FATH
Avenue Hippocrate 57/B1.57.04
1200 Woluwe-Saint-Lambert
- Accueil
- Répertoire
- Olivier Feron
Olivier Feron
Professeur ordinaire
Faculty positions
- 1997 - Instructor in Medicine, Harvard Medical School, Boston
- 1999 - Assistant Professor, UCLouvain, Brussels
- 2004 - Associate Professor, UCLouvain, Brussels
- 2008 - Professor, UCLouvain, Brussels
- 2011 - Full Professor, UCLouvain, Brussels
FNRS positions
- 1999 - Chercheur qualifié
- 2005 - Maître de recherches
- 2009 - Directeur de recherches
University positions (ongoing 2022- )
- Membre du CREC
- Membre de la COMUT
- Membre suppléant du CORA
- Membre de la CEFARM
- Membre de la Commission d'attribution FARM
- Secrétaire de Jury Master FARM
- Président du jury des mémoires FARM
- Diplômes
Année Label Institution 1990 Pharmacien Université catholique de Louvain 1992 Licencié en sciences biomédicales (3ème cycle) Université catholique de Louvain 1995 Docteur en sciences pharmaceutiques Université catholique de Louvain 2004 Agrégé de l'enseignement supérieur Université catholique de Louvain
- Les cours
Nom ID Eléments de physiologie générale WFARM1212 Physiologie des systèmes et éléments de physiopathologie WFARM1213 Eléments de pathologie humaine WFARM1305 Séminaire de pharmacothérapie intégrée (1re partie) WFARM2111 Pharmacologie spéciale et éléments de pharmacothérapie 1re partie WFARM2114 Pharmacologie spéciale et éléments de pharmacothérapie 2e partie WFARM2116 Organotoxicité et cancer : aspects moléculaires, cellulaires et fonctionnels WFARM2180 Séminaire d'intégration pharmaceutique (finalité approfondie) WFARM2249 Séminaire d'intégration pharmaceutique (finalité spécialisée) WFARM2259 Physiologie générale WSBIM1201 Signalisation intercellulaire et biologie des tumeurs WSBIM2141 Cellular and molecular pathophysiology of human diseases (Part 1) WSBIM2184 Special issues in cancerology WSBIM2244 In-session seminar in biomedicine WSBIM2245
The O. Feron lab is located on the UCLouvain campus in Brussels (Tour Vésale 5th floor). Current research topics include the study of different aspects of the tumor metabolism impacting on, or influenced by, the tumor microenvironment (hypoxia and acidosis), the dietary intake, the circadian rhythms and the immune response. The lab of Prof. O. Feron has also implemented a technological platform to identify and validate new chemical entities (NCE) and innovative prognostic cancer biomarkers.
Among the most recent discoveries of O. Feron's research group are the link between cycling hypoxia and tumor progression, the role of lactate as a key actor of tumor metabolic symbiosis, the metabolic shift from glucose toward glutamine and fatty acids in response to tumor microenvironment acidosis. These different findings led to innovative therapeutic strategies including the development of new drug candidates (MCT, MPC and OXPHOS inhibitors) and adjuvant dietary supplements (cocktail of polyunsaturated fatty acids).
The research group currently consists of 4 post-docs, 6 PhD students and 2 technicians; administrative resources (secretary and account manager) are shared with the other research groups of the FATH Pole.
2023
Moghassemi, Saeid ; Dadashzadeh, Arezoo ; Camboni, Alessandra ; Feron, Olivier ; Azevedo, Ricardo Bentes ; Andrade Amorim, Christiani. Ex vivo purging of cancer cells from ovarian tissue using photodynamic therapy: a novel strategy to restore fertility in leukemia patients.. In: Human reproduction open, Vol. 2023, no.2, p. hoad005 (2023). doi:10.1093/hropen/hoad005.
2023
Van den Bossche, Valentin ; Vignau, Julie ; Vigneron, Engy ; Zaryouh, Hannah ; Wouters, An ; Ambroise, Jérôme ; Van Laere, Steven ; Mignion, Lionel ; Lepicard, Elise ; Jordan, Bénédicte ; Guilbaud, Céline ; Dahou, Hajar ; Mendola, Antonella ; Desgres, Manon ; Aubert, Léo ; Gerin, Isabelle ; Bommer, Guido ; Boidot, Romain ; Vermonden, Perrine ; Warnant, Aurélien ; Larondelle, Yvan ; Machiels, Jean-Pascal ; Feron, Olivier ; Schmitz, Sandra ; Corbet, Cyril. PPARα-mediated fatty acid metabolism reprogramming supports resistance to anti-EGFR targeted therapy in head and neck squamous cell carcinoma. In: Cell Metabolism, (2023) (Soumis).
2023
Cuvelier, Géraldine ; Vermonden, Perrine ; Rousseau, Justine ; Feron, Olivier ; Rezsohazy, René ; Larondelle, Yvan. Resistance to CLnA-induced ferroptosis is acquired in Caco-2 cells upon differentiation. In: Frontiers in Cell Death, Vol. 2, no.1, p. 1 (2023). doi:10.3389/fceld.2023.1219672.
2023
Tan, Yonghua ; Lefevre, Marine ; Pierrard, François ; Soetens, Mathieu ; Shoueiry, Maria ; Yildiz, Esra ; Ibanez, Sébastien ; Ozkan, Kubra ; Feron, Olivier ; Frédérick, Raphaël ; Riant, Olivier. Tandem Heck/Tsuji-Trost Reaction for Uncaging of Alloc-Protected Amines with Palladium Complexes in Living Cells. In: Journal of Organometallic Chemistry, Vol. 996, no.-, p. 122743 (2023). doi:10.1016/j.jorganchem.2023.122743.
2022
Lan, Junjie ; Cadassou, Octavia ; Corbet, Cyril ; Riant, Olivier ; Feron, Olivier. Discovery of Mitochondrial Complex I Inhibitors as Anticancer and Radiosensitizer Drugs Based on Compensatory Stimulation of Lactate Release. In: Cancers, Vol. 14, no.21, p. 5454 (2022). doi:10.3390/cancers14215454.
2022
Sancho, Patricia ; Feron, Olivier. Editorial: Insights in pharmacology of anti-cancer drugs: 2021.. In: Frontiers in pharmacology, Vol. 13, p. 1062640 [1-2] (2022). doi:10.3389/fphar.2022.1062640.
2022
Catanzaro, Elena ; Feron, Olivier ; Skirtach, André G ; Krysko, Dmitri V. Immunogenic Cell Death and Role of Nanomaterials Serving as Therapeutic Vaccine for Personalized Cancer Immunotherapy.. In: Frontiers in immunology, Vol. 13, p. 925290 [1-18] (2022). doi:10.3389/fimmu.2022.925290.
2022
Van de Gucht, Melissa ; Dufait, Inès ; Kerkhove, Lisa ; Corbet, Cyril ; de Mey, Sven ; Jiang, Heng ; Law, Ka Lun ; Gevaert, Thierry ; Feron, Olivier ; De Ridder, Mark. Inhibition of Phosphoglycerate Dehydrogenase Radiosensitizes Human Colorectal Cancer Cells under Hypoxic Conditions. In: Cancers, Vol. 14, no.20, p. 5060 (2022). doi:10.3390/cancers14205060.
2022
Johanns, Manuel ; Corbet, Cyril ; Jacobs, Roxane ; Drappier, Melissa ; Bommer, Guido ; Herinckx, Gaëtan ; Vertommen, Didier ; Tajeddine, Nicolas ; Young, David ; Messens, Joris ; Feron, Olivier ; Steinberg, Gregory R ; Hue Louis ; Rider, Mark H.. Inhibition of basal and glucagon-induced hepatic glucose production by 991 and other pharmacological AMPK activators.. In: The Biochemical journal, Vol. 479, no.12, p. 1317-1336 (2022). doi:10.1042/BCJ20220170.
2022
Moghassemi, Saeid ; Dadashzadeh, Arezoo ; Camboni, Alessandra ; Feron, Olivier ; Azevedo, Ricardo Bentes ; Andrade Amorim, Christiani. Photodynamic therapy using OR141-loaded nanovesicles for eradication of leukemic cells from ovarian tissue.. In: Photodiagnosis and photodynamic therapy, Vol. 40, no.-, p. 103139 (2022). doi:10.1016/j.pdpdt.2022.103139.
2022
Deskeuvre, Marine ; Lan, Junjie ; Dierge, Emeline ; Messens, Joris ; Riant, Olivier ; Corbet, Cyril ; Feron, Olivier ; Frédérick, Raphaël. Targeting cancer cells in acidosis with conjugates between the carnitine palmitoyltransferase 1 inhibitor etomoxir and pH (low) insertion peptides. In: International Journal of Pharmaceutics, Vol. 624, no.1, p. 122041 (2022). doi:10.1016/j.ijpharm.2022.122041.
2022
Delprat, Victor ; Huart, Camille ; Feron, Olivier ; Soncin, Fabrice ; Michiels, Carine. The impact of macrophages on endothelial cells is potentiated by cycling hypoxia: Enhanced tumor inflammation and metastasis.. In: Frontiers in oncology, Vol. 12, p. 961753 [1-14] (2022). doi:10.3389/fonc.2022.961753.
2021
Valenti, Maria Teresa ; Mottes, Monica ; Dalle Carbonare, Luca ; Feron, Olivier. Editorial: Bone Metastases.. In: Frontiers in oncology, Vol. 11, p. 741515 (2021). doi:10.3389/fonc.2021.741515.
2021
Buyse, Chloé ; Joudiou, Nicolas ; Corbet, Cyril ; Feron, Olivier ; Mignion, Lionel ; Flament, Julien ; Gallez, Bernard. Impact of Inhibition of the Mitochondrial Pyruvate Carrier on the Tumor Extracellular pH as Measured by CEST-MRI. In: Cancers, Vol. 13, no.17, p. 4278 (2021). doi:10.3390/cancers13174278.
2021
Virga, Federico ; Cappellesso, Federica ; Stijlemans, Benoit ; Henze, Anne-Theres ; Trotta, Rosa ; Van Audenaerde, Jonas ; Mirchandani, Ananda S. ; Sanchez-Garcia, Manuel A. ; Vandewalle, Jolien ; Orso, Francesca ; Riera-Domingo, Carla ; Griffa, Alberto ; Ivan, Cristina ; Smits, Evelien ; Laoui, Damya ; Martelli, Fabio ; Langouche, Lies ; Van den Berghe, Greet ; Feron, Olivier ; Ghesquière, Bart ; Prenen, Hans ; Libert, Claude ; Walmsley, Sarah R. ; Corbet, Cyril ; Van Ginderachter, Jo A. ; Ivan, Mircea ; Taverna, Daniela ; Mazzone, Massimiliano. Macrophage miR-210 induction and metabolic reprogramming in response to pathogen interaction boost life-threatening inflammation. In: Science Advances, Vol. 7, no.19, p. eabf0466 (2021). doi:10.1126/sciadv.abf0466.
2021
Dierge, Emeline ; Debock, Elena ; Guilbaud, Céline ; Corbet, Cyril ; Mignolet, Eric ; Mignard, Louise ; Bastien, Estelle ; Dessy, Chantal ; Larondelle, Yvan ; Feron, Olivier. Peroxidation of n-3 and n-6 polyunsaturated fatty acids in the acidic tumor environment leads to ferroptosis-mediated anticancer effects. In: Cell Metabolism, Vol. S1550-4131, no.21, p. 00233-3 (2021). doi:10.1016/j.cmet.2021.05.016.
2021
Moghassemi, Saeid ; Dadashzadeh, Arezoo ; Azevedo, Ricardo Bentes ; Feron, Olivier ; Amorim, Christiani A. Photodynamic cancer therapy using liposomes as an advanced vesicular photosensitizer delivery system.. In: Journal of controlled release : official journal of the Controlled Release Society, Vol. 339, p. 75-90 (2021). doi:10.1016/j.jconrel.2021.09.024 (Accepté/Sous presse).
2021
Moghassemi, Saeid ; Dadashzadeh, Arezoo ; Azevedo, Ricardo Bentes ; Feron, Olivier ; Andrade Amorim, Christiani. Photodynamic cancer therapy using liposomes as an advanced vesicular photosensitizer delivery system.. In: Journal of controlled release : official journal of the Controlled Release Society, Vol. 339, no.-, p. 75-90 (2021). doi:10.1016/j.jconrel.2021.09.024.
2021
Vermonden, Perrine ; Vancoppenolle, Matthias ; Dierge, Emeline ; Mignolet, Eric ; Cuvelier, Géraldine ; Knoops, Bernard ; Page, Melissa ; Debier, Cathy ; Feron, Olivier ; Larondelle, Yvan. Punicic Acid Triggers Ferroptotic Cell Death in Carcinoma Cells. In: Nutrients, Vol. 13, no. 8, p. 2751 [1-16] (2021). doi:10.3390/nu13082751.
2021
Vander Linden, Catherine ; Corbet, Cyril ; Bastien, Estelle ; Martherus, Ruben ; Guilbaud, Céline ; Petit, Laurenne ; Wauthier, Loris ; Loriot, Axelle ; De Smet, Charles ; Feron, Olivier. Therapy-induced DNA methylation inactivates MCT1 and renders tumor cells vulnerable to MCT4 inhibition. In: Cell Reports, Vol. 35, no.9, p. 109202 (2021). doi:10.1016/j.celrep.2021.109202.
2021
Spillier, Quentin ; Ravez, Séverine ; Dochain Simon ; Vertommen, Didier ; Thabault, Léopold ; Feron, Olivier ; Frédérick, Raphaël. Unravelling the Allosteric Targeting of PHGDH at the ACT-Binding Domain with a Photoactivatable Diazirine Probe and Mass Spectrometry Experiments. In: Molecules, Vol. 26, no. 2, p. 477 (2021). doi:10.3390/molecules26020477.
2020
Yelek, Caner ; Mignion, Lionel ; Joudiou, Nicolas ; Terrasi, Romano ; Gourgue, Florian ; Van Hul, Matthias ; Delzenne, Nathalie M. ; Gallez, Bernard ; Corbet, Cyril ; Muccioli, Giulio ; Feron, Olivier ; Cani, Patrice D. ; Jordan, Bénédicte. Acetate: Friend or foe against breast tumour growth in the context of obesity?. In: Journal of Cellular and Molecular Medicine, Vol. 24, no. 24, p. 14195-14204 (2020). doi:10.1111/jcmm.16034.
2020
Trempolec, Natalia ; Degavre, Charline ; Doix, Bastien ; Brusa, Davide ; Corbet, Cyril ; Feron, Olivier. Acidosis-Induced TGF-β2 Production Promotes Lipid Droplet Formation in Dendritic Cells and Alters Their Potential to Support Anti-Mesothelioma T Cell Response. In: Cancers, Vol. 12, no. 5, p. 1284 [1-17] (2020). doi:10.3390/cancers12051284.
2020
Schoonjans, Céline ; Joudiou, Nicolas ; Brusa, Davide ; Corbet, Cyril ; Feron, Olivier ; Gallez, Bernard. Acidosis-induced metabolic reprogramming in tumor cells enhances the anti-proliferative activity of the PDK inhibitor dichloroacetate. In: Cancer Letters, Vol. 470, p. 18-28 (2020). doi:10.1016/j.canlet.2019.12.003.
2020
Dierge, Emeline ; Larondelle, Yvan ; Feron, Olivier. Cancer diets for cancer patients: Lessons from mouse studies and new insights from the study of fatty acid metabolism in tumors. In: Biochimie, Vol. 178, p. 56-68 (2020). doi:10.1016/j.biochi.2020.08.020.
2020
Delprat, Victor ; Tellier, Céline ; Demazy, Catherine ; Raes, Martine ; Feron, Olivier ; Michiels, Carine. Cycling hypoxia promotes a pro-inflammatory phenotype in macrophages via JNK/p65 signaling pathway. In: Scientific Report, Vol. 10, no. 1, p. 882 (2020).
2020
de Mey, Sven ; Dufait, Inès ; Jiang, Heng ; Corbet, Cyril ; Wang, Hui ; Van De Gucht, Melissa ; Kerkhove, Lisa ; Law, Ka Lun ; Vandenplas, Hugo ; Gevaert, Thierry ; Feron, Olivier ; De Ridder, Mark. Dichloroacetate Radiosensitizes Hypoxic Breast Cancer Cells. In: International Journal of Molecular Sciences, Vol. 21, no.24, p. 9367 (2020). doi:10.3390/ijms21249367.
2020
Fourniols, Thibaut ; Bastien, Estelle ; Canevat, Alizée ; Feron, Olivier ; Préat, Véronique. Inhibition of colorectal cancer-associated fibroblasts by lipid nanocapsules loaded with acriflavine or paclitaxel.. In: International journal of pharmaceutics, Vol. 584, p. 119337 (2020). doi:10.1016/j.ijpharm.2020.119337 (Accepté/Sous presse).
2020
Mignion, Lionel ; Acciardo, Stefania ; Gourgue, Florian ; Joudiou, Nicolas ; Caignet, Xavier ; Goebbels, Rose-Marie ; Corbet, Cyril ; Feron, Olivier ; Bouzin, Caroline ; Cani, Patrice D. ; Machiels, Jean-Pascal ; Schmitz, Sandra ; Jordan, Bénédicte. Metabolic imaging using hyperpolarized pyruvate-lactate exchange assesses response or resistance to the EGFR inhibitor cetuximab in patient-derived HNSCC xenografts.. In: Clinical cancer research, Vol. 15, no. 26(8), p. 1932-1943 (2020). doi:10.1158/1078-0432.CCR-19-1369.
2020
Gourgue, Florian ; Mignion, Lionel ; Van Hul, Matthias ; Dehaen, Natacha ; Bastien, Estelle ; Payen, Valery ; Leroy, Baptiste ; Joudiou, Nicolas ; Vertommen, Didier ; Bouzin, Caroline ; Delzenne, Nathalie M. ; Gallez, Bernard ; Feron, Olivier ; Jordan, Bénédicte ; Cani, Patrice D.. Obesity and triple-negative-breast-cancer: Is apelin a new key target?. In: Journal of cellular and molecular medicine, Vol. 24, p. 10233-44 (2020). doi:10.1111/jcmm.15639.
2020
Trempolec, Natalia ; Doix, Bastien ; Degavre, Charline ; Brusa, Davide ; Bouzin, Caroline ; Riant, Olivier ; Feron, Olivier. Photodynamic Therapy-Based Dendritic Cell Vaccination Suited to Treat Peritoneal Mesothelioma. In: Cancers, Vol. 12, no. 3, p. pii:E545 (2020).
2020
Ward, Jennifer A ; Pinto-Fernandez, Adan ; Cornelissen, Loïc ; Bonham, Sarah ; Díaz-Sáez, Laura ; Riant, Olivier ; Huber, Kilian V M ; Kessler, Benedikt M ; Feron, Olivier ; Tate, Edward W. Re-evaluating the mechanism of action of α,β-unsaturated carbonyl DUB inhibitors b-AP15 and VLX1570: a paradigmatic example of unspecific protein crosslinking with Michael acceptor motif-containing drugs.. In: Journal of medicinal chemistry, Vol. 63, no. 7, p. 3756-3762 (2020). doi:10.1021/acs.jmedchem.0c00144.
2020
Spillier, Quentin ; Ravez, Severine ; Unterlass, Judith ; Corbet, Cyril ; Degavre, Charline ; Feron, Olivier ; Frédérick, Raphaël. Structure–Activity Relationships (SARs) of α-Ketothioamides as Inhibitors of Phosphoglycerate Dehydrogenase (PHGDH). In: Pharmaceuticals, Vol. 13, no.2, p. 20 (2020). doi:10.3390/ph13020020.
2020
Corbet, Cyril ; Bastien, Estelle ; Santiago de Jesus, Joao Pedro ; Dierge, Emeline ; Martherus, Ruben ; Vander Linden, Catherine ; Doix, Bastien ; Degavre, Charline ; Guilbaud, Céline ; Petit, Laurenne ; Michiels, Carine ; Dessy, Chantal ; Larondelle, Yvan ; Feron, Olivier. TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells. In: Nature Communications, Vol. 11, no.1, p. 1 (2020). doi:10.1038/s41467-019-14262-3.
2020
Schoonjans, Céline A ; Mathieu, Barbara ; Joudiou, Nicolas ; Zampieri, Luca X ; Brusa, Davide ; Sonveaux, Pierre ; Feron, Olivier ; Gallez, Bernard. Targeting Endothelial Cell Metabolism by Inhibition of Pyruvate Dehydrogenase Kinase and Glutaminase-1.. In: Journal of clinical medicine, Vol. 9, no.10, p. 14pp (2020). doi:10.3390/jcm9103308.
2019
Spillier, Quentin ; Vertommen, Didier ; Séverine Ravez ; Marteau, Romain ; THÉMANS, Quentin ; Corbet, Cyril ; Feron, Olivier ; Wouters, Johan ; Frédérick, Raphaël. Anti-alcohol abuse drug disulfiram inhibits human PHGDH via disruption of its active tetrameric form through a specific cysteine oxidation. In: Scientific Reports, Vol. 9, no. 1, p. 4737 (2019).
2019
Li, Sha ; Bouchy, Sandra ; Penninckx, Sebastien ; Marega, Riccardo ; Fichera, Ornella ; Gallez, Bernard ; Feron, Olivier ; Martinive, Philippe ; HEUSKIN, Anne-Catherine ; Michiels, Carine ; Lucas, Stéphane. Antibody-functionalized gold nanoparticles as tumor targeting radiosensitizers for proton therapy.. In: Nanomedicine (London, England), Vol. 14, p. 317-333 (2019). doi:10.2217/nnm-2018-0161.
2019
Bernard, Antoine ; Chevrier, Sandy ; Beltjens, Françoise ; Dosset, Magalie ; Viltard, Etienne ; Lagrange, Anaïs ; Derangère, Valentin ; Oudot, Alexandra ; Ghiringhelli, François ; Collin, Bertrand ; Apetoh, Lionel ; Feron, Olivier ; Chen, Suzie ; Arnould, Laurent ; Végran, Frédérique ; Boidot, Romain. Cleaved Caspase-3 Transcriptionally Regulates Angiogenesis-Promoting Chemotherapy Resistance. In: Cancer Research, Vol. 79, no. 23, p. 5958-5970 (2019). doi:10.1158/0008-5472.CAN-19-0840.
2019
Dierge, Emeline ; Feron, Olivier. Dealing with saturated and unsaturated fatty acid metabolism for anticancer therapy.. In: Current opinion in clinical nutrition and metabolic care, Vol. 22, no.6, p. 427-433 (2019). doi:10.1097/MCO.0000000000000601.
2019
Bevernaegie, Robin ; Doix, Bastien ; Bastien, Estelles ; Diman, Aurélie ; Decottignies, Anabelle ; Feron, Olivier ; Elias, Benjamin. Exploring the phototoxicity of hypoxic active iridium(III)-based sensitizers in 3D tumor spheroids. In: Journal of the American chemical society, Vol. 141, no.46, p. 18486-18491 (2019).
2019
Doix, Bastien ; Trempolec, Natalia ; Riant, Olivier ; Feron, Olivier. Low Photosensitizer Dose and Early Radiotherapy Enhance Antitumor Immune Response of Photodynamic Therapy-Based Dendritic Cell Vaccination.. In: Frontiers in oncology, Vol. 9, p. 811 (2019). doi:10.3389/fonc.2019.00811 (Accepté/Sous presse).
2019
Wang, Hui ; Jiang, Heng ; Corbet, Cyril ; de Mey, Sven ; Law, Kalun ; Gevaert, Thierry ; Feron, Olivier ; De Ridder, Mark. Piperlongumine increases sensitivity of colorectal cancer cells to radiation: involvement of ROS production via dual inhibition of glutathione and thioredoxin systems. In: Cancer Letters, (2019). doi:10.1016/j.canlet.2019.02.034.
2019
Strickaert Aurélie ; Corbet, Cyril ; Spinette SA ; Craciun L ; Dom G ; Andry G ; Larsimont D ; Wattiez R ; Dumont JE ; Feron, Olivier ; Maenhaut C. Reprogramming of energetic metabolism: increased expression and roles of pyruvate carboxylase in papillary thyroid cancer.. In: Thyroid, (2019). doi:10.1089/thy.2018.0435.
2019
Feron, Olivier. The many metabolic sources of acetyl-CoA to support histone acetylation and influence cancer progression.. In: Annals of translational medicine, Vol. 7, no.Suppl 8, p. S277 (2019). doi:10.21037/atm.2019.11.140.
2019
Feron, Olivier. The many metabolic sources of acetyl-CoA to support histone acetylation and influence cancer progression.. In: Annals of translational medicine, Vol. 7, no.Suppl 8, p. S277 (2019). doi:10.21037/atm.2019.11.140.
2019
Feron, Olivier. The many metabolic sources of acetyl-CoA to support histone acetylation and influence cancer progression.. In: Annals of translational medicine, Vol. 7, no. Suppl 8, p. S277 (2019). doi:10.21037/atm.2019.11.140.
2019
Aboubakar Nana, Frank ; Lecocq, Marylène ; Ladjemi, Maha Zohra ; Detry, Bruno ; Dupasquier, Sébastien ; Feron, Olivier ; Massion, Pierre P. ; Sibille, Yves ; Pilette, Charles ; Ocak, Sebahat. Therapeutic Potential of Focal Adhesion Kinase Inhibition in Small Cell Lung Cancer. In: Molecular Cancer Therapeutics, Vol. 18, no. 1, p. 17-27 (2019). doi:10.1158/1535-7163.mct-18-0328.
2019
Choumessi Tchewonpi, Aphrodite ; Johanns, Manuel ; Beaufay, Claire ; Herent, Marie-France ; Stroobant, Vincent ; Vertommen, Didier ; Corbet, Cyril ; Jacobs, Roxane ; Herinckx, Gaëtan ; Steinberg, Gregory R ; Feron, Olivier ; Quetin-Leclercq, Joëlle ; Rider, Mark H.. Two isoprenylated flavonoids from Dorstenia psilurus activate AMPK, stimulate glucose uptake, inhibit glucose production and lower glycemia. In: Biochemical Journal, Vol. 476, no. 24, p. 3687-3704 (2019). doi:10.1042/BCJ20190326.
2018
de Mey, Sven ; Jiang, Heng ; Corbet, Cyril ; Wang, H. ; Dufait, Inès ; Law, Kalun ; Bastien, Estelle ; Verovski, Valeri ; Gevaert, Thierry ; Feron, Olivier ; De Ridder, Mark. Antidiabetic Biguanides Radiosensitize Hypoxic Colorectal Cancer Cells Through a Decrease in Oxygen Consumption. In: Frontiers in Pharmacology, Vol. 9, p. 1073 [1-12] (2018). doi:10.3389/fphar.2018.01073.
2018
Corbet, Cyril ; Bastien, Estelle ; Draoui, Nihed ; Doix, Bastien ; Mignion, Lionel ; Jordan, Bénédicte ; Marchand, Arnaud ; Vanherck, Jean-Christophe ; Chaltin, Patrick ; Schakman, Olivier ; Becker, Holger M ; Riant, Olivier ; Feron, Olivier. Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects.. In: Nature Communications, Vol. 9, no.1, p. 1208 (2018). doi:10.1038/s41467-018-03525-0.
2018
Montigaud, Yoann ; Ucakar, Bernard ; Krishnamachary, Balaji ; Bhujwalla, Zaver M ; Feron, Olivier ; Préat, Véronique ; Danhier, Fabienne ; Gallez, Bernard ; Danhier, Pierre. Optimized acriflavine-loaded lipid nanocapsules as a safe and effective delivery system to treat breast cancer.. In: International journal of pharmaceutics, Vol. 551, no.1-2, p. 322-328 (2018). doi:10.1016/j.ijpharm.2018.09.034.
2018
de Mey, Sven ; Jiang, Heng ; Wang, Hui ; Engels, Benedikt ; Gevaert, Thierry ; Dufait, Inès ; Feron, Olivier ; Aerts, Joeri ; Verovski, Valeri ; De Ridder, Mark. Potential of memory T cells in bridging preoperative chemoradiation and immunotherapy in rectal cancer.. In: Radiotherapy & Oncology, (2018). doi:10.1016/j.radonc.2018.04.003 (Accepté/Sous presse).
2018
Doix, Bastien ; Bastien, Estelle ; Rambaud, Alix ; Pinto, Adán ; Louis, Caroline ; Grégoire, Vincent ; Riant, Olivier ; Feron, Olivier. Preclinical Evaluation of White Led-Activated Non-porphyrinic Photosensitizer OR141 in 3D Tumor Spheroids and Mouse Skin Lesions.. In: Frontiers in oncology, Vol. 8, p. 393 (2018). doi:10.3389/fonc.2018.00393.