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- Luc Pilotte
Luc Pilotte
2023
Solvay, Marie ; Holfelder, Pauline ; Klaessens, Simon ; Pilotte, Luc ; Stroobant, Vincent ; Lamy, Juliette ; Naulaerts, Stefan ; Spillier, Quentin ; Frédérick, Raphaël ; De Plaen, Etienne ; Sers, Christine ; Opitz, Christiane A ; Van den Eynde, Benoit ; Zhu, Jingjing. Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes. In: Journal for ImmunoTherapy of Cancer, Vol. 11, no. 6, p. e006728 (2023). doi:10.1136/jitc-2023-006728.
2022
Kozlova, Arina ; Thabault, Léopold ; Dauguet, Nicolas ; Deskeuvre, Marine ; Stroobant, Vincent ; Pilotte, Luc ; Liberelle, Maxime ; Van den Eynde, Benoit ; Frédérick, Raphaël. Investigation of chalcogen bioisosteric replacement in a series of heterocyclic inhibitors of tryptophan 2,3-dioxygenase. In: European journal of medicinal chemistry, Vol. 227, p. 113892 [1-12] (2022). doi:10.1016/j.ejmech.2021.113892.
2021
Levy, Thomas ; Marchand, Laura ; Stroobant, Vincent ; Pilotte, Luc ; Van den Eynde, Benoît ; Rodriguez, Frédéric ; Delfourne, Evelyne. IDO1 and TDO inhibitory evaluation of analogues of the marine pyrroloiminoquinone alkaloids: Wakayin and Tsitsikammamines.. In: Bioorganic & medicinal chemistry letters, Vol. 40, p. 127910 (2021). doi:10.1016/j.bmcl.2021.127910.
2021
Kozlova, Arina ; Thabault, Léopold ; Liberelle, Maxime ; Klaessens, Simon ; Prévost, Julien R. C. ; Mathieu, Caroline ; Pilotte, Luc ; Stroobant, Vincent ; Van den Eynde, Benoît ; Frédérick, Raphaël. Rational Design of Original Fused-Cycle Selective Inhibitors of Tryptophan 2,3-Dioxygenase. In: Journal of Medicinal Chemistry, (2021). doi:10.1021/acs.jmedchem.1c00323 (Accepté/Sous presse).
2021
Canè, Stefania ; Van Snick, Jacques ; Uyttenhove, Catherine ; Pilotte, Luc ; Van den Eynde, Benoît. TGFβ1 neutralization displays therapeutic efficacy through both an immunomodulatory and a non-immune tumor-intrinsic mechanism.. In: Journal for immunotherapy of cancer, Vol. 9, no.2 (2021). doi:10.1136/jitc-2020-001798.
2021
Klaessens, Simon ; Stroobant, Vincent ; Hoffmann, Delia ; Gyrd-Hansen, Mads ; Pilotte, Luc ; Vigneron, Nathalie ; De Plaen, Etienne ; Van den Eynde, Benoît. Tryptophanemia is controlled by a tryptophan-sensing mechanism ubiquitinating tryptophan 2,3-dioxygenase. In: Proceedings of the National Academy of Sciences, Vol. 118, no.23, p. e2022447118 (2021). doi:10.1073/pnas.2022447118.
2020
Schramme, Florence ; Crosignani, Stefano ; Frederix, Kim ; Hoffmann, Delia ; Pilotte, Luc ; Stroobant, Vincent ; Preillon, Julie ; Driessens, Gregory ; Van den Eynde, Benoît. Inhibition of Tryptophan-Dioxygenase Activity Increases the Antitumor Efficacy of Immune Checkpoint Inhibitors.. In: Cancer immunology research, Vol. 8, no. 1, p. 32-45 (2020). doi:10.1158/2326-6066.CIR-19-0041.
2019
Hoffmann, Delia ; Pilotte, Luc ; Stroobant, Vincent ; Van den Eynde, Benoît. Induction of tryptophan 2,3-dioxygenase expression in human monocytic leukemia/lymphoma cell lines THP-1 and U937.. In: International journal of tryptophan research : IJTR, Vol. 12, no.1, p. 1178646919891736 (2019). doi:10.1177/1178646919891736.
2018
Orabona, Ciriana ; Mondanelli, Giada ; Pallotta, Maria T. ; Carvalho, Agostinho ; Albini, Elisa ; Fallarino, Francesca ; Vacca, Carmine ; Volpi, Claudia ; Belladonna, Maria L. ; Berioli, Maria G. ; Ceccarini, Giulia ; Esposito, Susanna M.R. ; Scattoni, Raffaella ; Verrotti, Alberto ; Ferretti, Alessandra ; De Giorgi, Giovanni ; Toni, Sonia ; Cappa, Marco ; Matteoli, Maria C. ; Bianchi, Roberta ; Matino, Davide ; Iacono, Alberta ; Puccetti, Matteo ; Cunha, Cristina ; Bicciato, Silvio ; Antognelli, Cinzia ; Talesa, Vincenzo N. ; Chatenoud, Lucienne ; Fuchs, Dietmar ; Pilotte, Luc ; Van den Eynde, Benoît ; Lemos, Manuel C. ; Romani, Luigina ; Puccetti, Paolo ; Grohmann, Ursula. Deficiency of immunoregulatory indoleamine 2,3-dioxygenase 1in juvenile diabetes. In: JCI Insight, Vol. 3, no.6, p. e96244 (2018). doi:10.1172/jci.insight.96244.
2017
Hennequart, Marc ; Pilotte, Luc ; Cane, Stefania ; Hoffmann, Delia ; Stroobant, Vincent ; De Plaen, Etienne ; Van den Eynde, Benoît. Constitutive IDO1 Expression in Human Tumors Is Driven by Cyclooxygenase-2 and Mediates Intrinsic Immune Resistance. In: Cancer Immunology Research, Vol. 5, no. 8, p. 695-709 (2017). doi:10.1158/2326-6066.cir-16-0400.
2016
Uzureau, Sophie ; Coquerelle, Caroline ; Vermeiren, Corentin ; Uzureau, Pierrick ; Van Acker, Annette ; Pilotte, Luc ; Monteyne, Daniel ; Acolty, Valérie ; Vanhollebeke, Benoit ; Van den Eynde, Benoît ; Pérez-Morga, David ; Moser, Muriel ; Pays, Etienne. Apolipoproteins L control cell death triggered by TLR3/TRIF signaling in dendritic cells. In: European Journal of Immunology, Vol. 46, no.8, p. 1854-1866 (2016). doi:10.1002/eji.201546252.
2015
Théate, Ivan ; van Baren, Nicolas ; Pilotte, Luc ; Moulin, Pierre ; Larrieu, Pierre ; Renauld, Jean-Christophe ; Hervé, Caroline ; Gutierrez-Roelens, Ilse ; Marbaix, Etienne ; Sempoux, Christine ; Van den Eynde, Benoît. Extensive Profiling of the Expression of the Indoleamine 2,3-Dioxygenase 1 Protein in Normal and Tumoral Human Tissues. In: Cancer Immunology Research, Vol. 3, no. 2, p. 161-72 (2015). doi:10.1158/2326-6066.CIR-14-0137.
2014
Röhrig, Ute F. ; Majjigapu, Somi Reddy ; Chambon, Marc ; Bron, Sylvian ; Pilotte, Luc ; Colau, Didier ; Van den Eynde, Benoît ; Turcatti, Gerardo ; Vogel, Pierre ; Zoete, Vincent ; Michielin, Olivier. Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors. In: European Journal of Medicinal Chemistry, Vol. 84, p. 284-301 (10/07/2014). doi:10.1016/j.ejmech.2014.06.078.
2013
Dolusic, Eduard ; Larrieu, Pierre ; Meinguet, Céline ; Colette, Delphine ; Rives, Arnaud ; Blanc, Sébastien ; Ferain, Thierry ; Pilotte, Luc ; Stroobant, Vincent ; Wouters, Johan ; Van den Eynde, Benoît ; Masereel, Bernard ; Delfourne, Evelyne ; Frédérick, Raphaël. Indoleamine 2,3-dioxygenase inhibitory activity of derivatives of marine alkaloid tsitsikammamine A.. In: Bioorganic & Medicinal Chemistry Letters, Vol. 23, no.1, p. 47-54 (2013). doi:10.1016/j.bmcl.2012.11.036.
2012
Huijbers, Ivo ; Soudja, Saïdi M. ; Uyttenhove, Catherine ; Buferne, Michel ; Inderberg-Suso, Else-Marit ; Colau, Didier ; Pilotte, Luc ; Powis de Tenbossche, Céline ; Chomez, Patrick ; Brasseur, Francis ; Schmitt-Verhulst, Anne-Marie ; Van den Eynde, Benoît. Minimal tolerance to a tumor antigen encoded by a cancer-germline gene. In: Journal of Immunology, Vol. 188, no. 1, p. 111-121 (01/01/2012). doi:10.4049/jimmunol.1002612.
2012
Röhrig, Ute F ; Majjigapu, Somi Reddy ; Grosdidier, Aurélien ; Bron, Sylvian ; Stroobant, Vincent ; Pilotte, Luc ; Colau, Didier ; Vogel, Pierre ; Van den Eynde, Benoît ; Zoete, Vincent ; Michielin, Olivier. Rational design of 4-aryl-1,2,3-triazoles for indoleamine 2,3-dioxygenase 1 inhibition.. In: Journal of Medicinal Chemistry, Vol. 55, no. 11, p. 5270-5290 (2012). doi:10.1021/jm300260v.
2012
Pilotte, Luc ; Larrieu, Pierre ; Stroobant, Vincent ; Colau, Didier ; Dolusic, Eduard ; Frédérick, Raphaël ; De Plaen, Etienne ; Uyttenhove, Catherine ; Wouters, Johan ; Masereel, Bernard ; Van den Eynde, Benoît. Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase.. In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, no. 7, p. 2497-2502 (2012). doi:10.1073/pnas.1113873109.
2011
Dolusic, Eduard ; Larrieu, Pierre ; Blanc, Sébastien ; Sapunaric, Frédéric ; Norberg, Bernadette ; Moineaux, Laurence ; Colette, Delphine ; Stroobant, Vincent ; Pilotte, Luc ; Colau, Didier ; Ferain, Thierry ; Fraser, Graeme ; Galleni, Moreno ; Frre, Jean-Marie ; Masereel, Bernard ; Van den Eynde, Benoît ; Wouters, Johan ; Frédérick, Raphaël. Corrigendum to "Indol-2-yl ethanones as novel indoleamine 2,3-dioxygenase (IDO) inhibitors" (Bioorganic and Medicinal Chemistry (2011) (1550-1561)). In: Bioorganic & Medicinal Chemistry : the tetrahedron journal for research at the interface of chemistry and biology, Vol. 19, no.9, p. 3029 (2011).
2011
Dolusic, Eduard ; Larrieu, Pierre ; Blanc, Sébastien ; Sapunaric, Frédéric ; Pouyez, Jenny ; Moineaux, Laurence ; Colette, Delphine ; Stroobant, Vincent ; Pilotte, Luc ; Colau, Didier ; Ferain, Thierry ; Fraser, Graeme ; Galleni, Moreno ; Frère, Jean-Marie ; Masereel, Bernard ; Van den Eynde, Benoît ; Wouters, Johan ; Frédérick, Raphaël. Discovery and preliminary SARs of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors. In: European Journal of Medicinal Chemistry, Vol. 46, no. 7, p. 3058-3065 (2011). doi:10.1016/j.ejmech.2011.02.049.
2011
Dolusic, Eduard ; Larrieu, Pierre ; Blanc, Sébastien ; Sapunaric, Frédéric ; Norberg, Bernadette ; Moineaux, Laurence ; Colette, Delphine ; Stroobant, Vincent ; Pilotte, Luc ; Colau, Didier ; Ferain, Thierry ; Fraser, Graeme ; Galleni, Moreno ; Frère, Jean-Marie ; Masereel, Bernard ; Van den Eynde, Benoît ; Wouters, Johan ; Frédérick, Raphaël. Indol-2-yl ethanones as novel indoleamine 2,3-dioxygenase (IDO) inhibitors. In: Bioorganic & Medicinal Chemistry, Vol. 19, no. 4, p. 1550-1561 (2011). doi:10.1016/j.bmc.2010.12.032.
2011
Dolusic, Eduard ; Larrieu, Pierre ; Moineaux, Laurence ; Stroobant, Vincent ; Pilotte, Luc ; Colau, Didier ; Pochet, Lionel ; Van den Eynde, Benoît ; Masereel, Bernard ; Wouters, Johan ; Frédérick, Raphaël. Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators. In: Journal of Medicinal Chemistry, Vol. 54, no. 15, p. 5320-5334 (11/08/2011). doi:10.1021/jm2006782.
2003
Uyttenhove, Catherine ; Pilotte, Luc ; Théate, Ivan ; Stroobant, Vincent ; Colau, Didier ; Parmentier, Nicolas ; Boon, Thierry ; Van den Eynde, Benoît. Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase. In: Nature Medicine, Vol. 9, no. 10, p. 1269-1274 (2003). doi:10.1038/nm934.