FATH
Avenue Hippocrate 57/B1.57.04
1200 Woluwe-Saint-Lambert
- Accueil
- Répertoire
- Olivier Feron
Olivier Feron
Professeur ordinaire
Faculty positions
1997 Instructor in Medicine, Harvard Medical School, Boston
1999 Assistant Professor, UCLouvain, Brussels
2004 Associate Professor, UCLouvain, Brussels
2008 Professor, UCLouvain, Brussels
2011 Full Professor, UCLouvain, Brussels
FNRS positions
1999 Chercheur qualifié
2005 Maître de recherches
2009 Directeur de recherches
- Diplômes
Année Label Institution 1990 Pharmacien Université catholique de Louvain 1992 Licencié en sciences biomédicales (3ème cycle) Université catholique de Louvain 1995 Docteur en sciences pharmaceutiques Université catholique de Louvain 2004 Agrégé de l'enseignement supérieur Université catholique de Louvain
- Les cours
Nom ID Eléments de physiologie générale WFARM1212 Physiologie des systèmes et éléments de physiopathologie WFARM1213 Eléments de pathologie humaine WFARM1305 Séminaire de pharmacothérapie intégrée (1re partie) WFARM2111 Pharmacologie spéciale et éléments de pharmacothérapie 1re partie WFARM2114 Pharmacologie spéciale et éléments de pharmacothérapie 2e partie WFARM2116 Organotoxicité et cancer : aspects moléculaires, cellulaires et fonctionnels WFARM2180 Séminaire de pharmacothérapie intégrée (2e partie) WFARM2211 Séminaire d'intégration pharmaceutique (finalité approfondie) WFARM2249 Séminaire d'intégration pharmaceutique (finalité spécialisée) WFARM2259 Pharmacologie moléculaire WFARM2515 Physiologie générale WSBIM1201 Signalisation intercellulaire et biologie des tumeurs WSBIM2141 Cellular and molecular pathophysiology of human diseases (Part 1) WSBIM2184 Special issues in cancerology WSBIM2244 In-session seminar in biomedicine WSBIM2245 Cellular and molecular pathophysiology of human diseases (Part 2) WSBIM2284
The O. Feron lab is located on the UCLouvain campus in Brussels (Tour Vésale 5th floor). Along the years, the focus of the lab has shifted from cardiovascular diseases to oncology. Current research topics include the study of different aspects of the tumor metabolism impacting on, or influenced by, the tumor microenvironment, in particular hypoxia and acidosis. The lab of Prof. O. Feron has also implemented a technological platform to identify and validate new chemical entities (NCE) and innovative prognostic cancer biomarkers.
Among the most recent discoveries of O. Feron's research group are the link between cycling hypoxia and tumor progression, the role of lactate as a key actor of tumor metabolic symbiosis and the metabolic shift from glucose toward glutamine and fatty acids in response to tumor microenvironment acidosis.
The research group currently consists of 3 post-docs, 6 PhD students and 3 technicians; administrative resources (secretary and account manager) are shared with the other research groups of the FATH Pole.
2020
Trempolec, Natalia ; Degavre, Charline ; Doix, Bastien ; Brusa, Davide ; Corbet, Cyril ; Feron, Olivier. Acidosis-Induced TGF-β2 Production Promotes Lipid Droplet Formation in Dendritic Cells and Alters Their Potential to Support Anti-Mesothelioma T Cell Response. In: Cancers, Vol. 12, no.5, p. 1284 (2020). doi:10.3390/cancers12051284.
2020
Schoonjans, Céline ; Joudiou, Nicolas ; Brusa, Davide ; Corbet, Cyril ; Feron, Olivier ; Gallez, Bernard. Acidosis-induced metabolic reprogramming in tumor cells enhances the anti-proliferative activity of the PDK inhibitor dichloroacetate. In: Cancer Letters, Vol. 470, p. 18-28 (2020). doi:10.1016/j.canlet.2019.12.003.
2020
Delprat, Victor ; Tellier, Céline ; Demazy, Catherine ; Raes, Martine ; Feron, Olivier ; Michiels, Carine. Cycling hypoxia promotes a pro-inflammatory phenotype in macrophages via JNK/p65 signaling pathway. In: Scientific Report, Vol. 10, no. 1, p. 882 (2020).
2020
Fourniols, Thibaut ; Bastien, Estelle ; Canevat, Alizée ; Feron, Olivier ; Préat, Véronique. Inhibition of colorectal cancer-associated fibroblasts by lipid nanocapsules loaded with acriflavine or paclitaxel.. In: International journal of pharmaceutics, Vol. 584, p. 119337 (2020). doi:10.1016/j.ijpharm.2020.119337 (Accepté/Sous presse).
2020
Gourgue, Florian ; Mignion, Lionel ; Van Hul, Matthias ; Dehaen, Natacha ; Bastien, Estelle ; Payen, Valery ; Leroy, Baptiste ; Joudiou, Nicolas ; Vertommen, Didier ; Bouzin, Caroline ; Delzenne, Nathalie M. ; Gallez, Bernard ; Feron, Olivier ; Jordan, Bénédicte ; Cani, Patrice D.. Obesity and triple-negative-breast-cancer: Is apelin a new key target?. In: Journal of cellular and molecular medicine, , p. [1-12] (2020). doi:10.1111/jcmm.15639 (Accepté/Sous presse).
2020
Trempolec, Natalia ; Doix, Bastien ; Degavre, Charline ; Brusa, Davide ; Bouzin, Caroline ; Riant, Olivier ; Feron, Olivier. Photodynamic Therapy-Based Dendritic Cell Vaccination Suited to Treat Peritoneal Mesothelioma. In: Cancers, Vol. 12, no. 3, p. pii:E545 (2020).
2020
Ward, Jennifer A ; Pinto-Fernandez, Adan ; Cornelissen, Loic ; Bonham, Sarah ; Díaz-Sáez, Laura ; Riant, Olivier ; Huber, Kilian V M ; Kessler, Benedikt M ; Feron, Olivier ; Tate, Edward W. Re-evaluating the mechanism of action of α,β-unsaturated carbonyl DUB inhibitors b-AP15 and VLX1570: a paradigmatic example of unspecific protein crosslinking with Michael acceptor motif-containing drugs.. In: J Med Chem, (2020).
2020
Spillier, Quentin ; Ravez, Severine ; Unterlass, Judith ; Corbet, Cyril ; Degavre, Charline ; Feron, Olivier ; Frédérick, Raphaël. Structure–Activity Relationships (SARs) of α-Ketothioamides as Inhibitors of Phosphoglycerate Dehydrogenase (PHGDH). In: Pharmaceuticals, Vol. 13, no.2, p. 20 (2020). doi:10.3390/ph13020020.
2020
Corbet, Cyril ; Bastien, Estelle ; Santiago de Jesus, Joao Pedro ; Dierge, Emeline ; Martherus, Ruben ; Vander Linden, Catherine ; Doix, Bastien ; Degavre, Charline ; Guilbaud, Céline ; Petit, Laurenne ; Michiels, Carine ; Dessy, Chantal ; Larondelle, Yvan ; Feron, Olivier. TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells. In: Nature Communications, Vol. 11, no.1, p. 1 (2020). doi:10.1038/s41467-019-14262-3.
2020
Schoonjans, Céline A ; Mathieu, Barbara ; Joudiou, Nicolas ; Zampieri, Luca X ; Brusa, Davide ; Sonveaux, Pierre ; Feron, Olivier ; Gallez, Bernard. Targeting Endothelial Cell Metabolism by Inhibition of Pyruvate Dehydrogenase Kinase and Glutaminase-1.. In: Journal of clinical medicine, Vol. 9, no.10, p. 14pp (2020). doi:10.3390/jcm9103308.
2019
Spillier, Quentin ; Vertommen, Didier ; Séverine Ravez ; Marteau, Romain ; THÉMANS, Quentin ; Corbet, Cyril ; Feron, Olivier ; Wouters, Johan ; Frédérick, Raphaël. Anti-alcohol abuse drug disulfiram inhibits human PHGDH via disruption of its active tetrameric form through a specific cysteine oxidation. In: Scientific Reports, Vol. 9, no. 1, p. 4737 (2019).
2019
Li, Sha ; Bouchy, Sandra ; Penninckx, Sebastien ; Marega, Riccardo ; Fichera, Ornella ; Gallez, Bernard ; Feron, Olivier ; Martinive, Philippe ; HEUSKIN, Anne-Catherine ; Michiels, Carine ; Lucas, Stéphane. Antibody-functionalized gold nanoparticles as tumor targeting radiosensitizers for proton therapy.. In: Nanomedicine (London, England), Vol. 14, p. 317-333 (2019). doi:10.2217/nnm-2018-0161.
2019
Bernard, Antoine ; Chevrier, Sandy ; Beltjens, Françoise ; Dosset, Magalie ; Viltard, Etienne ; Lagrange, Anaïs ; Derangère, Valentin ; Oudot, Alexandra ; Ghiringhelli, François ; Collin, Bertrand ; Apetoh, Lionel ; Feron, Olivier ; Chen, Suzie ; Arnould, Laurent ; Végran, Frédérique ; Boidot, Romain. Cleaved Caspase-3 Transcriptionally Regulates Angiogenesis-Promoting Chemotherapy Resistance. In: Cancer Research, Vol. 79, no. 23, p. 5958-5970 (2019).
2019
Dierge, Emeline ; Feron, Olivier. Dealing with saturated and unsaturated fatty acid metabolism for anticancer therapy.. In: Current opinion in clinical nutrition and metabolic care, Vol. 22, no.6, p. 427-433 (2019). doi:10.1097/MCO.0000000000000601.
2019
Bevernaegie, Robin ; Doix, Bastien ; Bastien, Estelles ; Diman, Aurélie ; Decottignies, Anabelle ; Feron, Olivier ; Elias, Benjamin. Exploring the phototoxicity of hypoxic active iridium(III)-based sensitizers in 3D tumor spheroids. In: Journal of the American chemical society, Vol. 141, no.46, p. 18486-18491 (2019).
2019
Doix, Bastien ; Trempolec, Natalia ; Riant, Olivier ; Feron, Olivier. Low Photosensitizer Dose and Early Radiotherapy Enhance Antitumor Immune Response of Photodynamic Therapy-Based Dendritic Cell Vaccination.. In: Frontiers in oncology, Vol. 9, p. 811 (2019). doi:10.3389/fonc.2019.00811 (Accepté/Sous presse).
2019
Mignion, Lionel ; Acciardo, Stefania ; Gourgue, Florian ; Joudiou, Nicolas ; Caignet, Xavier ; Goebbels, Rose-Marie ; Corbet, Cyril ; Feron, Olivier ; Bouzin, Caroline ; Cani, Patrice D. ; Machiels, Jean-Pascal ; Schmitz, Sandra ; Jordan, Bénédicte. Metabolic imaging using hyperpolarized pyruvate-lactate exchange assesses response or resistance to the EGFR inhibitor cetuximab in patient-derived HNSCC xenografts.. In: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. Z, no.ZZ, p. 6 (2019). doi:10.1158/1078-0432.CCR-19-1369.
2019
Wang, Hui ; Jiang, Heng ; Corbet, Cyril ; de Mey, Sven ; Law, Kalun ; Gevaert, Thierry ; Feron, Olivier ; De Ridder, Mark. Piperlongumine increases sensitivity of colorectal cancer cells to radiation: involvement of ROS production via dual inhibition of glutathione and thioredoxin systems. In: Cancer Letters, (2019). doi:10.1016/j.canlet.2019.02.034.
2019
Strickaert Aurélie ; Corbet, Cyril ; Spinette SA ; Craciun L ; Dom G ; Andry G ; Larsimont D ; Wattiez R ; Dumont JE ; Feron, Olivier ; Maenhaut C. Reprogramming of energetic metabolism: increased expression and roles of pyruvate carboxylase in papillary thyroid cancer.. In: Thyroid, (2019). doi:10.1089/thy.2018.0435 (Accepté/Sous presse).
2019
Feron, Olivier. The many metabolic sources of acetyl-CoA to support histone acetylation and influence cancer progression.. In: Annals of translational medicine, Vol. 7, no.Suppl 8, p. S277 (2019). doi:10.21037/atm.2019.11.140.
2019
Feron, Olivier. The many metabolic sources of acetyl-CoA to support histone acetylation and influence cancer progression.. In: Annals of translational medicine, Vol. 7, no.Suppl 8, p. S277 (2019). doi:10.21037/atm.2019.11.140.
2019
Aboubakar Nana, Frank ; Lecocq, Marylène ; Ladjemi, Maha Zohra ; Detry, Bruno ; Dupasquier, Sébastien ; Feron, Olivier ; Massion, Pierre P. ; Sibille, Yves ; Pilette, Charles ; Ocak, Sebahat. Therapeutic Potential of Focal Adhesion Kinase Inhibition in Small Cell Lung Cancer. In: Molecular Cancer Therapeutics, Vol. 18, no. 1, p. 17-27 (2019). doi:10.1158/1535-7163.mct-18-0328.
2019
Choumessi Tchewonpi, Aphrodite ; Johanns, Manuel ; Beaufay, Claire ; Herent, Marie-France ; Stroobant, Vincent ; Vertommen, Didier ; Corbet, Cyril ; Jacobs, Roxane ; Herinckx, Gaëtan ; Steinberg, Gregory R ; Feron, Olivier ; Quetin-Leclercq, Joëlle ; Rider, Mark. Two isoprenylated flavonoids from Dorstenia psilurus activate AMPK, stimulate glucose uptake, inhibit glucose production and lower glycemia. In: Biochemical Journal, Vol. 476, no. 24, p. 3687-3704 (2019). doi:10.1042/BCJ20190326.
2018
de Mey, Sven ; Jiang, Heng ; Corbet, Cyril ; Wang, H. ; Dufait, Inès ; Law, Kalun ; Bastien, Estelle ; Verovski, Valeri ; Gevaert, Thierry ; Feron, Olivier ; De Ridder, Mark. Antidiabetic Biguanides Radiosensitize Hypoxic Colorectal Cancer Cells Through a Decrease in Oxygen Consumption. In: Frontiers in Pharmacology, Vol. 9, p. 1073 [1-12] (2018). doi:10.3389/fphar.2018.01073.
2018
Corbet, Cyril ; Bastien, Estelle ; Draoui, Nihed ; Doix, Bastien ; Mignion, Lionel ; Jordan, Bénédicte ; Marchand, Arnaud ; Vanherck, Jean-Christophe ; Chaltin, Patrick ; Schakman, Olivier ; Becker, Holger M ; Riant, Olivier ; Feron, Olivier. Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects.. In: Nature Communications, Vol. 9, no.1, p. 1208 (2018). doi:10.1038/s41467-018-03525-0.
2018
Montigaud, Yoann ; Ucakar, Bernard ; Krishnamachary, Balaji ; Bhujwalla, Zaver M ; Feron, Olivier ; Préat, Véronique ; Danhier, Fabienne ; Gallez, Bernard ; Danhier, Pierre. Optimized acriflavine-loaded lipid nanocapsules as a safe and effective delivery system to treat breast cancer.. In: International journal of pharmaceutics, Vol. 551, no.1-2, p. 322-328 (2018). doi:10.1016/j.ijpharm.2018.09.034.
2018
de Mey, Sven ; Jiang, Heng ; Wang, Hui ; Engels, Benedikt ; Gevaert, Thierry ; Dufait, Inès ; Feron, Olivier ; Aerts, Joeri ; Verovski, Valeri ; De Ridder, Mark. Potential of memory T cells in bridging preoperative chemoradiation and immunotherapy in rectal cancer.. In: Radiotherapy & Oncology, (2018). doi:10.1016/j.radonc.2018.04.003 (Accepté/Sous presse).
2018
Doix, Bastien ; Bastien, Estelle ; Rambaud, Alix ; Pinto, Adán ; Louis, Caroline ; Grégoire, Vincent ; Riant, Olivier ; Feron, Olivier. Preclinical Evaluation of White Led-Activated Non-porphyrinic Photosensitizer OR141 in 3D Tumor Spheroids and Mouse Skin Lesions.. In: Frontiers in oncology, Vol. 8, p. 393 (2018). doi:10.3389/fonc.2018.00393.
2017
Baldini, Nicola ; De Milito, Angelo ; Feron, Olivier ; Gillies, Robert J ; Michiels, Carine ; Otto, Angela M ; Pastorekova, Silvia ; Perdersen, Stine F ; Porporato, Paolo ; Sonveaux, Pierre ; Supuran, Claudiu T ; Avnet, Sofia. Annual meeting of the International Society of Cancer Metabolism (ISCaM): metabolic networks in cancer. In: Frontiers in Pharmacology, Vol. 8, p. 411 [1-5] (2017). doi:10.3389/fphar.2017.00411.
2017
Wang, H. ; Bouzakoura, Soumaya ; de Mey, Sven ; Jiang, Heng ; Law, Kalun ; Dufait, Inès ; Corbet, Cyril ; Verovski, Valeri ; Gevaert, Thierry ; Feron, Olivier ; Van den Berge, Dirk ; Storme, Guy ; De Ridder, Mark. Auranofin radiosensitizes tumor cells through targeting thioredoxin reductase and resulting overproduction of reactive oxygen species.. In: OncoTarget, (2017). doi:10.18632/oncotarget.16113 (Accepté/Sous presse).
2017
Corbet, Cyril ; Feron, Olivier. Cancer cell metabolism and mitochondria: Nutrient plasticity for TCA cycle fueling.. In: Biochimica et Biophysica Acta : Reviews on Cancer, Vol. 1868, no. 1, p. 7-15 (2017). doi:10.1016/j.bbcan.2017.01.002.
2017
Stickaert, Aurélie ; Saiselet, Manuel ; Dom, Genevieve ; De Deken, Xavier ; Dumont, Jacques ; Feron, Olivier ; Sonveaux, Pierre ; Maenhaut, Carine. Cancer heterogeneity is not compatible with one unique cancer cell metabolic map. In: Oncogene, Vol. 36, no. 19, p. 2637-2642 (2017). doi:10.1038/onc.2016.411.
2017
Ravez, Séverine ; Spillier, Quentin ; Marteau, Romain ; Feron, Olivier ; Frédérick, Raphaël. Challenges and Opportunities in the Development of Serine Synthetic Pathway Inhibitors for Cancer Therapy.. In: Journal of Medicinal Chemistry, Vol. 60, no. 4, p. 1227-1237 (2017). doi:10.1021/acs.jmedchem.6b01167.
2017
Danhier, Pierre ; Deumer, Gladys ; Joudiou, Nicolas ; Bouzin, Caroline ; Levêque, Philippe ; Haufroid, Vincent ; Jordan, Bénédicte F ; Feron, Olivier ; Sonveaux, Pierre ; Gallez, Bernard. Contribution of macrophages in the contrast loss in iron oxide-based MRI cancer cell tracking studies.. In: OncoTarget, Vol. 8, no. 24, p. 38876-38885 (2017). doi:10.18632/oncotarget.17103.
2017
De Pauw, Aurelia ; Andre, Emilie ; Sekkali, Belaid ; Bouzin, Caroline ; Esfahani, Hrag ; Barbier, Nicolas ; Loriot, Axelle ; De Smet, Charles ; Vanhoutte, Laetitia ; Moniotte, Stéphane ; Gerber, Bernhard ; di Mauro, Vittoria ; Catalucci, Daniele ; Feron, Olivier ; Hilfiker-Kleiner, Denise ; Balligand, Jean-Luc. Dnmt3a-mediated inhibition of Wnt in cardiac progenitor cells improves differentiation and remote remodeling after infarction.. In: JCI insight, Vol. 2, no.12 (2017). doi:10.1172/jci.insight.91810.
2017
Corbet, Cyril ; Feron, Olivier. Emerging roles of lipid metabolism in cancer progression.. In: Current Opinion in Clinical Nutrition and Metabolic Care, , p. 1 (2017). doi:10.1097/MCO.0000000000000381 (Accepté/Sous presse).
2017
Bindels, Laure B. ; Porporato, Paolo ; Ducastel, Sarah ; Sboarina, Martina ; Neyrinck, Audrey M. ; Dewulf, Evelyne ; Feron, Olivier ; Lestavel, Sophie ; Cani, Patrice D. ; Staels, Bart ; Sonveaux, Pierre ; Delzenne, Nathalie M.. Ffar2 expression regulates leukaemic cell growth in vivo.. In: The British journal of cancer, Vol. 117, no. 9, p. 1336-1340 (2017). doi:10.1038/bjc.2017.307.
2017
Vanhoutte, Laetitia ; Guilbaud, Céline ; Martherus, Sarkies-Ruben-Matthe ; Bouzin, Caroline ; Gallez, Bernard ; Dessy, Chantal ; Balligand, Jean-Luc ; Moniotte, Stéphane ; Feron, Olivier. MRI Assessment of Cardiomyopathy Induced by β1-Adrenoreceptor Autoantibodies and Protection Through β3-Adrenoreceptor Overexpression.. In: Scientific Reports, Vol. 7, p. 43951 [1-10] (2017). doi:10.1038/srep43951.
2017
HEUSKIN, Anne-Catherine ; Gallez, Bernard ; Feron, Olivier ; Martinive, Philippe ; Michiels, Carine ; Lucas, Stéphane. Metallic nanoparticles irradiated by low energy protons for radiation therapy: are there significant physical effects to enhance the dose delivery?. In: Medical Physics, Vol. 44, no. 8, p. 4299-4312 (2017). doi:10.1002/mp.12362.
2017
Hautem, Nicolas ; Morelle, Johann ; Sow, Amadou Tidiane ; Corbet, Cyril ; Feron, Olivier ; Goffin, Eric ; Huaux, François ; Devuyst, Olivier. The NLRP3 Inflammasome Has a Critical Role in Peritoneal Dialysis-Related Peritonitis.. In: Journal of the American Society of Nephrology, Vol. 28, no. 7, p. 2038-2052 (2017). doi:10.1681/ASN.2016070729.
2017
Corbet, Cyril ; Feron, Olivier. Tumour acidosis: from the passenger to the driver's seat.. In: Nature Reviews. Cancer, Vol. 17, no.10, p. 577-593 (2017). doi:10.1038/nrc.2017.77.
2017
Bony, Emilie ; Mace, Yohan ; Pinto, Adán ; Delvaux, David ; Kiss, Robert ; Riant, Olivier ; Feron, Olivier ; Quetin-Leclercq, Joëlle. Validation of a SPE HPLC-UV method for the quantification of a new ER-specific photosensitizer OR-141 in blood serum using total error concept.. In: Journal of Pharmaceutical and Biomedical Analysis, Vol. 141, p. 87-94 (2017). doi:10.1016/j.jpba.2017.03.060.
2017
Ravez, Séverine ; Corbet, Cyril ; Spillier, Quentin ; Dutu, Alice ; Robin, Anita D ; Mullarky, Edouard ; Cantley, Lewis Clayton ; Feron, Olivier ; Frédérick, Raphaël. α-Ketothioamide derivatives: a promising tool to interrogate the phosphoglycerate dehydrogenase (PHGDH).. In: Journal of Medicinal Chemistry, (2017). doi:10.1021/acs.jmedchem.6b01166 (Accepté/Sous presse).
2016
Pinto Fernandez, Adan ; Mace, Yohan ; Drouet, Fleur ; Bony, Emilie ; Boidot, Romain ; Draoui, Nihed ; Lobysheva, Irina ; Corbet, Cyril ; Polet, Florence ; Martherus, Sarkies-Ruben-Matthe ; Deraedt, Quentin ; Rodríguez, Javier ; Lamy, ; Schicke, Olivier ; Delvaux, David ; Louis, Caroline ; Kiss, Robert ; Von Kriegsheim, Alexander ; Dessy, Chantal ; Elias, Benjamin ; Quetin-Leclercq, Joëlle ; Riant, Olivier ; Feron, Olivier. A new ER-specific photosensitizer unravels (1)O2-driven protein oxidation and inhibition of deubiquitinases as a generic mechanism for cancer PDT.. In: Oncogene, Vol. 35, no. 30, p. 3976-3985 (2016). doi:10.1038/onc.2015.474.
2016
Corbet, Cyril ; Pinto Fernandez, Adan ; Martherus, Sarkies-Ruben-Matthe ; Santiago de Jesus, Joao Pedro ; Polet, Florence ; Feron, Olivier. Acidosis Drives the Reprogramming of Fatty Acid Metabolism in Cancer Cells through Changes in Mitochondrial and Histone Acetylation.. In: Cell Metabolism, Vol. 24, no. 2, p. 311-323 (2016). doi:10.1016/j.cmet.2016.07.003.
2016
Karmani, Linda ; Levêque, Philippe ; Bouzin, Caroline ; Bol, Anne ; Dieu, Marc ; Walrand, Stephan ; Vander Borght, Thierry ; Feron, Olivier ; Grégoire, Vincent ; Bonifazi, Davide ; Michiels, Carine ; Lucas, Stéphane ; Gallez, Bernard. Biodistribution of (125)I-labeled anti-endoglin antibody using SPECT/CT imaging: Impact of in vivo deiodination on tumor accumulation in mice.. In: Nuclear Medicine and Biology, Vol. 43, no. 7, p. 415-423 (2016). doi:10.1016/j.nucmedbio.2016.03.007.
2016
Michiels, Carine ; Tellier, Céline ; Feron, Olivier. Cycling hypoxia: A key feature of the tumor microenvironment.. In: Biochimica et Biophysica Acta : Reviews on Cancer, (2016). doi:10.1016/j.bbcan.2016.06.004 (Accepté/Sous presse).
2016
Corbet, Cyril ; Ragelle, Héloïse ; Pourcelle, Vincent ; Vanvarenberg, Kevin ; Marchand-Brynaert, Jacqueline ; Préat, Véronique ; Feron, Olivier. Delivery of siRNA targeting tumor metabolism using non-covalent PEGylated chitosan nanoparticles: Identification of an optimal combination of ligand structure, linker and grafting method.. In: Journal of Controlled Release, Vol. 223, p. 53-63 (2016). doi:10.1016/j.jconrel.2015.12.020.
2016
Romero, Miguel ; Leon-Gomez, Elvira ; Lobysheva, Irina ; Rath, Géraldine ; Dogné, Jean-Michel ; Feron, Olivier ; Dessy, Chantal. Effects of BM-573 on Endothelial Dependent Relaxation and Increased Blood Pressure at Early Stages of Atherosclerosis.. In: PLoS One, Vol. 11, no.3, p. e0152579 (2016). doi:10.1371/journal.pone.0152579 (Accepté/Sous presse).
2016
Vanhoutte, Laetitia ; Balligand, Jean-Luc ; Feron, Olivier ; Gerber, Bernhard ; Gallez, Bernard ; Po, Chrystelle ; Magat, Julie ; Moniotte, Stéphane. High field magnetic resonance imaging of rodents in cardiovascular research.. In: Basic Research in Cardiology, Vol. 111, p. 46 [1-20] (2016). doi:10.1007/s00395-016-0565-2.
2016
Polet, Florence ; Martherus, Sarkies-Ruben-Matthe ; Corbet, Cyril ; Pinto Fernandez, Adan ; Feron, Olivier. Inhibition of glucose metabolism prevents glycosylation of the glutamine transporter ASCT2 and promotes compensatory LAT1 upregulation in leukemia cells.. In: Oncotarget, Vol. 7, no. 29, p. 46371-46383 (2016). doi:10.18632/oncotarget.6426.
2016
Li, Sha ; Penninckx, Sébastien ; Karmani, Linda ; HEUSKIN, Anne-Catherine ; Watillon , Kassandra ; Marega , Riccardo ; Zola, Jerome ; Corvaglia, Valentina ; Genard, Géraldine ; Gallez, Bernard ; Feron, Olivier ; Martinive , Philippe ; Bonifazi , Davide ; Michiels, Carine ; Lucas, Stéphane. LET-dependent radiosensitization effects of gold nanoparticles for proton irradiation. In: Nanotechnology, Vol. 27, no.45, p. 455101 [1-9] (2016). doi:10.1088/0957-4484/27/45/455101.
2016
Neveu, Marie-Aline ; De Preter, Géraldine ; Joudiou, Nicolas ; Bol, Anne ; Brender , Jeffery R. ; Saito , Keita ; Kishimoto , Shun ; Grégoire, Vincent ; Jordan, Bénédicte ; Krishna , Murali C. ; Feron, Olivier ; Gallez, Bernard. Multi-modality imaging to assess metabolic response to dichloroacetate treatment in tumor models. In: OncoTarget, Vol. 7, no.49, p. 81741-81749 (2016). doi:10.18632/oncotarget.13176.
2016
Neveu, Marie-Aline ; De Preter, Géraldine ; Marchand, Valérie ; Bol, Anne ; Brender, Jeffery R ; Saito, Keita ; Kishimoto, Shun ; Porporato, Paolo ; Sonveaux, Pierre ; Grégoire, Vincent ; Feron, Olivier ; Jordan, Bénédicte ; Krishna, Murali C ; Gallez, Bernard. Multimodality imaging identifies distinct metabolic profiles in vitro and in vivo. In: NeoPlasia : an international journal of oncology research, Vol. 18, no. 12, p. 742-752 (2016). doi:10.1016/j.neo.2016.10.010.
2016
Polet , Florence ; Corbet, Cyril ; Pinto, Adan ; Illan Rubio, Laila ; Martherus, Sarkies-Ruben-Matthe ; Bol, Vanesa ; Drozak, Xavier ; Grégoire , Vincent ; Riant, Olivier ; Feron, Olivier. Reducing the serine availability complements the inhibition of the glutamine metabolism to block leukemia cell growth. In: Oncotarget, Vol. 7, no.2, p. 1765-1776 (2016).
2016
Fruytier, Anne-Catherine ; Le Duff , Cécile S. ; Po, Chrystelle ; Magat, Julie ; Bouzin, Caroline ; Neveu, Marie-Aline ; Feron, Olivier ; Jordan, Bénédicte ; Gallez, Bernard. The Blood Flow Shutdown Induced by Combretastatin A4 Impairs Gemcitabine Delivery in a Mouse Hepatocarcinoma. In: Frontiers in Pharmacology, Vol. 7, p. 506 [1-8] (2016). doi:10.3389/fphar.2016.00506.
2015
Buescher, Joerg M ; Antoniewicz, Maciek R ; Boros, Laszlo G ; Burgess, Shawn C ; Brunengraber, Henri ; Clish, Clary B ; DeBerardinis, Ralph J ; Feron, Olivier ; Frezza, Christian ; Ghesquiere, Bart ; Gottlieb, Eyal ; Hiller, Karsten ; Jones, Russell G ; Kamphorst, Jurre J ; Kibbey, Richard G ; Kimmelman, Alec C ; Locasale, Jason W ; Lunt, Sophia Y ; Maddocks, Oliver Dk ; Malloy, Craig ; Metallo, Christian M ; Meuillet, Emmanuelle J ; Munger, Joshua ; Nöh, Katharina ; Rabinowitz, Joshua D ; Ralser, Markus ; Sauer, Uwe ; Stephanopoulos, Gregory ; St-Pierre, Julie ; Tennant, Daniel A ; Wittmann, Christoph ; Vander Heiden, Matthew G ; Vazquez, Alexei ; Vousden, Karen ; Young, Jamey D ; Zamboni, Nicola ; Fendt, Sarah-Maria. A roadmap for interpreting (13)C metabolite labeling patterns from cells.. In: Current Opinion in Biotechnology, Vol. 34, p. 189-201 (2015). doi:10.1016/j.copbio.2015.02.003.
2015
Tellier, Céline ; Desmet, Déborah ; Petit, Laurenne ; Finet, Laure ; Graux, Carlos ; Raes, Martine ; Feron, Olivier ; Michiels, Carine. Cycling hypoxia induces a specific amplified inflammatory phenotype in endothelial cells and enhances tumor-promoting inflammation in vivo.. In: NeoPlasia : an international journal of oncology research, Vol. 17, no. 1, p. 66-78 (2015). doi:10.1016/j.neo.2014.11.003.
2015
Macé, Yohan ; Bony, Emilie ; Delvaux, David ; Pinto Fernandez, Adan ; Mathieu, Véronique ; Kiss, Robert ; Feron, Olivier ; Quetin-Leclercq, Joëlle ; Riant, Olivier. Cytotoxic activities and metabolic studies of new combretastatin analogues. In: Medicinal Chemistry Research, Vol. 24, no. 8, p. 3143-3156 (2015). doi:10.1007/s00044-015-1363-3.
2015
Danhier, Pierre ; Magat, Julie ; Levêque, Philippe ; De Preter, Géraldine ; Porporato, Paolo ; Bouzin, Caroline ; Jordan, Bénédicte ; Demeur, Gladys ; Haufroid, Vincent ; Feron, Olivier ; Sonveaux, Pierre ; Gallez, Bernard. In vivo visualization and ex vivo quantification of murine breast cancer cells in the mouse brain using MRI cell tracking and electron paramagnetic resonance.. In: NMR in Biomedicine, Vol. 28, no. 3, p. 367-375 (2015). doi:10.1002/nbm.3259.
2015
Ragelle, Héloïse ; Colombo, Stefano ; Pourcelle, Vincent ; Vanvarenberg, Kevin ; Vandermeulen, Gaëlle ; Bouzin, Caroline ; Marchand-Brynaert, Jacqueline ; Feron, Olivier ; Foged, Camilla ; Préat, Véronique. Intracellular siRNA delivery dynamics of integrin-targeted, PEGylated chitosan-poly(ethylene imine) hybrid nanoparticles: A mechanistic insight. In: Journal of Controlled Release, Vol. 211, p. 1-9 (2015). doi:10.1016/j.jconrel.2015.05.274.
2015
Corbet, Cyril ; Feron, Olivier. Metabolic and mind shifts: from glucose to glutamine and acetate addictions in cancer.. In: Current Opinion in Clinical Nutrition and Metabolic Care, Vol. 18, no. 4, p. 346-353 (2015). doi:10.1097/MCO.0000000000000178.
2015
Lucas, Stéphane ; Feron, Olivier ; Gallez, Bernard ; Masereel, Bernard ; Michiels, Carine ; Vander Borght, Thierry. Monte Carlo Calculation of Radioimmunotherapy with (90)Y-, (177)Lu-, (131)I-, (124)I-, and (188)Re-Nanoobjects: Choice of the Best Radionuclide for Solid Tumour Treatment by Using TCP and NTCP Concepts.. In: Computational and Mathematical Methods in Medicine, Vol. 2015, p. 284360 [1-15] (2015). doi:10.1155/2015/284360.
2015
Radi, Smaail ; Tighadouini, Said ; Feron, Olivier ; Riant, Olivier ; Bouakka, Mohammed ; Benabbes, Redouane ; Mabkhot, Yahia N. Synthesis of Novel β-Keto-Enol Derivatives Tethered Pyrazole, Pyridine and Furan as New Potential Antifungal and Anti-Breast Cancer Agents.. In: Molecules : a journal of synthetic organic and natural product chemistry, Vol. 20, no.11, p. 20186-20194 (2015). doi:10.3390/molecules201119684.
2015
Neveu, Marie-Aline ; Bol, Vanesa ; Bol, Anne ; Bouzin, Caroline ; Grégoire, Vincent ; Feron, Olivier ; Jordan, Bénédicte ; Gallez, Bernard. The increase in tumor oxygenation under carbogen breathing induces a decrease in the uptake of [(18)F]-fluoro-deoxy-glucose. In: Radiotherapy & Oncology, Vol. 116, no. 3, p. 400–403 (2015). doi:10.1016/j.radonc.2015.04.023.
2015
Vanhoutte, Laetitia ; Gallez, Bernard ; Feron, Olivier ; Balligand, Jean-Luc ; Esfahani, Hrag ; D'Hoore, William ; Moniotte, Stéphane. Variability of Mouse Left Ventricular Function Assessment by 11.7 Tesla MRI.. In: Journal of Cardiovascular Translational Research, Vol. 8, no. 6, p. 362-371 (2015). doi:10.1007/s12265-015-9638-0.