MEMI
Avenue Hippocrate 74/B1.74.11
1200 Woluwe-Saint-Lambert
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- Répertoire
- Nick van Gastel
Nick van Gastel
Chercheur qualifié FNRS
Professeur
- Diplômes
Année Label Institution 2004 (informations manquantes) Rijksuniversitaire Centrum Antwerpen 2004 Bio-ingénieur Universitaire Instelling Antwerpen 2007 Biochimie et biologie moléculaire et cellulaire Rijksuniversiteit Gent 2007 Master bioingénieur: biotechnologie cellulaire et génétique Rijksuniversiteit Gent 2013 Docteur en Biochimie et biologie moléculaire et cellulaire Katholieke Universiteit Leuven 2013 Doctor of Biomedical Sciences Katholieke Universiteit Leuven
2024
Bonora, Massimo ; Morganti, Claudia (co-first author) ; van Gastel, Nick (co-first author) ; Ito, Kyoko ; Calura, Enrica ; Zanolla, Ilaria ; Ferroni, Letizia ; Zhang, Yang ; Jung, Yookyung ; Sales, Gabriele ; Martini, Paolo ; Nakamura, Takahisa ; Lasorsa, Francesco Massimo ; Finkel, Toren ; Lin, Charles P. ; Zavan, Barbara ; Pinton, Paolo ; Georgakoudi, Irene ; Romualdi, Chiara ; Scadden, David T. ; Ito, Keisuke. A mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate. In: Cell Stem Cell, Vol. 31, no. 3, p. 359-377 (2024).
2024
Nielsen, Célina ; Liu, Youzhong ; Leguay, Fleur ; Tirado Cardenas, Hernan Andres ; Dauguet, Nicolas ; van Gastel, Nick. Optimization of pre-enrichment strategies for mouse hematopoietic stem cell isolation and metabolomic analysis.. In: Experimental hematology, , p. 104588 (2024). doi:10.1016/j.exphem.2024.104588 (Accepté/Sous presse).
2023
Tirado Cardenas, Hernan ; Balasundaram, Nithya ; Laaouimir, Lotfi ; Erdem, Aysegül ; van Gastel, Nick. Metabolic crosstalk between stromal and malignant cells in the bone marrow niche. In: Bone Reports, Vol. 18, p. 101669 (2023). doi:10.1016/j.bonr.2023.101669 (Accepté/Sous presse).
2022
Sohn, Jihee ; Milosevic, Jelena ; Brouse, Thomas ; Aziz, Najihah ; Elkhoury, Jenna ; Wang, Suya ; Hauschild, Alexander ; van Gastel, Nick ; Cetinbas, Murat ; Tufa, Sara F ; Keene, Douglas R ; Sadreyev, Ruslan ; Pu, William T ; Sykes, David Brian. A new murine model of Barth Syndrome neutropenia links TAFAZZIN deficiency to increased ER stress induced apoptosis.. In: Blood advances, Vol. 6, no. 8, p. 2557-2577 (2022). doi:10.1182/bloodadvances.2021005720.
2022
Tournaire, Guillaume ; Loopmans, Shauni ; Stegen, Steve ; Rinaldi, Gianmarco ; Eelen, Guy ; Torrekens, Sophie ; Moermans, Karen ; Carmeliet, Peter ; Ghesquière, Bart ; Thienpont, Bernard ; Fendt, Sarah-Maria ; van Gastel, Nick ; Carmeliet, Geert. Skeletal progenitors preserve proliferation and self-renewal upon inhibition of mitochondrial respiration by rerouting the TCA cycle.. In: Cell reports, Vol. 40, no. 4, p. 111105 [1-24] (2022). doi:10.1016/j.celrep.2022.111105.
2021
van Gastel, Nick ; Spinelli, Jessica B ; Haigis, Marcia C ; Scadden, David T. Analysis of Leukemia Cell Metabolism through Stable Isotope Tracing in Mice.. In: Bio-protocol, Vol. 11, no.19, p. e4171 (2021). doi:10.21769/BioProtoc.4171.
2021
van Gastel, Nick. De rol van metabole regulering in het fuctioneren van de skeletcel. In: Ortho-rheumato, Vol. 19, no. 3, p. 7-11 (2021).
2021
Oki, Toshihiko ; Mercier, Francois ; Kato, Hiroki ; Jung, Yookyung ; McDonald, Thomas O. ; Spencer, Joel A. ; Mazzola, Michael C. ; van Gastel, Nick ; Lin, Charles P. ; Michor, Franziska ; Kitamura, Toshio ; Scadden, David T.. Imaging dynamic mTORC1 pathway activity in vivo reveals marked shifts that support time-specific inhibitor therapy in AML. In: Nature Communications, Vol. 12, no.1, p. 245 (2021). doi:10.1038/s41467-020-20491-8.
2021
van Gastel, Nick. Le rôle de la régulation métabolique dans le fonctionnement des cellules du squelette. In: Ortho-rhumato, Vol. 19, no. 3, p. 7-11 (2021).
2021
Wang, Yi-Ping ; Sharda, Azeem ; Xu, Shuang-Nian ; van Gastel, Nick ; Man, Cheuk Him ; Choi, Una ; Leong, Wei Zhong ; Li, Xi ; Scadden, David T.. Malic enzyme 2 connects the Krebs cycle intermediate fumarate to mitochondrial biogenesis. In: Cell Metabolism, Vol. 33, no.5, p. 1027-1041.e8 (2021). doi:10.1016/j.cmet.2021.03.003.
2021
Daniels, Veerle W. ; Zoeller, Jason J. ; van Gastel, Nick ; McQueeney, Kelley E. ; Parvin, Salma ; Potter, Danielle S. ; Fell, Geoffrey G. ; Ferreira, Vinícius G. ; Yilma, Binyam ; Gupta, Rajat ; Spetz, Johan ; Bhola, Patrick D. ; Endress, Jennifer E. ; Harris, Isaac S. ; Carrilho, Emanuel ; Sarosiek, Kristopher A. ; Scadden, David T. ; Brugge, Joan S. ; Letai, Anthony. Metabolic perturbations sensitize triple-negative breast cancers to apoptosis induced by BH3 mimetics. In: Science Signaling, Vol. 14, no.686, p. eabc7405 (2021). doi:10.1126/scisignal.abc7405.
2021
van Gastel, Nick ; Carmeliet, Geert. Metabolic regulation of skeletal cell fate and function in physiology and disease. In: Nature Metabolism, Vol. 3, no.1, p. 11-20 (2021). doi:10.1038/s42255-020-00321-3.
2021
van Gastel, Nick ; Scadden, David T.. Young haematopoietic stem cells are picky eaters. In: Cell Research, Vol. 31, no.4, p. 377-378 (2021). doi:10.1038/s41422-021-00488-8.
2020
Yusuf, Rushdia Z. ; Saez, Borja ; Sharda, Azeem ; van Gastel, Nick ; Yu, Vionnie W.C. ; Baryawno, Ninib ; Scadden, Elizabeth W. ; Acharya, Sanket ; Chattophadhyay, Shrikanta ; Huang, Cherrie ; Viswanathan, Vasanthi ; S'aulis, Dana ; Cobert, Julien ; Sykes, David B. ; Keibler, Mark A. ; Das, Sudeshna ; Hutchinson, John N. ; Churchill, Michael ; Mukherjee, Siddhartha ; Lee, Dongjun ; Mercier, Francois ; Doench, John ; Bullinger, Lars ; Logan, David J. ; Schreiber, Stuart ; Stephanopoulos, Gregory ; Rizzo, William B. ; Scadden, David T.. Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers. In: Blood, Vol. 136, no.11, p. 1303-1316 (2020). doi:10.1182/blood.2019001808.
2020
Burberry, Aaron ; Wells, Michael F. ; Limone, Francesco ; Couto, Alexander ; Smith, Kevin S. ; Keaney, James ; Gillet, Gaëlle ; van Gastel, Nick ; Wang, Jin-Yuan ; Pietilainen, Olli ; Qian, Menglu ; Eggan, Pierce ; Cantrell, Christopher ; Mok, Joanie ; Kadiu, Irena ; Scadden, David T. ; Eggan, Kevin. C9orf72 suppresses systemic and neural inflammation induced by gut bacteria. In: Nature, Vol. 582, no.7810, p. 89-94 (2020). doi:10.1038/s41586-020-2288-7.
2020
van Gastel, Nick ; Spinelli, Jessica B. ; Sharda, Azeem ; Schajnovitz, Amir ; Baryawno, Ninib ; Rhee, Catherine ; Oki, Toshihiko ; Grace, Eliane ; Soled, Heather J. ; Milosevic, Jelena ; Sykes, David B. ; Hsu, Peggy P. ; Vander Heiden, Matthew G. ; Vidoudez, Charles ; Trauger, Sunia A. ; Haigis, Marcia C. ; Scadden, David T.. Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance. In: Cell Metabolism, Vol. 32, no.3, p. 391-403.e6 (2020). doi:10.1016/j.cmet.2020.07.009.
2020
van Gastel, Nick ; Stegen, Steve ; Eelen, Guy ; Schoors, Sandra ; Carlier, Aurélie ; Daniëls, Veerle W. ; Baryawno, Ninib ; Przybylski, Dariusz ; Depypere, Maarten ; Stiers, Pieter-Jan ; Lambrechts, Dennis ; Van Looveren, Riet ; Torrekens, Sophie ; Sharda, Azeem ; Agostinis, Patrizia ; Lambrechts, Diether ; Maes, Frederik ; Swinnen, Johan V. ; Geris, Liesbet ; Van Oosterwyck, Hans ; Thienpont, Bernard ; Carmeliet, Peter ; Scadden, David T. ; Carmeliet, Geert. Lipid availability determines fate of skeletal progenitor cells via SOX9. In: Nature, Vol. 579, no.7797, p. 111-117 (2020). doi:10.1038/s41586-020-2050-1.
2020
Tournaire, Guillaume ; Stegen, Steve ; Giacomini, Greta ; Stockmans, Ingrid ; Moermans, Karen ; Carmeliet, Geert ; van Gastel, Nick. Nestin-GFP transgene labels skeletal progenitors in the periosteum. In: Bone, Vol. 133, no.1, p. 115259 (2020). doi:10.1016/j.bone.2020.115259.
2019
Stiers, Pieter-Jan ; Stegen, Steve ; van Gastel, Nick ; Van Looveren, Riet ; Torrekens, Sophie ; Carmeliet, Geert. Inhibition of the Oxygen Sensor PHD2 Enhances Tissue-Engineered Endochondral Bone Formation.. In: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 34, no.2, p. 333-348 (2019). doi:10.1002/jbmr.3599.
2018
Stiers, Pieter-Jan ; van Gastel, Nick ; Moermans, Karen ; Stockmans, Ingrid ; Carmeliet, Geert. An Ectopic Imaging Window for Intravital Imaging of Engineered Bone Tissue. In: JBMR Plus, Vol. 2, no.2, p. 92-102 (2018). doi:10.1002/jbm4.10028.
2018
Chai, Yoke Chin ; Freitas Mendes, Luis ; van Gastel, Nick ; Carmeliet, Geert ; Luyten, Frank P.. Fine-tuning pro-angiogenic effects of cobalt for simultaneous enhancement of vascular endothelial growth factor secretion and implant neovascularization. In: Acta Biomaterialia, Vol. 72, no.1, p. 447-460 (2018). doi:10.1016/j.actbio.2018.03.048.
2018
Kerckhofs, Greet ; Stegen, Steve ; van Gastel, Nick ; Sap, Annelies ; Falgayrac, Guillaume ; Penel, Guillaume ; Durand, Marjorie ; Luyten, Frank ; Geris, Liesbet ; Vandamme, Katleen ; Parac-Vogt, Tatjana ; Carmeliet, Geert. Simultaneous three-dimensional visualization of mineralized and soft skeletal tissues by a novel microCT contrast agent with polyoxometalate structure. In: Biomaterials, Vol. 159, no.-, p. 1-12 (2018). doi:10.1016/j.biomaterials.2017.12.016.
2017
Stiers, Pieter-Jan ; van Gastel, Nick ; Moermans, Karen ; Stockmans, Ingrid ; Carmeliet, Geert. Regulatory elements driving the expression of skeletal lineage reporters differ during bone development and adulthood. In: Bone, Vol. 105, no.1, p. 154-162 (2017). doi:10.1016/j.bone.2017.08.029.
2016
Stegen, Steve ; van Gastel, Nick ; Eelen, Guy ; Ghesquière, Bart ; D'Anna, Flora ; Thienpont, Bernard ; Goveia, Jermaine ; Torrekens, Sophie ; Van Looveren, Riet ; Luyten, Frank P ; Maxwell, Patrick H ; Wielockx, Ben ; Lambrechts, Diether ; Fendt, Sarah-Maria ; Carmeliet, Peter ; Carmeliet, Geert. HIF-1α promotes glutamine-mediated redox homeostasis and glycogen-dependent bioenergetics to support postimplantation bone cell survival. In: Cell Metabolism, Vol. 23, no.2, p. 265-279 (2016). doi:10.1016/j.cmet.2016.01.002.
2016
Dauwe, Dieter ; Pelacho, Beatriz ; Wibowo, Arief ; Walravens, Ann-Sophie ; Verdonck, Kristoff ; Gillijns, Hilde ; Caluwe, Ellen ; Pokreisz, Peter ; van Gastel, Nick ; Carmeliet, Geert ; Depypere, Maarten ; Maes, Frederik ; Van den Driessche, Nina ; Droogne, Walter ; van Cleemput, Johan ; Vanhaecke, Johan ; Prosper, Felipe ; Verfaillie, Catherine ; Luttun, Aernout ; Janssens, Stefan. Neovascularization potential of blood outgrowth endothelial cells from patients with stable ischemic heart failure is preserved. In: Journal of the American Heart Association, Vol. 5, no.4, p. e002288 (2016). doi:10.1161/JAHA.115.002288.
2016
Stiers, Pieter-Jan ; van Gastel, Nick ; Carmeliet, Geert. Targeting the hypoxic response in bone tissue engineering: A balance between supply and consumption to improve bone regeneration. In: Molecular and Cellular Endocrinology, Vol. 432, no.1, p. 96-105 (2016). doi:10.1016/j.mce.2015.12.024.
2015
Stegen, Steve ; van Gastel, Nick ; Carmeliet, Geert. Bringing new life to damaged bone: The importance of angiogenesis in bone repair and regeneration. In: Bone, Vol. 70, no.1, p. 19-27 (2015). doi:10.1016/j.bone.2014.09.017.
2015
Vandersmissen, Ine ; Craps, Sander ; Depypere, Maarten ; Coppiello, Giulia ; van Gastel, Nick ; Maes, Frederik ; Carmeliet, Gerrt ; Schrooten, Jan ; Jones, Elizabeth A.V. ; Umans, Lieve ; Devlieger, Roland ; Koole, Michel ; Gheysens, Olivier ; Zwijsen, An ; Aranguren, Xabier L. ; Luttun, Aernout. Endothelial Msx1 transduces hemodynamic changes into an arteriogenic remodeling response. In: Journal of Cell Biology, Vol. 210, no.7, p. 1239-1256 (2015). doi:10.1083/jcb.201502003.
2015
Manesia, Javed K ; Xu, Zhuofei ; Broekaert, Dorien ; Boon, Ruben ; van Vliet, Alex ; Eelen, Guy ; Vanwelden, Thomas ; Stegen, Steve ; van Gastel, Nick ; Pascual-Montano, Alberto ; Fendt, Sarah-Maria ; Carmeliet, Geert ; Carmeliet, Peter ; Khurana, Satish ; Verfaillie, Catherine M.. Highly proliferative primitive fetal liver hematopoietic stem cells are fueled by oxidative metabolic pathways.. In: Stem cell research, Vol. 15, no.3, p. 715-721 (2015). doi:10.1016/j.scr.2015.11.001.
2015
Carlier, Aurélie ; Geris, Liesbet ; van Gastel, Nick ; Carmeliet, Geert ; Van Oosterwyck, Hans. Oxygen as a critical determinant of bone fracture healing-a multiscale model.. In: Journal of theoretical biology, Vol. 365, no.1, p. 247-64 (2015). doi:10.1016/j.jtbi.2014.10.012.
2015
Raymaekers, Koen ; Stegen, Steve ; van Gastel, Nick ; Carmeliet, Geert. The vasculature: a vessel for bone metastasis.. In: BoneKEy reports, Vol. 4, no.1, p. 742 (2015). doi:10.1038/bonekey.2015.111.
2015
Roberts, Scott J. ; van Gastel, Nick (co-first author) ; Carmeliet, Geert ; Luyten, Frank P.. Uncovering the periosteum for skeletal regeneration: The stem cell that lies beneath. In: Bone, Vol. 70, no.1, p. 10-18 (2015). doi:10.1016/j.bone.2014.08.007.
2014
van Gastel, Nick ; Stegen, Steve ; Stockmans, Ingrid ; Moermans, Karen ; Schrooten, Jan ; Graf, Daniel ; Luyten, Frank P. ; Carmeliet, Geert. Expansion of murine periosteal progenitor cells with fibroblast growth factor 2 reveals an intrinsic endochondral ossification program mediated by bone morphogenetic protein 2. In: Stem Cells, Vol. 32, no.9, p. 2407-2418 (2014). doi:10.1002/stem.1783.
2014
Carlier, Aurélie ; van Gastel, Nick ; Geris, Liesbet ; Carmeliet, Geert ; Van Oosterwyck, Hans. Size Does Matter: An Integrative In Vivo-In Silico Approach for the Treatment of Critical Size Bone Defects. In: PLoS Computational Biology, Vol. 10, no.11, p. e1003888 (2014). doi:10.1371/journal.pcbi.1003888.
2021
Van Gastel, Nick. You are what you eat: modulating metabolism to direct stem cell fate. 6th TERMIS World Congress (Maastricht, The Netherlands, du 15/11/2021 au 19/11/2021).
2017
Van Gastel, Nick ; Chea, Philip L. ; Keibler, Mark A. ; Vidoudez, Charles ; Trayger, Sunia A. ; Stephanopoulos, Gregory ; Scadden, David T.. Combinatorial metabolic compound screening reveals differential metabolic plasticity between normal hematopoietic stem/progenitor cells and AML cells. Harvard Stem Cell Institute Malkin Retreat 2017 (Cambridge, MA, USA, 15/05/2017).
2017
Kerckhofs, Greet ; Stegen, Steve ; Van Gastel, Nick ; Sap, Annelies ; Falgayrac, Guilaume ; Penel, Guillaume ; Durand, Marjorie ; Luyten, Frank ; Geris, Liesbet ; Vandamme, Katleen ; Parac-Vogt, Tatjana ; Carmeliet, Geert. Novel Micro-CT contrast agent for quantitative virtual 3D histology of mineralized and soft skeletal tissues. Congres of the European Society of Biomechanics (ESB) 2017 (Seville, Spain, 2-6 July 2017) (Soumis).
2017
Kerckhofs, Greet ; Stegen, Steve ; Van Gastel, Nick ; Sap, Annelies ; Falgayrac, Guillaume ; Penel, Guillaume ; Durand, Marjorie ; Luyten, Frank ; Geris, Liesbet ; Vandamme, Katleen ; Parac-Vogt, Tatjana ; Carmeliet, Geert. Novel non-invasive micro-CT contrast agent for quantitative virtual 3D histology of mineralized and soft skeletal tissues. IEEE International Symposium on Biomedical Imaging (Melbourne, Australia, 18-21 April 2017).
2017
Kerckhofs, Greet ; Stegen, Steve ; Van Gastel, Nick ; Sap, Annelies ; Falgayrac, Guillaume ; Penel, Guillaume ; Durand, Marjorie ; Luyten, Frank ; Geris, Liesbet ; Vandamme, Katleen ; Parac-Vogt, Tatjana ; Carmeliet, Geert. Novel non-invasive micro-CT contrast agent for quantitative virtual 3D histology of mineralized and soft skeletal tissues. ISBI 2017 (Melbourne, 21 April 2017).
2016
Kerckhofs, Greet ; Sap, Annelies ; Van Gastel, Nick ; Kvasnytsia, Maryna ; Vandamme, Katleen ; Carmeliet, Geert ; Geris, Liesbet ; Parac-Vogt, Tatjana ; Luyten, Frank. Novel non-invasive contrast agents for virtual histology and 3D quantification of soft tissues. User Meeting Bruker MicroCT (Mondorf, Luxemburg, 9-12 May 2016).
2016
Kerckhofs, Greet ; Van Gastel, Nick ; Sap, Annelies ; Durand, Marjorie ; Vangoitsenhoven, Roman ; Van Der Schueren, Bart ; Parac-Vogt, Tatjana ; Luyten, Frank ; Geris, Liesbet ; Carmeliet, Geert ; Vandamme, Katleen. Simultaneous 3D visualization and quantification of the bone marrow adiposity and vascularity using novel contrast agents for contrast-enhanced computed tomography. International Bone and Mineral Society (IBMS2016) (Brugge, Belgium, 28 February - 1 March 2016).
2015
Kerckhofs, Greet ; Sap, Annelies ; Van Gastel, Nick ; Durand, Marjorie ; Vangoitsenhoven, Roman ; Van Der Schueren, Bart ; Vandamme, Katleen ; Carmeliet, Geert ; Parac-Vogt, Tatjana ; Luyten, Frank ; Geris, Liesbet. Novel contrast agents for contrast-enhanced CT to visualize in 3D the blood vessel network and fat cell distribution in bone marrow. TERMIS World Congress (Boston, USA, 8-11 September 2015).
2015
Kerckhofs, Greet ; Sap, Annelies ; Plougonven, Erwan ; Van Gastel, Nick ; Durand, Marjorie ; Vangoitsenhoven, Roman ; Van Der Schueren, Bart ; Léonard, Angélique ; Vandamme, Katleen ; Carmeliet, Geert ; Parac-Vogt, Tatjana ; Luyten, Frank ; Geris, Liesbet. Novel contrast agents for contrast-enhanced CT to visualize in 3D the blood vessel network and fat cell distribution in bone marrow. Belgian Symposium on Tissue Engineering (BSTE) (Leuven, 19-20 March 2015).
2015
Kerckhofs, Greet ; Sap, Annelies ; Plougonven, Erwan ; Van Gastel, Nick ; Durand, Marjorie ; Vangoitsenhoven, Roman ; Van Der Schueren, Bart ; Léonard, Angélique ; Vandamme, Katleen ; Carmeliet, Geert ; Parac-Vogt, Tatjana ; Luyten, Frank ; Geris, Liesbet. Novel contrast agents for contrast-enhanced CT to visualize in 3D the blood vessel network and fat cell distribution in bone marrow. User Meeting Bruker MicroCT (Brugge, 4-7 May 2015).
2015
Kerckhofs, Greet ; Durand, Marjorie ; Van Gastel, Nick ; Carmeliet, Geert ; Vandamme, Katleen. Novel contrast agents for contrast-enhanced CT to visualize in 3D the blood vessel network and fat cell distribution in bone marrow. First European Meeting on Bone Marrow Adiposity (BMA) 2015 (Lille, France, 28-29 August 2015).
2015
Kerckhofs, Greet ; Sap, Annelies ; Van Gastel, Nick ; Durand, Marjorie ; Vangoitsenhoven, Roman ; Van Der Schueren, Bart ; Vandamme, Katleen ; Carmeliet, Geert ; Parac-Vogt, Tatjana ; Luyten, Frank ; Geris, Liesbet. Novel contrast agents for contrast-enhanced computed tomography that allow 3D visualization of the blood vessel network and fat cell distribution in bone marrow. International Symposium on Computer Methods in Biomechanics and Biomedical Engineering (Montréal, Canada, 1-5 September 2015).