GECE -Avenue Hippocrate, 75, Bte.7529
1200 Bruxelles (Woluwe-Sa
- Accueil
- Répertoire
- Charles De Smet
Charles De Smet
Professeur ordinaire
- Diplômes
Année Label Institution 1985 Candidat en sciences pour le groupe des sciences biologiques Université catholique de Louvain 1987 Licencié en sciences pour le groupe des sciences zoologiques Université catholique de Louvain 1993 Diplômé d'études approfondies en biologie Université catholique de Louvain 1994 Docteur en sciences Université catholique de Louvain
- Les cours
Nom ID Biologie et physiologie cellulaire LGBIO1111 Biologie générale et approche expérimentale de la biologie WMD1120 Biologie et embryologie générale WMEDE1112 Biologie moléculaire (dont l'épigénétique) et travaux dirigés WSBIM1226 Embryologie WSBIM1310 Design expérimental en sciences biomédicales WSBIM1313 Séminaire d'accompagnement du mémoire en sciences biomédicales WSBIM2061 Génétique et épigénétique des tumeurs WSBIM2142 Special issues in cancerology WSBIM2244 In-session seminar in biomedicine WSBIM2245 Scientific communication workshop WSBIM2280
Le maintien des programmes d’expression génique est essentiel pour assurer le bon fonctionnement de l’ensemble des cellules qui composent l’organisme. Les cellules disposent à cette fin de mécanismes de régulation dits “épigénétiques“, basés sur l’ajout de modifications chimiques au niveau des gènes. Il est maintenant évident que ces mécanismes sont profondément perturbés dans la majorité des cancers. Notre équipe investigue les causes et les conséquences des altérations épigénétiques dans les tumeurs.
2024
Fain, Jean S. ; Wangermez, Camille ; Loriot, Axelle ; Denoue, Claudia ; De Smet, Charles. DNA Hypomethylation Underlies Epigenetic Swapping between AGO1 and AGO1-V2 Isoforms in Tumors. In: Epigenomes, Vol. 8, no.3, p. 24 (2024). doi:10.3390/epigenomes8030024.
2023
Diacofotaki, Anna ; Loriot, Axelle ; De Smet, Charles. An abundance of brain-expressed genes show ectopic activation in lung adenocarcinoma. In: bioRxiv, Vol. -, no.-, p. 557389 (2023). doi:10.1101/2023.09.12.557389.
2023
De Smet, Charles. DNA methylation profiling in early lung adenocarcinoma to predict response to immunotherapy. In: Translational Lung Cancer Research, Vol. 12, no. 4, p. 657-660 (2023). doi:10.21037/tlcr-23-96.
2022
Diacofotaki, Anna ; Loriot, Axelle ; De Smet, Charles. Identification of tissue-specific gene clusters induced by DNA demethylation in lung adenocarcinoma: more than germline genes. In: Cancers, Vol. 14, no. 4, p. 1007 (2022). doi:10.3390/cancers14041007.
2021
Viceconte, Nikenza ; Loriot, Axelle ; Lona Abreu, Patricia ; Scheibe, Marion ; Fradera Sola, Albert ; Butter, Falk ; De Smet, Charles ; Azzalin, Claus M ; Arnoult, Nausica ; Decottignies, Anabelle. PAR-TERRA is the main contributor to telomeric repeat-containing RNA transcripts in normal and cancer mouse cells. In: RNA, Vol. 27, no. 1, p. 106-121 (2021). doi:10.1261/rna.076281.120.
2021
Vander Linden, Catherine ; Corbet, Cyril ; Bastien, Estelle ; Martherus, Ruben ; Guilbaud, Céline ; Petit, Laurenne ; Wauthier, Loris ; Loriot, Axelle ; De Smet, Charles ; Feron, Olivier. Therapy-induced DNA methylation inactivates MCT1 and renders tumor cells vulnerable to MCT4 inhibition. In: Cell Reports, Vol. 35, no.9, p. 109202 (2021). doi:10.1016/j.celrep.2021.109202.
2021
Fain, Jean ; Loriot, Axelle ; Diacofotaki, Anna ; Van Tongelen, Aurélie ; De Smet, Charles. Transcriptional overlap links DNA hypomethylation with DNA hypermethylation at adjacent promoters in cancer. In: Scientific Reports, Vol. 11, p. 17346 (2021). doi:10.1038/s41598-021-96844-0.
2019
Fain, Jean ; Van Tongelen, Aurélie ; Loriot, Axelle ; De Smet, Charles. Epigenetic Coactivation of MAGEA6 and CT-GABRA3 Defines Orientation of a Segmental Duplication in the Human X Chromosome.. In: Cytogenetic and Genome Research, (2019). doi:10.1159/000502933 (Accepté/Sous presse).
2017
De Pauw, Aurelia ; Andre, Emilie ; Sekkali, Belaid ; Bouzin, Caroline ; Esfahani, Hrag ; Barbier, Nicolas ; Loriot, Axelle ; De Smet, Charles ; Vanhoutte, Laetitia ; Moniotte, Stéphane ; Gerber, Bernhard ; di Mauro, Vittoria ; Catalucci, Daniele ; Feron, Olivier ; Hilfiker-Kleiner, Denise ; Balligand, Jean-Luc. Dnmt3a-mediated inhibition of Wnt in cardiac progenitor cells improves differentiation and remote remodeling after infarction.. In: JCI insight, Vol. 2, no.12 (2017). doi:10.1172/jci.insight.91810.
2017
Van Tongelen, Aurélie ; Loriot, Axelle ; De Smet, Charles. Oncogenic roles of DNA hypomethylation through the activation of cancer-germline genes. In: Cancer Letters, Vol. 396, p. 130-137 (28/06/2017). doi:10.1016/j.canlet.2017.03.029.
2015
Cannuyer, Julie ; Van Tongelen, Aurélie ; Loriot, Axelle ; De Smet, Charles. A gene expression signature identifying transient DNMT1 depletion as a causal factor of cancer-germline gene activation in melanoma.. In: Clinical Epigenetics, Vol. 7, no. 1, p. 114 [1-17] (2015). doi:10.1186/s13148-015-0147-4.
2015
Van Tongelen, Aurélie ; Loriot, Axelle ; De Backer, Olivier ; De Smet, Charles. Application of CRISPR/cas9-Directed Homologous Recombination to the Generation of Human Tumor Cells with Conditional Knockout of an X-Linked MicroRNA Locus. In: Gene Technology, Vol. 04, no. 02, p. 1000124 (2015). doi:10.4172/2329-6682.1000124.
2014
Loriot, Axelle ; Van Tongelen, Aurélie ; Blanco, Jordi ; Klaessens, Simon ; Cannuyer, Julie ; van Baren, Nicolas ; Decottignies, Anabelle ; De Smet, Charles. A novel cancer-germline transcript carrying pro-metastatic miR-105 and TET-targeting miR-767 induced by DNA hypomethylation in tumors.. In: Epigenetics, Vol. 9, no. 8, p. 1163-1171 (2014). doi:10.4161/epi.29628.
2014
Hendrickx, Aurélie ; Pierrot, Nathalie ; Tasiaux, Bernadette ; Schakman, Olivier ; Kienlen-Campard, Pascal ; De Smet, Charles ; Octave, Jean-Noël. Epigenetic regulations of immediate early genes expression involved in memory formation by the amyloid precursor protein of Alzheimer disease. In: PLoS One, Vol. 9, no. 6, p. e99467 [1-9] (2014). doi:10.1371/journal.pone.0099467.
2013
Cannuyer, Julie ; Loriot, Axelle ; Parvizi, Grégory K ; De Smet, Charles. Epigenetic Hierarchy within the MAGEA1 Cancer-Germline Gene: Promoter DNA Methylation Dictates Local Histone Modifications.. In: PLoS One, Vol. 8, no.3, p. e58743 (2013). doi:10.1371/journal.pone.0058743.
2013
Hendrickx, Aurélie ; Pierrot, Nathalie ; Tasiaux, Bernadette ; Schakman, Olivier ; Brion, Jean-Pierre ; Kienlen-Campard, Pascal ; De Smet, Charles ; Octave, Jean-Noël. Epigenetic induction of EGR-1 expression by the amyloid precursor protein during exposure to novelty.. In: PloS one, Vol. 8, no. 9, p. e74305 (2013). doi:10.1371/journal.pone.0074305.
2012
Tilman, Gaëlle ; Arnoult, Nausica ; Lenglez, Sandrine ; Van Beneden, Amandine ; Loriot, Axelle ; De Smet, Charles ; Decottignies, Anabelle. Cancer-linked satellite 2 DNA hypomethylation does not regulate Sat2 non-coding RNA expression and is initiated by heat shock pathway activation.. In: Epigenetics, Vol. 7, no.8, p. 903-13 (2012). doi:10.4161/epi.21107.
2012
Lucas, Sophie ; van Baren, Nicolas ; De Smet, Charles ; Coulie, Pierre G.. Demethylation of the FOXP3 gene in human melanoma cells precludes the use of this epigenetic mark for quantification of Tregs in unseparated melanoma samples.. In: International Journal of Cancer, Vol. 130, no. 8, p. 1960-1966 (2012). doi:10.1002/ijc.26198.
2012
Loriot, Axelle ; Parvizi, Grégory K ; Reister, Sven ; De Smet, Charles. Silencing of cancer-germline genes in human preimplantation embryos: evidence for active de novo DNA methylation in stem cells.. In: Biochemical and Biophysical Research Communications, Vol. 417, no.1, p. 187-91 (2012). doi:10.1016/j.bbrc.2011.11.120.
2010
Bazhin, Alexandr V. ; De Smet, Charles ; Golovastova, Marina O. ; Schmidt, Jan ; Philippov, Pavel P.. Aberrant demethylation of the recoverin gene is involved in the aberrant expression of recoverin in cancer cells. In: Experimental Dermatology, Vol. 19, no. 11, p. 1023-5 (2010). doi:10.1111/j.1600-0625.2010.01126.x.
2010
De Smet, Charles ; Loriot, Axelle. DNA hypomethylation in cancer: Epigenetic scars of a neoplastic journey.. In: Epigenetics : official journal of the DNA Methylation Society, Vol. 5, no. 3 (2010).
2009
Stockis, Julie ; Fink, Wolfram ; François, Violaine ; Connerotte, Thierry ; De Smet, Charles ; Knoops, Laurent ; van der Bruggen, Pierre ; Boon, Thierry ; Coulie, Pierre G. ; Lucas, Sophie. Comparison of stable human Treg and Th clones by transcriptional profiling.. In: European Journal of Immunology, Vol. 39, no. 3, p. 869-882 (2009). doi:10.1002/eji.200838807.
2009
Loriot, Axelle ; Reister, Sven ; Parvizi, Gregory K ; Lysy, Philippe ; De Smet, Charles. DNA Methylation-Associated Repression of Cancer-Germline Genes in Human Embryonic and Adult Stem Cells.. In: Stem Cells : the international journal of cell differentiation and proliferation, Vol. 27, no. 4, p. 822-824 (2009). doi:10.1002/stem.8.
2009
Tilman, Gaëlle ; Loriot, Axelle ; Van Beneden, A ; Arnoult, N ; Londoño-Vallejo, J A ; De Smet, Charles ; Decottignies, Anabelle. Subtelomeric DNA hypomethylation is not required for telomeric sister chromatid exchanges in ALT cells.. In: Oncogene, Vol. 28, no. 14, p. 1682-93 (2009). doi:10.1038/onc.2009.23.
2008
Kholmanskikh, Olga ; Loriot, Axelle ; Brasseur, Francis ; De Plaen, Etienne ; De Smet, Charles. Expression of BORIS in melanoma: lack of association with MAGE-A1 activation.. In: International journal of cancer. Journal international du cancer, Vol. 122, no. 4, p. 777-84 (2008). doi:10.1002/ijc.23140.
2008
Loriot, Axelle ; Sterpin, Christiane ; De Backer, Olivier ; De Smet, Charles. Mouse embryonic stem cells induce targeted DNA demethylation within human MAGE-A1 transgenes.. In: Epigenetics : official journal of the DNA Methylation Society, Vol. 3, no. 1, p. 38-42 (2008).
2007
Bazhin, Alexandr V. ; Schadendorf, Dirk ; Willner, Nadine ; De Smet, Charles ; Heinzelmann, Anita ; Tikhemirova, Natalya K. ; Umansky, Viktor ; Philippov, Pavel P. ; Eichmüller, Stefan B.. Photoreceptor proteins as cancer-retina antigens. In: International Journal of Cancer, Vol. 120, no. 6, p. 1268-1276 (2007). doi:10.1002/ijc.22458.
2006
Loriot, Axelle ; De Plaen, Etienne ; Boon, Thierry ; De Smet, Charles. Transient down-regulation of DNMT1 methyltransferase leads to activation and stable hypomethylation of MAGE-A1 in melanoma cells.. In: The Journal of biological chemistry, Vol. 281, no. 15, p. 10118-10126 (2006). doi:10.1074/jbc.M510469200.
2005
Brenner, Carmen ; Deplus, Rachel ; Didelot, Céline ; Loriot, Axelle ; Vire, Emmanuelle ; De Smet, Charles ; Gutierrez, Arantxa ; Danovi, Davide ; Bernard, David ; Boon, Thierry ; Pelicci, Pier Giuseppe ; Amati, Bruno ; Kouzarides, Tony ; de Launoit, Yvan ; Di Croce, Luciano ; Fuks, François. Myc represses transcription through recruitment of DNA methyltransferase corepressor. In: The EMBO journal, Vol. 24, no. 2, p. 336-346 (2005). doi:10.1038/sj.emboj.7600509.
2004
Laduron, Sandra ; Deplus, Rachel ; Zhou, Sifang ; Kholmanskikh, Olga ; GODELAINE, Danièle ; De Smet, Charles ; Hayward, S Diane ; Fuks, François ; Boon, Thierry ; De Plaen, Etienne. MAGE-A1 interacts with adaptor SKIP and the deacetylase HDAC1 to repress transcription.. In: Nucleic Acids Research, Vol. 32, no. 14, p. 4340-4350 (2004). doi:10.1093/nar/gkh735.
2004
De Smet, Charles ; Loriot, Axelle ; Boon, Thierry. Promoter-dependent mechanism leading to selective hypomethylation within the 5 ' region of gene MAGE-A1 in tumor cells. In: Molecular and Cellular Biology, Vol. 24, no. 11, p. 4781-4790 (2004). doi:10.1128/MCB.24.11.4781-4790.2004.
2003
Rousseau, Emmanuel ; Ruchoux, M-M ; Scaravilli, F. ; Chapon, F ; Vinchon, M ; De Smet, Charles ; Godfraind, Catherine ; Vikkula, Miikka. CDKN2A, CDKN2B and p14ARF are frequently and differentially methylated in ependymal tumours.. In: Neuropathology and applied neurobiology, Vol. 29, no. 6, p. 574-83 (2003). doi:10.1046/j.0305-1846.2003.00505.x.
2003
Loriot, Axelle ; Boon, Thierry ; De Smet, Charles. Five new human cancer-germline genes identified among 12 genes expressed in spermatogonia. In: International Journal of Cancer, Vol. 105, no. 3, p. 371-376 (2003). doi:10.1002/ijc.11104.
2003
Karanikas, V ; Lurquin, C. ; Colau, Didier ; van Baren, Nicolas ; De Smet, Charles ; Lethé, Bernard ; Connerotte, Thierry ; Corbiere, Véronique ; Demoitie, MA ; Lienard, D. ; Dréno, B. ; Velu, T ; Boon, Thierry ; Coulie, Pierre G.. Monoclonal anti-MAGE-3 CTL responses in melanoma patients displaying tumor regression after vaccination with a recombinant canarypox virus. In: Journal of Immunology, Vol. 171, no. 9, p. 4898-4904 (2003). doi:10.4049/jimmunol.171.9.4898.
2002
De Smet, Charles ; Nishimori, Hiroyuki ; Furnari, Frank B ; Bögler, Oliver ; Huang, H-J Su ; Cavenee, Webster K. A novel seven transmembrane receptor induced during the early steps of astrocyte differentiation identified by differential expression.. In: Journal of neurochemistry, Vol. 81, no. 3, p. 575-88 (2002).
2000
Martelange, V ; De Smet, Charles ; De Plaen, Etienne ; Lurquin, C. ; Boon, Thierry. Identification on a human sarcoma of two new genes with tumor-specific expression.. In: Cancer research, Vol. 60, no. 14, p. 3848-55 (2000).
1999
De Backer, Olivier ; Arden, Karen C. ; Boretti, Mauro ; Vantomme, Valérie ; De Smet, Charles ; Czekay, Suzanne ; Viars, Carrie S. ; De Plaen, Etienne ; Brasseur, Francis ; Chomez, Patrick ; Van den Eynde, Benoît ; Boon-Falleur, Thierry ; van der Bruggen, Pierre. Characterization of the GAGE genes that are expressed in various human cancers and in normal testis. In: Cancer Research, Vol. 59, no. 13, p. 3157-3165 (1999).
1999
De Smet, Charles ; Lurquin, Christophe ; Lethé, Bernard ; Martelange, Valérie ; Boon, Thierry. DNA methylation is the primary silencing mechanism for a set of germ line- and tumor-specific genes with a CpG-rich promoter. In: Molecular and Cellular Biology, Vol. 19, no. 11, p. 7327-7335 (1999). doi:10.1128/mcb.19.11.7327.
1999
Louahed, Jamila ; Grasso, Luigi ; De Smet, Charles ; Van Roost, Emiel ; Wildmann, Claude ; Nicolaides, Nicholas C. ; Levitt, Roy C. ; Renauld, Jean-Christophe. Interleukin-9-induced expression of M-Ras/R-Ras3 oncogene in T-helper clones. In: Blood, Vol. 94, no. 5, p. 1701-1710 (1999). doi:10.1182/blood.V94.5.1701.
1999
Janssen, BLM ; van de Locht, LTF ; Fourkour, A ; De Smet, Charles ; Mensink, EJBM ; van Muijen, GNP ; de Vries, TJ. Transcription of the MAGE-1 gene and the methylation status of its Ets binding promoter elements: a quantitative analysis in melanoma cell lines using a real-time polymerase chain reaction technique. In: Melanoma Research : an international journal of rapid communications of basic and clinical research in melanoma, Vol. 9, no. 3, p. 213-222 (1999). doi:10.1097/00008390-199906000-00002.
1998
Lucas, Sophie ; De Smet, Charles ; Arden, KC. ; Viars, CS ; Lethé, Bernard ; Lurquin, C. ; Boon, Thierry. Identification of a new MAGE gene with tumor-specific expression by representational difference analysis. In: Cancer Research, Vol. 58, no. 4, p. 743-752 (1998).
1998
Lethé, B ; Lucas, Sophie ; Michaux, Lucienne ; De Smet, Charles ; Godelaine, D. ; Serrano, A ; De Plaen, Etienne ; Boon, Thierry. LAGE-1, a new gene with tumor specificity.. In: International journal of cancer. Journal international du cancer, Vol. 76, no. 6, p. 903-8 (1998). doi:10.1002/(SICI)1097-0215(19980610)76:6<903::AID-IJC22>3.0.CO;2-1.
1997
De Plaen, Etienne ; Naerhuyzen, Bénédicte ; De Smet, Charles ; Szikora, Jean-Pierre ; Boon-Falleur, Thierry. Alternative promoters of gene MAGE4a. In: Genomics, Vol. 40, no. 2, p. 305-313 (1997). doi:10.1006/geno.1996.4566.
1997
Ikeda, Hideyuki ; Lethé, Bernard ; Lehmann, Frédéric ; van Baren, Nicolas ; Baurain, Jean-François ; De Smet, Charles ; Chambost, Hervé ; Vitale, Massimo ; Moretta, Alessandro ; Boon-Falleur, Thierry ; Coulie, Pierre G.. Characterization of an antigen that is recognized on a melanoma showing partial HLA loss by CTL expressing an NK inhibitory receptor. In: Immunity, Vol. 6, no. 2, p. 199-208 (1997). doi:10.1016/S1074-7613(00)80426-4.
1997
De Smet, Charles ; Lurquin, Christophe ; De Plaen, Etienne ; Brasseur, Francis ; Zarour, Hassane ; De Backer, Olivier ; Coulie, Pierre G. ; Boon-Falleur, Thierry. Genes coding for melanoma antigens recognised by cytolytic T lymphocytes. In: Eye, Vol. 11, p. 243-248 (1997). doi:10.1038/eye.1997.59.
1997
De Smet, Charles ; Martelange, Valérie ; Lucas, Sophie ; Brasseur, Francis ; Lurquin, Christophe ; Boon-Falleur, Thierry. Identification of human testis-specific transcripts and analysis of their expression in tumor cells. In: Biochemical and Biophysical Research Communications, Vol. 241, no. 3, p. 653-657 (1997). doi:10.1006/bbrc.1997.7868.
1997
Lurquin, Christophe ; De Smet, Charles ; Brasseur, Francis ; Muscatelli, Françoise ; Martelange, Valérie ; De Plaen, Etienne ; Brasseur, Roger ; Monaco, Anthony P. ; Boon-Falleur, Thierry. Two members of the human MAGEB gene family located in Xp21.3 are expressed in tumors of various histological origins. In: Genomics, Vol. 46, no. 3, p. 397-408 (1997). doi:10.1006/geno.1997.5052.
1996
De Smet, Charles ; Debacker, O. ; Faraoni, I. ; Lurquin, C. ; Brasseur, Francis ; Boon, Thierry. The activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation. In: National Academy of Sciences. Proceedings, Vol. 93, no. 14, p. 7149-7153 (1996). doi:10.1073/pnas.93.14.7149.
1996
Zarour, H ; De Smet, Charles ; Lehmann, F. ; Marchand, Maurice ; Lethé, B ; Romero, P. ; Boon, Thierry ; Renauld, Jean-Christophe. The majority of autologous cytolytic T-lymphocyte clones derived from peripheral blood lymphocytes of a melanoma patient recognize an antigenic peptide derived from gene Pmel17/gp100.. In: The Journal of investigative dermatology, Vol. 107, no. 1, p. 63-7 (1996). doi:10.1111/1523-1747.ep12298177.
1995
De Smet, Charles ; Courtois, SJ. ; Faraoni, I. ; Lurquin, C. ; Szikora, Jean-Pierre ; Debacker, O. ; Boon, Thierry. Involvement of 2 Ets Binding-sites in the Transcriptional Activation of the Mage1 Gene. In: Immunogenetics, Vol. 42, no. 4, p. 282-290 (1995).
1994
van der Bruggen, Pierre ; Bastin, Judy ; Gajewski, Thomas ; Coulie, Pierre G. ; Boël, Pascale ; De Smet, Charles ; Traversari, Catia ; Townsend, Alain ; Boon-Falleur, Thierry. A peptide encoded by human gene MAGE-3 and presented by HLA-A2 induces cytolytic T lymphocytes that recognize tumor cells expressing MAGE-3. In: European Journal of Immunology, Vol. 24, no. 12, p. 3038-3043 (1994). doi:10.1002/eji.1830241218.
1994
De Smet, Charles ; Lurquin, C. ; van der Bruggen, Pierre ; De Plaen, Etienne ; Brasseur, Francis ; Boon-Falleur, Thierry. Sequence and Expression Pattern of the Human Mage2 Gene. In: Immunogenetics, Vol. 39, no. 2, p. 121-129 (1994). doi:10.1007/BF00188615.
1994
De Plaen, Etienne ; Arden, Karen ; Traversari, Catia ; Gaforio, José Juan ; Szikora, Jean-Pierre ; De Smet, Charles ; Brasseur, Francis ; van der Bruggen, Pierre ; Lethé, Bernard ; Lurquin, Christophe ; Brasseur, Robert ; Chomez, Patrick ; De Backer, Olivier ; Cavenee, Webster ; Boon-Falleur, Thierry. Structure, Chromosomal Localization, and Expression of 12 Genes of the Mage Family. In: Immunogenetics, Vol. 40, no. 5, p. 360-369 (1994). doi:10.1007/BF01246677.
1992
Chomez, P. ; De Plaen, Etienne ; Van Pel, Aline ; De Smet, Charles ; Szikora, Jean-Pierre ; Lurquin, C. ; Lebacqverheyden, AM. ; Boon, Thierry. Efficient Expression of Tum- Antigen P91a By Transfected Subgenic Fragments. In: Immunogenetics, Vol. 35, no. 4, p. 241-252 (1992). doi:10.1007/BF00166829.
1992
Dyson, PJ. ; De Smet, Charles ; Knight, AM. ; Simonchazottes, D. ; Guénet, J.-L. ; Boon, Thierry. Mapping of the Genes Encoding Tum- Transplantation Antigen-p91a, Antigen-p35b, and Antigen-p198. In: Immunogenetics, Vol. 35, no. 5, p. 316-323 (1992). doi:10.1007/BF00189894.
1992
Dyson, P J ; De Smet, Charles ; Knight, A M ; Simon-Chazottes, D ; Guénet, J L ; Boon, T. Mapping of the genes encoding tum- transplantation antigens P91A, P35B, and P198.. In: Immunogenetics, Vol. 35, no. 5, p. 316-23 (1992).
2013
De Smet, Charles ; Loriot, Axelle. DNA hypomethylation and activation of germline-specific genes in cancer.. In: Adam R. Karpf, Epigenetic alterations in oncogenesis, Springer New York LLC, Adam R. Karpf: Nebraska, USA, 2013, 149-166. 978-1-4419-9966-5. doi:10.1007/978-1-4419-9967-2_7.
2023
De Smet, Charles. Epigenetic causes and consequences of cancer-germline gene activation in cancer. FASEB Catalyst Conference – How gametogenic genes promote cancer (Virtual Meeting, 08/11/2023).
2021
De Smet, Charles. Transcriptional overlap links DNA hypomethylation with DNA hypermethylation at adjacent promoters in cancer. Epigenetics in Cancer Symposium (Singapour-Paris, du 15/02/2021 au 17/02/2021).
2018
De Smet, Charles. Transcriptional overlap links DNA hypo-methylation and hyper-methylation of contiguous promoters in cancer. 4th International Congress on Epigenetics & Chromatin (Londres, du 03/09/2018 au 05/09/2018). In: Hereditary Genetics, Vol. 07, no.1, p. 80 (2018). doi:10.4172/2161-1041-c1-001.
2018
De Smet, Charles. Transcriptional overlap links DNA hypomethylation and hypermethylation of contiguous promoters in cancer. International congress on Epigenetics and chromatin (London, UK, 03/09/2018).
2015
De Smet, Charles. Genome hypomethylation and activation of germline-specific genes in tumors: causes and consequences. EPI-Nantes-2015 (Nantes, France, du 05/10/2015 au 06/10/2015).
2013
Aurelie Hendrickx ; Tasiaux, Bernadette ; Pierrot, Nathalie ; Schakman, Olivier ; Renauld, Jean-Christophe ; De Smet, Charles ; Octave, Jean-Noël ; Kienlen-Campard, Pascal. EPIGENETIC REGULATION OF EGR-1 EXPRESSION BY THE AMYLOID PRECURSOR PROTEIN OF ALZHEIMER DISEASE. The 11th International Conference on Alzheimer's and Parkinson Diseases (Florence, Italy, du 06/03/2013 au 10/04/2013). In: Neurodegenerative Diseases, Vol. 11.
2010
Loriot, Axelle ; Parvizi Nejad, Kian ; De Smet, Charles. Genome hypomethylation and activation of germline-specific genes in tumors. Epigenetics Europe (Dublin, Ireland, du 14/09/2010 au 15/09/2010).
2009
Tilman, Gaëlle ; Loriot, Axelle ; Van Beneden, Amandine ; Arnoult, Nausica ; Londono-Vallejo, Arturo ; De Smet, Charles ; Decottignies, Anabelle. Subtelomeric DNA hypomethylation is not required for telomeric sister chromatid exchanges in ALT cells. Chromatin and Cancer (Cambridge (UK) , du 06/07/2009 au 09/07/2009).
2004
De Smet, Charles ; Loriot, Axelle ; Boon, Thierry. Genome hypomethylation and activation of MAGE genes in tumor cells . The 27th Annual meeting of the Molecular Biology Society of Japan (Kobe, Japan, du 8/12/2004 au 11/12/2004).
2001
De Smet, Charles ; Lurquin, Christophe ; Boon, Thierry. Hypomethylation in human cancers is causally related to transcriptional activation of MAGE-type genes. AACR Special conference, Epigenetics of Cancer (Palm Desert, CA (USA), du 17/10/2001 au 21/10/2001).
1994
Boon-Falleur, Thierry ; Van den Eynde, Benoît ; Hirsch, Hans ; Moroni, Christoph ; De Plaen, Etienne ; van der Bruggen, Pierre ; De Smet, Charles ; Lurquin, Christophe ; Szikora, Jean-Pierre ; De Backer, Olivier. Genes coding for tumor-specific rejection antigens. 59th Symposium on Quantitative Biology (du 02/06/1994 au 08/06/1994). In: Cold Spring Harbor Laboratory. Symposia on Quantitative Biology, Vol. 59, p. 617-622 (1994). doi:10.1101/sqb.1994.059.01.070.
1993
De Smet, Charles. Etude du gène humain MAGE-1 qui code un antigène de rejet des tumeurs, prom. : Delcour, Jean ; Boon, Thierry, 1993.