Biomedical Engineering

Several research groups carry out research in the field of biomedical engineering. It involves the following activities summarized in more details below: Bioinformatics and computational biology, Biomedical data analysis, Biosensors, Medical Imaging, Modelling of biological and physiological systems.

Principal Investigators :

Pierre-Antoine Absil, Frédéric Crevecoeur, Pierre Dupont, Denis Flandre, Laurent Jacques, Philippe Lefèvre, Benoit Macq, Michel Verleysen

Research Labs :

Machine Learning Group, INMA (Mathematical Engineering research division), Image and Signal Processing Group (ISPGroup)

Research Areas :

ICTEAM is involved in Transcriptomics and High-Throughput Technologies. This research activity focuses on the identification of biomarkers from gene expression data, as measured by high-throughput technologies such as high-density DNA microarrays or next generation sequencing platforms. These biomarkers may be used for medical diagnosis, prognosis or prediction of the response to a treatment. Our research objectives also include the link between transcriptomic data and functional analysis from a system biology viewpoint. Several collaborations exist on those topics with the UCL Institute for Experimental and Clinical Research in the context of cancer research, allergy prediction among newborns and early diagnosis of arthritis.

Current projects also involve analysis and filtering of biomedical data and signals. It concerns a wide variety of applications based on the expert knowledge on data analysis and processing to the biomedical field:

  • analysis of biomedical signals (including ECG, EEG, etc.) for automatic pre-diagnosis
  • filtering of medical scan images for contour extraction

Several research projects aim at developing biosensors and biomedical applications of electronics:

  • application to monitoring of respiration (micro-systems)
  • low power systems for biomedical applications
  • security and cryptography for biomedical applications

ICTEAM pursues research on image processing tools and applications for the use in various medical contexts (radiotherapy, proton therapy, brachytherapy, surgery) and at different stages of treatment (planning, execution and follow-up). The research focuses on:

  • rigid and non-rigid image registrations methods for 2D-3D and 3D-3D images both for single and multiple modalities as well as for surfaces;
  • segmentation techniques either using prior knowledge (atlas-based) or allowing user interaction (graph cuts)
  • human-computer interactions to create intuitive user interfaces for the clinical world.

Another field of research is the solving of inverse problems from generalized sparsity prior (with applications in optics and X-ray CT), Compressed Sensing (theory and application), theoretical questions linked to the design of new sensors (for computer vision), applied mathematics for astronomical and biomedical signal processing questions, and representation of data on strange spaces (e.g., sphere, manifolds, or graphs). Besides, research is pursued on EEG reconstruction, transcranial magnetic stimulation, as well as on the use of functional imaging for measuring motion disorders.

The institute is also involved in shape analysis for protein docking. This includes 3D mesh processing and the analysis of protein surface properties.

ICTEAM also has research activities investigating the neural control movement. These activities are based on experimental, clinical and modelling approaches. Among the ongoing projects:

  • interaction between vision and the neural control of movement
  • experimental and modelling study of eye and head movements as well as eye-hand coordination
  • clinical studies: the influence of Duane Retraction Syndrome and Cerebral Palsy on vision and eye movements (St Luc Hospital and fondation JED).
  • dextrous manipulation in micro- and hyper-gravity (supported by Prodex and ESA)
  • the role of internal models: prediction and anticipation in smooth pursuit and saccade programming

Most recent publications

Below are listed the 10 most recent journal articles and conference papers produced in this research area. You also can access all publications by following this link : see all biomedical engineering publications

Journal Articles

1. Orban de Xivry, Jean-Jacques; Legrain, Valéry; Lefèvre, Philippe. Overlap of movement planning and movement execution reduces reaction time. In: Journal of Neurophysiology, Vol. 117, no. 1, p. 117-122 (2017). doi:10.1152/jn.00728.2016.

2. Li, Chengnan; Ye, Ran; Bouckaert, Julie; Zurutuza, Amaia; Drider, Djamel; Dumych, Tetiana; Paryzhak, Solomiya; Vovk, Volodymyr; Bilyy, Rostyslav O.; Melinte, Sorin; Li, Musen; Boukherroub, Rabah; Szunerits, Sabine. Flexible Nanoholey Patches for Antibiotic-Free Treatments of Skin Infections. In: ACS Applied Materials and Interfaces, Vol. 9, p. 36665-36674. doi:10.1021/acsami.7b12949.

3. Crevecoeur, Frédéric; Barrea, Allan; Libouton, Xavier; Thonnard, Jean-Louis; Lefèvre, Philippe. Multisensory Components of Rapid Motor Responses to Fingertip Loading. In: Journal of Neurophysiology, Vol. 118, no. 1, p. 331-343 (2017). doi:10.1152/jn.00091.2017.

4. Orban de Xivry, Jean-Jacques; Legrain, Valéry; Lefèvre, Philippe. Overlap of movement planning and movement execution reduces reaction time by up to 100ms. In: Journal of Neurophysiology, Vol. 117, no. /, p. 117-122 (2017). doi:10.1101/039842.

5. Ego, Caroline; Bonhomme, Lucie; Orban de Xivry, Jean-Jacques; Da Fonseca, David; Lefèvre, Philippe; Masson, Guillaume S.; Deruelle, Christine. Behavioral characterization of prediction and internal models in adolescents with autistic spectrum disorders. In: Neuropsychologia, Vol. 91, p. 335-345 (August 21, 2016). doi:10.1016/j.neuropsychologia.2016.08.021.

6. Orban de Xivry, Jean-Jacques; Lefevre, Philippe. A switching cost for motor planning. In: Journal of Neurophysiology, (2016). doi:10.1101/047621.

7. Barrea, Allan; Cordova Bulens, David; Lefèvre, Philippe; Thonnard, Jean-Louis. Simple and reliable method to estimate the fingertip static coefficient of friction in precision grip. In: IEEE Transactions on Haptics, Vol. 9, no. 4, p. 492-498 (2016). doi:10.1109/TOH.2016.2609921.

8. Crevecoeur, Frédéric; Thonnard, Jean-Louis; Lefèvre, Philippe; Scott, Stephen. Long-latency feedback coordinates upper-limb and hand muscles during object manipulation tasks. In: eNeuro, Vol. 3, no. 1, p. 1-12 (2016). doi:10.1523/ENEURO.0129-15.2016.

9. Ego, Caroline; Yüksel, Demet; Orban de Xivry, Jean-Jacques; Lefèvre, Philippe. Development of internal models and predictive abilities for visual tracking during childhood. In: Journal of Neurophysiology, Vol. 115, no. 1, p. 301-309 (2016). doi:10.1152/jn.00534.2015.

10. Boutaayamou , Mohamed; Schwartz, Cédric; Stamatakis, Julien. Development and validation of an accelerometer-based method for quantifying gait events. In: Medical Engineering & Physics, Vol. 37, no.2, p. 226-232 (February 2015).

Conference Papers

1. Verfaille, Charlotte; Cordova Bulens, David; Filbrich, Lieve; Barbier, Olivier; Libouton, Xavier; Fraselle, Virginie; Mouraux, Dominique; Berquin, Anne; Legrain, Valéry. Does CRPS impair visuo-motor coordination in peripersonal space?.

2. Hédouin, Renaud; Commowick, Olivier; Taquet, Maxime; Bannier, Elise; Scherrer, Benoit; Warfield, Simon; Barillot, Christian. SYMMETRIC BLOCK-MATCHING REGISTRATION FOR THE DISTORTION CORRECTION OF ECHO-PLANAR IMAGES.

3. Branders, Samuel; Frenay, Benoît; Dupont, Pierre. Survival Analysis with Cox Regression and Random Non-linear Projections. In: Proceedings of the 23th European Symposium on Artificial Neural Networks, Computational Intelligence and Machine Learning, 2015.

4. Filbrich, Lieve; Orban de Xivry, Jean-Jacques; Verfaille, Charlotte; Lefèvre, Philippe; Legrain, Valéry. Robot-assisted line bisection in virtual reality.

5. Gallego Ortiz, Nicolas; Orban de Xivry, Jonathan; Descampe, Antonin; Goossens, Samuel; Geets, Xavier; Janssens, Guillaume; Macq, Benoît. Respiratory motion variations from skin surface on lung cancer patients from 4D CT data. In: Progress in Biomedical Optics and Imaging. Vol. 9034, p. 90342Y (2014). SPIE - International Society for Optical Engineering: (United States) Bellingham, WA, 2014. doi:10.1117/12.2043477.

6. Lombard, Catherine; André, Floriane; Paul, Jérôme; Wanty, Catherine; Vosters, Olivier; Bernard, Pierre; Pilette, Charles; Dupont, Pierre; Sokal, Etienne; Smets, Françoise. Decrease in IL-15 production by cord blood mononuclear cells as a marker of atopic disease. In: Journal of Pediatric Gastroenterology and Nutrition. Vol. 58, no.sup 1, p. p534 (june 2014). Lippincott Williams & Wilkins: (United States) Philadelphia, 2014.

7. Branders, Samuel; D'Ambrosio, Roberto; Dupont, Pierre. The Coxlogit model: feature selection from survival and classification data. In: Computational Intelligence in Multi-Criteria Decision-Making (MCDM), 2014 IEEE Symposium on, IEEE, 2014, 137-143. doi:10.1109/MCDM.2014.7007199.

8. Dessy, Adrien; Dupont, Pierre. Computationally Efficient Test for Gene Set Dysregulation.

9. Pletser, Vladimir; Sundblad, Patrik; Thonnard, Jean-Louis; Lefèvre, Philippe; Mclntyre, Joe; Kassel, Ronald; Desoete, Bart; Derkinderen, Wim; Penta, Massimo; André, Thibaut. Experiments during aircraft parabolic flights to prepare for the international space station. In: International Astronautical Federation. Proceedings of the Congress. Vol. 1, p. 532-537 (2012). Pergamon Press plc: (France) Paris, 2012.

10. Van Overstraeten-Schlögel, Nancy; Lefèvre, O.; Flandre, Denis. Assessment of different functionalization methods for grafting a protein to an alumina-covered biosensor. In: Proceedings of the 2012 IEEE-EMBS Micro- and Nanoengineering in Medicine Conference (MNMC 2012), IEEE, 2012, 1.