Publications
2022
Knoops, Adrien ; Ledesma-García, Laura ; Waegemans, Alexandra ; Lamontagne, Morgane ; Decat, Baptiste ; Degand, Hervé ; Morsomme, Pierre ; Soumillion, Patrice ; Delvigne, Frank ; Hols, Pascal. Competence shut-off by intracellular pheromone degradation in salivarius streptococci. In: PLOS Genetics, Vol. 18, no.5, p. e1010198 (2022). doi:10.1371/journal.pgen.1010198.
2022
Knoops, Adrien ; Vande Capelle, Florence ; Fontaine, Laetitia ; Verhaegen, Marie ; Mignolet, Johann ; Goffin, Philippe ; Mahillon, Jacques ; Sass, Andrea ; Coenye, Tom ; Ledesma-García, Laura ; Hols, Pascal. The CovRS Environmental Sensor Directly Controls the ComRS Signaling System To Orchestrate Competence Bimodality in Salivarius Streptococci. In: mBio, Vol. 13, no.1, p. e03125-21 (2022). doi:10.1128/mbio.03125-21.
2021
Ledesma-García, Laura ; Ensinck, Imke ; Dereinne, Denis ; Viela Bovio, Felipe ; Mignolet, Johann ; Dufrêne, Yves ; Soumillion, Patrice ; Nessler, Sylvie ; Hols, Pascal. Co-evolution of the bacterial pheromone ComS and sensor ComR fine-tunes natural transformation in streptococci.. In: The Journal of biological chemistry, , p. 101346 (2021). doi:10.1016/j.jbc.2021.101346.
2020
Ledesma-García, Laura ; Thuillier, Jordhan ; Guzman-Espinola, Armando ; Ensinck, Imke ; Li de la Sierra-Gallay, Inès ; Lazar, Noureddine ; Aumont-Nicaise, Magali ; Mignolet, Johann ; Soumillion, Patrice ; Nessler, Sylvie ; Hols, Pascal. Molecular dissection of pheromone selectivity in the competence signaling system ComRS of streptococci. In: Proceedings of the National Academy of Sciences, Vol. 117, no.14, p. 201916085 (2020). doi:10.1073/pnas.1916085117.
2020
Desguin, Benoît ; Urdiain-Arraiza, Julian ; Da Costa, Matthieu ; Fellner, Matthias ; Hu, Jian ; Hausinger, Robert P ; Desmet, Tom ; Hols, Pascal ; Soumillion, Patrice. Uncovering a superfamily of nickel-dependent hydroxyacid racemases and epimerases.. In: Scientific reports, Vol. 10, no.1, p. 18123 (2020). doi:10.1038/s41598-020-74802-6.
2019
Duchêne, Marie-Clémence ; Rolain, Thomas ; Knoops, Adrien ; Courtin, Pascal ; Chapot-Chartier, Marie-Pierre ; Dufrêne, Yves ; Hallet, Bernard ; Hols, Pascal. Distinct and Specific Role of NlpC/P60 Endopeptidases LytA and LytB in Cell Elongation and Division of .. In: Frontiers in microbiology, Vol. 10, p. 713 (2019). doi:10.3389/fmicb.2019.00713.
2019
Fléchard, Maud ; Lucchetti-Miganeh, Céline ; Hallet, Bernard ; Hols, Pascal ; Gilot, Philippe. Intensive targeting of regulatory competence genes by transposable elements in streptococci.. In: Molecular Genetics and Genomics : an international journal, Vol. 294, no. 3, p. 531-548 (2019). doi:10.1007/s00438-018-1507-5.
2019
Hols, Pascal ; Ledesma-García, Laura ; Gabant, Philippe ; Mignolet, Johann. Mobilization of Microbiota Commensals and Their Bacteriocins for Therapeutics. In: Trends in Microbiology, (2019). doi:10.1016/j.tim.2019.03.007.
2019
Mignolet, Johann ; Cerckel, Guillaume ; Damoczi, Julien ; Ledesma-García, Laura ; Sass, Andrea ; Coenye, Tom ; Nessler, Sylvie ; Hols, Pascal. Subtle selectivity in a pheromone sensor triumvirate desynchronizes competence and predation in a human gut commensal.. In: eLife, Vol. 8 (2019). doi:10.7554/eLife.47139.
2018
Desguin, Benoît ; Fellner, Matthias ; Riant, Olivier ; Hu, Jian ; Hausinger, Robert ; Hols, Pascal ; Soumillion, Patrice. Biosynthesis of the nickel-pincer nucleotide cofactor of lactate racemase requires a CTP-dependent cyclometallase.. In: Journal of Biological Chemistry, (2018). doi:10.1074/jbc.RA118.003741.
2018
Mignolet, Johann ; Fontaine, Laetitia ; Sass, Andrea ; Nannan, Catherine ; Mahillon, Jacques ; Coenye, Tom ; Hols, Pascal. Circuitry Rewiring Directly Couples Competence to Predation in the Gut Dweller Streptococcus salivarius. In: Cell Reports, Vol. 22, no. 7, p. 1627-1638 (2018). doi:10.1016/j.celrep.2018.01.055.
2018
David, Blandine ; Duchêne, Marie-Clémence ; Haustenne, Gabrielle Laurie ; Pérez-Núñez, Daniel ; Chapot-Chartier, Marie-Pierre ; De Bolle, Xavier ; Guédon, Eric ; Hols, Pascal ; Hallet, Bernard. PBP2b plays a key role in both peripheral growth and septum positioning in Lactococcus lactis.. In: PLoS One, Vol. 13, no.5, p. e0198014 (2018). doi:10.1371/journal.pone.0198014.
2018
Fernández Ramírez, Mónica D ; Nierop Groot, Masja N ; Smid, Eddy J ; Hols, Pascal ; Kleerebezem, Michiel ; Abee, Tjakko. Role of cell surface composition and lysis in static biofilm formation by Lactobacillus plantarum WCFS1.. In: International journal of food microbiology, Vol. 271, p. 15-23 (2018). doi:10.1016/j.ijfoodmicro.2018.02.013.
2017
David, Blandine ; Radziejwoski, Amandine ; Toussaint, Frédéric ; Fontaine, Laetitia ; Henry de Frahan, Marie ; Patout, Cédric ; van Dillen, Sabine ; Boyaval, Patrick ; Horvath, Philippe ; Fremaux, Christophe ; Hols, Pascal. Natural DNA transformation is functional in Lactococcus lactis ssp. cremoris KW2.. In: Applied and Environmental Microbiology, Vol. 83, no.16, p. e01074-17 (2017). doi:10.1128/AEM.01074-17 (Accepté/Sous presse).
2017
Desguin, Benoît ; Soumillion, Patrice ; Hausinger, Robert P. ; Hols, Pascal. Unexpected complexity in the lactate racemization system of lactic acid bacteria. In: FEMS Microbiology Reviews, Vol. 41, no. Supp_1, p. S71-S83 (2017 Aug 1). doi:10.1093/femsre/fux021.
2020
Dorrazehi, Gol Mohammad ; Worms, Sebastian ; Chirakadavil, Jason Baby ; Mignolet, Johann ; Hols, Pascal ; Soumillion, Patrice. Building scarless gene libraries in the chromosome of bacteria. In: Iranzo, Olga, Roque, Ana Cecília, Springer Protocols – Peptide and Protein Engineering, From Concepts to Biotechnological Applications, 2020. 978-1-0716-0719-0 (Accepté/Sous presse).
2017
Desguin, Benoît ; Soumillion, Patrice ; Hols, Pascal ; Hu, Jian ; Hausinger, Robert P.. Lactate Racemase and Its Niacin-Derived, Covalently-Tethered, Nickel Cofactor. In: Deborah Zamble, Magdalena Rowińska-Żyrek, Henryk Kozłowski, The Biological Chemistry of Nickel (Metallobiology Series; 10), The Royal Society of Chemistry, 2017. 978-1-78262-498-1. doi:10.1039/9781788010580.
2017
Mignolet, Johann ; Hols, Pascal. Ubiquitous rewiring of transcriptional control in streptococci: lesson from competence and predation coupling in Streptococcus salivarius.. 12th Symposium on Lactic Acid Bacteria (Egmond aan Zzee, du 27/08/2017 au 31/08/2017).
2017
Mignolet, Johann ; Fontaine, Laetitia ; Hols, Pascal. Ubiquitous rewiring of transcriptional control in streptococci: lessons from competence and predation coupling in Streptococcus salivarius. 19th International Conference on Bacilli and other Gram-Positive Bacteria (Berlin, DE, du 11/06/2017 au 15/06/2017).
2018
Fremaux, Christophe ; Horvath, Philippe ; Boyaval, Patrick ; Hols, Pascal ; David, Blandine ; Radziejwoski, Amandine ; Fontaine, Laetitia ; Toussaint, Frédéric. A method for transforming a strain of the Lactococcus genus by natural competence. Numéro de priorité. .
2018
Mignolet, Johann ; Ledesma-García, Laura ; Hols, Pascal. Peptides for inducing bacteriocin synthesis and methods to identify and/ or select and/or optimize the same. Numéro de priorité ; Déposé (22 November 2018). EUR.
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