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Institute Of NeuroScience

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Institute Of NeuroScience

CUSL neurosurgery research group

ions | Bruxelles Woluwe, Louvain-la-Neuve

Research

The Neurosurgery research group is focused on advancing the understanding, diagnosis, and treatment of neurological conditions that require surgical intervention. Our group collaborates on projects related to brain and spine surgery, neuroimaging, neuromodulation, and the development of new surgical techniques or technologies improving surgical outcomes for brain tumors, developing minimally invasive procedures, exploring the effects of neuromodulation in various neurological disorders etc.

Our activities are mainly clinical but various collaborations with labs more active in fundamental research (see below) have been developed to insure a multidisciplinary approach on more complex topics.

The common goal is to translate scientific discoveries into clinical applications that can improve patient care and outcomes.

Patrice Finet

Edward Fomekong

Vincent Joris

Loïc de Nijs

Herbert Rooijakkers

Guus Koerts

Morel Tevi Lawson

Georges Chehade

Eric Vigneul 

  • ENL (Epilepsy and Neuromodulation Lab)
  • EPL (école polytechnique de Louvain)
  • NIMA (Neuro-imaging platform)

Epilepsy surgery

  • The analysis of epileptogenic networks by functional resting MRI and microfingerprinting (EPIVAM study).

  • Improving accuracy of stereoelectroencephalography using robotic surgery.

  • A first in human study for resistant epilepsy with the vagus nerve stimulation device by Synergia Medical (AURORA - CL-DO-003).

Neuromodulation outcome

  • DBS for dystonia: how to improve the targeting of the GPi.

  • DBS for essential tremor: does the orientable electrode improve the results.
  • Comparison of the effectiveness of tonic and high frequency spinal cord stimulation techniques for the treatment of chronic back and/or leg pain in patients with failed back surgery syndrome (FBSS).
  • DBS for obsessive compulsive disorder: target, mechanism of action and results.

Neuro-oncology

  • Intracranial tumors with PATZ 1 fusion: literature review and description of an additional case

  • Against the overuse of MRI in neurofibromatosis type 1.

  • Onecut-2 and pilocytic astrocytoma 

  • Otx2 in medulloblastoma

  • Of traveling homeoproteins and medulloblastomas

  • HOXA1, a transcription factor upregulated in glioblastoma, is able to travel between cells with their nuclei as target 

  • Long-term survival analysis of pediatric patients operated of a brain tumor. 

Neurovascular

  • Development of an automatized 3-dimensionnal analysis of intracranial aneurisms.

Miscellaneous

  • Posterior fossa ring-enhancing lesions in the adult immunocompetent host: illustrative cases, systematic review, and proposed diagnostic algorithm 

  • Management of Enterobacter cloacae meningoventriculitis: a systematic review

  •  Treating seizures in SYN1-related epilepsy: a systematic review 

  • Stereoelectroencephalography Implantation Using Frameless Neuronavigation and Varioguide: Prospective Analysis of Accuracy and Safety in a Case Series of 11 Patients. Joris V, Ribeiro-Vaz JG, Finet P, El Tahry R, Elkaim LM, Raftopoulos C, Ferrao-Santos S. World Neurosurg. 2023 Jun;174:e62-e71. doi: 10.1016/j.
  • Tubular Microdiscectomy for Recurrent Lumbar Disc Herniation: A Valuable Alternative to Endoscopic Techniques. de Nijs L, Fomekong E, Raftopoulos C.World Neurosurg. 2023 May;173:e401-e407. doi: 10.1016/j.
  • DIAPH3 predicts survival of patients with MGMT-methylated glioblastoma.
  • Chehade G, El Hajj N, Aittaleb M, Alkailani MI, Bejaoui Y, Mahdi A, Aldaalis AAH, Verbiest M, Lelotte J, Ruiz-Reig N, Durá I, Raftopoulos C, Tajeddine N, Tissir F.Front Oncol. 2024 Feb 22;14:1359652. doi: 10.3389