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Avenue Hippocrate 75/B1.75.02
1200 Woluwe-Saint-Lambert
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- Audrey Nedelec
Audrey Nedelec
Assistante de recherche
2023
Papadopoulos, Nicolas ; Pristavec, Ajda ; Nedelec, Audrey ; Levy, Gabriel ; Stärk, Judith ; Constantinescu, Stefan N.. Modulation of human thrombopoietin receptor conformations uncouples JAK2 V617F-driven activation from cytokine-induced stimulation.. In: Blood, Vol. 142, no. 21, p. 1818-1830 (2023). doi:10.1182/blood.2022019580.
2023
Papadopoulos, Nicolas ; Nedelec, Audrey ; Derenne, Allison ; Şulea, Teodor Asvadur ; Pecquet, Christian ; Chachoua, Ilyas ; Vertenoeil, Gaëlle ; Tilmant, Thomas ; Petrescu, Andrei-Jose ; Mazzucchelli, Gabriel ; Iorga, Bogdan I ; Vertommen, Didier ; Constantinescu, Stefan N.. Oncogenic CALR mutant C-terminus mediates dual binding to the thrombopoietin receptor triggering complex dimerization and activation.. In: Nature communications, Vol. 14, no.1, p. 1881 (2023). doi:10.1038/s41467-023-37277-3.
2023
Pecquet, Christian ; Papadopoulos, Nicolas (co-first author) ; Balligand, Thomas (co-first author) ; Chachoua, Ilyas (co-first author) ; Tisserand, Amandine (co-first author) ; Vertenoeil, Gaëlle ; Nedelec, Audrey ; Vertommen, Didier ; Roy, Anita ; Marty, Caroline ; Nivarthi, Harini ; Defour, Jean-Philippe ; El-Khoury, Mira ; Hug, Eva ; Xu, Erica ; Zagrijtschuk, Oleh ; Fertig, Emmanuel ; Marta, Daciana ; Gisslinger, Heinz ; Gisslinger, Bettina ; Schalling, Martin ; Casetti, Ilaria ; Rumi, Elisa ; Pietra, Daniela ; Cavalloni, Chiara ; Arcaini, Luca ; Cazzola, Mario ; Komatsu, Norio ; Kihara, Yoshihiko ; Sunami, Yoshitaka ; Edahiro, Yoko ; Araki, Marito ; Lesyk, Roman ; Buxhofer-Ausch, Veronika ; Heibl, Sonja ; Pasquier, Florence ; Havelange, Violaine ; Plo, Isabelle ; Vainchenker, William ; Kralovics, Robert ; Constantinescu, Stefan N.. Secreted Mutant Calreticulins As Rogue Cytokines in Myeloproliferative Neoplasms. In: Secreted Mutant Calreticulins As Rogue Cytokines in Myeloproliferative Neoplasms, Vol. 141, no. 8, p. 917-929 (2023).
2022
Nedelec, Audrey ; Guérit, Emilie ; Dachy, Guillaume ; Lenglez, Sandrine ; Wong, Lok San ; Arts, Florence ; Demoulin, Jean-Baptiste. Penttinen syndrome-associated PDGFRB Val665Ala variant causes aberrant constitutive STAT1 signalling.. In: Journal of cellular and molecular medicine, Vol. 26, no.99, p. 99 (2022). doi:10.1111/jcmm.17427.
2021
Jia, Ruochen ; Balligand, Thomas ; Atamanyuk, Vasyl ; Nivarthi, Harini ; Xu, Erica ; Kutzner, Leon ; Weinzierl, Jakob ; Nedelec, Audrey ; Kubicek, Stefan ; Lesyk, Roman ; Zagrijtschuk, Oleh ; Constantinescu, Stefan N. ; Kralovics, Robert. Hematoxylin binds to mutant calreticulin and disrupts its abnormal interaction with thrombopoietin receptor.. In: Blood, Vol. 137, no. 14, p. 1920-1931 (2021). doi:10.1182/blood.2020006264.
2020
Benlabiod, Camélia ; Cacemiro, Maira da Costa ; Nedelec, Audrey ; Edmond, Valérie ; Muller, Delphine ; Rameau, Philippe ; Touchard, Laure ; Gonin, Patrick ; Constantinescu, Stefan N. ; Raslova, Hana ; Villeval, Jean-Luc ; Vainchenker, William ; Plo, Isabelle ; Marty, Caroline. Calreticulin del52 and ins5 knock-in mice recapitulate different myeloproliferative phenotypes observed in patients with MPN.. In: Nature communications, Vol. 11, no. 1, p. 4886 [1-15] (2020). doi:10.1038/s41467-020-18691-3.
2019
Bollaert, Emeline ; Nedelec, Audrey ; Demoulin, Jean-Baptiste. The HMG box transcription factor HBP1: a cell cycle inhibitor at the crossroads of cancer signaling pathways.. In: Cellular and molecular life sciences : CMLS, Vol. 76, no.8, p. 1529-1539 (2019). doi:10.1007/s00018-019-03012-9 (Soumis).
2018
Bollaert, Emeline ; Johanns, Manuel ; Herinckx, Gaëtan ; Nedelec, Audrey ; Vandewalle, Virginie A ; Havelange, Violaine ; Rider, Mark H ; Vertommen, Didier ; Demoulin, Jean-Baptiste. HBP1 phosphorylation by AKT regulates its transcriptional activity and glioblastoma cell proliferation.. In: Cellular signalling, Vol. 44, p. 158-170 (2018). doi:10.1016/j.cellsig.2018.01.014 (Soumis).
2018
Beaumont, Martin ; Neyrinck, Audrey M ; Olivares, Marta ; Rodriguez, Julie ; Nedelec, Audrey ; Roumain, Martin ; Bindels, Laure B ; Cani, Patrice D ; Evenepoel, Pieter ; Muccioli, Giulio G ; Demoulin, Jean-Baptiste ; Delzenne, Nathalie M. The gut microbiota metabolite indole alleviates liver inflammation in mice.. In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 32, no.12, p. fj201800544 (2018). doi:10.1096/fj.201800544 (Soumis).
2018
Beaumont, Martin ; Neyrinck, Audrey M ; Olivares, Marta ; Rodriguez, Julie ; Nedelec, Audrey ; Roumain, Martin ; Bindels, Laure B ; Cani, Patrice D ; Evenepoel, Pieter ; Muccioli, Giulio G ; Demoulin, Jean-Baptiste ; Delzenne, Nathalie M. The gut microbiota metabolite indole alleviates liver inflammation in mice.. In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 32, no.12, p. fj201800544 (2018). doi:10.1096/fj.201800544 (Soumis).
2017
Coomans de Brachène, Alexandra ; Dif, Nicolas ; Nedelec, Audrey ; Bonnineau, Chloé ; Velghe, Amélie I ; Larondelle, Yvan ; Tyteca, Donatienne ; Demoulin, Jean-Baptiste. PDGF-induced fibroblast growth requires monounsaturated fatty acid production by stearoyl-CoA desaturase.. In: FEBS open bio, Vol. 7, no.3, p. 414-423 (2017). doi:10.1002/2211-5463.12194 (Soumis).
2017
Arts, Florence A ; Sciot, Raf ; Brichard, Bénédicte ; Renard, Marleen ; Nedelec, Audrey ; Dachy, Guillaume ; Noël, Laura A ; Velghe, Amélie I ; Galant, Christine ; Debiec-Rychter, Maria ; Van Damme, An ; Vikkula, Miikka ; Helaers, Raphaël ; Limaye, Nisha ; Poirel, Hélène A ; Demoulin, Jean-Baptiste. PDGFRB gain-of-function mutations in sporadic infantile myofibromatosis.. In: Human molecular genetics, Vol. 26, no.10, p. 1801-1810 (2017). doi:10.1093/hmg/ddx081 (Soumis).
2015
Tajan, Mylène ; Nedelec, Audrey ; Valet, Philippe ; Edouard, Thomas ; Yart, Armelle. SHP2 sails from physiology to pathology.. In: European journal of medical genetics, Vol. 58, no.10, p. 509-25 (2015). doi:10.1016/j.ejmg.2015.08.005 (Soumis).
2014
Tajan, Mylène ; Batut, Aurélie ; Cadoudal, Thomas ; Deleruyelle, Simon ; Le Gonidec, Sophie ; Saint Laurent, Céline ; Vomscheid, Maëlle ; Wanecq, Estelle ; Tréguer, Karine ; Nedelec, Audrey ; Vinel, Claire ; Marques, Marie-Adeline ; Pozzo, Joffrey ; Kunduzova, Oksana ; Salles, Jean-Pierre ; Tauber, Maithé ; Raynal, Patrick ; Cavé, Hélène ; Edouard, Thomas ; Valet, Philippe ; Yart, Armelle. LEOPARD syndrome-associated SHP2 mutation confers leanness and protection from diet-induced obesity.. In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, no.42, p. E4494-503 (2014). doi:10.1073/pnas.1406107111 (Soumis).
2014
Coomans de Brachène, Alexandra ; Bollaert, Emeline ; Eijkelenboom, Astrid ; Nedelec, Audrey ; van der Vos, Kristan E ; Burgering, Boudewijn M T ; Coffer, Paul J ; Essaghir, Ahmed ; Demoulin, Jean-Baptiste. The expression of the tumour suppressor HBP1 is down-regulated by growth factors via the PI3K/PKB/FOXO pathway.. In: The Biochemical journal, Vol. 460, no.1, p. 25-34 (2014). doi:10.1042/BJ20131467 (Soumis).
2012
Nedelec, Audrey ; Edouard, Thomas ; Tréguer, Karine ; Tajan, Mylène ; Araki, Toshiyuki ; Dance, Marie ; Mus, Marianne ; Montagner, Alexandra ; Tauber, Maïté ; Salles, Jean-Pierre ; Valet, Philippe ; Neel, Benjamin G ; Raynal, Patrick ; Yart, Armelle. Noonan syndrome-causing SHP2 mutants inhibit insulin-like growth factor 1 release via growth hormone-induced ERK hyperactivation, which contributes to short stature.. In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, no.11, p. 4257-62 (2012). doi:10.1073/pnas.1119803109 (Soumis).
2010
Edouard, Thomas ; Combier, Jean-Philippe ; Nedelec, Audrey ; Bel-Vialar, Sophie ; Métrich, Mélanie ; Conte-Auriol, Francoise ; Lyonnet, Stanislas ; Parfait, Béatrice ; Tauber, Maithé ; Salles, Jean-Pierre ; Lezoualc'h, Frank ; Yart, Armelle ; Raynal, Patrick. Functional effects of PTPN11 (SHP2) mutations causing LEOPARD syndrome on epidermal growth factor-induced phosphoinositide 3-kinase/AKT/glycogen synthase kinase 3beta signaling.. In: Molecular and cellular biology, Vol. 30, no.10, p. 2498-507 (2010). doi:10.1128/MCB.00646-09 (Soumis).
2023
Constantinescu, Stefan N. ; Nedelec, Audrey ; Papadopoulos, Nicolas. Soluble Thrombopoietin Receptor Fragments and Uses Thereof . Numéro de priorité ; Déposé (31/03/2023) ; Publié (31/03/2023). Belgium Belgium.
2023
Constantinescu, Stefan N. ; Nedelec, Audrey ; Papadopoulos, Nicolas. THROMBOPOIETIN RECEPTOR FRAGMENTS AND USES THEREOF. Numéro de priorité ; Déposé (31/03/2023) ; Publié (31/03/2023). Belgium Belgium.