IBST
Croix du sud 4-5/L7.07.02
1348 Louvain-la-Neuve
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- Bernard Knoops
Bernard Knoops
Professeur ordinaire
Bernard Knoops, Master in Biology (Catholic University of Louvain, 1984), PhD in Neurobiology (Catholic University of Louvain, 1990) is born in Brussels, Belgium, in 1962. He was postdoctoral fellow at McGill University, Canada (Profs. Albert Aguayo and Salvatore Carbonetto) and at the Catholic University of Louvain (Prof. Jean-Noel Octave and Prof. Alfred Bernard). He was then appointed to a faculty position (1997 to present) at the School of Biological Sciences, Faculty of Science, Catholic University of Louvain in Louvain-la-Neuve, Belgium. Bernard Knoops currently holds the position of Full Professor of Animal Biology, Histology and Molecular Cell Biology. He is titular or co-titular of six lectures at the Catholic University of Louvain.
From 1984 until 1997, research activities of Bernard Knoops were focused on axonal regeneration in the peripheral and central nervous system of mammals. Since 1997, his research is mainly focused on the characterization of peroxiredoxins and thioredoxins, and their physiological roles in animal cells. In particular, his group in collaboration with Belgian and foreign groups, has made important contributions to the identification and the characterization of mammalian peroxiredoxin-5. In 1999, he cloned the sequence of the cDNA coding for human peroxiredoxin-5 and published the first characterization of this thioredoxin peroxidase highly conserved in mammals and defining a new subfamily among peroxiredoxins. This first publication on peroxiredoxin-5 was followed by the determination of the tridimensional structure of the reduced enzyme obtained in collaboration with Prof. Jean-Paul Declercq. Since this seminal work, the group of Bernard Knoops pursued the study of human peroxiredoxin-5 as well as other animal peroxiredoxins and thioredoxins at the molecular and cellular level. His main recent research projects have been focused on the cytoprotective and signaling functions, the subcellular targeting, the enzymatic activity and the evolution of peroxiredoxins. More recently, the functions of peroxiredoxins and thioredoxins in the nervous system have been investigated in vivo and in vitro.
Bernard Knoops published over 70 papers and 2 book chapters. His work has been cited over 2,900 times and the H index over his 20 years research activities is 30 (Google Scholar March 2017). He obtained more than 20 national and international grants. In addition to his role as teacher at the Faculty of Science at the Catholic University of Louvain, he supervised 15 PhD theses and more than 50 Master degree theses. Bernard Knoops has been referee for more than 15 international journals and was foreign grant reviewer for 3 Foundations. He has been elected Vice-president (2004-2010) and President (2010-2013) of the Institute of Life Sciences (Catholic University of Louvain).
- Diplômes
Année Label Institution 1982 Candidat en sciences pour le groupe des sciences biologiques Université catholique de Louvain 1984 Licencié en sciences pour le groupe des sciences zoologiques Université catholique de Louvain 1991 Docteur en sciences Université catholique de Louvain
- Les cours
Nom ID Animal and human molecular genetics and genomics LBBMC2110 Animal and human cellular physiology LBBMC2111 Molecular and cellular pharmacology seminar LBBMC2214 Histologie animale LBIO1234 Biologie animale intégrée : coordination, perception et locomotion LBIO1236 Travaux pratiques intégrés de physiologie, histologie et biochimie animales LBIO1338 Compléments de biologie cellulaire animale LVETE1295
2021
Vermonden, Perrine ; Vancoppenolle, Matthias ; Dierge, Emeline ; Mignolet, Eric ; Cuvelier, Géraldine ; Knoops, Bernard ; Page, Melissa ; Debier, Cathy ; Feron, Olivier ; Larondelle, Yvan. Punicic Acid Triggers Ferroptotic Cell Death in Carcinoma Cells. In: Nutrients, Vol. 13, no. 8, p. 2751 [1-16] (2021). doi:10.3390/nu13082751.
2021
Poncin, Mégane A. ; Van Meerbeeck, Pierre ; Simpson, Joshua D. ; Clippe, André ; Tyckaert, François ; Bouillenne, Fabrice ; Degand, Hervé ; Matagne, André ; Morsomme, Pierre ; Knoops, Bernard ; Alsteens, David. Role of the Redox State of Human Peroxiredoxin-5 on Its TLR4-Activating DAMP Function. In: Antioxidants, Vol. 10, no.12, p. 1902 (2021). doi:10.3390/antiox10121902.
2018
Knoops, Bernard ; Becker, Sarah ; Poncin, Mégane ; Glibert, Julien ; Derclaye, Sylvie ; Clippe, André ; Alsteens, David. Specific interactions measured by AFM on living cells between peroxiredoxin-5 and TLR4: relevance for mechanisms of innate immunity.. In: Cell Chemical Biology, Vol. 25, p. 1-12. doi:10.1016/j.chembiol.2018.02.006.
2018
Pirson, Marc ; Clippe, André ; Knoops, Bernard. The curious case of peroxiredoxin-5 : what its absence in aves can tell us and how it can be used.. In: BMC Evolutionary Biology, Vol. 18, no.1, p. 1-11. doi:10.1186/s12862-018-1135-z.
2017
Lismont Celien ; Nordgren Marcus ; Brees Chantal ; Knoops, Bernard ; Van Veldhoven Paul P. ; Fransen Marc. Peroxisomes as modulators of cellular protein thiol oxidation: a new model system. . In: Antioxidants & Redox Signaling, Vol. xxx, p. xxx-xxx. doi:10.1089/ars.2017.6997 (Accepté/Sous presse).
2016
Colin, I.M. ; Colin, Henri ; Dufour, Inès ; Gielen, Charles-Edouard ; Many, Marie-Christine ; Saey, Jean ; Knoops, Bernard ; Gerard, Anne-Catherine. Extrapancreatic effects of incretin hormones: evidence for weight-independent changes in morphological aspects and oxidative status in insulin-sensitive organs of the obese nondiabetic Zucker rat (ZFR).. In: Physiological Reports, Vol. 4, no.15, p. 1-13 (2016). doi:10.14814/phy2.12886.
2016
Knoops, Bernard ; Argyropoulou, Vasiliki ; Becker, Sarah ; Ferté, Laura ; Kuznetsova, Oksana. Multiple roles of peroxiredoxins in inflammation.. In: Molecules and Cells, Vol. 39, no.1, p. 60-64 (2016). doi:10.14348/molcells.2016.2341.
2015
Walbrecq, Geoffroy ; Wang, Bo ; Becker, Sarah ; Hannotiau, Amandine ; Fransen, Marc ; Knoops, Bernard. Antioxidant cytoprotection by peroxisomal peroxiredoxin-5.. In: Free Radical Biology & Medicine, Vol. 84, p. 215-226 (2015). doi:10.1016/j.freeradbiomed.2015.02.032.
2015
Chidlow, Glyn ; Wood, John P.M. ; Knoops, Bernard ; Casson, Robert J.. Expression and distribution of peroxiredoxins in the retina and optic nerve.. In: Brain Structure Function, Vol. 221, no. 8, p. 3903-3925 (2015). doi:10.1007/s00429-015-1135-3.
2015
Pirson, Marc ; Knoops, Bernard. Expression of peroxiredoxins and thioredoxins in the mouse spinal cord during embryonic development.. In: Journal of Comparative Neurology, Vol. 523, no. 000, p. 2599-2617 (2015). doi:10.1002/cne.23807.
2015
Pirson, Marc ; Debrulle, Stéphanie ; Clippe, André ; Clotman, Frédéric ; Knoops, Bernard. Thioredoxin-2 modulates neuronal programmed cell death in the embryonic chick spinal cord in basal and target-deprived conditions.. In: PLoS One, Vol. 000, no.000, p. 1-21 (2015). doi:10.1371/journal.pone.0142280.
2014
Manta, Bernard ; Tourn, Maria Victoria ; Clippe, André ; Knoops, Bernard ; Alvarez, Beatriz ; Coitino, E. Laura ; Ferrer-Sueta, Gerardo ; Portillo-Ledesma, F. ; Sardi, F.. Deconstructing the catalytic efficiency of peroxiredoxin-5 peroxidatic cysteine.. In: Biochemistry (including biophysical chemistry and molecular biology), Vol. 53, no.n, p. 6113-6125 (2014). doi:10.1021/bi500389m.
2014
Degand, Simon ; Knoops, Bernard ; Dupont-Gillain, Christine C.. Design and characterization of surfaces presenting mechanical nanoheterogeneities for a better control of cell-material interactions.. In: Colloids and Surfaces A: Physicochemical and Engineering Aspects, Vol. 442, no./, p. 164-172 (2014). doi:10.1016/j.colsurfa.2013.05.024.
2013
Van Der Eecken, Valérie ; Clippe, André ; Dekoninck, Sophie ; Goemaere, Julie ; Walbrecq, Geoffroy ; Van Veldhoven, Paul ; Knoops, Bernard. Abolition of peroxiredoxin-5 mitochondrial targeting during canid evolution.. In: PLoS One, Vol. 8, no. 9, p. e72844 (2013). doi:10.1371/journal.pone.0072844.
2013
Sardi, Florencia ; Manta, Bruno ; Portillo-Ledesma, Stephanie ; Knoops, Bernard ; Comini , Marcelo A. ; Ferrer-Sueta, Gerardo. Determination of acidity and nucleophilicity in thiols by reaction with monobromobimane and fluorescence detection.. In: Analytical Biochemistry, Vol. 435, no.n/0, p. 74-82 (2013). doi:10.1016/j.ab.2012.12.017.
2013
Genard, Bertrand ; Marie, Benjamin ; Loumaye, Eleonore ; Knoops, Bernard ; Legendre, Pierre ; Rees, Jean-François. Living in a hot redox soup: antioxidant defences of the hydrothermal worm Alvinella pompejana. . In: Aquatic Biology, Vol. 18, p. 217-228 (2013). doi:10.3354/ab00498.
2013
De Simoni, Stéphanie ; Linard, Dominique ; Hermans, Emmanuel ; Knoops, Bernard ; Goemaere, Julie. Mitochondrial peroxiredoxin-5 as potential modulator of mitochondria-ER crosstalk in MPP+-induced cell death.. In: Journal of Neurochemistry, Vol. 125, p. 473-485 (2013). doi:10.1111/jnc.12117.
2018
Becker, Sarah ; Lauwers Eric ; Glibert, Julien ; Haumont, Alice ; Knoops, Bernard. Modulation of peroxiredoxin-5 by LPS and MicroRNAs in mouse and human phagocytes.. Toll 2018 - Editing innate immunity (Porto, Portugal, du 6/06/2018 au 12/06/2018).
2018
Argyropoulou, Vasiliki ; Goemaere Julie ; Lefort, Charlotte ; Tissir, Fadel ; Huaux, François ; Guiot, Yves ; Marbaix, Etienne ; Galant, Christine ; Knoops, Bernard. Role of peroxiredoxin-5 in inflammation and tumor suppression.. Groupe de contact FNRS "Oxidative Processes and Antioxidants" meeting on "Oxidative Stress in Subcellular Compartments" (Namur, Belgium, 02/02/2018).
2018
Poncin M. ; Glibert, Julien ; Becker, Sarah ; Derclaye, Sylvie ; Clippe, André ; Knoops, Bernard ; Alsteens, David. Specific interactions between peroxiredoxin-5 and Toll-like receptor-4 measured by atomic force microscopy.. Groupe de contact FNRS "Oxidative Processes and Antioxidants" meeting on "Oxidative Stress in Subcellular Compartments" (Namur, Belgium, 02/02/2017).
2017
Argyropoulou, Vasiliki ; Goemaere Julie ; Lefort C. ; Tissir, Fadel ; Huaux, François ; Guiot, Yves ; Marbaix, Etienne ; Galant, Christine ; Knoops, Bernard. Role of peroxiredoxin-5 in inflammation and tumor suppression.. Macrophage Biology in the Single-Cell Era VIB conferences. (Ghent, Belgium, du 26/10/2017 au 27/10/2017).
2017
Becker, Sarah ; Lauwers Eric ; Glibert, Julien ; Haumont, Alice ; Knoops, Bernard. Up-regulation of peroxiredoxin-5 upon microglial activation and modulation by micro RNAs.. BSCDB and Euron Spring Meeting (Hasselt, Belgium, du 4/05/2017 au 5/05/2017).
2016
Degand, Simon ; Knoops, Bernard ; Riehle, M. ; Dupont-Gillain, Christine C.. Control of cell-material interactions through the use of mechanical nanoheterogeneities.. World Biomaterials Congress (Montreal (Canada)).
2016
Becker, Sarah ; Lauwers, Eric ; Glibert, Julien ; Knoops, Bernard. Identification and characterization of mcroRNAs modulating peroxiredoxin-5 expression during inflammation.. SFRBM/SFRRI 23rd annual meeting (San Francisco, USA, du 16/11/2016 au 19/11/2016).
2016
Argyropoulou, Vasiliki ; Goemaere, Julie ; Clippe, André ; Lefort, Charlotte ; Tissir, Fadel ; Schackman, O. ; Gailly, Philippe ; Ahn, Marie-Thérèse ; Guiot, Yves ; Galant, Christine ; Knoops, Bernard. Peroxiredoxin-5 as a novel actor in inflammation and tumor suppression.. SFRBM/SFRRI 23rd annual meeting (San Francisco, USA, du 16/11/2016 au 19/11/2016).
2015
Becker, Sarah ; Lauwers, Eric ; Knoops, Bernard. Identification of miRNAs targeting PRDX5.. 212th meeting of the Belgian Society of Biochemistry and Molecular Biology (Louvain-la-Neuve, Belgium, 21/05/2015).
2015
Becker, Sarah ; Lauwers, Eric ; Knoops, Bernard. Identification of miRNAs targeting PRDX5.. 212th meeting of the Belgian Society of Biochemistry and Molecular Biology (Louvain-la-Neuve, Belgique, 21/05/2015).
2015
Knoops, Bernard. Peroxiredoxin-5: really atypical?. First International Symposium on Peroxiredoxins (Seoul, du 26/10/2015 au 27/10/2015).
2014
Kuznetsova, Oksana ; Knoops, Bernard. Antioxidant status of astroglia in a rat model of amyotrophic lateral sclerosis: role of peroxiredoxins.. 11th meeting of the Groupe de contact FNRS Stress Oxydant (Liège, Belglique, 25/04/2014).
2014
Pirson, Marc ; Debrulle, Stéphanie ; Willot, Quentin ; Clippe, André ; Knoops, Bernard. Implication of mitochondrial thioredoxin-2 in spinal cord development, redox regulation.. Redox regulation in health and disease, a celebration of 50 years of the Keilin Memorial Lecture (Edimboug, du 19/03/2014 au 21/03/2014).
2014
Pirson, Marc ; Debrulle, Stéphanie ; Willot, Quentin ; Clippe, André ; Knoops, Bernard. Implication of mitochondrial thioredoxin-2 in spinal cord development. Redox regulation in health and disease.. 11th meeting of the Groupe de contact FNRS Stress Oxydant (Liège, Belgique, 25/04/2014).
2013
Walbrecq, Geoffroy ; Becker, Sarah ; Wang, B. ; Hannotiau, Amandine ; Fransen, M. ; Knoops, Bernard. Cytoprotective function of peroxisomal peroxiredoxin-5 in glial cells. . 5th Conference on advances in molecular mechanisms underlying neurological disorders. (Bath, U.K., du 23/06/2013 au 26//06/2013).
2013
Portillo-Ledesma, S. ; Manta, B. ; Clippe, André ; Knoops, Bernard ; Coitino, L. ; Ferrer-Sueta, G.. Structural and energetic aspects of peroxiredoxin 5 catalysis: an experimental and computational approach.. VIII Meeting of the Society for Free Radical in Biology and Medicine (South American Group) (Buenos Aires, Argentina, du 14/10/2013 au 17/10/2013).