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- François Carlier
François Carlier
Chef de clinique adjoint Mont-Godinne
Spécialiste post-doctorant
Professeur
Professional history
2021-present: Lung Transplantation and Pneumology associate specialist | CHU UCL Namur, site Godinne B-5530 (UCLouvain, Belgium)
2021-2022: Lung Transplantation and Pneumology resident | CHU UCL Namur, site Godinne B-5530 (UCLouvain, Belgium)
2019-2020: Foreign experience in Lung Transplantation | Service de Pneumologie B, Hôpital Bichat-Claude-Bernard, Assistance Publique Hôpitaux de Paris (Université Paris-Diderot, France) | Supervisor: Pr. H. Mal
2019-2020: Foreign experience in research in pneumology | INSERM U1152, Universités Paris-Diderot and Paris-Descartes, Paris, France | Supervisors: Pr. O. Brugière and Dr. M. Pretolani
2015-2021: PhD in Pneumology | Institute of experimental and clinical research, pôle pneumologie, ORL et dermatologie (IREC-PNEU) (UCLouvain, Belgium) | Supervisor: Pr. Ch. Pilette
2014-2020: Pneumology Assistant | CHU UCL Namur, site Godinne B-5530 (UCLouvain, Belgium)
2012-2014: Physician Assistant, Internal Medicine | University Hospital of Mont-Godinne B-5530 (UCLouvain, Belgium)
2011-2012: Physician Assistant, Internal Medicine | Jolimont Hospital B-7100
Education and Qualifications
2015-2021: Ph.D. in Medical Sciences | Catholic University of Louvain (UCLouvain, Belgium). Thesis Title: “Exploring the plasticity of the airway epithelium in chronic obstructive pulmonary disease” (Promotor: Pr. Charles Pilette)
2011-2020: Additional master degree in Pneumology | Catholic University of Louvain (UCLouvain, Belgium) | Grade: Summa cum Laude
2007-2011: Master degree in Medicine | Catholic University of Louvain (UCLouvain, Belgium) | Grade: Magna cum Laude
2004-2007: Bachelor degree in Medicine | Catholic University of Louvain (UCLouvain, Belgium) | Grade: Cum Laude
2004: Passed the entrance examination | Royal Conservatory of Mons, section piano
2004: Passed the entrance examination | Polytechnic School of Louvain (UCLouvain, Belgium)
Publications
Upcoming articles
2023: Carlier FM, Detry B, Lecocq M, Planté-Bordeneuve T, Collin AM, Verleden SE, Stanciu-Pop CM, Janssens W, Ambroise J, Vanaudenaerde BM, Gohy ST, Pilette C. The memory of airway epithelium damage in smokers and COPD patients. Preprint on BioRxiv doi: https://doi.org/10.1101/2021.04.21.439437
Published articles
2022: Catry E, Favresse J, Gillot C, Bayart J-L, Frérotte D, Dumonceaux M, Evrard P, Mullier F, Douxfils J, Carlier FM*, Closset M*. Lung-transplant recipients immunogenicity after heterologous ChAdOx1 nCoV-19 - BNT162b2 mRNA vaccination. Viruses 2022, 14(7), 1470; https://doi.org/10.3390/v14071470 (IF 2021 5,048)
2022: de Fays C*, Carlier FM*, Gohy S, Pilette C. Secretory Immunoglobulin A Immunity in Chronic Obstructive Respiratory Diseases. Cells. 2022 Apr 13;11(8):1324. doi: 10.3390/cells11081324. (IF 2022 7,666)
2021: Carlier FM, de Fays C, Pilette C. Epithelial barrier dysfunction in chronic respiratory diseases. Front Physiol. 2021 Jun 24;12:691227. doi: 10.3389/fphys.2021.691227. eCollection 2021.PMID: 34248677. (IF 2020: 4,755)
2021: Collin AM, Lecocq M, Detry B, Carlier FM, Bouzin C, de Sany P, Hoton D, Verleden S, Froidure A, Pilette C, Gohy S. Loss of ciliated cells and altered airway epithelial integrity in cystic fibrosis are independent from the CFTR defect. J Cyst Fibros. 2021 Oct 14:S1569-1993(21)01424-7. doi: 10.1016/j.jcf.2021.09.019. PMID: 34657818 (IF 2021: 5,527)
2020: Carlier FM, Dupasquier S, Ambroise J, Detry B, Lecocq M, Biétry-Claudet C, Boukala Y, Gala JL, Bouzin C, Verleden SE, Hoton D, Gohy S, Bearzatto B, Pilette C. Canonical WNT pathway is activated in the airway epithelium in chronic obstructive pulmonary disease. EBioMedicine. 2020 Nov;61:103034. doi: 10.1016/j.ebiom.2020.103034. Epub 2020 Oct 10. PMID: 33045470 (IF 2020: 8,143)
2020: Collin AM, Lecocq M, Noel S, Detry B, Carlier FM, Aboubakar Nana F, Bouzin C, Leal T, Vermeersch M, De Rose V, Regard L, Martin C, Burgel PR, Hoton D, Verleden S, Froidure A, Pilette C, Gohy S. Lung immunoglobulin A immunity dysregulation in cystic fibrosis. EBioMedicine. 2020 Oct;60:102974. doi: 10.1016/j.ebiom.2020.102974. Epub 2020 Sep 11. PMID: 32927272 (IF 2020: 8,143)
2019: Gohy S, Carlier FM, Fregimilicka C, Detry B, Lecocq M, Ladjemi MZ, Verleden S, Hoton D, Weynand B, Bouzin C, Pilette C. Altered generation of ciliated cells in chronic obstructive pulmonary disease. Sci Rep. 2019 Nov 29;9(1):17963. doi: 10.1038/s41598-019-54292-x. PMID: 31784664 (IF 2019: 4,00)
2019: Ladjemi MZ, Martin C, Lecocq M, Detry B, Nana FA, Moulin C, Weynand B, Fregimilicka C, Bouzin C, Thurion P, Carlier F, Serré J, Gayan-Ramirez G, Delos M, Ocak S, Burgel PR, Pilette C. Increased IgA Expression in Lung Lymphoid Follicles in Severe Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2019 Mar 1;199(5):592-602. doi: 10.1164/rccm.201802-0352OC. PMID: 30339768 (IF 2019: 17,45)
2016: Carlier FM, Sibille Y & Pilette C. The epithelial barrier and immunoglobulin A system in allergy. Clin Exp Allergy 46, 1372-1388 (2016) (IF 2016: 5,26)
Scientific experience
14.10.2022: Poster presentation at the Journées de Recherche Respiratoire 2022, Reims (FR). Impaired pIgR/S-IgA mucosal immunity in bronchiolitis obliterans syndrome.
16.09.2022: Oral presentation at the Belgian Transplantation Society annual congress, Brussels (BE). Impaired pIgR/S-IgA mucosal immunity in bronchiolitis obliterans syndrome.
04.09.2022: Oral presentation at the European Respiratory Society annual Congress 2022, Barcelona (ES). Impaired pIgR/S-IgA mucosal immunity in bronchiolitis obliterans syndrome.
28.04.2022: Short oral communication at the 2022 Annual Congress of the International Society of Heart and Lung Transplantation, Boston (USA). Online presentation. Immunogenicity of two doses of ChAdOx1 nCoV-19 vaccine in lung transplant recipients.
11.03.2022: Poster presentation at the ERS Lung Science Conference 2022, Estoril (PT). Airway epithelium memory of injury in chronic obstructive pulmonary disease.
20.05.2021: Oral presentation at IREC Masterclass 2021, Online meeting. Airway epithelium memory of injury in chronic obstructive pulmonary disease.
19.03.2021: Oral presentation at the First RSRQ/J2R/BeRS meeting, Online meeting. Airway epithelium memory of injury in chronic obstructive pulmonary disease.
18.09.2019: Poster presentation at the Journées de Recherche Respiratoire 2019, Bruxelles (BE) – Wnt/β-catenin signalling is upregulated in the COPD bronchial epithelium.
15.09.2019: Poster discussion at the European Respiratory Society annual Congress 2019, Madrid (ES). Wnt/β-catenin signalling is upregulated in the COPD bronchial epithelium.
15.09.2019: Poster discussion at the European Respiratory Society 2019 annual Congress, Madrid (ES). STAT-3 is activated in COPD airway epithelial cells.
08.05.2019: Oral presentation at the 2019 Glaxo-Smith-Klein Awards in Pneumology, Brussels (BE). Wnt/β-catenin signalling is increased in the airway epithelium in COPD.
09.03.2019: Poster presentation at the Lung Science Conference 2019, Estoril (PO). STAT-3 is activated in in COPD airway epithelial cells.
12.10.2018: Poster presentation at the Journées de Recherche Respiratoire 2018, Marseille (FR). Persistence of the COPD broncho-epithelial phenotype in vitro, in long-term primary air/liquid interface culture.
17.09.2018: Poster presentation at the European Respiratory Society annual Congress 2018, Paris (FR). COPD-related epithelial inflammation drives EMT in primary epithelial ALI-cultures.
16.09.2018: Oral presentation at the European Respiratory Society annual Congress 2018, Paris (FR). COPD epithelial phenotype shows partial reversibility in long-term primary epithelial ALI-cultures.
30.05.2018: Oral presentation at the 2018 Glaxo-Smith-Klein Awards in Pneumology, Brussels (BE)? Persistence of the COPD broncho-epithelial phenotype in vitro, in long-term primary air/liquid interface cultures
13.10.2017: Oral presentation at the Biennale de l’Espace francophone de pneumologie -Journées de Recherche Respiratoire de la Société de Pneumologie de Langue française (SPLF), Québec (CA). Les voies de signalisation Wnt et Notch dans la BPCO.
13.10.2017: Poster presentation at the Biennale de l’Espace francophone de pneumologie -Journées de Recherche Respiratoire de la Société de Pneumologie de Langue française (SPLF), Québec (CA). Rôle de l’inflammation dans la dédifférenciation épithéliale de la BPCO.
07.12.2012: Poster presentation at the annual congress of the Belgian Society of Internal Medicine (BSIM), Brussels (BE). Vascular purpura in adults: a Case Report.
2006-2008: Histology monitor |Catholic University of Louvain (UCL, Belgium).
Other scientific activities
2022-present: Reviewer for the Journal of Cellular Physiology (IF 2021: 6,513)
2022-present: Reviewer for Respiratory Medicine Review (IF 2022: 3,149)
2022-present: Reviewer for the abstracts submitted to the Congress of the Société française de transplantation
2022-present :Scientific expert : Appels d’offre 2022&2023 « Recherche et greffe » from Agence de la Biomédecine (FR)
2019-present: Reviewer for Scientific Reports (IF 2021: 4,996)
2021: External jury member for Olivier Lowyck’s graduation thesis (UCLouvain, Faculté de Médecine et médecine dentaire). Parésie gastrique, atteinte phrénique et complications bronchiques dans le décours d’une transplantation pulmonaire.
2018: Co-promotor of Yassine Boukala’s graduation thesis (Institut Paul Lambin). Validation de cibles transcriptionnelles de la voie Wnt dans l’épithélium bronchique de patients atteints de broncho-pneumopathie chronique obstructive.
2017: External jury member for Rami Berriche’s graduation thesis (UCLouvain, faculté de Sciences Biomédicales). Intérêt des complexes Budésonide – Cyclodextrines dans la modulation des voies signalétiques impliquées dans l’inflammation de la BPCO.
Scientific societies membership
2022-present: Active member of the Société de Pneumologie de Langue française (SPLF)
2022-present: Active member of the International Society for Heart and Lung Transplantation (ISHLT)
2015-present: Active member of the Belgian Respiratory Society (BeRS)
2022-present: Member of the working group ‘Thoracic Surgery and Lung Transplantation” of the BeRS
2015-present: Active member of the European Respiratory Society (ERS)
2021-present: Active member of the Belgian Transplantation Society (BTS)
2021-2023: Member of the working group ‘Respiratory Infections” of the BeRS
2024
Gerard, Ludovic ; Lecocq, Marylene ; Detry, Bruno ; Bouzin, Caroline ; Hoton, Delphine ; Pinto Pereira, Joao ; Carlier, François ; Plante-Bordeneuve, Thomas ; Gohy, Sophie ; Lacroix, Valérie ; Laterre, Pierre-François ; Pilette, Charles. Airway epithelium damage in acute respiratory distress syndrome.. In: Critical care (London, England), Vol. 28, no.1, p. 350 (2024). doi:10.1186/s13054-024-05127-3.
2024
Henry, Jean-Philippe ; Carlier, François ; Higny, Julien ; Benoit, Martin ; Xhaet, Olivier ; Blommaert, Dominique ; Telbis, Alin-Mihail ; Robaye, Benoît ; Gabriel, Laurence ; Guédès, Antoine ; Michaux, Isabelle ; Demeure, Fabian ; Luchian, Maria-Luiza. Impact of Pre-Transplant Left Ventricular Diastolic Pressure on Primary Graft Dysfunction after Lung Transplantation: A Narrative Review.. In: Diagnostics (Basel, Switzerland), Vol. 14, no.13 (2024). doi:10.3390/diagnostics14131340.
2024
Leclercq, Charline ; Sansen, Pierre-Yves ; Collinge, Elodie ; Thirionet, Robin ; Evrard, Patrick ; Plante-Bordeneuve, Thomas ; Fervaille, Caroline ; Pouplard, Marie ; Dumonceaux, MIchel ; Sonet, Anne ; Carlier, François. Late-Onset Hemophagocytic Lymphohistiocytosis in a Lung Transplant Patient: A Case of T-Cell Post-Transplant Lymphoproliferative Disorder.. In: The American journal of case reports, Vol. 25, p. e944761 (2024). doi:10.12659/AJCR.944761.
2024
Carlier, François ; Detry, Bruno ; Lecocq, Marylène ; Amandine Collin ; Plante-Bordeneuve, Thomas ; Gérard, Ludovic ; Stijn Verleden ; Delos, Monique ; Rondelet, Benoît ; Janssens, Wim ; Ambroise, Jérôme ; Vanaudenaerde, Bart M ; Gohy, Sophie ; Pilette, Charles. The memory of airway epithelium damage in smokers and COPD patients.. In: Life science alliance, (2024). doi:10.26508/lsa.202302341.
2023
de Fays, Charlotte ; Carlier, François ; Gohy, Sophie ; Pilette, Charles. Immunoglobulines A sécrétoires et maladies respiratoires chroniques. In: Vaisseaux Cœur Poumon, Vol. 28, no.2, p. 266-30 (2023).
2023
Aboubakar Nana, Frank ; Lamberts, Virginie ; Hoton, Delphine ; Stanciu Pop, Claudia Maria ; Lecocq, Marylène ; Carlier, François ; Duplaquet, Fabrice ; Pirard, Lionel ; Pilette, Charles ; Bihin, Benoit ; Ocak, Sebahat. Restin protein expression in non-small cell lung cancer.. In: Thoracic cancer, Vol. 14, no. 23, p. 2302-2309 (2023). doi:10.1111/1759-7714.15019.
2023
de Fays, Charlotte ; Carlier, François ; Gohy, Sophie ; Pilette, Charles. Secretoire immunoglobulines A en chronische ademhalingsziekten. In: Bloedvaten Hart Longen, Vol. 28, no.2, p. 26-30 (2023).
2022
Catry, Emilie ; Favresse, Julien ; Gillot, Constant ; Bayart, Jean-Louis ; Frerotte, Damien ; Dumonceaux, Michel ; Evrard, Patrick ; Mullier, François ; Douxfils, Jonathan ; Carlier, François ; Closset, Mélanie. Lung Transplant Recipients Immunogenicity after Heterologous ChAdOx1 nCoV-19—BNT162b2 mRNA Vaccination. In: Viruses, Vol. 14, no. 7, p. 1470 [1-11] (2022). doi:10.3390/v14071470.
2022
de Fays, Charlotte ; Carlier, François ; Gohy, Sophie ; Pilette, Charles. Secretory Immunoglobulin A Immunity in Chronic Obstructive Respiratory Diseases.. In: Cells, Vol. 11, no. 8, p. 1324 [1-8] (2022). doi:10.3390/cells11081324.
2021
Carlier, François ; de Fays, Charlotte ; Pilette, Charles. Epithelial Barrier Dysfunction in Chronic Respiratory Diseases.. In: Frontiers in physiology, Vol. 12, p. 691227 [1-27] (2021). doi:10.3389/fphys.2021.691227.
2021
Collin, Amandine ; Lecocq, Marylène ; Detry, Bruno ; Carlier, François ; Bouzin, Caroline ; De Sany, Philippe ; Hoton, Delphine ; Verleden, Stijn ; Froidure, Antoine ; Pilette, Charles ; Gohy, Sophie. Loss of ciliated cells and altered airway epithelial integrity in cystic fibrosis.. In: Journal of cystic fibrosis, Vol. 20, no. 6, p. e129-e139 (2021). doi:10.1016/j.jcf.2021.09.019.
2020
Carlier, François ; Dupasquier, Sébastien ; Ambroise, Jérôme ; Detry, Bruno ; Lecocq, Marylène ; Biétry–Claudet, Charline ; Boukala, Yassine ; Gala, Jean-Luc ; Bouzin, Caroline ; Verleden, Stijn E. ; Hoton, Delphine ; Gohy, Sophie ; Bearzatto, Bertrand ; Pilette, Charles. Canonical WNT pathway is activated in the airway epithelium in chronic obstructive pulmonary disease. In: EBioMedicine, Vol. 61, p. 103034 [1-17] (2020). doi:10.1016/j.ebiom.2020.103034.
2020
Collin, Amandine ; Lecocq, Marylène ; Noël, Sabrina ; Detry, Bruno ; Carlier, François ; Aboubakar Nana, Frank ; Bouzin, Caroline ; Leal, Teresinha ; Vermeersch, Marjorie ; De Rose, Virginia ; Regard, Lucile ; Martin, Clémence ; Burgel, Pierre-Régis ; Hoton, Delphine ; Verleden, Stijn ; Froidure, Antoine ; Pilette, Charles ; Gohy, Sophie. Lung immunoglobulin A immunity dysregulation in cystic fibrosis.. In: EBioMedicine, Vol. 60, p. 102974 [1-16] (2020). doi:10.1016/j.ebiom.2020.102974.
2019
Gohy, Sophie ; Carlier, François ; Fregimilicka, Chantal ; Detry, Bruno ; Lecocq, Marylène ; Maha Zohra Ladjemi ; Stijn Verleden ; Hoton Delphine ; Brigit Weynand ; Bouzin, Caroline ; Pilette, Charles. Altered generation of ciliated cells in chronic obstructive pulmonary disease. In: Altered generation of ciliated cells in chronic obstructive pulmonary disease, Vol. 9, no.17963, p. 1-12 (2019).
2019
Ladjemi, Maha Zohra ; Martin, Clémence ; Lecocq, Marylène ; Detry, Bruno ; Aboubakar Nana, Frank ; Moulin, Charlotte ; Weynand, Birgit ; Fregimilicka, Chantal ; Bouzin, Caroline ; Thurion, Pascal ; Carlier, François ; Serré, Jef ; Gayan-Ramirez, Ghislaine ; Delos, Monique ; Ocak, Sebahat ; Burgel, Pierre Régis ; Pilette, Charles. Increased IgA Expression in Lung Lymphoid Follicles in Severe COPD.. In: American journal of respiratory and critical care medicine, Vol. 199, no. 5, p. 592-602 (2019). doi:10.1164/rccm.201802-0352OC.
2016
Carlier, François ; Sibille, Yves ; Pilette, Charles. The epithelial barrier and immunoglobulin A system in Allergy.. In: Clinical and Experimental Allergy, Vol. 46, no. 11, p. 1372-1388 (2016). doi:10.1111/cea.12830.
2022
Carlier, François ; Closset, M. ; Catry, E. ; Dumonceaux, M. ; Douxfils, J. ; Frérotte, D. ; Evrard, P.. Immunogenicity of Two Doses of ChAdOx1 nCoV-19 Vaccine in Lung Transplant Recipients. 42nd International Society of Heart and Lung Transplantion Congress (Boston). In: The Journal of Heart and Lung Transplantation, Vol. 41, no.4, p. S134-S135 (2022). doi:10.1016/j.healun.2022.01.316.
2022
Carlier, François. Impaired pIgR/S-IgA mucosal immunity in bronchiolitis obliterans syndrome.. Belgian Transplantation Society Annual Congress 2022 (Bruxelles, 16/09/2022).
2022
Carlier, François. Impaired pIgR/S-IgA mucosal immunity in bronchiolitis obliterans syndrome.. Journées de Recherche Respiratoire 2022 (Reims, du 14/10/2022 au 15/10/2022).
2022
Carlier, François ; Pilette, Charles. The memory of airway epithelium damage in smokers and COPD patients. ERS Lung Science Conference 2022 abstracts (Estoril, du 09/03/2023 au 12/03/2023). In: ERJ Open Research, Vol. 8, no.Supp 8, p. 113 (2022). doi:10.1183/23120541.lsc-2022.113.
2019
Carlier, François ; Detry, Bruno ; Sibille, Yves ; Pilette, Charles. STAT-3 is activated in COPD airway epithelial cells.. Abstracts from the 17th ERS Lung Science Conference: ‘Mechanisms of Acute Exacerbation of Respiratory Disease’ (Estoril). In: ERJ Open Research, Vol. 5, no.2, p. PP214 (2019). doi:10.1183/23120541.lungscienceconference-2019.pp214.
2019
Carlier, François ; Ambroise, Jérôme ; Dupasquier, Sébastien ; Bearzatto, Bertrand ; Pilette, Charles. Wnt/ß-catenin signalling is upregulated in the COPD bronchial epithelium. ERS International Congress 2019. In: European Respiratory Journal. Supplement, Vol. 54, no.PA1680, p. PA1680 (2019). doi:10.1183/13993003.congress-2019.pa1680.
2018
Carlier, François ; Detry, Bruno ; Sibille, Yves ; Pilette, Charles. COPD epithelial phenotype shows partial reversibility in long-term primary epithelial ALI-cultures. ERS International Congress 2018 (Paris). In: European Respiratory Journal. Supplement, Vol. 52, no.OA502, p. OA205 (2018). doi:10.1183/13993003.congress-2018.oa502.
2018
Carlier, François ; Detry, Bruno ; Sibille, Yves ; Pilette, Charles. COPD-related epithelial inflammation drives EMT in primary epithelial ALI-cultures. ERS International Congress 2018 abstracts (Paris). In: European Respiratory Journal. Supplement, Vol. 52, no.PA4239, p. PA4239 (2018). doi:10.1183/13993003.congress-2018.pa4239.
2018
Collin, Amandine ; Lecocq, Marylène ; Detry, Bruno ; Carlier, François ; Noël, Sabrina ; Bouzin, Caroline ; Leal, Teresinha ; De Rose, V ; Martin, Clémence ; Burgel, PR ; Verleden, S ; Pilette, Charles ; Gohy, Sophie. Lung IgA immunity is upregulated in cystic fibrosis. . J2R (France, du 12/10/2018 au 13/10/2018).
2021
Carlier, François. Exploring the plasticity of the airway epithelium in chronic obstructive pulmonary disease, prom. : Pilette, Charles, 14/12/2021.