BCHM
Avenue Hippocrate 75/B1.75.08
1200 Woluwe-Saint-Lambert
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- Géraldine Laloux
Géraldine Laloux
Professeure
Chercheuse qualifiée FNRS
Research Positions
2017 - Present: F.R.S.-FNRS Research Associate (Chercheur Qualifié) & Assistant Professor UCLouvain
2013 - 2017: Post-doctoral researcher, group of Prof. J.-F. Collet, UCLouvain (bacterial envelope stress responses)
2010 - 2013: Post-doctoral researcher, group of Prof. C. Jacobs-Wagner, Yale University, New Haven, CT (USA) (bacterial cell cycle and polarity)
2005 - 2009: PhD student, group of Prof. X. De Bolle (UNamur) (host-pathogen interactions)
2005: Master student intern, group of Prof. M. Vidal, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA (USA) (interactomics)
Education
2009: PhD in Sciences, UNamur
2005: Licence (Master) en Science biologiques, orientation moléculaire et cellulaire, UNamur
2003: Bachelier en Sciences biologiques, UNamur
Fellowships
2014 - 2017: F.R.S.-FNRS Post-doctoral fellowship (Chargé de Recherche)
2011 : van Itallie Fellow of the Belgian American Educational Foundation
2005 - 2009: F.R.S.-FNRS Research Fellow (Aspirant)
- Diplômes
Année Label Institution 2005 Licence en Sciences Biologique Facultés Universitaires Notre Dame de la Paix à Namur 2009 Docteur en sciences Facultés Universitaires Notre Dame de la Paix à Namur
Identifying principles and molecular mechanisms of bacterial self-organization, especially those governing spatiotemporal organization of bacterial cells (e.g. protein subcellular localization, chromosome dynamics and cell cycle regulation). In my lab, we use the predatory bacterium Bdellovibrio bacteriovorus, which proliferates in a non-binary manner inside other bacteria, to investigate these processes and how they are coordinated to produce a non-canonical lifestyle. To this end, we apply various approaches of bacterial cell biology including live fluorescence microscopy and quantitative image analysis at the population and single-cell levels, molecular biology, bacterial genetics and biochemistry.
Lab website : http://www.lalouxlab.weebly.com
Group page on the de Duve Institute website : https://www.deduveinstitute.be/fr/bacterial-cell-biology
2023
Santin, Yoann ; Lamot, Thomas ; van Raaphorst, Renske ; Kaljevic, Jovana ; Laloux, Géraldine. Modulation of prey size reveals adaptability and robustness in the cell cycle of an intracellular predator.. In: Current biology : CB, Vol. 33, no.11, p. 2213-2222.e4 (2023). doi:10.1016/j.cub.2023.04.059.
2023
Maccioni, Luca ; Kasavuli, Joyce ; Leclercq, Sophie ; Pirlot, Boris ; Laloux, Géraldine ; Horsmans, Yves ; Leclercq, Isabelle ; Schnabl, Bernd ; Stärkel, Peter. Toll-like receptor 2 activation in monocytes contributes to systemic inflammation and alcohol-associated liver disease in humans.. In: Hepatology communications, Vol. 7, no.5, p. - (2023). doi:10.1097/HC9.0000000000000107.
2022
Remy, Ophélie ; Lamot, Thomas ; Santin, Yoann ; Kaljevic, Jovana ; de Pierpont, Charles ; Laloux, Géraldine. An optimized workflow to measure bacterial predation in microplates.. In: STAR protocols, Vol. 3, no.1, p. 101104 (2022). doi:10.1016/j.xpro.2021.101104.
2021
Kaljevic, Jovana ; Saaki, Terrens Norus Vargio ; Govers, Sander ; Remy, Ophélie ; van Raaphorst, Renske ; Lamot, Thomas ; Laloux, Géraldine. Chromosome choreography during the non-binary cell cycle of a predatory bacterium. In: Current biology, Vol. 31, no. 17, p. 3707-3720.e5 (2021). doi:10.1016/j.cub.2021.06.024.
2021
Kaljevic, Jovana ; Saaki, Terrens Norus Vargio ; Govers, Sander ; Remy, Ophélie ; van Raaphorst, Renske ; Lamot, Thomas ; Laloux, Géraldine. Uncovering the choreography of the chromosome during the non-binary cell cycle of the predatory bacterium Bdellovibrio bacteriovorus. In: bioRxiv, (2021). doi:10.1101/2020.12.21.419010.
2020
Laloux, Géraldine. Shedding Light on the Cell Biology of the Predatory Bacterium.. In: Frontiers in microbiology, Vol. 10, p. 3136 (2020). doi:10.3389/fmicb.2019.03136.
2019
Delhaye, Antoine ; Collet, Jean-François ; Laloux, Géraldine. A Fly on the Wall: How Stress Response Systems Can Sense and Respond to Damage to Peptidoglycan.. In: Frontiers in cellular and infection microbiology, Vol. 9, no.-, p. 380 (2019). doi:10.3389/fcimb.2019.00380.
2019
Delhaye, Antoine ; Laloux, Géraldine ; Collet, Jean-François. The lipoprotein NlpE is a Cpx sensor that serves as a sentinel for protein sorting and folding defects in the envelope.. In: Journal of bacteriology, Vol. 201, no. 10, p. e00611-18 (2019). doi:10.1128/JB.00611-18.
2018
Hussein, Nahla A ; Cho, Seung-Hyun ; Laloux, Géraldine ; Siam, Rania ; Collet, Jean-François. Distinct domains of Escherichia coli IgaA connect envelope stress sensing and down-regulation of the Rcs phosphorelay across subcellular compartments.. In: PLoS Genetics, Vol. 14, no.5, p. e1007398 (2018). doi:10.1371/journal.pgen.1007398.
2017
Laloux, Géraldine ; Collet, Jean-François. Major Tom to ground control: how lipoproteins communicate extra-cytoplasmic stress to the decision center of the cell. In: Journal of Bacteriology, Vol. 199, no. 21, p. e00216-17 [1-13] (2017). doi:10.1128/JB.00216-17.
2016
Arts, Isabelle S. ; Vertommen, Didier ; Baldin, Francesca ; Laloux, Géraldine ; Collet, Jean-François. Comprehensively Characterizing the Thioredoxin InteractomeIn VivoHighlights the Central Role Played by This Ubiquitous Oxidoreductase in Redox Control. In: Molecular and Cellular Proteomics, Vol. 15, no.6, p. 2125-2140 (2016). doi:10.1074/mcp.M115.056440.
2016
Delhaye, Antoine ; Collet, Jean-François ; Laloux, Géraldine. Fine-Tuning of the Cpx Envelope Stress Response Is Required for Cell Wall Homeostasis in Escherichia coli.. In: mBio, Vol. 7, no. 1, p. e00047-16 (2016). doi:10.1128/mBio.00047-16.
2015
Beaufay, François ; Coppine, Jérôme ; Mayard, Aurélie ; Laloux, Géraldine ; De Bolle, Xavier ; Hallez, Régis. A NAD-dependent glutamate dehydrogenase coordinates metabolism with cell division in Caulobacter crescentus. In: The EMBO journal, Vol. 34, no.13, p. 1786-1800 (2015). doi:10.15252/embj.201490730.
2014
Cho, Seung Hyun ; Szewczyk, Joanna ; Pesavento, Christina ; Zietek, Matylda ; Banzhaf, Manuel ; Roszczenko, Paula ; Asmar, Abir ; Laloux, Géraldine ; Hov, Ann-Kristin ; Leverrier, Pauline ; Van DerHenst, Charles ; Vertommen, Didier ; Typas, Athanasios ; Collet, Jean-François. Detecting Envelope Stress by Monitoring β-Barrel Assembly. In: Cell, Vol. 159, no.7, p. 1652-1664 (28 dec 2014). doi:10.1016/j.cell.2014.11.045.
2014
Deghelt, Michaël ; Mullier, Caroline ; Sternon, Jean-François ; Francis, Nayla ; Laloux, Géraldine ; Dotreppe, Delphine ; Van der Henst, Charles ; Jacobs-Wagner, Christine ; Letesson, Jean-Jacques ; De Bolle, Xavier. G1-arrested newborn cells are the predominant infectious form of the pathogen Brucella abortus. In: Nature Communications, Vol. 5, p. 4366 (2014). doi:10.1038/ncomms5366.
2014
Laloux, Géraldine ; Jacobs-Wagner, Christine. How do bacteria localize proteins to the cell pole?. In: Journal of Cell Science, Vol. 127, no.1, p. 11-19 (1/1/2014). doi:10.1242/jcs.138628.
2013
Laloux, Géraldine ; Jacobs-Wagner, Christine. Spatiotemporal control of PopZ localization through cell cycle-coupled multimerization. In: The Journal of Cell Biology, Vol. 201, no.6, p. 827-841 (10/06/2013). doi:10.1083/jcb.201303036.
2011
de Barsy, Marie ; Jamet, Alexandre ; Filopon, Didier ; Nicolas, Cécile ; Laloux, Géraldine ; Rual, Jean-Rual ; Muller, Alexandre ; Twizere, Jean-Claude ; Nkengfac, Bernard ; Vandenhaute, Jean ; Hill, David E. ; Salcedo, Suzana P. ; Gorvel, Jean-Pierre ; Letesson, Jean-Jacques ; De Bolle, Xavier. Identification of a Brucella spp. secreted effector specifically interacting with human small GTPase Rab2. In: Cellular Microbiology, Vol. 13, no.7, p. 1044-1058 (2011). doi:10.1111/j.1462-5822.2011.01601.x.
2010
Laloux, Géraldine ; Deghelt, Michaël ; de Barsy, Marie ; Letesson, Jean-Jacques ; De Bolle, Xavier. Identification of the essential Brucella melitensis porin Omp2b as a suppressor of Bax-induced cell death in yeast in a genome-wide screening.. In: PLoS One, Vol. 5, no.10, p. e13274 (2010). doi:10.1371/journal.pone.0013274.
2009
Dreze, Matjia ; Charloteaux, Benoit ; Milstein, Stuart ; Vidalain, Pierre-Olivier ; Yildirim, Muhammed A ; Zhong, Quan ; Svrzikapa, Nenad ; Romero, Viviana ; Laloux, Géraldine ; Brasseur, Robert ; Vandenhaute, Jean ; Boxem, Mike ; Cusick, Michael E. ; Hill, David E. ; Vidal, Marc. 'Edgetic' perturbation of a C. elegans BCL2 ortholog. In: Nature Methods, Vol. 6, no. 11, p. 843-849 (2009).