FATH
Avenue Hippocrate 57/B1.57.04
1200 Woluwe-Saint-Lambert
- Accueil
- Répertoire
- Pierre Sonveaux
Pierre Sonveaux
Directeur de recherche FNRS
Professeur extraordinaire
2002 Servier Young Investigator Award, International Union of Pharmacology (IUPHAR)
2003 EDRO fellowship European Society for Therapeutic Radiology and Oncology
2004-2005 Fellowship, Belgian American Educational Foundation (BAEF)
2005 National Prize, Belgian Society of Pharmaceutical Sciences
2007 ESTRO-VARIAN-Juliana Denekamp Award
2008 Federation of European Cancer Societies - European Journal of Cancer (FECS-EJC) Award
2008 Henri Fauconnier Prize, Royal Academy of Medicine of Belgium
2009-2014 European Research Council (ERC) Independent Researcher Starting Grantee
2010 Ferdinand Depelchin Prize 2007-2010, UCL Faculty of Medicine
2010 Burgen Scholarship, Academia Europaea
2010 Highly Commended Award, European Association for Cancer Research (EACR).
2010 Galien Prize in Pharmacology, Brussels, Belgium
2010 1st Henryk S. Taper Lecture as pursuing dynamic creativity in Cancer Biology and Medicine, UK
2011 Special EACR Lecture Award, France
2012 Elected ISPDC Board Member (now ISCaM)
2012 Clément Perdieus and Cécile Petit Prize 2009-2012, UCL Faculty of Medicine
2013 Cornélis-Lebègue Prize, Royal Academy of Medicine of Belgium
2013 Albert-Pierre – Jean Dustin Prize, Royal Academy of Medicine of Belgium
2013 Jean-Oscar Maes Award, UCL Health Sciences Sector
2014 Appointed Patron of the 10th Allan Sport –Télévie challenge
2015 Appointed Patron of the 11th Allan Sport –Télévie challenge
2016 Appointed Patron of the 12th Allan Sport –Télévie challenge
2016 Elected adjunct coordinator of the mitoGlobal network in COST action MITOEAGLE
2016 Elected President of ISCaM
2016 Award of the AstraZeneca Foundation - Oncology
- Diplômes
Année Label Institution 1995 Candidat en sciences pharmaceutiques Université catholique de Louvain 1998 Pharmacien Université catholique de Louvain 2000 Diplômé d'études approfondies en sciences pharmaceutiques Université catholique de Louvain 2004 Docteur en sciences pharmaceutiques Université catholique de Louvain
- Les cours
Nom ID Etude critique d'un article de recherche en sciences pharmaceutiques WFARM2175 Présentation d'un travail de recherche en sciences pharmaceutiques WFARM2176 Exercice de communication scientifique WFARM2275 Pharmacologie moléculaire WFARM2515 Recherche translationnelle : de la dysfonction biologique à la validation de nouveaux traitements WFARM2521 Signalisation intercellulaire et biologie des tumeurs WSBIM2141 Special issues in cancerology WSBIM2244 In-session seminar in biomedicine WSBIM2245
The P. Sonveaux lab is located on the UCLouvain campus in Brussels (Tour Vésale 4th floor).
The research group currently consists of 2 post-docs, 2 PhD students, 2 technicians and 1 research assistant, and together with the group of O. Feron, constitutes the cancer research lab within the Pole of Pharmacology and Therapeutics; administrative resources (secretary and account manager) are shared with the cardiovascular research groups of the Pole.
Hypoxia is a cancer hallmark that imposes a selection pressure on tumor cells. It promotes (i) the uncoupling between glycolysis and oxidative phosphorylation (OXPHOS) together with an increased glycolytic flux in order to optimize oxygen-independent energy production and cell proliferation (the glycolytic phenotype), (ii) the emergence of tumor cells able to directly or indirectly stimulate the formation of new blood vessels from pre-existing ones (the angiogenic phenotype), and (iii) tumor cell dissemination (the metastatic phenotype). While these adaptations are usually studied independently of each other, our research strategy is to consider a necessary coordination between them during tumor development. The general hypothesis is that the glycolytic switch, initially proceeding through inhibition of the Pasteur effect, precedes and favors angiogenesis and tumor metastasis, therefore potentially making of antimetabolic drugs bona fide anti-angiogenic and antimetastatic treatment options.
2024
Gallez, Bernard ; Mathieu, Barbara ; Sonveaux, Pierre. About metformin and its action on the mitochondrial respiratory chain in prostate cancer. In: Translational Andrology and Urology, Vol. 13, p. 909-914 (2024). doi:10.21037/tau-23-602.
2024
D'aria, Stefania ; Maquet, Celine ; Li, Shuang ; Dhup, Suveera ; Lepez, Anouk ; Kohler, Arnaud ; Van Hee, Vincent ; Dadhich, Rakesh ; Freniere, Marine ; Andris, Fabienne ; Nemazanyy, Ivan ; Sonveaux, Pierre ; Machiels, Benedicte ; Gillet, Laurent ; Braun, Michel. Expression of the monocarboxylate transporter MCT1 is required for virus-specific CD8+ T cell memory development. In: Proceedings of the National academy of sciences of the United States of America, Vol. 121, no. 13, p. e2306763121 (2024).
2024
Rondeau, Justin ; Van de Velde, Justine ; Bouidida, Yasmine ; Sonveaux, Pierre. Subclinical dose irradiation triggers human breast cancer migration via mitochondrial reactive oxygen species. In: Cancer & Metabolism, Vol. 12, p. 20 (2024).
2023
Colson, Arthur ; Depoix, Christophe ; Lambert, Isaline ; Leducq, Camille ; Bedin, Marie ; De Beukelaer, Michèle ; Gatto, Laurent ; Loriot, Axelle ; Peers de Nieuwburgh, Maureen ; Bouhna, Khadija ; Baldin, Paméla ; Hubinont, Corinne ; Sonveaux, Pierre ; Debiève, Frédéric. Specific hypoxia-inducible factor-2 (HIF-2α) inhibitor PT2385 mitigates placental dysfunction in vitro and in a rat model of preeclampsia (RUPP). In: Hypertension., Vol. 80, no. 5, p. 1011-1023 (2023). doi:10.1161/HYPERTENSIONAHA.122.20739.
2022
Thabault, Léopold ; Brustenga, Chiara ; Savoyen, Perrine ; Van Gysel, Mégane ; Wouters, Johan ; Sonveaux, Pierre ; Frédérick, Raphaël ; Liberelle, Maxime. Discovery of small molecules interacting at lactate dehydrogenases tetrameric interface using a biophysical screening cascade.. In: European journal of medicinal chemistry, Vol. 230, p. 114102 [1-10] (2022). doi:10.1016/j.ejmech.2022.114102.
2022
d'Hose, Donatienne ; Mathieu, Barbara ; Mignion, Lionel ; Hardy, Micael ; Ouari, Olivier ; Jordan, Bénédicte ; Sonveaux, Pierre ; Gallez, Bernard. EPR Investigations to Study the Impact of Mito-Metformin on the Mitochondrial Function of Prostate Cancer Cells.. In: Molecules (Basel, Switzerland), Vol. 27, no.18, p. 5872 (2022). doi:10.3390/molecules27185872.
2022
Kemps, Hannelore ; Dessy, Chantal ; Dumas, Laurent ; Sonveaux, Pierre ; Alders, Lotte ; Van Broekhoven, Jana ; Perez Font, Lena ; Lambrichts, Sara ; Foulquier, Sebastien ; Hendrix, Sven ; Brone, Bert ; Lemmens, Robin ; Bronckaers, Annelies. Extremely low frequency electromagnetic stimulation reduces ischemic stroke volume by improving central collateral blood flow. In: Journal of cerebral blood flow and metabolism, Vol. 42, no. 6, p. 979-996 (2022). doi:10.1177/0271678X221084410.
2022
De Miranda Capeloa, Tania Isabel ; Van de Velde, Justine ; d'Hose, Donatienne ; Lipari, Sara ; Derouane, Françoise ; Hamelin, Loïc ; Bedin, Marie ; Vazeille, Thibaut ; Duhoux, François ; Murphy, Michael P ; Porporato, Paolo E ; Gallez, Bernard ; Sonveaux, Pierre. Inhibition of Mitochondrial Redox Signaling with MitoQ Prevents Metastasis of Human Pancreatic Cancer in Mice.. In: Cancers, Vol. 14, no. 19, p. 4918 [1-20] (2022). doi:10.3390/cancers14194918.
2022
Weber DD ; Aminzadeh-Gohari S ; Thapa M ; Redtenbacher AS ; Catalano L ; De Miranda Capeloa, Tania Isabel ; Vazeille, Thibaut ; Emberger M ; Felder TK ; Feichtinger RG ; Koelblinger P ; Dallmann G ; Sonveaux, Pierre ; Lang R ; Kofler B. Ketogenic diets slow melanoma growth in vivo regardless of tumor genetics and metabolic plasticity. In: Cancer & metabolism, Vol. 10, no. 1, p. 12 [1-20] (2022). doi:10.1186/s40170-022-00288-7.
2022
Ippolito, Luigi ; Sonveaux, Pierre ; Chiarugi, Paola. Lactate: unconventional roles of a nutrient along the tumor landscape. In: Trends in Endocrinology and Metabolism, Vol. 33, no. 4, p. 231-235 (2022).
2022
De Miranda Capeloa, Tania Isabel ; Krzystyniak, Joanna ; d'Hose, Donatienne ; canas Rodriguez, Amanda ; Payen, Valery L ; Zampieri, Luca ; Van de Velde, Justine ; Benyahia, Zohra ; Pranzini, Erica ; Vazeille, Thibaut ; Fransolet, Maude ; Bouzin, Caroline ; Brusa, Davide ; Michiels, Carine ; Gallez, Bernard ; Murphy, Michael P ; Porporato, Paolo E ; Sonveaux, Pierre. MitoQ inhibits human breast cancer cell migration, invasion and clonogenicity. In: Cancers, Vol. 14, no. 6, p. 1516 [1-20] (2022). doi:10.3390/cancers14061516.
2022
De Miranda Capeloa, Tania Isabel ; Krzystyniak, Joanna ; Canas Rodriguez, Amanda ; Payen, Valery L ; Zampieri, Luca ; Pranzini, Erica ; Derouane, Françoise ; Vazeille, Thibaut ; Bouzin, Caroline ; Duhoux, Francois ; Murphy, Michael P. ; Porporato, Paolo E ; Sonveaux, Pierre. MitoQ prevents human breast cancer recurrence and lung metastasis in mice. In: Cancers, Vol. 14, no. 6, p. 1488 [1-13] (2022). doi:10.3390/cancers14061488.
2022
Blackman, Marine ; De Miranda Capeloa, Tania Isabel ; Rondeau, Justin ; Zampieri, Luca ; Benyahia, Zohra ; Van de Velde, Justine ; Fransolet, Maude ; Daskalopoulos, Evangelos-Panagiotis ; Michiels, Carine ; Beauloye, Christophe ; Sonveaux, Pierre. Mitochondrial Protein Cox7b Is a Metabolic Sensor Driving Brain-Specific Metastasis of Human Breast Cancer Cells. In: Cancers, Vol. 14, no. 18, p. 4371 [1-24] (2022). doi:10.3390/cancers14184371.
2022
Macchi, Chiara ; Moregola, Annalisa ; Greco, Maria Francesca ; Svecla, Monika ; Bonacina, Fabrizia ; Dhup, Suveera ; Dadhich, Rajesh Kumar ; Audano, Matteo ; Sonveaux, Pierre ; Mauro, Claudio ; Mitro, Nico ; Ruscica, Massimiliano ; Norata, Giuseppe D. Monocarboxylate transporter 1 deficiency impacts CD8 T lymphocytes proliferation and recruitment to adipose tissue during obesity.. In: iScience, Vol. 25, no. 6, p. 104435 [1-26] (2022). doi:10.1016/j.isci.2022.104435.
2022
d'Hose, Donatienne ; Mignion, Lionel ; Hamelin, Loïc ; Sonveaux, Pierre ; Jordan, Bénédicte ; Gallez, Bernard. Statins Alleviate Tumor Hypoxia in Prostate Cancer Models by Decreasing Oxygen Consumption: An Opportunity for Radiosensitization?. In: Biomolecules, Vol. 12, no. 10, p. 1418 [1-14] (2022). doi:10.3390/biom12101418.
2022
Ippolito, Luigi ; Sonveaux, Pierre ; Chiarugi, Paola. Unconventional roles of lactate along the tumor and immune landscape.. In: Trends in endocrinology and metabolism, Vol. 33, no.4, p. 231-235 (2022). doi:10.1016/j.tem.2022.01.005.
2021
Colson, Arthur ; Sonveaux, Pierre ; Debiève, Frédéric ; Sferruzzi-Perri, Amanda N. Adaptations of the human placenta to hypoxia: opportunities for interventions in fetal growth restriction. In: Human Reproduction Update, Vol. 27, no. 3, p. 531-569 (2021). doi:10.1093/humupd/dmaa053.
2021
Colson, Arthur ; Depoix, Christophe ; Dessilly, Géraldine ; Baldin, Paméla ; Danhaive, Olivier ; Hubinont, Corinne ; Sonveaux, Pierre ; Debiève, Frédéric. Clinical and in Vitro Evidence against Placenta Infection at Term by Severe Acute Respiratory Syndrome Coronavirus 2.. In: The American journal of pathology, Vol. 191, no. 9, p. 1610-1623 (2021). doi:10.1016/j.ajpath.2021.05.009.
2021
Thabault, Léopold ; Liberelle, Maxime ; Koruza, Katarina ; Yildiz, Esra ; Joudiou, Nicolas ; Messens, Joris ; Brisson, Lucie ; Wouters, Johan ; Sonveaux, Pierre ; Frédérick, Raphaël. Discovery of a novel lactate dehydrogenase tetramerization domain using epitope mapping and peptides. In: Journal of Biological Chemistry, Vol. 296, p. 100422 (2021). doi:10.1016/j.jbc.2021.100422.
2021
Benyahia, Zohra ; Blackman, Marine ; Hamelin, Loïc ; Zampieri, Luca ; De Miranda Capeloa, Tania Isabel ; Bedin, Marie ; Vazeille, Thibaut ; Schakman, Olivier ; Sonveaux, Pierre. In Vitro and In Vivo Characterization of MCT1 Inhibitor AZD3965 Confirms Preclinical Safety Compatible with Breast Cancer Treatment. In: Cancers, Vol. 13, no.3, p. 569 (2021). doi:10.3390/cancers13030569.
2021
Zampieri, Luca ; Da Silva Almeida, Ana Catarina ; Rondeau, Justin ; Sonveaux, Pierre. Mitochondrial Transfer in Cancer: A Comprehensive Review. In: International Journal of Molecular Sciences, Vol. 22, no.6, p. 3245 (2021). doi:10.3390/ijms22063245.
2021
Zampieri, Luca ; Sboarina, Martina ; Cacace, Andrea ; Grasso, Debora ; Thabault, Léopold ; Hamelin, Loïc ; Vazeille, Thibaut ; Dumon, Elodie ; Rossignol, Rodrigue ; Frédérick, Raphaël ; Sonveaux, Etienne ; Lefranc, Florence ; Sonveaux, Pierre. Olaparib is a mitochondrial Complex I inhibitor that kills temozolomide-resistant human glioblastoma cells. In: International Journal of Molecular Sciences, Vol. 22, no.11938, p. 17 (2021). doi:10.3390/ijms222111938.
2020
Scheinok, Samantha ; De Miranda Capeloa, Tania Isabel ; Porporato, Paolo E ; Sonveaux, Pierre ; Gallez, Bernard. An EPR study using cyclic hydroxylamines to assess the level of mitochondrial ROS in superinvasive cancer cells. In: Cell biochemistry and biophysics, Vol. 78, no. 3, p. 249-254 (2020). doi:10.1007/s12013-020-00921-6.
2020
de Miranda Vasconcellos Vilela, Janice ; Dolmans, Marie-Madeleine ; Maruhashi, Emi ; Blackman, Marine ; Sonveaux, Pierre ; Miranda-Vilela, Ana Luisa ; Andrade Amorim, Christiani. Evidence of metabolic activity during low-temperature ovarian tissue preservation in different media.. In: Journal of assisted reproduction and genetics, Vol. 37, no. 10, p. 2477-2486 (2020). doi:10.1007/s10815-020-01935-y.
2020
Grasso, Debora ; Medeiros, Hyllana C ; Zampieri, Luca ; Bol, Vanesa ; Danhier, Pierre ; van Gisbergen, Marike W ; Bouzin, Caroline ; Brusa, Davide ; Grégoire, Vincent ; Smeets, Hubert ; Stassen, Alphons P ; Dubois, Ludwig ; Lambin, Philippe ; Dutreix, Marie ; Sonveaux, Pierre. Fitter mitochondria are associated with radioresistance in human head and neck SQD9 cancer cells. In: Frontiers in Pharmacology, Vol. 11, p. 263 [1-16] (2020). doi:10.3389/fphar.2020.00263.
2020
Colson, Arthur ; Depoix, Christophe ; Baldin, Paméla ; Hubinont, Corinne ; Sonveaux, Pierre ; Debiève, Frédéric. Hypoxia-inducible factor 2 alpha impairs human cytotrophoblast syncytialization: new insights in placental dysfunction and fetal growth restriction. In: The FASEB Journal, Vol. 34, no. 11, p. 15222-15235 (2020). doi:10.1096/fj.202001681R.
2020
Thabault, Léopold ; Brisson, Lucie ; Brustenga, Chiara ; Martinez Gache, Santiago A ; Prévost, Julien ; Kozlova, Arina ; Spillier, Quentin ; Liberelle, Maxime ; Benyahia, Zohra ; Messens, Joris ; Copetti, Tamara ; Sonveaux, Pierre ; Frédérick, Raphaël. Interrogating the lactate dehydrogenase tetramerization site using (stapled) peptides.. In: Journal of medicinal chemistry, Vol. 63, no.9, p. 4628-4643 (2020). doi:10.1021/acs.jmedchem.9b01955.
2020
De Miranda Capeloa, Tania Isabel ; Benyahia, Zohra ; Zampieri, Luca ; Blackman, Marine ; Sonveaux, Pierre. Metabolic and non-metabolic pathways that control cancer resistance to anthracyclines.. In: Seminars in cell & developmental biology, Vol. 98, p. 181-191 (2020). doi:10.1016/j.semcdb.2019.05.006.
2020
Grasso, Debora ; Zampieri, Luca ; De Miranda Capeloa, Tania Isabel ; Van de Velde, Justine ; Sonveaux, Pierre. Mitochondria in cancer. In: Cell stress, Vol. 4, no. 6, p. 114-146 (2020).
2020
Zampieri, Luca ; Grasso, Debora ; Bouzin, Caroline ; Brusa, Davide ; Rossignol, Rodrigue ; Sonveaux, Pierre. Mitochondria participate in chemoresistance to cisplatin in human ovarian cancer cells. In: Molecular Cancer Research, Vol. 18, no. 9, p. 1379-1391 (2020). doi:10.1158/1541-7786.mcr-19-1145.
2020
Payen, Valéry ; Mina, Erica ; Van Hee, Vincent ; Porporato, Paolo E ; Sonveaux, Pierre. Monocarboxylate transporters in cancer.. In: Molecular Metabolism, Vol. 33, p. 48-66 (2020). doi:10.1016/j.molmet.2019.07.006.
2020
Baselet, Bjorn ; Driesen, Ronald B ; Coninx, Emma ; Belmans, Niels ; Sieprath, Tom ; Lambrichts, Ivo ; De Vos, Winnok H ; Baatout, Sarah ; Sonveaux, Pierre ; Aerts, An. Rosiglitazone protects endothelial cells from irradiation-induced mitochondrial dysfunction. In: Frontiers in Pharmacology, Vol. 11, p. 268 (2020). doi:10.3389/fphar.2020.00268.
2020
Schoonjans, Céline A ; Mathieu, Barbara ; Joudiou, Nicolas ; Zampieri, Luca X ; Brusa, Davide ; Sonveaux, Pierre ; Feron, Olivier ; Gallez, Bernard. Targeting Endothelial Cell Metabolism by Inhibition of Pyruvate Dehydrogenase Kinase and Glutaminase-1.. In: Journal of clinical medicine, Vol. 9, no.10, p. 14pp (2020). doi:10.3390/jcm9103308.
2020
Haguet, Hélène ; Bouvy, Céline ; Delvigne, Anne-Sophie ; Modaffari, Elise ; Wannez, Adeline ; Sonveaux, Pierre ; Dogne, Jean-Michel ; Douxfils, Jonathan. The risk of arterial thrombosis in patients with chronic myeloid leukemia treated with second and third generation BCR-ABL tyrosine kinase inhibitors may be explained by their impact on endothelial cells: an in-vitro study. In: Frontiers in Pharmacology, Vol. 11, p. 1007 (2020). doi:10.3389/fphar.2020.01007.
2019
Avnet, Sofia ; Baldini, Nicola ; Brisson, Lucie ; Pedersen, Stine Falsig ; Porporato, Paolo E ; Sonveaux, Pierre ; Szabadkai, Gyorgy ; Pastorekova, Silvia. Annual Meeting of the International Society of Cancer Metabolism (ISCaM): Metabolic Adaptations and Targets in Cancer.. In: Frontiers in oncology, Vol. 9, p. 1332 (2019). doi:10.3389/fonc.2019.01332.
2019
Ippolito, Luigi ; Morandi, Andrea ; Taddei, Maria Letizia ; Parri, Matteo ; Comito, Giuseppina ; Iscaro, Alessandra ; Raspollini, Maria Rosaria ; Magherini, Francesca ; Rapizzi, Elena ; Masquelier, Julien ; Muccioli, Giulio ; Sonveaux, Pierre ; Chiarugi, Paola ; Giannoni, Elisa. Cancer-associated fibroblasts promote prostate cancer malignancy via metabolic rewiring and mitochondrial transfer.. In: Oncogene, Vol. 38, no. 27, p. 5339-5355 (2019). doi:10.1038/s41388-019-0805-7 (Accepté/Sous presse).
2019
Baselet, Bjorn ; Sonveaux, Pierre ; Baatout, Sarah ; Aerts, An. Pathological effects of ionizing radiation: endothelial activation and dysfunction. In: Cellular and Molecular Life Sciences, Vol. 76, no. 4, p. 699-728 (2018).
2019
Payen, Valéry L ; Zampieri, Luca ; Porporato, Paolo E ; Sonveaux, Pierre. Pro- and antitumor effects of mitochondrial reactive oxygen species.. In: Cancer metastasis reviews, Vol. 38, no. 1-2, p. 189-203 (2019). doi:10.1007/s10555-019-09789-2.
2019
Milosevic, Tamara ; Vertenoeil, Gaëlle ; Payen, Valéry ; Sonveaux, Pierre ; Tulkens, Paul M. ; Constantinescu, Stefan N. ; Van Bambeke, Françoise. Prolonged inhibition and incomplete recovery of mitochondrial function in oxazolidinone-treated megakaryoblastic cell lines.. In: International journal of antimicrobial agents, Vol. 54, no. 5, p. 661-667 (2019). doi:10.1016/j.ijantimicag.2019.07.021.
2019
Silva, Cláudia ; Correia-Branco, Ana ; Andrade, Nelson ; Ferreira, António Carlos ; Soares, Miguel Luz ; Sonveaux, Pierre ; Stephenne, Jean ; Martel, Fátima. Selective pro-apoptotic and antimigratory effects of polyphenol complex catechin:lysine 1:2 in breast, pancreatic and colorectal cancer cell lines.. In: European journal of pharmacology, , p. 172533 (2019). doi:10.1016/j.ejphar.2019.172533.
2019
Scheinok, Samantha ; Driesschart, Benoit ; d'Hose, Donatienne ; Sonveaux, Pierre ; Robiette, Raphaël ; Gallez, Bernard. Synthesis and characterization of a 5-membered ring cyclic hydroxylamine coupled to triphenylphosphonium to detect mitochondrial superoxide by EPR spectrometry.. In: Free radical research, Vol. 53, no. 11-12, p. 1135-1143 (2019). doi:10.1080/10715762.2019.1692137.
2018
Vanderstraeten, Jessica ; Derradji, Hanane ; Sonveaux, Pierre ; Colin, Ides ; Many, Marie-Christine ; Gérard, Anne-Catherine. Acute iodine deficiency induces a transient VEGF dependent microvascular response in mammary glands involving HIF-1, ROS and mTOR.. In: American journal of physiology. Cell physiology, Vol. 315, no. 4, p. C554-C557 (2018). doi:10.1152/ajpcell.00095.2017.
2018
Avnet, Sofia ; Baldini, Nicola ; Brisson, Lucie ; De Milito, Angelo ; Otto, Angela M ; Pastoreková, Silvia ; Porporato, Paolo E ; Szabadkai, Gyorgy ; Sonveaux, Pierre. Annual Meeting of the International Society of Cancer Metabolism (ISCaM): Cancer Metabolism.. In: Frontiers in oncology, Vol. 8, p. 329 (2018). doi:10.3389/fonc.2018.00329.
2018
Scheinok, Samantha ; Levêque, Philippe ; Sonveaux, Pierre ; Driesschaert, Benoit ; Gallez, Bernard. Comparison of different methods for measuring the superoxide radical by EPR spectroscopy in buffer, cell lysates and cells.. In: Free radical research, p. 1-15 (2018). doi:10.1080/10715762.2018.1541321.
2018
Bettonville, Marie ; Weatherly, Kathleen ; d'Aria, Stefania ; Porporato, Paolo E ; Zhang, Jinyu ; Bousbata, Sabrina ; Sonveaux, Pierre ; Braun, Michel Y. Long-term antigen exposure deeply modifies metabolic requirements for T cell function. In: eLife, Vol. 7, p. e30938 (2018).
2018
Milosevic, Tamara ; Payen, Valéry ; Sonveaux, Pierre ; Muccioli, Giulio ; Tulkens, Paul M. ; Van Bambeke, Françoise. Mitochondrial Alterations (Inhibition of Mitochondrial Protein Expression, Oxidative Metabolism, and Ultrastructure) Induced by Linezolid and Tedizolid at Clinically Relevant Concentrations in Cultured Human HL-60 Promyelocytes and THP-1 Monocytes.. In: Antimicrobial Agents and Chemotherapy, Vol. 62, no. 3, p. e01599-17 [1-17] (2018). doi:10.1128/AAC.01599-17.
2017
Payen, Valéry ; Porporato, Paolo ; Danhier, Pierre ; Vazeille, Thibaut ; Blackman, Marine ; May, Bronislav H ; Niebes, Paul ; Sonveaux, Pierre. (+)-Catechin in a 1:2 Complex with Lysine Inhibits Cancer Cell Migration and Metastatic Take in Mice.. In: Frontiers in pharmacology, Vol. 8, p. 869 [1-11] (2017). doi:10.3389/fphar.2017.00869.
2017
Baldini, Nicola ; De Milito, Angelo ; Feron, Olivier ; Gillies, Robert J ; Michiels, Carine ; Otto, Angela M ; Pastorekova, Silvia ; Perdersen, Stine F ; Porporato, Paolo ; Sonveaux, Pierre ; Supuran, Claudiu T ; Avnet, Sofia. Annual meeting of the International Society of Cancer Metabolism (ISCaM): metabolic networks in cancer. In: Frontiers in Pharmacology, Vol. 8, p. 411 [1-5] (2017). doi:10.3389/fphar.2017.00411.
2017
Stickaert, Aurélie ; Saiselet, Manuel ; Dom, Genevieve ; De Deken, Xavier ; Dumont, Jacques ; Feron, Olivier ; Sonveaux, Pierre ; Maenhaut, Carine. Cancer heterogeneity is not compatible with one unique cancer cell metabolic map. In: Oncogene, Vol. 36, no. 19, p. 2637-2642 (2017). doi:10.1038/onc.2016.411.
2017
Danhier, Pierre ; Banski, Piotr ; Payen, Valéry ; Grasso, Debora ; Ippolito, Luigi ; Sonveaux, Pierre ; Porporato, Paolo. Cancer metabolism in space and time: beyond the Warburg effect.. In: Biochimica et Biophysica Acta : international journal of biochemistry and biophysics, Vol. 1858, no. 8, p. 556–572 (2017). doi:10.1016/j.bbabio.2017.02.001.
2017
Danhier, Pierre ; Deumer, Gladys ; Joudiou, Nicolas ; Bouzin, Caroline ; Levêque, Philippe ; Haufroid, Vincent ; Jordan, Bénédicte F ; Feron, Olivier ; Sonveaux, Pierre ; Gallez, Bernard. Contribution of macrophages in the contrast loss in iron oxide-based MRI cancer cell tracking studies.. In: OncoTarget, Vol. 8, no. 24, p. 38876-38885 (2017). doi:10.18632/oncotarget.17103.
2017
Baselet, Bjorn ; Azimzadeh, Omid ; Erbeldinger, Nadine ; Bakshi, Mayur V ; Dettmering, Till ; Janssen, Ann ; Ktitareva, Svetlana ; Lowe, Donna J ; Michaux, Arlette ; Quintens, Roel ; Raj, Kenneth ; Durante, Marco ; Fournier, Claudia ; Benotmane, Mohammed A ; Baatout, Sarah ; Sonveaux, Pierre ; Tapio, Soile ; Aerts, An. Differential Impact of Single-Dose Fe Ion and X-Ray Irradiation on Endothelial Cell Transcriptomic and Proteomic Responses.. In: Frontiers in Pharmacology, Vol. 8, p. 570 [1-15] (2017). doi:10.3389/fphar.2017.00570.
2017
Bindels, Laure B. ; Porporato, Paolo ; Ducastel, Sarah ; Sboarina, Martina ; Neyrinck, Audrey M. ; Dewulf, Evelyne ; Feron, Olivier ; Lestavel, Sophie ; Cani, Patrice D. ; Staels, Bart ; Sonveaux, Pierre ; Delzenne, Nathalie M.. Ffar2 expression regulates leukaemic cell growth in vivo.. In: The British journal of cancer, Vol. 117, no. 9, p. 1336-1340 (2017). doi:10.1038/bjc.2017.307.
2017
Baselet, Bjorn ; Belmans, Niels ; Coninx, Emma ; Lowe, Donna ; Janssen, Ann ; Michaux, Arlette ; Tabury, Kevin ; Raj, Kenneth ; Quintens, Roel ; Benotmane, Mohammed A ; Baatout, Sarah ; Sonveaux, Pierre ; Aerts, An. Functional Gene Analysis Reveals Cell Cycle Changes and Inflammation in Endothelial Cells Irradiated with a Single X-ray Dose.. In: Frontiers in Pharmacology, Vol. 8, no. 213 (2017) (2017). doi:10.3389/fphar.2017.00213.
2017
Cacace, Andrea ; Sboarina, Martina ; Vazeille, Thibaut ; Sonveaux, Pierre. Glutamine activates STAT3 to control cancer cell proliferation independently of glutamine metabolism. In: Oncogene : including Oncogene Reviews, Vol. 36, no. 15, p. 2074-2084 (2017). doi:10.1038/onc.2016.364.
2017
Panisova, Elena ; Kery, Martin ; Sedlakova, Olga ; Brisson, Lucie ; Debreova, Michaela ; Sboarina, Martina ; Sonveaux, Pierre ; Pastorekova, Silvia ; Svastova, Eliska. Lactate stimulates CA IX expression in normoxic cancer cells.. In: OncoTarget, Vol. 8, p. 77819-77835 (2017). doi:10.18632/oncotarget.20836.
2017
Lemma, Silvia ; Di Pompo, Gemma ; Porporato, Paolo ; Sboarina, Martina ; Russell, Shonagh ; Gillies, Robert J ; Baldini, Nicola ; Sonveaux, Pierre ; Avnet, Sofia. MDA-MB-231 breast cancer cells fuel osteoclast metabolism and activity: A new rationale for the pathogenesis of osteolytic bone metastases.. In: Biochimica et Biophysica Acta : international journal of biochemistry and biophysics, Vol. 117, no. 9, p. 1336-1340 (2017). doi:10.1016/j.bbadis.2017.08.030.
2017
Gasparre, Giuseppe ; Rossignol, Rodrigue ; Sonveaux, Pierre. Mitochondria in cancer. In: BBA. Bioenergetics, Vol. 1858, no.8, p. 553-555 (2017). doi:10.1016/j.bbabio.2017.05.004.
2017
Payen, Valéry ; Hsu, Myriam ; Radecke, Kristin ; Wyart, Elisabeth ; Vazeille, Thibaut ; Bouzin, Caroline ; Porporato, Paolo ; Sonveaux, Pierre. Monocarboxylate transporter MCT1 promotes tumor metastasis independently of its activity as a lactate transporter.. In: Cancer Research, Vol. 77, no. 20, p. 5591-5601 (2017). doi:10.1158/0008-5472.CAN-17-0764.
2017
Contino, Sabrina ; Porporato, Paolo ; Bird, Matthew ; Marinangeli, Claudia ; Opsomer, Rémi ; Sonveaux, Pierre ; Bontemps, Françoise ; Dewachter, Ilse ; Octave, Jean-Noël ; Bertrand, Luc ; Stanga, Serena ; Kienlen-Campard, Pascal. Presenilin 2-Dependent Maintenance of Mitochondrial Oxidative Capacity and Morphology.. In: Frontiers in Physiology, Vol. 8, p. 796 [1-11] (2017). doi:10.3389/fphys.2017.00796.
2017
Sonveaux, Pierre. ROS and radiotherapy: more we care.. In: OncoTarget, Vol. 8, no. 22, p. 35482-35483 (2017). doi:10.18632/oncotarget.16613.
2017
Van Hee, Vincent F ; Labar, Daniel ; Dehon, Gwenaël ; Grasso, Debora ; Gregoire, Vincent ; Muccioli, Giulio ; Frédérick, Raphaël ; Sonveaux, Pierre. Radiosynthesis and validation of (±)-[18F]-3-fluoro-2-hydroxypropionate ([18F]-FLac) as a PET tracer of lactate to monitor MCT1-dependent lactate uptake in tumors. In: OncoTarget, Vol. 8, no. 15, p. 24415-24428 (2017). doi:10.18632/oncotarget.14705.
2016
De Preter, Géraldine ; Deriemaeker, Caroline ; Danhier, Pierre ; Brisson, Lucie ; Cao Pham, Thanh Trang ; Grégoire, Vincent ; Jordan, Bénédicte ; Sonveaux, Pierre ; Gallez, Bernard. A Fast Hydrogen Sulfide-Releasing Donor Increases the Tumor Response to Radiotherapy. In: Molecular Cancer Therapeutics, Vol. 15, no. 1, p. 154-161 (2016). doi:10.1158/1535-7163.MCT-15-0691-T.
2016
Sonveaux, Pierre ; Maechler, Pierre ; Martinou, Jean-Claude. Channels and transporters in cell metabolism.. In: BBA - Molecular Cell Research, Vol. 1863, no. 10, p. 2359-2361 (2016). doi:10.1016/j.bbamcr.2016.06.001.
2016
De Preter, Géraldine ; Danhier, Pierre ; Porporato, Paolo ; Payen, Valery L ; Jordan, Benedicte ; Sonveaux, Pierre ; Gallez, Bernard. Direct Evidence of the Link Between Energetic Metabolism and Proliferation Capacity of Cancer Cells In Vitro.. In: Advances in Experimental Medicine and Biology, Vol. 876, p. 209-14 (2016). doi:10.1007/978-1-4939-3023-4_26.
2016
Lemma, Silvia ; Sboarina, Martina ; Porporato, Paolo ; Zini, Nicoletta ; Sonveaux, Pierre ; Di Pompo, Gemma ; Baldini, Nicola ; Avnet, Sofia. Energy metabolism in osteoclast formation and activity.. In: The International Journal of Biochemistry & Cell Biology, Vol. 79, no.1, p. 168-180 (2016). doi:10.1016/j.biocel.2016.08.034.
2016
De Preter, Géraldine ; Neveu, Marie-Aline ; Danhier, Pierre ; Brisson, Lucie ; Payen, Valéry ; Porporato, Paolo ; Jordan, Bénédicte ; Sonveaux, Pierre ; Gallez, Bernard. Inhibition of the pentose phosphate pathway by dichloroacetate unravels a missing link between aerobic glycolysis and cancer cell proliferation. In: OncoTarget, Vol. 7, no. 3, p. 2910-2920 (2016). doi:10.18632/oncotarget.6272.
2016
Craps, Julie ; Joris, Virginie ; De Jongh, Britt ; Sonveaux, Pierre ; Horman, Sandrine ; Lengelé, Benoît ; Bertrand, Luc ; Many, Marie-Christine ; Colin, Idesbald ; Gerard, Anne-Catherine. Involvement of mTOR and regulation by AMPK in TSH-independent iodine deficiency-induced thyroid microvascular activation. In: Endocrinology, Vol. 157, no. 6, p. 2545-2559 (2016). doi:10.1210/en.2015-1911.
2016
Vanderstraeten, Jessica ; Derradji, H ; Craps, Julie ; Sonveaux, Pierre ; Colin, Idesbald ; Many, Marie-Christine ; Gerard, Anne-Catherine. Iodine deficiency induces a VEGF-dependent microvascular response in salivary glands and in the stomach. In: Histology and Histopathology : cellular and molecular biology, Vol. 31, no. 8, p. 897-909 (2016). doi:10.14670/HH-11-727.
2016
Brisson, Lucie ; Banski, Piotr ; Sboarina, Martina ; Dethier, Coralie ; Danhier, Pierre ; Fontenille, Marie-Joséphine ; Van Hee, Vincent F ; Vazeille, Thibaut ; Tardy, Morgane ; Falces Ramos, Jorge ; Bouzin, Caroline ; Porporato, Paolo ; Frédérick, Raphaël ; Michiels, Carine ; Copetti, Tamara ; Sonveaux, Pierre. Lactate Dehydrogenase B Controls Lysosome Activity and Autophagy in Cancer.. In: Cancer Cell, Vol. 30, no.3, p. 418-431 (2016). doi:10.1016/j.ccell.2016.08.005.
2016
Perez Escuredo, Jhudit ; Dadhich, Rajesh Kumar ; Dhup, Suveera ; Cacace, Andrea ; Van Hee, Vincent F ; De Saedeleer, Christophe ; Sboarina, Martina ; Rodriguez, Fabien ; Fontenille, Marie-Joséphine ; Brisson, Lucie ; Porporato, Paolo ; Sonveaux, Pierre. Lactate promotes glutamine uptake and metabolism in oxidative cancer cells.. In: Cell Cycle, Vol. 15, no. 1, p. 72-83 (2016). doi:10.1080/15384101.2015.1120930.
2016
Payen, Valéry ; Porporato, Paolo ; Baselet, Bjorn ; Sonveaux, Pierre. Metabolic changes associated with tumor metastasis, part 1: tumor pH, glycolysis and the pentose phosphate pathway. In: Cellular and Molecular Life Sciences, Vol. 73, no. 7, p. 1333-1348 (2016). doi:10.1007/s00018-015-2098-5.
2016
Porporato, Paolo ; Payen, Valéry ; Baselet, Bjorn ; Sonveaux, Pierre. Metabolic changes associated with tumor metastasis, part 2: Mitochondria, lipid and amino acid metabolism. In: Cellular and Molecular Life Sciences, Vol. 73, no. 7, p. 1349-1363 (2016). doi:10.1007/s00018-015-2100-2.
2016
Baldini, Nicola ; Sonveaux, Pierre ; De Milito, Angelo ; Supuran, Claudiu T ; Otto, Angela M ; Stock, Christian M ; Pedersen, Stine F ; Favicchio, Rosy ; Avnet, Sofia. Metabolism and microenvironment in cancer plasticity. In: Cancer & Metabolism, Vol. 4, no. Suppl. 1, p. 1 (2016).
2016
Perez Escuredo, Jhudit ; Van Hee, Vincent F ; Sboarina, Martina ; Falces Ramos, Jorge ; Payen, Valéry ; Pellerin, Luc ; Sonveaux, Pierre. Monocarboxylate transporters in the brain and in cancer. In: BBA - Molecular Cell Research, Vol. 1863, p. 2481-2497 (2016). doi:10.1016/j.bbamcr.2016.03.013.
2016
Neveu, Marie-Aline ; De Preter, Géraldine ; Marchand, Valérie ; Bol, Anne ; Brender, Jeffery R ; Saito, Keita ; Kishimoto, Shun ; Porporato, Paolo ; Sonveaux, Pierre ; Grégoire, Vincent ; Feron, Olivier ; Jordan, Bénédicte ; Krishna, Murali C ; Gallez, Bernard. Multimodality imaging identifies distinct metabolic profiles in vitro and in vivo. In: NeoPlasia : an international journal of oncology research, Vol. 18, no. 12, p. 742-752 (2016). doi:10.1016/j.neo.2016.10.010.
2016
Mignion, Lionel ; Danhier, Pierre ; Magat, Julie ; Porporato, Paolo ; Masquelier, Julien ; Grégoire, Vincent ; Muccioli, Giulio ; Sonveaux, Pierre ; Gallez, Bernard ; Jordan, Bénédicte. Non-invasive in vivo imaging of early metabolic tumor response to therapies targeting choline metabolism.. In: International Journal of Cancer, Vol. 138, no. 8, p. 2043-2049 (2016). doi:10.1002/ijc.29932.
2016
De Pauw, Aurélia ; Massion, Paul ; Sekkali, Belaid ; André, Emilie ; Dubroca, Caroline ; Kmecova, Jana ; Bouzin, Caroline ; Friart, Ann ; Sibille, Catherine ; Gilon, Patrick ; De Mulder, Delphine ; Esfahani, Hrag ; Strapart, Adrien ; Martherus, Sarkies-Ruben-Matthe ; Payen, Valéry ; Sonveaux, Pierre ; Brouckaert, Peter ; Janssens, Stefan ; Balligand, Jean-Luc. Paracrine Nitric Oxide induces expression of cardiac sarcomeric proteins in adult progenitor cells through soluble Guanylyl Cyclase/cyclic-GMP and Wnt/β-catenin inhibition.. In: Cardiovascular Research, Vol. 112, no. 1, p. 478-490 (2016). doi:10.1093/cvr/cvw196.
2016
Chano, Tokuhiro ; Avnet, Sofia ; Kusuzali, Katsuyuki ; Bonuccelli, Gloria ; Sonveaux, Pierre ; Rotili, Dante ; Mai, Antonello ; Baldini, Nicola. Tumour-specific metabolic adaptation to acidosis is coupled to epigenetic stability in osteosarcoma cells. In: American Journal of Cancer Research, Vol. 6, no. 4, p. 859-875 (2016).
2015
Desmet, Celine ; Lafosse, Aurore ; Veriter, Sophie ; Porporato, Paolo ; Sonveaux, Pierre ; Dufrane, Denis ; Levêque, Philippe ; Gallez, Bernard. Application of Electron Paramagnetic Resonance (EPR) Oximetry to Monitor Oxygen in Wounds in Diabetic Models.. In: PLoS One, Vol. 10, no. 12, p. e0144914 [1-16] (2015). doi:10.1371/journal.pone.0144914.
2015
Chereddy, Kiran Kumar ; Lopes, Alessandra ; Koussoroplis, Salomé ; Payen, Valéry ; Moia, Claudia ; Zhu, Huijun ; Sonveaux, Pierre ; Carmeliet, Peter ; des Rieux, Anne ; Vandermeulen, Gaëlle ; Préat, Véronique. Combined effects of PLGA and vascular endothelial growth factor promote the healing of non-diabetic and diabetic wounds.. In: Nanomedicine: Nanotechnology, Biology and Medicine, Vol. 11, no. 8, p. 1975-1984 (2015). doi:10.1016/j.nano.2015.07.006.
2015
Payen, Valéry ; Brisson, Lucie ; Dewhirst, Mark W ; Sonveaux, Pierre. Common responses of tumors and wounds to hypoxia.. In: The Cancer Journal, Vol. 21, no. 2, p. 75-87 (2015). doi:10.1097/PPO.0000000000000098.
2015
Danhier, Pierre ; Magat, Julie ; Levêque, Philippe ; De Preter, Géraldine ; Porporato, Paolo ; Bouzin, Caroline ; Jordan, Bénédicte ; Demeur, Gladys ; Haufroid, Vincent ; Feron, Olivier ; Sonveaux, Pierre ; Gallez, Bernard. In vivo visualization and ex vivo quantification of murine breast cancer cells in the mouse brain using MRI cell tracking and electron paramagnetic resonance.. In: NMR in Biomedicine, Vol. 28, no. 3, p. 367-375 (2015). doi:10.1002/nbm.3259.
2015
Craps, Julie ; Wilvers, Christine ; Joris, Virginie ; De Jongh, Britt ; Vanderstraeten, Jessica ; Lobysheva, Irina ; Balligand, Jean-Luc ; Sonveaux, Pierre ; Gilon, Patrick ; Many, Marie-Christine ; Gérard, Anne-Catherine ; Colin, Idesbald. Involvement of nitric oxide in iodine deficiency-induced microvascular remodeling in the thyroid gland: role of nitric oxide synthase 3 and ryanodine receptors.. In: Endocrinology, Vol. 156, no. 2, p. 707-720 (2015). doi:10.1210/en.2014-1729.
2015
Van Hee, Vincent ; Perez Escuredo, Jhudit ; Cacace, Andrea ; Copetti, Tamara ; Sonveaux, Pierre. Lactate does not activate NF-κB in oxidative tumor cells.. In: Frontiers in Pharmacology, Vol. 6, p. 228 (2015). doi:10.3389/fphar.2015.00228.
2015
Danhier, Fabienne ; Danhier, Pierre ; De Saedeleer, Christophe ; Fruytier, Anne-Catherine ; Schleich, Nathalie ; des Rieux, Anne ; Sonveaux, Pierre ; Gallez, Bernard ; Préat, Véronique. Paclitaxel-loaded micelles enhance transvascular permeability and retention of nanomedicines in tumors. In: International Journal of Pharmaceutics, Vol. 479, no. 2, p. 399-407 (2015). doi:10.1016/j.ijpharm.2015.01.009.
2014
Porporato, Paolo ; Payen, Valéry ; Perez Escuredo, Jhudit ; De Saedeleer, Christophe ; Danhier, Pierre ; Copetti, Tamara ; Dhup, Suveera ; Tardy, Morgane ; Vazeille, Thibaut ; Bouzin, Caroline ; Feron, Olivier ; Michiels, Carine ; Sonveaux, Pierre. A mitochondrial switch promotes tumor metastasis. In: Cell Reports, Vol. 8, p. 754-766 (2014). doi:10.1016/j.celrep.2014.06.043.
2014
Draoui, Nihed ; Schicke, Olivier ; Seront, Emmanuel ; Bouzin, Caroline ; Sonveaux, Pierre ; Riant, Olivier ; Feron, Olivier. Antitumor activity of 7-aminocarboxycoumarin derivatives, a new class of potent inhibitors of lactate influx but not efflux.. In: Molecular Cancer Therapeutics, Vol. 13, no. 6, p. 1410-1418 (2014). doi:10.1158/1535-7163.MCT-13-0653.
2014
Sonveaux, Pierre. Découverte d'une stratégie capable d'empêcher la dissémination des métastases cancéreuses. In: Louvain médical, Vol. 133, no.9, p. 639-645 (30/11/2014).
2014
Danhier, Pierre ; De Preter, Géraldine ; Magat, Julie ; Godechal, Quentin ; Porporato, Paolo ; Jordan, Bénédicte ; Feron, Olivier ; Sonveaux, Pierre ; Gallez, Bernard. Multimodal cell tracking of a spontaneous metastasis model: comparison between MRI, electron paramagnetic resonance and bioluminescence.. In: Contrast Media & Molecular Imaging, Vol. 9, no. 2, p. 143-153 (2014). doi:10.1002/cmmi.1553.
2014
Chereddy, Kiran Kumar ; Her, Charles-henry ; Comune, Michela ; Moia, Claudia ; Lopes, Alessandra ; Porporato, Paolo ; Vanacker, Julie ; Lam, Martin C ; Steinstraesser, Lars ; Sonveaux, Pierre ; Zhu, Huijun ; Ferreira, Lino S ; Vandermeulen, Gaëlle ; Préat, Véronique. PLGA nanoparticles loaded with host defense peptide LL37 promote wound healing.. In: Journal of Controlled Release, Vol. 194, no. C, p. 138-147 (2014). doi:10.1016/j.jconrel.2014.08.016.
2014
Porporato, Paolo ; Sonveaux, Pierre. Paving the way for a therapeutic prevention of tumor metastasis with agents targeting mitochondrial superoxide. In: Molecular & Cellular Oncology, Vol. 2, no. 3, p. e968043 (2014). doi:10.4161/23723548.2014.968043.
2014
Spugnini, Enrico ; Sonveaux, Pierre ; Stock, Christian ; Perez-Sayans, Mario ; De Milito, Angelo ; Avnet, Sofia ; Garcia Garcia, Abel ; Harguidey, Salvador ; Fais, Stefano. Proton channels and exchangers in cancer. In: BBA - Biomembranes, Vol. 1848, no. 10 Pt B, p. 2715-2726. doi:10.1016/j.bbamem.2014.10.015.
2014
Bol, Vanesa ; Bol, Anne ; Bouzin, Caroline ; Labar, Daniel ; Lee, John Aldo ; Janssens, Guillaume ; Porporato, Paolo ; Sonveaux, Pierre ; Feron, Olivier ; Grégoire, Vincent. Reprogramming of tumor metabolism by targeting mitochondria improves tumor response to irradiation.. In: Acta Oncologica, Vol. 54, no. 2, p. 266-274 (2015). doi:10.3109/0284186X.2014.932006.
2014
de Meester, Carole ; Timmermans, Aurélie ; Balteau, Magali ; Ginion, Audrey ; Roelants, Véronique ; Noppe, Gauthier ; Porporato, Paolo ; Sonveaux, Pierre ; Viollet, Benoît ; Sakamoto, Kei ; Feron, Olivier ; Horman, Sandrine ; Vanoverschelde, Jean-Louis ; Beauloye, Christophe ; Bertrand, Luc. Role of AMP-activated protein kinase in regulating hypoxic survival and proliferation of mesenchymal stem cells.. In: Cardiovascular Research, Vol. 101, no. 1, p. 20-29 (2014). doi:10.1093/cvr/cvt227.
2014
Steinstraesser, Lars ; Lam, Martin C ; Jacobsen, Frank ; Porporato, Paolo ; Chereddy, Kiran Kumar ; Becerikli, Mustafa ; Stricker, Ingo ; Hancock, Robert Ew ; Lehnhardt, Marcus ; Sonveaux, Pierre ; Préat, Véronique ; Vandermeulen, Gaëlle. Skin electroporation of a plasmid encoding hCAP-18/LL-37 host defense peptide promotes wound healing.. In: Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 22, no. 4, p. 734-742 (2014). doi:10.1038/mt.2013.258.
2013
Kennedy, Kelly M ; Scarbrough, Peter M ; Ribeiro, Anthony ; Richardson, Rachel ; Yuan, Hong ; Sonveaux, Pierre ; Landon, Chelsea D ; Chi, Jen-Tsan ; Pizzo, Salvatore ; Schroeder, Thies ; Dewhirst, Mark W. Catabolism of exogenous lactate reveals it as a legitimate metabolic substrate in breast cancer. In: PLoS One, Vol. 8, no. 9, p. e75154 (2013). doi:10.1371/journal.pone.0075154.
2013
De Saedeleer, Christophe ; Porporato, Paolo ; Copetti, Tamara ; Perez Escuredo, Jhudit ; Payen, Valéry ; Brisson, Lucie ; Feron, Olivier ; Sonveaux, Pierre. Glucose deprivation stimulates monocarboxylate transporter 1 (MCT1) expression and MCT1-dependent tumor cell migration. In: Oncogene : including Oncogene Reviews, Vol. 33, no. 31, p. 4060-4068 (2014). doi:10.1038/onc.2013.454.
2013
Danhier, Pierre ; Copetti, Tamara ; De Preter, Géraldine ; Levêque, Philippe ; Feron, Olivier ; Jordan, Bénédicte ; Sonveaux, Pierre ; Gallez, Bernard. Influence of cell detachment on the respiration rate of tumor and endothelial cells. In: PLoS One, Vol. 8, no. 1, p. e53324 [1-11] (2013). doi:10.1371/journal.pone.0053324.
2013
Danhier, Pierre ; De Saedeleer, Christophe ; Karroum, Oussama ; De Preter, Géraldine ; Porporato, Paolo ; Jordan, Bénédicte ; Gallez, Bernard ; Sonveaux, Pierre. Optimization of tumor radiotherapy with modulators of cell metabolism: towards clinical applications. In: Seminars in Radiation Oncology, Vol. 23, no. 4, p. 262-272 (2013). doi:10.1016/j.semradonc.2013.05.008.
2013
Hick, Anne-Christine ; Delmarcelle, Anne-Sophie ; Bouquet, Mahé ; Klotz, Sabrina ; Copetti, Tamara ; Forez, Celine ; Van Der Smissen, Patrick ; Sonveaux, Pierre ; Collet, Jean-François ; Feron, Olivier ; Courtoy, Pierre J. ; Pierreux, Christophe. Reciprocal epithelial: Endothelial paracrine interactions during thyroid development govern follicular organization and C-cells differentiation.. In: Developmental Biology, Vol. 381, no. 1, p. 227-240 (2013). doi:10.1016/j.ydbio.2013.04.022.
2013
Draoui, Nihed ; Schicke, Olivier ; Fernandes, Antony E. ; Drozak, Xavier ; Nahra, Fady ; Dumont, Amélie ; Douxfils, Jonathan ; Hermans, Emmanuel ; Dogné, Jean-Michel ; Corbau, Romu ; Marchand, Arnaud ; Chaltin, Patrick ; Sonveaux, Pierre ; Feron, Olivier ; Riant, Olivier. Synthesis and pharmacological evaluation of carboxycoumarins as a new antitumor treatment targeting lactate transport in cancer cells.. In: Bioorganic & Medicinal Chemistry : the tetrahedron journal for research at the interface of chemistry and biology, Vol. 21, no. 22, p. 7107-7117 (2013). doi:10.1016/j.bmc.2013.09.010.
2012
Danhier, Pierre ; De Preter, Géraldine ; Boutry, Simon ; Mahieu, I. ; Levêque, Philippe ; Magat, Julie ; Haufroid, Vincent ; Sonveaux, Pierre ; Bouzin, Caroline ; Feron, Olivier ; Muller, R. N. ; Jordan, Bénédicte ; Gallez, Bernard. Electron paramagnetic resonance as a sensitive tool to assess the iron oxide content in cells for MRI cell labeling studies.. In: Contrast Media & Molecular Imaging, Vol. 7, no. 3, p. 302-307 (2012). doi:10.1002/cmmi.497.
2012
Bindels, Laure B. ; Porporato, Paolo ; Dewulf, Evelyne ; Verrax, Julien ; Neyrinck, Audrey M. ; Martin, J C ; Scott, K P ; Buc Calderon, Pedro ; Feron, Olivier ; Muccioli, Giulio ; Sonveaux, Pierre ; Cani, Patrice D. ; Delzenne, Nathalie M.. Gut microbiota-derived propionate reduces cancer cell proliferation in the liver. In: The British journal of cancer, Vol. 107, no. 8, p. 1337-1344 (2012). doi:10.1038/bjc.2012.409.
2012
Gérard, Anne-Catherine ; Humblet, Kevin ; Wilvers, Cindy ; Poncin, Sylvie ; Derradji, Hanane ; de Ville de Goyet, Christine ; Abou-El-Ardat, Khalil ; Baatout, Sarah ; Sonveaux, Pierre ; Denef, Jean-François ; Colin, Idesbald. Iodine-deficiency-induced long lasting angiogenic reaction in thyroid cancers occurs via a vascular endothelial growth factor-hypoxia inducible factor-1-dependent, but not a reactive oxygen species-dependent, pathway.. In: Thyroid, Vol. 22, no. 7, p. 699-708 (2012). doi:10.1089/thy.2011.0387.
2012
De Saedeleer, Christophe ; Copetti, Tamara ; Porporato, Paolo ; Verrax, Julien ; Feron, Olivier ; Sonveaux, Pierre. Lactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cells. In: PLoS One, Vol. 7, no. 10, p. e46571 (2012). doi:10.1371/journal.pone.0046571.
2012
Porporato, Paolo ; Payen, Valéry ; De Saedeleer, Christophe ; Préat, Véronique ; Thissen, Jean-Paul ; Feron, Olivier ; Sonveaux, Pierre. Lactate stimulates angiogenesis and accelerates the healing of superficial and ischemic wounds in mice.. In: Angiogenesis, Vol. 15, p. 581-592 (2012). doi:10.1007/s10456-012-9282-0.
2012
Végran, Frédérique ; Seront, Emmanuel ; Sonveaux, Pierre ; Feron, Olivier. Lactate-induced IL-8 pathway in endothelial cells – Response. In: Cancer Research, Vol. 72, no. 4, p. 1903-1904 (2012). doi:10.1158/0008-5472.CAN-12-0012.
2012
Dhup, Suveera ; Dadhich, Rajesh Kumar ; Porporato, Paolo ; Sonveaux, Pierre. Multiple Biological Activities of Lactic Acid in Cancer: Influences on Tumor Growth, Angiogenesis and Metastasis. In: Current Pharmaceutical Design, Vol. 18, no. 10, p. 1319-1330 (2012). doi:10.2174/138161212799504902.
2012
Boidot, Romain ; Végran, Frédérique ; Meulle, Aline ; Le Breton, Aude ; Dessy, Chantal ; Sonveaux, Pierre ; Lizard-Nacol, Sarab ; Feron, Olivier. Regulation of monocarboxylate transporter MCT1 expression by p53 mediates inward and outward lactate fluxes in tumors. In: Cancer Research, Vol. 72, no. 4, p. 939-948 (2011). doi:10.1158/0008-5472.CAN-11-2474.
2012
Sonveaux, Pierre ; Copetti, Tamara ; De Saedeleer, Christophe ; Végran, Frédérique ; Verrax, Julien ; Kennedy, Kelly M ; Moon, Eui Jung ; Dhup, Suveera ; Danhier, Pierre ; Frérart, Françoise ; Gallez, Bernard ; Ribeiro, Anthony ; Michiels, Carine ; Dewhirst, Mark W ; Feron, Olivier. Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis. In: PLoS One, Vol. 7, no.3, p. e33418 [1-13] (2012). doi:10.1371/journal.pone.0033418.
2012
Jordan, Bénédicte ; Sonveaux, Pierre. Targeting tumor perfusion and oxygenation to improve the outcome of anticancer therapy.. In: Frontiers in Pharmacology, Vol. 3, no. 1, p. 94 (2012). doi:10.3389/fphar.2012.00094.
2012
Karroum, Oussama ; Kengen, Julie ; Danhier, Pierre ; Magat, Julie ; Mignion, Lionel ; Bouzin, Caroline ; Verrax, Julien ; Charette, Nicolas ; Starkel, Peter ; Buc Calderon, Pedro ; Sonveaux, Pierre ; Feron, Olivier ; Grégoire, Vincent ; Gallez, Bernard ; Jordan, Bénédicte. Tumor reoxygenation following administration of Mitogen-Activated Protein Kinase inhibitors : A rationale for combination with radiation therapy.. In: Radiotherapy & Oncology, Vol. 105, no. 1, p. 64-71 (2012). doi:10.1016/j.radonc.2012.05.005.
2011
Porporato, Paolo ; Dhup, Suveera ; Dadhich, Rajesh Kumar ; Copetti, Tamara ; Sonveaux, Pierre. Anticancer targets in the glycolytic metabolism of tumors : a comprehensive review.. In: Frontiers in Pharmacology, Vol. 2, p. 49 (2011). doi:10.3389/fphar.2011.00049.
2011
Godechal, Quentin ; Defresne, Florence ; Danhier, Pierre ; Levêque, Philippe ; Porporato, Paolo Ettore ; Sonveaux, Pierre ; Baurain, Jean-François ; Feron, Olivier ; Gallez, Bernard. Assessment of melanoma extent and melanoma metastases invasion using electron paramagnetic resonance and bioluminescence imaging. In: Contrast Media & Molecular Imaging, Vol. 6, no. 4, p. 282-288 (2011). doi:10.1002/cmmi.430.
2011
Végran, Frédérique ; Boidot, Romain ; Michiels, Carine ; Sonveaux, Pierre ; Feron, Olivier. Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-κB/IL-8 pathway that drives tumor angiogenesis.. In: Cancer Research, Vol. 71, no. 7, p. 2550-2560 (2011). doi:10.1158/0008-5472.CAN-10-2828.
2011
Sonveaux, Pierre. Loss of CC3/TIP30 allows tumor cells to cope with low glucose.. In: Cell Cycle, Vol. 10, no. 3, p. 376 (2011). doi:10.4161/cc.10.3.14646.
2010
Jiang, Heng ; De Ridder, Mark ; Verovski, Valeri N. ; Sonveaux, Pierre ; Jordan, Bénédicte ; Law, Kalun ; Monsaert, Christinne ; Van den Berge, Dirk L. ; Verellen, Dirk ; Feron, Olivier ; Gallez, Bernard ; Storme, Guy A.. Activated macrophages as a novel determinant of tumor cell radioresponse: the role of nitric oxide-mediated inhibition of cellular respiration and oxygen sparing. In: International Journal of Radiation: Oncology - Biology - Physics, Vol. 76, no. 5, p. 1520-1527 (2010). doi:10.1016/j.ijrobp.2009.10.047.
2010
Moon, Eui Jung ; Sonveaux, Pierre ; Porporato, Paolo ; Danhier, Pierre ; Gallez, Bernard ; Batinic-Haberle, Ines ; Nien, Yu-Chih ; Schroeder, Thies ; Dewhirst, Mark W.. NADPH oxidase-mediated reactive oxygen species production activates hypoxia-inducible factor-1 (HIF-1) via the ERK pathway after hyperthermia treatment.. In: Proceedings of the National academy of sciences of the United States of America, Vol. 107, no. 47, p. 20477-20482 (2010). doi:10.1073/pnas.1006646107.
2009
Sonveaux, Pierre ; Végran, Frédérique ; Verrax, Julien ; De Saedeleer, Christophe ; Diepart, Caroline ; Jordan, Bénédicte ; Gallez, Bernard ; Feron, Olivier. Cancer : lorsque recycler devient une faiblesse.. In: Médecine, sciences - MS, Vol. 25, no. 4, p. 327-329 (2009). doi:10.1051/medsci/2009254327.
2009
Sonveaux, Pierre ; Jordan, Bénédicte ; Gallez, Bernard ; Feron, Olivier. Nitric oxide delivery to cancer : why and how?. In: European Journal of Cancer, Vol. 45, no. 8, p. 1352-1369 (2009). doi:10.1016/j.ejca.2008.12.018.
2008
Sonveaux, Pierre. Développement et validation de nouvelles approches provasculaires ciblant les vaisseaux tumoraux. In: Bull. Acad. Roy. Bel., Vol. 163, no. 5, p. 269-279 (2008).
2008
Gérard, Anne-Catherine ; Poncin, Sylvie ; Caetano, Bertrand ; Sonveaux, Pierre ; Audinot, Jean-Nicolas ; Feron, Olivier ; Colin, Idesbald ; Soncin, Fabrice. Iodine deficiency induces a thyroid stimulating hormone-independent early phase of microvascular reshaping in the thyroid. In: The American Journal of Pathology : cellular and molecular biology of disease, Vol. 172, no. 3, p. 748-760 (2008). doi:10.2353/ajpath.2008.070841.
2008
Sonveaux, Pierre. Provascular strategy: Targeting functional adaptations of mature blood vessels in tumors to selectively influence the tumor vascular reactivity and improve cancer treatment.. In: Radiotherapy & Oncology, Vol. 86, no. 3, p. 300-313 (2008). doi:10.1016/j.radonc.2008.01.024.
2008
Sonveaux, Pierre ; Végran, Frédérique ; Schroeder, Thies ; Wergin, Melanie C. ; Verrax, Julien ; Rabbani, Zahid N. ; De Saedeleer, Christophe ; Kennedy, Kelly M. ; Diepart, Caroline ; Jordan, Bénédicte ; Kelley, Michael J. ; Gallez, Bernard ; Wahl, Miriam L. ; Feron, Olivier ; Dewhirst, Mark W.. Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. In: Journal of Clinical Investigation, Vol. 118, no. 12, p. 3930-3942 (2008). doi:10.1172/JCI36843.
2008
Frérart, Françoise ; Sonveaux, Pierre ; Rath, Géraldine ; Smoos, Alexandra ; Meqor, Ahlam ; Charlier, Nicolas ; Jordan, Bénédicte ; Saliez, Julie ; Noël, Agnès ; Dessy, Chantal ; Gallez, Bernard ; Feron, Olivier. The acidic tumor microenvironment promotes the reconversion of nitrite into nitric oxide : towards a new and safe radiosensitizing strategy. In: Clinical Cancer Research, Vol. 14, no. 9, p. 2768-2774 (2008). doi:10.1158/1078-0432.CCR-07-4001.
2007
Dewever, Julie ; Frérart, Françoise ; Bouzin, Caroline ; Baudelet, Christine ; Ansiaux, Réginald ; Sonveaux, Pierre ; Gallez, Bernard ; Dessy, Chantal ; Feron, Olivier. Caveolin-1 is critical for the maturation of tumor blood vessels through the regulation of both endothelial tube formation and mural cell recruitment.. In: The American journal of pathology, Vol. 171, no. 5, p. 1619-28 (2007). doi:10.2353/ajpath.2007.060968.
2007
Sonveaux, Pierre ; Frérart, Françoise ; Bouzin, Caroline ; Brouet, Agnès ; Dewever, Julie ; Jordan, Bénédicte ; Gallez, Bernard ; Feron, Olivier. Irradiation promotes Akt-targeting therapeutic gene delivery to the tumor vasculature. In: International Journal of Radiation: Oncology - Biology - Physics, Vol. 67, no. 4, p. 1155-1162 (2007). doi:10.1016/j.ijrobp.2006.11.031.
2007
Li, Fang ; Sonveaux, Pierre ; Rabbani, Zahid N. ; Liu, Shanling ; Yan, Bin ; Huang, Qian ; Vujaskovic, Zeljko ; Dewhirst, Mark W. ; Li, Chuan-Yuan. Regulation of HIF-1 alpha stability through S-nitrosylation. In: Molecular Cell, Vol. 26, no. 1, p. 63-74 (2007). doi:10.1016/j.molcel.2007.02.024.
2007
Cao, Yiting ; Sonveaux, Pierre ; Liu, Shanling ; Zhao, Yulin ; Mi, Jing ; Clary, Bryan M. ; Li, Chuan-Yuan ; Kontos, Christopher D. ; Dewhirst, Mark W.. Systemic overexpression of angiopoietin-2 promotes tumor microvessel regression and inhibits angiogenesis and tumor growth. In: Cancer Research, Vol. 67, no. 8, p. 3835-3844 (2007). doi:10.1158/0008-5472.CAN-06-4056.
2007
Sonveaux, Pierre ; Lobysheva, Irina ; Feron, Olivier ; McMahon, Timothy J.. Transport and peripheral bioactivities of nitrogen oxides carried by red blood cell hemoglobin: role in oxygen delivery.. In: Physiology (Bethesda, Md.), Vol. 22, p. 97-112 (2007). doi:10.1152/physiol.00042.2006.
2006
Martinive, Philippe ; De Wever, Julie ; Bouzin, Caroline ; Baudelet, Christine ; Sonveaux, Pierre ; Grégoire, Vincent ; Gallez, Bernard ; Feron, Olivier. Reversal of temporal and spatial heterogeneities in tumor perfusion identifies the tumor vascular tone as a tunable variable to improve drug delivery.. In: Molecular cancer therapeutics, Vol. 5, no. 6, p. 1620-7 (2006). doi:10.1158/1535-7163.MCT-05-0472.
2005
Brouet, Agnès ; DeWever, Julie ; Martinive, Philippe ; Havaux, Xavier ; Bouzin, Caroline ; Sonveaux, Pierre ; Feron, Olivier. Antitumor effects of in vivo caveolin gene delivery are associated with the inhibition of the proangiogenic and vasodilatory effects of nitric oxide.. In: The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 19, no. 6, p. 602-4 (2005). doi:10.1096/fj.04-2682fje.
2005
Crokart, Nathalie ; Jordan, Bénédicte ; Baudelet, Christine ; Ansiaux, Réginald ; Sonveaux, Pierre ; Grégoire, Vincent ; Beghein, Nelson ; DeWever, Julie ; Bouzin, Caroline ; Feron, Olivier ; Gallez, Bernard. Early reoxygenation in tumors after irradiation: determining factors and consequences for radiotherapy regimens using daily multiple fractions. In: International Journal of Radiation: Oncology - Biology - Physics, Vol. 63, no. 3, p. 901-910 (2005). doi:10.1016/j.ijrobp.2005.02.038.
2005
Sonveaux, Pierre ; Kaz, Andrew M ; Snyder, Stacey A ; Richardson, Rachel A ; Cárdenas-Navia, L Isabel ; Braun, Rodney D ; Pawloski, John R ; Tozer, Gillian M ; Bonaventura, Joseph ; McMahon, Timothy J ; Stamler, Jonathan S ; Dewhirst, Mark W. Oxygen regulation of tumor perfusion by S-nitrosohemoglobin reveals a pressor activity of nitric oxide.. In: Circulation research, Vol. 96, no. 10, p. 1119-26 (2005). doi:10.1161/01.RES.0000168740.04986.a7.
2005
Jackson, I.L. ; Batinic-Haberle, I. ; Sonveaux, Pierre ; Dewhirst, M.W.. ROS production and angiogenic regulation by macrophages in response to heat therapy.. In: International Journal of Hyperthermia, Vol. 22, no. 4, p. 263-273 (2006). doi:10.1080/02656730600594027.
2005
Ansiaux, Réginald ; Baudelet, Christine ; Jordan, Bénédicte ; Beghein, Nelson ; Sonveaux, Pierre ; De Wever, Julie ; Martinive, Philippe ; Grégoire, Vincent ; Feron, Olivier ; Gallez, Bernard. Thalidomide radiosensitizes tumors through early changes in the tumor microenvironment. In: Clinical Cancer Research, Vol. 11, no. 2 Pt 1, p. 743-750 (2005).
2004
Sonveaux, Pierre ; Martinive, Philippe ; DeWever, Julie ; Batova, Zuzana ; Daneau, Géraldine ; Pelat, Michel ; Ghisdal, Philippe ; Grégoire, Vincent ; Dessy, Chantal ; Balligand, Jean-Luc ; Feron, Olivier. Caveolin-1 expression is critical for vascular endothelial growth factor-induced ischemic hindlimb collateralization and nitric oxide-mediated angiogenesis.. In: Circulation Research, Vol. 95, no. 2, p. 154-161 (2004). doi:10.1161/01.RES.0000136344.27825.72.
2004
Sonveaux, Pierre ; Dessy, Chantal ; Martinive, Philippe ; Havaux, Xavier ; Jordan, Bénédicte ; Gallez, Bernard ; Grégoire, Vincent ; Balligand, Jean-Luc ; Feron, Olivier. Endothelin-1 is a critical mediator of myogenic tone in tumor arterioles: implications for cancer treatment. In: Cancer Research, Vol. 64, no. 9, p. 3209-3214 (2004). doi:10.1158/0008-5472.CAN-03-1291.
2004
Jordan, Bénédicte ; Sonveaux, Pierre ; Feron, Olivier ; Grégoire, Vincent ; Beghein, Nelson ; Dessy, Chantal ; Gallez, Bernard. Nitric oxide as a radiosensitizer: evidence for an intrinsic role in addition to its effect on oxygen delivery and consumption. In: International Journal of Cancer. Journal international du cancer, Vol. 109, no. 5, p. 768-73 (2004). doi:10.1002/ijc.20046.
2003
Sonveaux, Pierre ; Feron, Olivier. Cibler les vaisseaux pour traiter le cancer..... In: Journal de pharmacie de Belgique, Vol. 58, no. 3, p. 79-80 (2003).
2003
Sonveaux, Pierre ; Brouet, Agnès ; Havaux, Xavier ; Grégoire, Vincent ; Dessy, Chantal ; Balligand, Jean-Luc ; Feron, Olivier. Irradiation-induced angiogenesis through the up-regulation of the nitric oxide pathway: implications for tumor radiotherapy.. In: Cancer research, Vol. 63, no. 5, p. 1012-9 (2003).
2003
Jordan, Bénédicte ; Sonveaux, Pierre ; Feron, Olivier ; Grégoire, Vincent ; Beghein, Nelson ; Gallez, Bernard. Nitric oxide-mediated increase in tumor blood flow and oxygenation of tumors implanted in muscles stimulated by electric pulses. In: International Journal of Radiation: Oncology - Biology - Physics, Vol. 55, no. 4, p. 1066-1073 (2003). doi:10.1016/S0360-3016(02)04505-4.
2002
Jordan, Bénédicte ; Grégoire, Vincent ; Demeure, Roger J. ; Sonveaux, Pierre ; Feron, Olivier ; O'Hara, Julia ; Vanhulle, Valérie P. ; Delzenne, Nathalie M. ; Gallez, Bernard. Insulin increases the sensitivity of tumors to irradiation: involvement of an increase in tumor oxygenation mediated by a nitric oxide-dependent decrease of the tumor cells oxygen consumption. In: Cancer Research, Vol. 62, no. 12, p. 3555-3561 (2002).
2002
Sonveaux, Pierre ; Dessy, Chantal ; Brouet, Agnès ; Jordan, Bénédicte ; Grégoire, Vincent ; Gallez, Bernard ; Balligand, Jean-Luc ; Feron, Olivier. Modulation of the tumor vasculature functionality by ionizing radiation accounts for tumor radiosensitization and promotes gene delivery. In: The FASEB Journal, Vol. 16, no. 14, p. 1979-1981 (2002). doi:10.1096/fj.02-0487fje.
2001
Brouet, Agnès ; Sonveaux, Pierre ; Dessy, Chantal ; Moniotte, Stéphane ; Balligand, Jean-Luc ; Feron, Olivier. Hsp90 and caveolin are key targets for the proangiogenic nitric oxide-mediated effects of statins.. In: Circulation Research, Vol. 89, no. 10, p. 866-873 (2001). doi:10.1161/hh2201.100319.
2001
Brouet, Agnès ; Sonveaux, Pierre ; Dessy, Chantal ; Balligand, Jean-Luc ; Feron, Olivier. Hsp90 ensures the transition from the early Ca2+-dependent to the late phosphorylation-dependent activation of the endothelial nitric-oxide synthase in vascular endothelial growth factor-exposed endothelial cells.. In: The Journal of biological chemistry, Vol. 276, no. 35, p. 32663-9 (2001). doi:10.1074/jbc.M101371200.
1999
Lambert, Didier ; DiPaolo, Federica G. ; Sonveaux, Pierre ; Kanyonyo, Martial ; Govaerts, Sophie ; Hermans, Emmanuel ; Bueb, Jean-Luc ; Delzenne, Nathalie M. ; Tschirhart, Eric J.. Analogues and homologues of N-palmitoylethanolamide, a putative endogenous CB(2) cannabinoid, as potential ligands for the cannabinoid receptors. In: Biochimica et Biophysica Acta : international journal of biochemistry and biophysics, Vol. 1440, no. 2-3, p. 266-274 (1999). doi:10.1016/s1388-1981(99)00132-8.