoshiro ; Delanghe, Joris R ; van Meerbeeck, Jan P. The effect of clinical covariates on the diagnostic and prognostic value of soluble mesothelin and megakaryocyte potentiating factor. In: Chest, Vol. 141, no. 2, p. 477-484 (2012). doi:10.1378/chest.11-0129.
2012
Munda, Marco ; Rotolo, Federico ; Legrand, Catherine. parfm: Parametric Frailty Models in R. In: Journal of Statistical Software, Vol. 51, no.11 (2012).
2011
Forget, Patrice ; Tombal, Bertrand ; Scholtes, Jean-Louis ; Nzimbala, Jolio ; Meulders, Catherine ; Legrand, Catherine ; Van Cangh, Paul ; Cosyns, Jean-Pierre ; De Kock, Marc. Do intraoperative analgesics influence oncological outcomes after radical prostatectomy for prostate cancer?. In: European Journal of Anaesthesiology, Vol. 28, no. 12, p. 830-835 (2011). doi:10.1097/EJA.0b013e32834b7d9a.
2011
Ha, Il Do ; Sylvester, Richard ; Legrand, Catherine ; MacKenzie, Gilbert. Frailty modelling for survival data from multi-centre clinical trials. In: Statistics in Medicine, Vol. 30, no.17, p. 2144–2159 (July 2011). doi:10.1002/sim.4250.
2011
Collée, Audrey ; Legrand, Catherine ; Govaerts, Bernadette ; Van Der Veken, Paul ; De Broodt, Franck ; Degrave, Etienne. Occupational exposure to noise and the prevalence of hearing loss in a Belgian military population : a cross-sectional study. In: Noise & Health : a quarterly inter-disciplinary international journal, Vol. 13, no. 50, p. 64-70 (2011). doi:10.4103/1463-1741.73997.
2011
Hollevoet, Kevin ; Nackaerts, Kristiaan ; Gosselin, Robert ; De Wever, Walter ; Bosquée, Lionel ; De Vuyst, Paul ; Germonpré, Paul ; Kellen, Eliane ; Legrand, Catherine ; Kishi, Yoshiro ; Delanghe, Joris R ; van Meerbeeck, Jan P. Soluble mesothelin, megakaryocyte potentiating factor, and osteopontin as markers of patient response and outcome in mesothelioma.. In: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, Vol. 6, no. 11, p. 1930-7 (2011). doi:10.1097/JTO.0b013e3182272294.
2010
Surmont, V. ; Aerts, J.G.J.V ; Van Klaveren, R.J. ; Tournoy, K. ; Tan, K.Y. ; Vernhout, R.M. ; Schmitz, P.I.M ; Legrand, Catherine ; Hoogsteden, H.C. ; van Meerbeeck, J.P.. A randomized phase II study comparing two schedules of the 21-day regime of Gemcitabine and Carboplatin in advanced NSCLC. In: Oncology, Vol. 78, no. 3/4, p. 267-270 (2010). doi:10.1159/000315733.
2010
Camargo, C.A. ; Gurner, D. ; Smithline, H. ; Chapela, R. ; Fabbri, L. ; Green, S. ; Malice, M. ; Legrand, Catherine ; Dass, S.B. ; Knorr, B. ; Reiss, T.. A randomized placebo-controlled study of intravenous montelukast for the treatment of acute asthma. In: Journal of Allergy and Clinical Immunology, Vol. 125, no. 2, p. 374-380 (2010). doi:10.1016/j.jaci.2009.11.015.
2010
Hollevoet, Kevin ; Nackaerts, Kristiaan ; Thimpont, Joel ; Germonpre, Paul ; Bosquee, Lionel ; De Vuyst, Paul ; Legrand, Catherine ; Kellen, Eliane ; Kishi, Yoshiro ; Delanghe, Joris R. ; van Meerbeeck, Jan P.. Diagnostic Performance of Soluble Mesothelin and Megakaryocyte Potentiating Factor in Mesothelioma. In: American Journal of Respiratory and Critical Care Medicine, Vol. 181, no. 6, p. 620-625 (2010). doi:10.1164/rccm.200907-1020OC.
2010
Forget, Patrice ; Vandenhende, Julie ; Berlière, Martine ; Machiels, Jean-Pascal ; Nussbaum, Benoît ; Legrand, Catherine ; De Kock, Marc. Do intraoperative analgesics influence breast cancer recurrence after mastectomy? : A retrospective analysis. In: Anesthesia and Analgesia, Vol. 110, no. 6, p. 1630-1635 (2010). doi:10.1213/ANE.0b013e3181d2ad07.
2009
Francart, Julie ; Vaes, Evelien ; Henrard, Séverine ; Legrand, Catherine ; Baas, P ; Gaafar, R. ; van Meerbeeck, J P ; Sylvester, Richard J. ; Robert, Annie. A prognostic index for progression-free survival in malignant mesothelioma with application to the design of phase II trials: A combined analysis of 10 EORTC trials.. In: European journal of cancer (Oxford, England : 1990), Vol. 45, no. 13, p. 2304-11 (2009). doi:10.1016/j.ejca.2009.04.028.
2009
Legrand, Catherine ; Efficace, Fabio. Implementing patient-reported health-related quality-of-life data in cancer routine practice to improve accuracy of prognosis. Are we there yet?. In: Expert review of pharmacoeconomics & outcomes research, Vol. 9, no. 6, p. 493-6 (2009). doi:10.1586/erp.09.59.
2009
Legrand, Catherine ; Duchateau, L. ; Janssen, P. ; Ducrocq, V. ; Sylvester, Richard J.. Validation of prognostic indices using the frailty model. In: Lifetime Data Analysis, Vol. 15, no. 1, p. 59-78 (2009). doi:10.1007/s10985-008-9092-2.
2007
Komarek, Arnost ; Lesaffre, Emmanuel ; Legrand, Catherine. Baseline and treatment effect heterogeneity for survival times between centers using a random effects accelerated failure time model with flexible error distribution. In: Statistics in Medicine, Vol. 26, no. 30, p. 5457-5472 (2007). doi:10.1002/sim.3083.
2007
Cortinas Abrahantes, Jose ; Legrand, Catherine ; Burzykowski, Tomasz ; Janssen, Paul ; Ducrocq, Vincent ; Duchateau, Luc. Comparison of different estimation procedures for proportional hazards model with random effects. In: Computational Statistics & Data Analysis, Vol. 51, no. 8, p. 3913-3930 (2007). doi:10.1016/j.csda.2006.03.009.
2007
Surmont, V. ; Van Klaveren, R.J. ; Goor, C. ; Schramel, F. ; Manegold, C. ; Legrand, Catherine ; Van Schil, P. ; Van Meerbeeck, J.P.. Lessons to learn from EORTC study 08981: A feasibility study of induction chemoradiotherapy followed by surgical resection for stage IIIB non-small cell lung cancer. In: Lung Cancer, Vol. 55, no.1, p. 95-99 (January 2007). doi:10.1016/j.lungcan.2006.09.015.
2007
Belderbos, José ; Uitterhoeve, Lon ; van Zandwijk, Nico ; Belderbos, Huub ; Rodrigus, Patrick ; van de Vaart, Paul ; Price, Allan ; van Walree, Nico ; Legrand, Catherine ; Dussenne, Sonia ; Bartelink, Harry ; Giaccone, Giuseppe ; Koning, Caro. Randomised trial of sequential versus concurrent chemo-radiotherapy in patients with inoperable non-small cell lung cancer (EORTC 08972-22973). In: European Journal of Cancer, Vol. 43, no.1, p. 114–121 (January 2007). doi:10.1016/j.ejca.2006.09.005.
2007
van Meerbeeck, Jan P. ; Kramer, Gijs w.P.M. ; Van Schil, Paul E. Y. ; Legrand, Catherine ; Smit, Egbert F. ; Schramel, Franz ; Tjan-Heijnen, Vivianne ; Biesma, Bonne ; Debruyne, Channa ; van Zandwijk, Nico ; Splinter, Ted A.W. ; Giaccone, Giuseppe. Randomized Controlled Trial of Resection Versus Radiotherapy After Induction Chemotherapy in Stage IIIA-N2 Non–Small-Cell Lung Cancer. In: Journal of the National Cancer Institute, Vol. 99, no.6, p. 442-450 (March 2007). doi:10.1093/jnci/djk093.
2007
Philip, George ; Pearlman, David S. ; Villarán, César ; Legrand, Catherine ; Loeys, Tom ; Langdon, Ronald B. ; Reiss, Theodore. Single-Dose Montelukast or Salmeterol as Protection Against Exercise-Induced Bronchoconstriction. In: Chest : the cardiopulmonary and critical care journal, Vol. 132, no.3, p. 875-883 (Sept. 2007). doi:10.1378/chest.07-0550.
2007
Bottomley, Andrew ; Coens, Corneel ; Efficace, Fabio ; Gaafar, Rabab ; Manegold, Christian ; Burgers, Sjaak ; Vincent, Mark ; Legrand, Catherine ; van Meerbeeck, Jan P.. Symptoms and patient-reported well-being: Do they predict survival in malignant pleural mesothelioma? A prognostic factor analysis of EORTC-NCIC 08983: Randomized phase III study of cisplatin with or without raltitrexed in patients with malignant pleural mesothelioma. In: Journal of Clinical Oncology, Vol. 25, no. 36, p. 5770-5776 (2007). doi:10.1200/JCO.2007.12.5294.
2006
Biesma, Bonne ; Manegold, C. ; Smit, H.J.M ; Willems, L. ; Legrand, Catherine ; Passioukov, A. ; van Meerbeeck, J.P. ; Giaccone, Giuseppe. Docetaxel and cisplatin as induction chemotherapy in patients with pathologically-proven stage IIIA N2 non-small cell lung cancer: a phase II study of the European organization for research and treatment of cancer (EORTC 08984). In: European Journal of Cancer, Vol. 42, no.10, p. 1399-1406 (July 2006). doi:10.1016/j.ejca.2006.01.049.
2006
Legrand, Catherine ; Duchateau, L. ; Sylvester, Richard J. ; Janssen, P. ; van der Hage, JA ; van de Velde, CJH ; Therasse, Patrick. Heterogeneity in disease free survival between centers: lessons learned from an EORTC breast cancer trial. In: Clinical Trials, Vol. 3, no. 1, p. 10-18 (2006). doi:10.1191/1740774506cn132oa.
2006
Efficace, F ; Bottomley, A ; Smit, E. ; Lianes, P ; Legrand, Catherine ; Debruyne, C ; Schramel, F ; Smit, H. ; Gaafar, R ; Biesma, B ; Manegold, C ; Coens, C ; Giaccone, G ; Van Meerbeeck, J. Is a patient's self-reported health-related quality of life a prognostic factor for survival in non-small-cell lung cancer patients? A multivariate analysis of prognostic factors of EORTC study 08975. In: Annals of Oncology, Vol. 17, no.11, p. 1698-1704 (2006). doi:10.1093/annonc/mdl183.
2006
Francart, Julie ; Legrand, Catherine ; Sylvester, Richard ; Van Glabbeke, Martine ; van Meerbeeck, Jan P ; Robert, Annie. Progression-free survival rate as primary end point for phase II cancer clinical trials : application to mesothelioma--The EORTC Lung Cancer Group.. In: Journal of Clinical Oncology, Vol. 24, no. 19, p. 3007-12 (2006). doi:10.1200/JCO.2005.05.1359.
2006
Kramer, G.W.P.M. ; Legrand, Catherine ; van Schil, Paul ; Uitterhoeve, Lon ; Smit, Egbert F. ; Schramel, Franz ; Biesma, Bonne ; Tjan-Heijnen, Vivianne ; van Zandwijk, Nico ; Splinter, Ted ; Giaccone, Giuseppe ; van Meerbeeck, Jan P.. Quality assurance of thoracic radiotherapy in EORTC 08941: A randomised trial of surgery versus thoracic radiotherapy in patients with stage IIIA non-small-cell lung cancer (NSCLC) after response to induction chemotherapy. In: European Journal of Cancer, Vol. 42, no.10, p. 1391–1398 (July 2006). doi:10.1016/j.ejca.2006.01.052.
2006
Bottomley, Andrew ; Vincent, Marie-Françoise ; Gaafa, R ; Manegold, C. ; Burgers, S ; Coens, Corneel ; Legrand, Catherine ; Giaccone, Giuseppe ; van Meerbeeck, J.. Short-term treatment-related symptoms and quality of life: Results from an international randomized phase III study of cisplatin with or without raltitrexed in patients with malignant pleural mesothelioma: An EORTC Lung-Cancer Group and National Cancer Institute, Canada, Intergroup Study. In: Journal of Clinical Oncology, Vol. 24, no. 9, p. 1435-1442 (2006). doi:10.1200/JCO.2005.03.3027.
2005
Legrand, Catherine. 1687Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials : Early Breast Cancer Trialists' Collaborative Group (EBCTCG). In: The Lancet, Vol. 365, no. 9472, p. 1687-1717 (2005). doi:10.1016/S0140-6736(05)66544-0.
2005
Legrand, Catherine ; Ducrocq, V. ; Janssen, P. ; Sylvester, Richard J. ; Duchateau, L.. A Bayesian approach to jointly estimate centre and treatment by centre heterogeneity in a proportional hazards model. In: Statistics in Medicine, Vol. 24, no. 24, p. 3789-3804 (2005). doi:10.1002/sim.2475.
2005
Scagliotti, Giorgio V. ; Smit, Egbert ; Bosquee, Lionel ; O'Brien, Mary ; Ardizzoni, Andrea ; Zatloukaf, Peter ; Eberhardt, Wilfried ; Smid-Geirnaerdt, Maartje ; de Bruin, Hein G. ; Dussenne, Sonia ; Legrand, Catherine ; Giaccone, Giuseppe. A phase II study of paclitaxel in advanced bronchioloalveolar carcinoma (EORTC trial 08956). In: Lung Cancer, Vol. 50, no. 1, p. 91-96 (2005). doi:10.1016/j.lungcan.2005.05.012.
2005
Van Schil, P ; Van Meerbeeck, J ; Kramer, G ; Splinter, T ; Legrand, Catherine ; Giaccone, Giuseppe ; Manegold, C. ; van Zandwijk, N. Morbidity and mortality in the surgery arm of EORTC 08941 trial. In: The European Respiratory Journal, Vol. 26, no. 2, p. 192-197 (2005). doi:10.1183/09031936.05.00127204.
2005
Giaccone, Giuseppe ; Debruyne, Channa ; Felip, Enriqueta ; Chapman, Paul B. ; Grant, Stefan C. ; Millward, Michael ; Thiberville, Luc ; D'addario, Giannicola ; Coens, Corneel ; Rome, Lisa S. ; Zatloukal, Petr ; Masso, Oriol ; Legrand, Catherine. Phase III Study of Adjuvant Vaccination With Bec2/Bacille Calmette-Guerin in Responding Patients With Limited-Disease Small-Cell Lung Cancer (European Organisation for Research and Treatment of Cancer 08971-08971B; Silva Study). In: Journal of Clinical Oncology, Vol. 23, no. 28, p. 6854-6864 (2005). doi:10.1200/JCO.2005.17.186.
2005
van Meerbeeck, Jan P. ; Gaafar, Rabab ; Manegold, Christian ; Van Klaveren, Rob. J. ; Van Marck, Eric A. ; Vincent, Mark ; Legrand, Catherine ; Bottomley, Andrew ; Debruyne, Channa ; Giaccone, Giuseppe. Randomized Phase III Study of Cisplatin With or Without Raltitrexed in Patients With Malignant Pleural Mesothelioma : An Intergroup Study of the European Organisation for Research and Treatment of Cancer Lung Cancer Group and the National Cancer Institute of Canada. In: Journal of Clinical Oncology, Vol. 23, no. 28, p. 6881-6889 (2005). doi:10.1200/JCO.20005.14.589.
2004
Kramer, Gijsbert W.P.M. ; Gans, Steven ; Ullmann, Eric ; van Meerbeeck, Jan P. ; Legrand, Catherine ; Leer, Jan-Willem H. Hypofractionated external beam radiotherapy as retreatment for symptomatic non–small-cell lung carcinoma : an effective treatment ?. In: International Journal of Radiation: Oncology - Biology - Physics, Vol. 58, no. 5, p. 1388-1393 (2004). doi:10.1016/j.ijrobp.2003.09.087.
2004
van der Hage, JA ; van den Broek, LJCM ; Legrand, Catherine ; Clahsen, PC. ; Bosch, CJA ; Robanus-Maandag, EC ; van de Velde, CJH ; van de Vijver, MJ. Overexpression of P70 S6 kinase protein is associated with increased risk of locoregional recurrence in node-negative premenopausal early breast cancer patients. In: The British journal of cancer, Vol. 90, no. 8, p. 1543-1550 (2004). doi:10.1038/sj.bjc.6601741.
2003
O'Brien, M.E.R. ; Splinter, T. ; Smit, E.F. ; Biesma, Bonne ; Krzakowski, M. ; Tjan-Heijnen, V.c.G ; Van Bochove, A. ; Stigt, J. ; Smid-Geirnaerdt, M.J.A. ; Debruyne, C. ; Legrand, Catherine ; Giaccone, Giuseppe. Carboplatin and paclitaxol (Taxol) as an induction regimen for patients with biopsy-proven stage IIIA N2 non-small cell lung cancer : an EORTC phase II study (EORTC 08958). In: European Journal of Cancer, Vol. 39, no. 10, p. 1416-1422 (2003). doi:10.1016/S0959-8049(03)00319-8.
2003
Ardizzoni, A. ; Manegold, C. ; Debruyne, Channa ; Gaafar, R. ; Buchholz, E. ; Smit, E. F. ; Lianes, P. ; ten Velde, G. ; Bosquée, L. ; Legrand, Catherine ; Neumaier, C. ; King, K. ; Giaccone, Giuseppe. European Organization for Research and Treatment of Cancer (EORTC) 08957 phase II study of topotecan in combination with cisplatin as second-line treatment of refractory and sensitive small cell lung cancer. In: Clinical Cancer Research, Vol. 9, no. 1, p. 143-150 (2003).
2003
Dziadziuszko, R. ; Ardizzoni, A ; Postmus, P.E. ; Smit, E.F. ; Price, A ; Debruyne, C. ; Legrand, Catherine ; Giaccone, Giuseppe. Temozolomide in patients with advanced non-small cell lung cancer with and without brain metastases : a phase II study of the EORTC Lung Cancer Group (08965). In: European Journal of Cancer, Vol. 39, no. 9, p. 1271-1276 (2003). doi:10.1016/S0959-8049(03)00234-X.
2003
Baas, P. ; Ardizzoni, A. ; Grossi, F. ; Nackaerts, K. ; Numico, G. ; Van Marck, E. ; van de Vijver, M. ; Monetti, F. ; Smid-Geirnaerdt, M.J.A. ; van Zandwijk, N. ; Debruyne, C. ; Legrand, Catherine ; Giaccone, Giuseppe. The activity of raltitrexed (Tomudex®) in malignant pleural mesothelioma : an EORTC phase II study (08992). In: European Journal of Cancer, Vol. 39, no. 3, p. 353-357 (2003). doi:10.1016/S0959-8049(02)00668-8.
2003
Smit, Egbert, F. ; van Meerbeeck, Jan P.A.M. ; Lianes, Pilar ; Debruyne, Channa ; Legrand, Catherine ; Schramel, Franz ; Smit, Hans ; Gaafar, Rabab ; Biesma, Bonne ; Manegold, Chris ; Neymark, Niels ; Giaccone, Giuseppe. Three-Arm Randomized Study of Two Cisplatin-Based Regimens and Paclitaxel Plus Gemcitabine in Advanced Non–Small-Cell Lung Cancer : A Phase III Trial of the European Organization for Research and Treatment of Cancer Lung Cancer Group—EORTC 08975. In: Journal of Clinical Oncology, Vol. 21, no. 21, p. 3909-3917 (2003). doi:10.1200/JCO.2003.03.195..
2003
Fentiman, IS ; Christiaens, MR. ; Paridaens, Robert ; Van Geel, A ; Rutgers, E ; Berner, J ; de Keizer, G ; Wildiers, J ; Nagadowska, M ; Legrand, Catherine ; Therasse, Patrick. Treatment of operable breast cancer in the elderly: a randomised clinical trial EORTC 10851 comparing tamoxifen alone with modified radical mastectomy. In: European Journal of Cancer, Vol. 39, no. 3, p. 309-316 (2003). doi:10.1016/S0959-8049(02)00673-1.
2002
Theys, Serge ; Deltombe, Thierry ; Scavée, V. ; Legrand, Catherine ; Schoevaerdts, J.C.. Safety of long-term of retrograde-intermittent pneumatic compression in lower limb lymphoedema. In: Lymphology, Vol. 35, no.Suppl, p. 293-297 (2002).
2002
Ardizzoni, Andrea ; Tjan-Heijnen, Vivianne C. G. ; Postmus, Pieter E. ; Buchholz, Erica ; Biesma, Bonne ; Karnicka-Mlodkowska, Hanna ; Dziadziusko, Rafal ; Burghouts, Jos ; Van Meerbeeck, Jan P. ; Gans, Stevens ; Legrand, Catherine ; Debruynne, Channa ; Giaccone, Giuseppe. Standard Versus Intensified Chemotherapy With Granulocyte Colony-Stimulating Factor Support in Small-Cell Lung Cancer : A Prospective European Organization for Research and Treatment of Cancer–Lung Cancer Group Phase III Trial—08923. In: Journal of Clinical Oncology, Vol. 20, no. 19, p. 3947-3955 (2002). doi:10.1200/JCO.2002.02.069.
2002
Sylvester, R ; Van Glabbeke, M ; Collette, L ; Suciu, S ; Baron, B ; Legrand, Catherine ; Gorlia, T ; Collins, G ; Coens, C ; Declerck, L ; Therasse, P. Statistical methodology of phase III cancer clinical trials: advances and future perspectives. In: European Journal of Cancer, Vol. 38, p. 162-168 (2002). doi:10.1016/S0959-8049(01)00442-7.
2002
Duchateau, Luc ; Janssen, Paul ; Lindsey, Patrick ; Legrand, Catherine ; Nguti, Rosemary ; Sylvester, Richard J.. The shared frailty model and the power for heterogeneity tests in multicenter trials. In: Computational Statistics & Data Analysis, Vol. 40, no. 3, p. 603-620 (2002). doi:10.1016/S0167-9473(02)00057-9.
2002
Legrand, Catherine ; Sylvester, Richard J. ; Duchateau, L. ; Janssen, P. ; Therasse, Patrick. Treatment outcome studies: pitfalls in current methods and practice. In: European Journal of Cancer, Vol. 38, no. 9, p. 1173-1180 (2002). doi:10.1016/S0959-8049(02)00085-0.
2001
Baron, Benoit ; Legrand, Catherine ; Levi, F. ; Hoctin-Boes, G.. Chronomodulation: optimal time finding design. In: Controlled Clinical Trials, Vol. 22, no. suppl. 1, p. S59-S60 (2001). doi:10.1016/S0197-2456(01)00130-1.
2001
Van Der Hage, J.A. ; Robanus, E. ; van den Broeck, L.J.C.M. ; Bosch, C. ; van de Velde, C.J.H. ; Clahsen, P. ; Legrand, Catherine ; Duchateau, L. ; van de Vijver, M.J.. Prognostic significance of PS6K in node-negative premenopausal breast cancer patients. In: European Journal of Cancer, Vol. 37, no. suppl. 6, p. S269 (April 2001). doi:10.1016/S0959-8049(01)81485-4.
2001
Stallenberg, Bernard ; Rommens, Jacques ; Legrand, Catherine ; de Maertelaer, Viviane ; Metens, Thierry ; Genevois, Pierre Alain. Radiographic diagnosis of rotator cuff tear based on the supraspinatus muscle radiodensity. In: Skeletal Radiology : journal of radiology, pathology and orthopedics, Vol. 30, no. 1, p. 31-38 (2001). doi:10.1007/s002560000301.
2001
Tjan-Heijnen, V.C.G. ; Postmus, P.E. ; Ardizzoni, A. ; Manegold, Ch. ; Burghouts, J. ; van Meerbeeck, J. ; Mollers, M. ; Gans, S. ; Buchholz, E. ; Biesma, Bonne ; Legrand, Catherine ; Debruyne, C. ; Giaccone, Giuseppe. Reduction of chemotherapy-induced febrile leucopenia by prophylactic use of ciprofloxacin and roxithromycin in small-cell lung cancer patients : an EORTC double-blind placebo-controlled phase III study. In: Annals of Oncology, Vol. 12, no. 10, p. 1359-1368 (2001). doi:10.1023/A:1012545507920.
2000
Ardizzoni, A ; Manegold, C ; Debruyne, C ; Gaafar, R ; Buchholz, E ; Dussenne, S ; Legrand, Catherine ; King, K ; Giaccone, Giuseppe. EORTC LCCG Phase II study of topotecan in combination with cisplatin as second line chemotherapy of sensitive and refractory small cell lung cancer (SCLC). In: Lung Cancer, Vol. 29, no. suppl. 1, p. 51 (suppl. 2000). doi:10.1016/S0169-5002(00)80166-X.
2000
van Dongen, Joop A. ; Voogd, Adri C. ; Fentiman, Ian S. ; Legrand, Catherine ; Sylvester, Richard J. ; Tong, David ; van der Schueren, Emmanuel ; Helle, Peter A. ; van Zijl, Kobus ; Bartelink, Harry. Long-Term Results of a Randomized Trial Comparing Breast-Conserving Therapy With Mastectomy : European Organization for Research and Treatment of Cancer 10801 Trial. In: Journal of the National Cancer Institute, Vol. 92, no. 14, p. 1143-1150 (2000). doi:10.1093/jnci/92.14.1143.
2021
Legrand, Catherine. Advanced Survival Models, 1st ed. (Biostatistics Series), Chapman and Hall/CRC Press, 2021. 9780429054167. 360 p. doi:10.1201/9780429054167.
2009
Legrand, Catherine. Assessing Heterogeneity in Clinical Trials Using the Frailty Model : Quantifying, interpreting and explaining heterogeneity over centers in multicenter cancer clinical trials, VDM Verlag Dr. Müller e.K., 2009. 978-3-639-21334-8. 188 p.
2019
Legrand, Catherine ; Bertrand, Aurélie. Cure models in oncology clinical trials. In: Susan Halabi, Stefan Michiels, Textbook of Clinical Trials in Oncology : A Statistical Perspective (1st Edition), Chapman & Hall/CRC Press I Taylor & Francis Group, 2019, 465-492. 9781138083776.
2010
Gagliolo, M. ; Legrand, Catherine. Algorithm survival analysis. In: Thomas Bartz-Beielstein, Marco Chiarandini, Luís Paquete, Experimental Methods for the Analysis of Optimization Algorithms, Springer, 2010, p. 161-184. 978-3-642-02537-2.
2011
Fusaro, Fabio ; Benoît, Anne ; De Meyer, Martine ; De Pauw, Luc ; Patrono, D. ; Chaïb-Eddour, D. ; Goffin, Eric ; Kanaan, Nada ; Pirson, Yves ; Legrand, Catherine ; Mourad, Michel. Living donor kidney transplantation in a single center : 45 years’experience. American Society of Nefrology - Kidney Week ((United States) Philadelphia, PA, du 30/04/2011 au 04/05/2011). In: American Journal of Transplantation, Vol. 11, no. Suppl 2, p. 512 (2011).
2010
Hollevoet, K. ; Van Cleemput, J. ; Thimpont, J. ; De Vuyst, P. ; Bosquée, L. ; Nackaerts, Kristiaan ; Kishi, Y. ; Legrand, Catherine ; Delanghe, J. R. ; van Meerbeeck, J. P.. Follow-up of Asbestos-exposed Individuals Using Mesothelioma Serum Biomarkers. In: Journal of Thoracic Oncology : official scientific publication of the International Association for the Study of Lung Cancer, Vol. 5, no. 5, p. S106-S106 (2010).
2009
Hollevoet, K. ; Nackaerts, Kristiaan ; Thimpont, J. ; Germonpre, P. ; De Vuyst, P. ; Bosquée, L. ; Legrand, Catherine ; Yoshiro, K. ; Delanghe, J. ; van Meerbeeck, J.. Diagnostic performance of soluble mesothelin and megakaryocyte potentiating factor as biomarkers of mesothelioma. Annual Meeting of the EORTC/NCI/ASCO on Molecular Markers in Cancer (Brussels(Belgium), Oct 15-17, 2009). In: EJC - Supplements, Vol. 7, no. 4, p. 9 (2009).
2009
Gagliolo, M. ; Legrand, Catherine ; Birattari, M.. Mixed-effects modeling of optimisation algorithm performance. Engineering Stochastic Local Search Algorithms. Designing, Implementing and Analyzing Effective Heuristics. Second International Workshop, SLS 2009 (Brussels, Belgium, du 03/09/2008 au 04/09/2008). In: Engineering Stochastic Local Search Algorithms. Designing, Implementing and Analyzing Effective Heuristics. Second International Workshop, SLS 2009 (Lecture Notes in Computer Science; 5752), Springer verlag, 2009. 978-3-642-03750-4, p. 150-154.
2009
Hollevoet, Kevin ; Kellen, Eliane ; Nackaerts, Kristiaan ; Bosquee, Lionel ; Germonpre, Paul ; Delanghe, Joris ; Legrand, Catherine ; van Meerbeeck, Jan P.. Soluble mesothelin as a monitoring tool in the management of malignant mesothelioma patients. In: Journal of Thoracic Oncology : official scientific publication of the International Association for the Study of Lung Cancer, Vol. 4, no. 9, p. S761-S762 (2009). doi:10.1097/JTO.0b013e3181a1084f.
2009
Hollevoet, Kevin ; Van Cleemput, Joris ; Thimpont, Joel ; Vandeweerdt, Marc ; De Vuyst, Paul ; Nackaerts, Kristiaan ; Delanghe, Joris ; Legrand, Catherine ; van Meerbeeck, Jan P.. Soluble mesothelin as a tool for early detection of malignant mesothelioma in asbestos-exposed workers. In: Journal of Thoracic Oncology : official scientific publication of the International Association for the Study of Lung Cancer, Vol. 4, no. 9, p. S458-S458 (2009).
2009
Hollevoet, Kevin ; Kellen, Eliane ; Nackaerts, Kristiaan ; Thimpont, Joel ; Germonpre, Paul ; De Vuyst, Paul ; Bosquee, Lionel ; Delanghe, Joris ; Legrand, Catherine ; van Meerbeeck, Jan P.. Validation of soluble mesothelin: design and preliminary results of a Belgian multicentric observational study. In: Journal of Thoracic Oncology : official scientific publication of the International Association for the Study of Lung Cancer, Vol. 4, no. 9, p. S345-S345 (2009).
2003
Legrand, Catherine. Induction chemotherapy (CT) in stage IIIA-N2 non-small cell lung cancer (NSCLC): An analysis of different regimens used in EORTC 08941. 10th World Conference on Lung Cancer (Vancouver, Canada, du 10/08/2003 au 14/08/2003). In: Lung Cancer, Vol. 41, no. suppl. 2, p. S79-S80 (2003). doi:10.1016/S0169-5002(03)91931-3.
2003
Legrand, Catherine. Surgery after induction chemotherapy: Morbidity and mortality in the first 100 patients of the surgery arm of EORTC 08941 trial. 10th World Conference on Lung Cancer (Vancouver, Canada, du 10/08/2003 au 14/08/2003). In: Lung Cancer, Vol. 41, no. suppl. 2, p. S45 (2003). doi:10.1016/S0169-5002(03)91805-8.
2018
Denuit, Michel ; Legrand, Catherine ; Haine, Luc ; Segers, Johan. Rapport d'autoévaluation des cursus en mathématique, sciences actuarielles, statistique et biostatistique, 2018.
2024
Soetewey, Antoine ; Legrand, Catherine ; Denuit, Michel ; Silversmit, Geert. Health indices for disease incidence risk and duration in the Semi-Markov setting (LIDAM Discussion Paper ISBA; 2023/13), 2024. 26 p.
2023
Soetewey, Antoine ; Legrand, Catherine ; Denuit, Michel ; Silversmit, Geert. Right to be forgotten for mortgage insurance issued to cancer survivors: critical assessment and new proposal (LIDAM Discussion Paper ISBA; 2023/35), 2023. 28 p.
2017
Bertrand, Aurélie ; Van Keilegom, Ingrid ; Legrand, Catherine. Flexible parametric approach to classical measurement error variance estimation without auxiliary data (ISBA Discussion Paper; 2017/25), 2017. 28 p.
2016
Scolas, Sylvie ; Legrand, Catherine ; Oulhaj, Abderrahim ; El Ghouch, Anouar. Diagnostic checks in mixture cure models with interval-censoring (ISBA Discussion Paper; 2016/14), 2016. 27 p.
2016
Denuit, Michel ; Legrand, Catherine. Risk Classification in Life Insurance: Extension to Continuous Covariates (ISBA Discussion Paper; 2016/45), 2016. 6 p.
2016
Bertrand, Aurélie ; Legrand, Catherine ; Léonard, Daniel ; Van Keilegom, Ingrid. Robustness of estimation methods in a survival cure model with mismeasured covariates (ISBA Discussion Paper; 2016/06), 2016. 31 p.
2016
Scolas, Sylvie ; El Ghouch, Anouar ; Legrand, Catherine. The SNP representation in mixture cure models with interval-censoring: estimation and goodness-of-fit testing (ISBA Discussion Paper; 2016/49), 2016. 23 p.
2014
Bertrand, Aurélie ; Legrand, Catherine ; Carroll, Raymond J. ; de Meester de Ravenstein, Christophe ; Van Keilegom, Ingrid. Inference in a Survival Cure Model with Mismeasured Covariates using a SIMEX Approach (ISBA Discussion Paper; 2014/34), 2014. 30 p.
2014
Scolas, Sylvie ; El Ghouch, Anouar ; Legrand, Catherine ; Oulhaj, Abderrahim. Variable selection in a flexible parametric mixture cure model with interval-censored data (ISBA Discussion Paper; 2014/41), 2014. 25 p.
2013
Munda, Marco ; Legrand, Catherine. A diagnostic plot for guiding the choice of the frailty distribution in clustered survival data (ISBA Discussion Paper; 2013/37), 2013. 21 p.
2013
Munda, Marco ; Legrand, Catherine. Adjusting for centre differences in multicentre clinical trials: a simulation-based investigation for time-to-event outcomes (ISBA Discussion Paper; 2013/36), 2013. 21 p.
2013
Dewé, Walthère ; Benoît, Anne ; Legrand, Catherine. Assessing Vaccine Efficacy in Influenze Clinical Trials - Challenges and Difficulties (ISBA Discussion Paper; 2013/21), 2013. 20 p.
2013
Loeys, Tom ; Legrand, Catherine ; Schettino, Antonio. Semi-parametric proportional hazards models with crossed random effects for psychometric response times (ISBA Discussion Paper; 2013/42), 2013.
2013
Munda, Marco ; Legrand, Catherine ; Duchateau, Luc ; Janssen, Paul. Testing for Decreasing Heterogeneity Between Hospitals in Time to Death from Chronic Myeloid Leukemia (ISBA Discussion Paper; 2013/55), 2013. 20 p.
2012
Legrand, Catherine ; Munda, Marco ; Janssen, P. ; Duchateau, L.. A general class of time-varying coefficients models for right censored data (ISBA Discussion Paper; 2012/41), 2012. 41 p.
2012
Forget, P. ; Machiels, J-P. ; Coulie, Pierre G. ; Berlière, M. ; Poncelet, A. ; Tombal, P. ; Stainier, A. ; Legrand, Catherine ; Canon, J-L. ; Kremer, Y. ; De Kock, M.. Neutrophil: lymphocyte ratio and intraoperative use of ketorolac or diflofenac are prognostic factors in breast, lung and kidney cancer surgery (ISBA Discussion Paper; 2012/40), 2012.
2012
Munda, Marco ; Rotolo, Federico ; Legrand, Catherine. parfm: Parametric Frailty Models in R (ISBA Discussion Paper; 2012/05), 2012. 20 p.
2011
Heuchenne, Cédric ; Laurent, Stéphane ; Legrand, Catherine ; Van Keilegom, Ingrid. Likelihood based inference for semi-competing risks (ISBA Discussion Paper; 2011/22), 2011. 26 p.
2011
Rotolo, Federico ; Legrand, Catherine ; Van Keilegom, Ingrid. Simulation of clustered multi-state survival data based on a copula model (ISBA Discussion Paper; 2011/40), 2011. 20 p.
2010
Collée, A. ; Legrand, Catherine ; Govaerts, Bernadette ; Van der Veken, P. ; De Boodt, V. ; Degrave, E. Occupational exposure to noise and the prevalence of hearing loss in a Belgian military population : a cross-sectional study (ISBA Discussion Paper; 1004), 2010.
2010
Meyer, N. ; Legrand, Catherine ; Giaccone, Giuseppe. Samples sizes in oncology trials : a survey (ISBA Discussion Paper; 1005), 2010.
2009
Laurent, Stéphane ; Legrand, Catherine. A Bayesian framework for the ratio of two Poisson rates in the context of vaccine efficacy trials (STAT Discussion Paper; 0911), 2009. 26 p.
2009
Surmont, V. ; Aerts, J. ; Van Klaveren, R.J. ; Tournoy, K. ; Tan, K. ; Vernhout, R.M. ; Schmitz, P.I.M. ; Legrand, Catherine ; Hoogsteden, H.C. ; Van Meerbeeck, J.P.. A randomized phase II study comparing two schedules of the 21-day regime of Gemcitabine and Carboplatin in advanced NSCLC (STAT Discussion Paper; 0927), 2009.
2009
Hollevoet, K. ; Kellen, E. ; Thimpont, J. ; Germonpré, P. ; De Vuyst, P. ; Bosquée, L. ; Legrand, Catherine ; Kishi, Y. ; Nackaerts, K. ; Delanghe, J.R. ; Van Meerbeeck, J.P.. Diagnostic performance of soluble mesothelin and megakaryocyte potentiating factor as biomarkers of mesothelioma (STAT Discussion Paper; 0928), 2009.
2009
Meyer, Nicolas ; Legrand, Catherine ; Giaccone, Giuseppe. Sample size in randomized clinical trials in oncology: usefull basic statistical knowledge for the clinician (STAT Discussion Paper; 0929), 2009.