BCHM
Avenue Hippocrate 75/B1.75.08
1200 Woluwe-Saint-Lambert
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- Géraldine Laloux
Géraldine Laloux
Professeure
Chercheuse qualifiée FNRS
Research Positions
2017 - Present: F.R.S.-FNRS Research Associate (Chercheur Qualifié) & Assistant Professor UCLouvain
2013 - 2017: Post-doctoral researcher, group of Prof. J.-F. Collet, UCLouvain (bacterial envelope stress responses)
2010 - 2013: Post-doctoral researcher, group of Prof. C. Jacobs-Wagner, Yale University, New Haven, CT (USA) (bacterial cell cycle and polarity)
2005 - 2009: PhD student, group of Prof. X. De Bolle (UNamur) (host-pathogen interactions)
2005: Master student intern, group of Prof. M. Vidal, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA (USA) (interactomics)
Education
2009: PhD in Sciences, UNamur
2005: Licence (Master) en Science biologiques, orientation moléculaire et cellulaire, UNamur
2003: Bachelier en Sciences biologiques, UNamur
Fellowships
2014 - 2017: F.R.S.-FNRS Post-doctoral fellowship (Chargé de Recherche)
2011 : van Itallie Fellow of the Belgian American Educational Foundation
2005 - 2009: F.R.S.-FNRS Research Fellow (Aspirant)
- Diplômes
Année Label Institution 2005 Licence en Sciences Biologique Facultés Universitaires Notre Dame de la Paix à Namur 2009 Docteur en sciences Facultés Universitaires Notre Dame de la Paix à Namur
Identifying principles and molecular mechanisms of bacterial self-organization, especially those governing spatiotemporal organization of bacterial cells (e.g. protein subcellular localization, chromosome dynamics and cell cycle regulation). In my lab, we use the predatory bacterium Bdellovibrio bacteriovorus, which proliferates in a non-binary manner inside other bacteria, to investigate these processes and how they are coordinated to produce a non-canonical lifestyle. To this end, we apply various approaches of bacterial cell biology including live fluorescence microscopy and quantitative image analysis at the population and single-cell levels, molecular biology, bacterial genetics and biochemistry.
Lab website : http://www.lalouxlab.weebly.com
Group page on the de Duve Institute website : https://www.deduveinstitute.be/fr/bacterial-cell-biology
Santin, Yoann ; Lamot, Thomas ; van Raaphorst, Renske ; Kaljevic, Jovana ; Laloux, Géraldine. Modulation of prey size reveals adaptability and robustness in the cell cycle of an intracellular predator.. In: Current biology : CB, Vol. 33, no.11, p. 2213-2222.e4 (2023). doi:10.1016/j.cub.2023.04.059.
Maccioni, Luca ; Kasavuli, Joyce ; Leclercq, Sophie ; Pirlot, Boris ; Laloux, Géraldine ; Horsmans, Yves ; Leclercq, Isabelle ; Schnabl, Bernd ; Stärkel, Peter. Toll-like receptor 2 activation in monocytes contributes to systemic inflammation and alcohol-associated liver disease in humans.. In: Hepatology communications, Vol. 7, no.5, p. - (2023). doi:10.1097/HC9.0000000000000107.
Remy, Ophélie ; Lamot, Thomas ; Santin, Yoann ; Kaljevic, Jovana ; de Pierpont, Charles ; Laloux, Géraldine. An optimized workflow to measure bacterial predation in microplates.. In: STAR protocols, Vol. 3, no.1, p. 101104 (2022). doi:10.1016/j.xpro.2021.101104.
Kaljevic, Jovana ; Saaki, Terrens Norus Vargio ; Govers, Sander ; Remy, Ophélie ; van Raaphorst, Renske ; Lamot, Thomas ; Laloux, Géraldine. Chromosome choreography during the non-binary cell cycle of a predatory bacterium. In: Current biology, Vol. 31, no. 17, p. 3707-3720.e5 (2021). doi:10.1016/j.cub.2021.06.024.
Kaljevic, Jovana ; Saaki, Terrens Norus Vargio ; Govers, Sander ; Remy, Ophélie ; van Raaphorst, Renske ; Lamot, Thomas ; Laloux, Géraldine. Uncovering the choreography of the chromosome during the non-binary cell cycle of the predatory bacterium Bdellovibrio bacteriovorus. In: bioRxiv, (2021). doi:10.1101/2020.12.21.419010.
Laloux, Géraldine. Shedding Light on the Cell Biology of the Predatory Bacterium.. In: Frontiers in microbiology, Vol. 10, p. 3136 (2020). doi:10.3389/fmicb.2019.03136.
Delhaye, Antoine ; Collet, Jean-François ; Laloux, Géraldine. A Fly on the Wall: How Stress Response Systems Can Sense and Respond to Damage to Peptidoglycan.. In: Frontiers in cellular and infection microbiology, Vol. 9, no.-, p. 380 (2019). doi:10.3389/fcimb.2019.00380.
Delhaye, Antoine ; Laloux, Géraldine ; Collet, Jean-François. The lipoprotein NlpE is a Cpx sensor that serves as a sentinel for protein sorting and folding defects in the envelope.. In: Journal of bacteriology, Vol. 201, no. 10, p. e00611-18 (2019). doi:10.1128/JB.00611-18.
Hussein, Nahla A ; Cho, Seung-Hyun ; Laloux, Géraldine ; Siam, Rania ; Collet, Jean-François. Distinct domains of Escherichia coli IgaA connect envelope stress sensing and down-regulation of the Rcs phosphorelay across subcellular compartments.. In: PLoS Genetics, Vol. 14, no.5, p. e1007398 (2018). doi:10.1371/journal.pgen.1007398.
Laloux, Géraldine ; Collet, Jean-François. Major Tom to ground control: how lipoproteins communicate extra-cytoplasmic stress to the decision center of the cell. In: Journal of Bacteriology, Vol. 199, no. 21, p. e00216-17 [1-13] (2017). doi:10.1128/JB.00216-17.
Arts, Isabelle S. ; Vertommen, Didier ; Baldin, Francesca ; Laloux, Géraldine ; Collet, Jean-François. Comprehensively Characterizing the Thioredoxin InteractomeIn VivoHighlights the Central Role Played by This Ubiquitous Oxidoreductase in Redox Control. In: Molecular and Cellular Proteomics, Vol. 15, no.6, p. 2125-2140 (2016). doi:10.1074/mcp.M115.056440.
Delhaye, Antoine ; Collet, Jean-François ; Laloux, Géraldine. Fine-Tuning of the Cpx Envelope Stress Response Is Required for Cell Wall Homeostasis in Escherichia coli.. In: mBio, Vol. 7, no. 1, p. e00047-16 (2016). doi:10.1128/mBio.00047-16.
Beaufay, François ; Coppine, Jérôme ; Mayard, Aurélie ; Laloux, Géraldine ; De Bolle, Xavier ; Hallez, Régis. A NAD-dependent glutamate dehydrogenase coordinates metabolism with cell division in Caulobacter crescentus. In: The EMBO journal, Vol. 34, no.13, p. 1786-1800 (2015). doi:10.15252/embj.201490730.
Cho, Seung Hyun ; Szewczyk, Joanna ; Pesavento, Christina ; Zietek, Matylda ; Banzhaf, Manuel ; Roszczenko, Paula ; Asmar, Abir ; Laloux, Géraldine ; Hov, Ann-Kristin ; Leverrier, Pauline ; Van DerHenst, Charles ; Vertommen, Didier ; Typas, Athanasios ; Collet, Jean-François. Detecting Envelope Stress by Monitoring β-Barrel Assembly. In: Cell, Vol. 159, no.7, p. 1652-1664 (28 dec 2014). doi:10.1016/j.cell.2014.11.045.
Deghelt, Michaël ; Mullier, Caroline ; Sternon, Jean-François ; Francis, Nayla ; Laloux, Géraldine ; Dotreppe, Delphine ; Van der Henst, Charles ; Jacobs-Wagner, Christine ; Letesson, Jean-Jacques ; De Bolle, Xavier. G1-arrested newborn cells are the predominant infectious form of the pathogen Brucella abortus. In: Nature Communications, Vol. 5, p. 4366 (2014). doi:10.1038/ncomms5366.
Laloux, Géraldine ; Jacobs-Wagner, Christine. How do bacteria localize proteins to the cell pole?. In: Journal of Cell Science, Vol. 127, no.1, p. 11-19 (1/1/2014). doi:10.1242/jcs.138628.
Laloux, Géraldine ; Jacobs-Wagner, Christine. Spatiotemporal control of PopZ localization through cell cycle-coupled multimerization. In: The Journal of Cell Biology, Vol. 201, no.6, p. 827-841 (10/06/2013). doi:10.1083/jcb.201303036.
de Barsy, Marie ; Jamet, Alexandre ; Filopon, Didier ; Nicolas, Cécile ; Laloux, Géraldine ; Rual, Jean-Rual ; Muller, Alexandre ; Twizere, Jean-Claude ; Nkengfac, Bernard ; Vandenhaute, Jean ; Hill, David E. ; Salcedo, Suzana P. ; Gorvel, Jean-Pierre ; Letesson, Jean-Jacques ; De Bolle, Xavier. Identification of a Brucella spp. secreted effector specifically interacting with human small GTPase Rab2. In: Cellular Microbiology, Vol. 13, no.7, p. 1044-1058 (2011). doi:10.1111/j.1462-5822.2011.01601.x.
Laloux, Géraldine ; Deghelt, Michaël ; de Barsy, Marie ; Letesson, Jean-Jacques ; De Bolle, Xavier. Identification of the essential Brucella melitensis porin Omp2b as a suppressor of Bax-induced cell death in yeast in a genome-wide screening.. In: PLoS One, Vol. 5, no.10, p. e13274 (2010). doi:10.1371/journal.pone.0013274.
Dreze, Matjia ; Charloteaux, Benoit ; Milstein, Stuart ; Vidalain, Pierre-Olivier ; Yildirim, Muhammed A ; Zhong, Quan ; Svrzikapa, Nenad ; Romero, Viviana ; Laloux, Géraldine ; Brasseur, Robert ; Vandenhaute, Jean ; Boxem, Mike ; Cusick, Michael E. ; Hill, David E. ; Vidal, Marc. 'Edgetic' perturbation of a C. elegans BCL2 ortholog. In: Nature Methods, Vol. 6, no. 11, p. 843-849 (2009).