Programme

Module 1 – Introduction/basics principles of Toxicology :
Completed in 2019

> Calendar and detailed programme.

• Dose/exposure

• Tools in toxicology

• In vitro experimental toxicology

• In vivo experimental toxicology

• Human toxicology

• Environmental toxicology

• Target organs/systems of toxicity through practical exercises

Module 3 – Regulatory Toxicology of Chemicals:
21-25 October 2019

> Background and aims

> Calendar and detailed programme.

• Introduction

• Hazard identification and characterization of the dose-response

• Hazard identification and communication

• Exposure assessment

• Risk Management: main principles and hierarchy of risk management measures

• Examples of frameworks

• Regulatory Toxicology and society

Module 4 – In vitro toxicology (in collaboration with ESTIV)
5-10 April 2020

> Calendar and detailed programme

• European legislative framework and international guidelines for in vitro toxicity testing of chemicals.

• Use and validation of 3R-alternative methods in Europe.

• In vitro methods for assessing cytotoxicity, skin sensitization, skin/eye irritation/corrosion, immunotoxicity, genotoxicity, carcinogenicity and developmental toxicity.

• Development and application of cell lines, organ-specific models, tridimensional and reconstructed models, bioreactors and stem cell models in in vitro toxicology.

• Use of “omics”-based methods in in vitro toxicology.

• Good in vitro method practices/good cell culture practice.

• In vitro kinetics and in vitro-in vivo extrapolation.

• In vitro aspects of pathway-based toxicology.

• Non-animal testing technologies and strategies used for chemical hazard and

• risk assessment in Europe.

• Hands-on training on skin and eye irritation testing in vitro.