DDUV
Avenue Hippocrate 74/B1.74.03
1200 Woluwe-Saint-Lambert
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- Jingjing Zhu
Jingjing Zhu
Collaboratrice scientifique
- Diplômes
Année Label Institution 2006 (informations manquantes) Northwest university 2009 Master of Science Northwest university 2013 (informations manquantes) Katholieke Universiteit Leuven
2023
Zhu, Jingjing. Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes. In: bioRxiv, (2023).
2022
Vermorken, Alphons ; Zhu, Jingjing ; Cui, Yali. Can niacin supplementation prevent congenital malformations associated with maternal use of proton pump inhibitors? . In: European Journal of Nutrition, (2022). doi:10.1007/s00394-022-03060-1 (Accepté/Sous presse).
2022
Petit, Pierre-Florent ; Bombart, Raphaële ; Desimpel, Pierre-Hubert ; Naulaert, Stefan ; Thouvenel, Laurie ; Collet, Jean-François ; Van den Eynde, Benoît ; Zhu, Jingjing. T-cell mediated targeted delivery of anti-PD-L1 nanobody overcomes poor 1 antibody penetration and improves PD-L1 blocking at the tumor site. In: Cancer Immunology Research, Vol. 10, no. 6, p. 713-727 (2022). doi:10.1158/2326-6066.CIR-21-0801.
2021
Vermorken, Alphons J.M. ; Zhu, Jingjing ; Holvoet, Paul ; Cui, Yali. The marker of cobalamin deficiency, plasma methylmalonic acid, may help identifying lysosomal iron trapping in patients. Its possible utility for heart failure. In: Redox Biology, Vol. 44, p. 102011 (2021). doi:10.1016/j.redox.2021.102011.
2020
Vermorken, Alphons J M ; Zhu, Jingjing ; Cui, Yali. Letter: does Helicobacter pylori infection limit the health effects of the Mediterranean diet?. In: Alimentary pharmacology & therapeutics, Vol. 52, no.5, p. 935-936 (2020). doi:10.1111/apt.15945.
2018
Zhu, Jingjing ; Petit, Pierre-Florent ; Van den Eynde, Benoît. Apoptosis of tumor-infiltrating T lymphocytes: a new immune checkpoint mechanism. In: Cancer Immunology, Immunotherapy, (2018). doi:10.1007/s00262-018-2269-y (Accepté/Sous presse).
2017
Zhu, Jingjing ; Powis de Tenbossche, Céline G ; Cané, Stefania ; Colau, Didier ; van Baren, Nicolas ; Lurquin, Christophe ; Schmitt-Verhulst, Anne-Marie ; Liljeström, Peter ; Uyttenhove, Catherine ; Van den Eynde, Benoît. Resistance to cancer immunotherapy mediated by apoptosis of tumor-infiltrating lymphocytes.. In: Nature Communications, Vol. 8, p. 1404 (2017). doi:10.1038/s41467-017-00784-1.
2014
Vermorken, Alphons JM ; Zhu, Jingjing ; Andrès, Emmanuel. Obesity and colorectal cancer risk, the role of oxidative stress. In: Gut, . doi:10.1136/gutjnl-2013-305561 (Accepté/Sous presse).
2013
Zhu, Jingjing ; Bultynck, Geert ; Luyten, Tomas ; Parys, Jan B ; Creemers, John WM ; Van de Ven, Wim JM ; Vermorken, Alphons JM. Curcumin affects proprotein convertase activity: elucidation of the molecular and subcellular mechanism. In: Biochimica et Biophysica Acta : international journal of biochemistry and biophysics, Vol. 1833, no.8, p. 1924-1935 (08/2013). doi:10.1016/j.bbamcr.2013.04.002.
2013
Zhu, Jingjing ; Van de Ven, Wim JM ; Verbiest, Thierry ; Koeckelberghs, Guy ; Chen, Chao ; Cui, Yali ; Vermorken, Alphons JM. Polyphenols Can Inhibit Furin In Vitro As A Result of the Reactivity of their Auto-oxidation Products to Proteins. In: Current Medicinal Chemistry, Vol. 20, no.6, p. 840-850 (01/02/2013). doi:10.2174/0929867311320060009.
2013
Zhu, Jingjing ; Van de Ven, Wim JM ; Vermorken, Alphons JM. Polyphenols with indirect proprotein convertase inhibitory activity. In: International Journal of Oncology, Vol. 43, no.3, p. 947-955 (09/2013). doi:10.3892/ijo.2013.2009.
2013
Andrès, Emmanuel ; Serraj, Khalid ; Zhu, Jingjing ; Vermorken, Alphons JM. The pathophysiology of elevated vitamin B12 in clinical practice. In: QJM : an international journal of medicine, Vol. 106, no.6, p. 505-515 (06/2013). doi:10.1093/qjmed/hct051.
2012
Chao, Xu ; Guo, Lili ; Zhang, Zhuoli ; Zhu, Jingjing ; Vermorken, Alphons JM ; Van de Ven, Wim JM ; Chao, Chen ; Cui, Yali. A novel magnetic nanoparticle drug carrier for enhanced cancer chemotherapy. In: PLoS One, Vol. 7, no.10, p. e40388 (08/10/2012). doi:10.1371/journal.pone.0040388.
2012
Vermorken, Alphons JM ; Zhu, Jingjing ; Van de Ven, Wim JM ; Andrès, Emmanuel. Comment on: Monoclonal gammopathy of undetermined significance, smoldering multiple myeloma, and curcumin: a randomized, double-blind placebo-controlled crossover 4g study and an open-label 8g extension study.. In: American Journal of Hematology, Vol. 87, no.10, p. E80 (10/2012). doi:10.1002/ajh.23276.
2012
Vermorken, Alphons JM ; Zhu, Jingjing ; Van de Ven, Wim JM ; Andrès, Emmanuel. Curcumin for monoclonal gammopathies. What can we hope for, what should we fear?. In: Critical Reviews in Oncology / Hematology, Vol. 84, no.3, p. 350-360 (12/2012). doi:10.1016/j.critrevonc.2012.04.005.
2012
Zhu, Jingjing ; Declercq, Jeroen ; Roucourt, Bart ; Ghassabeh, Gholamreza H ; Meulemans, Sandra ; Kinne, Jörg ; David, Guido ; Vermorken, Alphons JM ; Van de Ven, Wim JM ; Lindberg, Iris ; Muyldermans, Serge ; Creemers, John WM. Generation and characterization of non-competitive furin-inhibiting nanobodies. In: Biochemical Journal, Vol. 448, no.1, p. 73-82 (15/11/2012). doi:10.1042/BJ20120537.
2012
Zhu, Jingjing ; Declercq, Jeroen ; Creemers, John ; Chen, Chao ; Cui, Yali ; Van de Ven, Wim JM ; Vermorken, Alphons JM. Limitations of inhibitory activities of polyphenols on furin-mediated substrate processing. In: Current Medicinal Chemistry, Vol. 19, no.21, p. 3641-3650 (2012).
2010
Vermorken, Alphons J. M. ; Zhu, Jingjing ; Van de Ven, Wim JM ; Cui, Yali ; Fryns, Jean-Pierre. Curcumin for the prevention of progression in monoclonal gammopathy of undetermined significance: A word of caution. In: Experimental and Therapeutic Medicine, Vol. 1, no.2, p. 265-269 (03/2010). doi:10.3892/etm_00000041.
2010
Vermorken, Alphons JM ; Zhu, Jingjing ; Van de Ven, Wim JM. Is curcumin for monoclonal gammopathy of undetermined significance without risk?. In: Clinical Cancer Research, Vol. 16, no.7, p. 2225 (01/04/2010). doi:10.1158/1078-0432.CCR-10-0218.
2009
Zhu, Jingjing ; Yang, Liu ; Yang, Lei ; Chen, Chao ; Cui, Yali. [Purification of glutathione-S-transferase fusion protein by glutathione coupled magnetic particles]. In: Sheng Wu Gong Cheng Xue Bao, Vol. 25, no.8, p. 1254-1260 (2009).
2011
Zhu, Jingjing ; Vermorken, Alphons JM ; Van de Ven, Wim JM. Proprotein convertases in homeostasis and pathophysiology; perspectives of targeting furin-mediated proprotein processing to affect tumor development involving IGF axis signalling. In: Recent Research Developments in Cancer, Vol.9, 2011. 978-81-7895-536-0.
2022
Bombart, Raphaële ; Zhu, Jingjing ; Van den Eynde, Benoit J.. Uncovering molecular actors of IDO-mediated T cell dysfunction with genome-wide CRISPR/Cas9 knockout screens. Abstracts: AACR Virtual Special Conference: Tumor Immunology and Immunotherapy (du 05/10/2021 au 06/10/2021). In: Cancer Immunology Research, Vol. 10, no.1, p. 2326-6074 (2022). doi:10.1158/2326-6074.tumimm21-p025.
2021
Zhu, Jingjing. Invited Lecture: Local delivery of anti-PD-L1 nanobodies overcomes poor antibody penetration and allows improved blocking of PD-L1 at the tumor site. 5th Annual MarketsandMarkets Next Gen Immuno-Oncology Virtual Congress (du 26/10/2021 au 29/10/2021).
2021
Zhu, Jingjing. Invited Lecture: T-cell mediated targeted delivery of anti-PD-L1 nanobodies overcomes poor antibody penetration and improves PD-L1 blocking at the tumor site. 6th Annual MarketandMarkets Biomarker and Companion Diagnostics Virtual Conference (du 12/10/2021 au 14/10/2021).
2020
Petit, P-F. ; Zhu, Jingjing ; van den Eynde, B.J.. Improving efficacy and reducing toxicity of anti-PD-L1 treatment: T-cells as delivery vehicles for anti-PD-L1 blocking nanobodies. ESMO Immuno-Oncology Vitual Congress 2020 (du 09/12/2020 au 12/12/2020). In: Annals of Oncology, Vol. 31, no.Supplement 7, p. S1425 (2020). doi:10.1016/j.annonc.2020.10.511.
2019
Zhu, Jingjing. Invited Lecture: Deciphering the role of cancer stem cells in tumoral immune resistance in an autochthonous melanoma model. XI Melanoma Workshop 2019 (Otranto, Italy, du 16/05/2019 au 17/05/2019).
2019
Zhu, Jingjing. Invited Lecture: Tumoral immune resistance based on apoptosis of tumor-infiltrating T cells in an inducible mouse melanoma model. Departmental Research Seminar (Dept. Pharmaceutical Chemistry, Peking Union Medical College, du 25/10/2019 au 25/10/2019).
2019
Zhu, Jingjing. Invited Lecture: Understanding the tumor immune escape and the immune modulatory function of cancer stem cells. 17th International Congress of Immunology (Beijing, China, du 19/10/2019 au 23/10/2019).
2019
Petit, Pierre-Florent ; Zhu, Jingjing ; Van den Eynde, Benoit. T cells secreting nanobody-based immune checkpoint inhibitors. CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference (Paris, France, du 25/09/2019 au 28/09/2019).
2019
Krendyukov, A. ; Kneisel, N. ; Zhu, Jingjing ; Merz, C. ; Richards, D. ; Gieffers, C. ; van den Eynde, B.. The Role of Asunercept as a Selective CD95L Inhibitor in Cutaneous Melanoma: Rationale and Results from an Enhanced TiRP Model. ESMO Immuno-Oncology Congress 2019 (Geneva, Switzerland, du 11/12/2019 au 14/12/2019). In: Annals of Oncology, Vol. 30, no.S11, p. xi43-xi44 (2019). doi:10.1093/annonc/mdz451.026.
2019
Zhu, Jingjing ; Colau, Didier ; Boudhan, Loubna ; Van den Eynde, Benoit. Understanding the tumor immune escape and the immune modulatory function of cancer stem cells. 17th International Congress of Immunology (Beijing, China, du 19/10/2019 au 23/10/2019). In: European Journal of Immunology, Vol. 49, no.Supplement S3, p. 1243 (2019). doi:10.1002/eji.201970400.
2017
Zhu, Jingjing. Invited Lecture: Discovery of novel immuno-oncology targets. Departmental Research Seminar (National Engineering Center for Miniaturized Detection System, Northwest University, du 17/10/2017 au 17/10/2017).
2017
Zhu, Jingjing ; Céline G. Powis de Tenbossche ; Stefania Cané ; Didier Colau ; Van den Eynde, Benoit. Resistance to cancer immunotherapy mediated by apoptosis of tumor-infiltrating lymphocytes. Ludwig Oxford 10th Anniversary Symposium (Oxford, United Kingdom, du 11/09/2017 au 12/09/2017).
2017
Zhu, Jingjing ; Céline G. Powis de Tenbossche ; Stefania Cané ; Didier Colau ; Van den Eynde, Benoit. Resistance to cancer immunotherapy mediated by apoptosis of tumor-infiltrating lymphocytes. Third CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference (Mainz/Frankfurt, Germany, du 06/09/2017 au 09/09/2017).
2014
Declercq, Jeroen ; Zhu, Jingjing ; Lindberg, Iris ; Ghassabeh, Gholamreza H. ; Meulemans, Sandra ; Vermorken, Alphons J.M. ; Van de Ven, Wim J.M. ; Muyldermans, Serge ; Creemers, John W.M.. Generation and characterization of non-competitive furin-inhibiting nanobodies. Proceedings: AACR 103rd Annual Meeting 2012 (Chicago, United States, du 31/03/2012 au 04/04/2012). In: Experimental and Molecular Therapeutics, Vol. 72, no.8, p. 1538-7445 (2012). doi:10.1158/1538-7445.am2012-4627.
2012
Declercq, Jeroen ; Zhu, Jingjing ; Lindberg, Iris ; Ghassabeh, Gholamreza ; Meulemans, Sandra ; Vermorken, Alphons ; Van de Ven, Wim ; Muyldermans, Serge ; Creemers, John. Generation and characterization of non-competitive furin-inhibiting nanobodies. AACR Annual Meeting (Chicago, USA, du 31/03/2012 au 04/04/2012).
2012
Declercq, Jeroen ; Zhu, Jingjing ; Roucourt, Bart ; Ghassabeh, Gholamreza ; Meulemans, Sandra ; Kinne, Jörg ; David, Guido ; Vermorken, Alphons ; Van de Ven, Wim ; Lindberg, Iris ; Muyldermans, Serge ; Creemers, John. Generation and characterization of non-competitive furin-inhibiting nanobodies. Tenth Gordon conference (Colby-Sawyer College New London, NH, USA, du 15/07/2012 au 20/07/2012).
2012
Zhu, Jingjing ; Declercq, Jeroen ; Willekens, Karen ; Creemers, John ; Vermorken, Alphons ; Van de Ven, Willem. Interference of the polyphenolic compound curcumin with expression regulation of target genes of the PLAG1 oncogenic transcription factor. AACR Annual Meeting (Chicago, USA, du 31/03/2012 au 4/04/2012). In: Cancer Research Journal, Vol. 72, no. 8. doi:10.1158/1538-7445.AM2012-4627 Published April 2012.
2010
Zhu, Jingjing ; Vermorken, Alphons ; Van de Ven, Wim. Are proprotein convertases therapeutic targets for prevention of malignant progression of MGUS?. The 3rd Annual Protein and Peptide Conference (Beijing, P.R. China, du 21/03/2010 au 23/03/2010).
2010
Zhu, Jingjing. Inhibition of Proprotein convertase Furin as a target for cancer therapy. Invited Lecture (National Engineering Center for Miniaturized Detection System, Northwest University, 25/03/2010).
2010
Zhu, Jingjing. Invited Lecture: Inhibition of Proprotein convertase Furin as a target for cancer therapy. Departmental Research Seminar (National Engineering Center for Miniaturized Detection System, Northwest University, 25/03/2010).
2010
Zhu, Jingjing ; Van de Ven, Wim ; Verbiest , Thierry ; Vermorken, Alphons. Is the main green tea component epigallocatechin gallate a genuine inhibitor of the proprotein convertase furin?. 8th Annual Congress of International Drug Discovery Science and Technology (Beijing, P.R. China, du 22/10/2010 au 26/10/2010).
2010
Zhu, Jingjing ; Cui, Yali ; Vermorken, Alphons ; Van de Ven, Wim. Optimization of an in-vitro processing assay for the proprotein convertase furin. The 3rd Annual Protein and Peptide Conference (Beijing, P.R. China, du 21/03/2010 au 23/03/2010).
2010
Vermorken, Alphons ; Zhu, Jingjing ; Van de Ven, Wim. Proprotein convertases are therapeutic targets for prevention of malignant progression of MGUS?. The 3rd Annual Protein and Peptide Conference (Beijing, P.R. China, du 21/03/2010 au 23/03/2010).
2021
Zhu, Jingjing ; Van den Eynde, Benoit. ALPHA-2 ADRENERGIC RECEPTOR AGONISTS FOR THE PREVENTION AND/OR THE TREATMENT OF SPLEEN DISORDERS. .
2021
Zhu, Jingjing ; Van den Eynde, Benoit. ALPHA-2 ADRENERGIC RECEPTOR AGONISTS FOR THE TREATMENT OF CANCER. .
2020
Zhu, Jingjing ; Van den Eynde, Benoit. GUANABENZ AS AN ADJUVANT FOR IMMUNOTHERAPY . .