Publications

Hoste, Emilia ; Haufroid, Vincent ; Deldicque, Louise ; Balligand, Jean-Luc ; Elens, Laure. Atorvastatin-associated myotoxicity: A toxicokinetic review of pharmacogenetic associations to evaluate the feasibility of precision pharmacotherapy. In: Clinical Biochemistry, Vol. 124, no. 1, p. 110707 (2024). doi:10.1016/j.clinbiochem.2024.110707.

http://hdl.handle.net/2078.1/285489

Delvau, N. ; Elens, Laure ; Penaloza, A. ; Liistro, G. ; Thys, F. ; Roy, P.M. ; Gianello, P. ; Hantson, P.. Carboxyhemoglobin half-life toxicokinetic profiles during and after normobaric oxygen therapy: on a swine model. In: Toxicology Reports, Vol. 12, no.June 2024, p. 271-279 (2024). doi:10.1016/j.toxrep.2024.02.005.

http://hdl.handle.net/2078.1/285545

Ward, Bradley ; Pyr dit Ruys, Sébastien ; Balligand, Jean-Luc ; Belkhir, Leïla ; Cani, Patrice D. ; Collet, Jean-François ; De Greef, Julien ; Dewulf, Joseph P. ; Gatto, Laurent ; Haufroid, Vincent ; Jodogne, Sébastien ; Kabamba-Mukadi, Benoît ; Lingurski, Maxime ; Yombi, Jean Cyr ; Vertommen, Didier ; Elens, Laure. Deep Plasma Proteomics with Data-Independent Acquisition: Clinical Study Protocol Optimization with a COVID-19 Cohort.. In: Journal of proteome research, Vol. 23, no. 9, p. 3806-3822 (2024). doi:10.1021/acs.jproteome.4c00104.

http://hdl.handle.net/2078.1/291172

De Greef, Julien ; Akue, Mathilde ; Panin, Nadtha ; Delongie, Kévin-Alexandre ; Andre, Marina ; Mahieu, Gwenaëlle ; Hoste, Emilia ; Elens, Laure ; Belkhir, Leïla ; Haufroid, Vincent. Effect of ABCB1 most frequent polymorphisms on the accumulation of bictegravir in recombinant HEK293 cell lines.. In: Scientific reports, Vol. 14, no.1, p. 16290 (2024). doi:10.1038/s41598-024-66809-0.

http://hdl.handle.net/2078.1/289989

Degraeve, Alexandra ; Bindels, Laure B. ; Haufroid, Vincent ; Moudio Ebosse Timba, Moussinga Serge ; Boland, Lidvine ; Delongie, Kévin-Alexandre ; Dewulf, Joseph P. ; Chaib Eddour, Djamila ; Mourad, Michel ; Elens, Laure. Tacrolimus pharmacokinetics is associated with gut microbiota diversity in kidney transplant patients: results from a pilot cross‐sectional study. In: Clinical pharmacology and therapeutics, Vol. 115, no. 1, p. 104-115 (2024). doi:10.1002/cpt.3077.

http://hdl.handle.net/2078.1/278913

Mahieu, Gwenaëlle ; Sennesael, Anne-Laure ; Pochet, Lionel ; Haufroid, Vincent ; Van Bambeke, Françoise ; Spinewine, Anne ; Elens, Laure. assessment of the risk of ABCB1-mediated drug-drug interaction between rivaroxaban and tacrolimus in human embryonic kidney 293 recombinant cell lines.. In: Research and practice in thrombosis and haemostasis, Vol. 8, no.5, p. 102521 (2024). doi:10.1016/j.rpth.2024.102521.

http://hdl.handle.net/2078.1/291206

Hoste, Emilia ; Paquot, Adrien ; Panin, Nadtha ; Horion, Shaleena ; El-Hamdaoui, Halima ; Muccioli, Giulio ; Haufroid, Vincent ; Elens, Laure. Genetic polymorphisms in SLCO2B1 and ABCC1 conjointly modulate atorvastatin intracellular accumulation in HEK293 recombinant cell lines. In: Therapeutic drug monitoring, Vol. 45, no. 3, p. 400-408 (2023). doi:10.21203/rs.3.rs-1520877/v1 (Accepté/Sous presse).

http://hdl.handle.net/2078.1/262904

Degraeve, Alexandra ; Haufroid, Vincent ; Loriot, Axelle ; Gatto, Laurent ; Andries, Vanessa ; Vereecke, Lars ; Elens, Laure ; Bindels, Laure B.. Gut microbiome modulates tacrolimus pharmacokinetics through the transcriptional regulation of ABCB1. In: Microbiome, Vol. 11, no. 1, p. 138 [1-20] (2023). doi:10.1186/s40168-023-01578-y.

http://hdl.handle.net/2078.1/275888

Lagreula, Juliette ; Ferraiolo, Mattia ; de Timary, Philippe ; Delatte, Benoit ; Elens, Laure ; Hermans, Emmanuel ; Dalleur, Olivia. Impact of a Caffeine Restriction Policy on Inpatients With Schizophrenia- A Pre-Post Comparison Using Electronic Health Records. In: Journal of Clinical Psychopharmacology, Vol. 43, no.2, p. 167-170 (2023). doi:10.1097/JCP.0000000000001670.

http://hdl.handle.net/2078.1/273171

Lagreula, Juliette ; Vincent Dagenais-Beaulé ; de Timary, Philippe ; Elens, Laure ; Dalleur, Olivia. Prescribing and deprescribing trends in schizophrenia : An overview of inpatients in Belgium and in the Canadian province of Québec. In: Basic & Clinical Pharmacology & Toxicology, p. 1-12 (2023). doi:10.1111/bcpt.13867.

http://hdl.handle.net/2078.1/274223

Lemaitre, Florian ; Budde, Klemens ; Van Gelder, Teun ; Bergan, Stein ; Lawson, Roland ; Noceti, Ofelia ; Venkataramanan, Raman ; Elens, Laure ; Moes, Dirk Jan A. R. ; Hesselink, Dennis A. ; Pawinski, Tomasz ; Johnson-Davis, Kamisha L. ; De Winter, Brenda C. M. ; Pattanaik, Smita ; Brunet, Mercè ; Masuda, Satohiro ; Langman, Loralie J.. Therapeutic Drug Monitoring and Dosage Adjustments of Immunosuppressive Drugs When Combined With Nirmatrelvir/Ritonavir in Patients With COVID-19. In: Therapeutic Drug Monitoring, Vol. 45, no.2, p. 191-199 (2023). doi:10.1097/ftd.0000000000001014.

http://hdl.handle.net/2078.1/274450

Lagreula, Juliette ; de Timary, Philippe ; Elens, Laure ; Dalleur, Olivia. Antipsychotic polypharmacy and clozapine prescribing patterns: evolution and correlates before and after a psychiatric hospitalisation. In: Therapeutic advances in psychopharmacology, Vol. 12, p. [1-12] (2022). doi:10.1177/20451253221112587.

http://hdl.handle.net/2078.1/263023

Ward, Bradley ; Yombi, Jean Cyr ; Balligand, Jean-Luc ; Cani, Patrice D. ; Collet, Jean-François ; De Greef, Julien ; Dewulf, Joseph P. ; Gatto, Laurent ; Haufroid, Vincent ; Jodogne, Sébastien ; Kabamba-Mukadi, Benoît ; Pyr dit Ruys, Sébastien ; Vertommen, Didier ; Elens, Laure ; Belkhir, Leïla. HYGIEIA: HYpothesizing the Genesis of Infectious Diseases and Epidemics through an Integrated Systems Biology Approach. In: Viruses, Vol. 14, no. 7, p. 1373 [1-17] (2022). doi:10.3390/v14071373.

http://hdl.handle.net/2078.1/262895

Ngougni Pokem, Perrin ; Wittebole, Xavier ; Collienne, Christine ; Rodriguez-Villalobos, Hector ; Tulkens, Paul M. ; Elens, Laure ; Van Bambeke, Françoise ; Laterre, Pierre-François. Population Pharmacokinetics of Temocillin Administered by Continuous Infusion in Patients with Septic Shock Associated with Intra-Abdominal Infection and Ascitic Fluid Effusion. In: Antibiotics, Vol. 11, no. 7, p. 898 [1-19] (2022). doi:10.3390/antibiotics11070898.

http://hdl.handle.net/2078.1/264675

Stillemans, Gabriel ; Paquot, Adrien ; Muccioli, Giulio ; Hoste, Emilia ; Panin, Nadtha ; Åsberg, Anders ; Balligand, Jean-Luc ; Haufroid, Vincent ; Elens, Laure. Atorvastatin population pharmacokinetics in a real‐life setting: Influence of genetic polymorphisms and association with clinical response. In: Clinical and Translational Science, (2021). doi:10.1111/cts.13185.

http://hdl.handle.net/2078.1/253932

Mulder, Tessa A. M. ; van Eerden, Ruben A. G. ; de With, Mirjam ; Elens, Laure ; Hesselink, Dennis A. ; Matic, Maja ; Bins, Sander ; Mathijssen, Ron H. J. ; van Schaik, Ron H. N.. CYP3A4∗22 Genotyping in Clinical Practice: Ready for Implementation?. In: Frontiers in Genetics, Vol. 12, no. 12, p. 711943 (2021). doi:10.3389/fgene.2021.711943.

http://hdl.handle.net/2078.1/253993

Stillemans, Gabriel ; Djokoto, Happy Phanio ; Delongie, Kévin-Alexandre ; El-Hamdaoui, Halima ; Panin, Nadtha ; Haufroid, Vincent ; Elens, Laure. Effect of four ABCB1 genetic polymorphisms on the accumulation of darunavir in HEK293 recombinant cell lines. In: Scientific Reports, Vol. 11, no. 1, p. 9000 [1-7] (2021). doi:10.1038/s41598-021-88365-7.

http://hdl.handle.net/2078.1/249099

Stillemans, Gabriel ; Belkhir, Leïla ; Vandercam, Bernard ; Vincent, Anne ; Haufroid, Vincent ; Elens, Laure. Exploration of reduced doses and short cycle therapy for darunavir/cobicistat in HIV patients using population pharmacokinetic modeling and simulations. In: Clinical Pharmacokinetics, Vol. 60, no. 2, p. 177-189 (2021). doi:10.1007/s40262-020-00920-z.

http://hdl.handle.net/2078.1/231312

Stillemans, Gabriel ; Belkhir, Leïla ; Vandercam, Bernard ; Vincent, Anne ; Haufroid, Vincent ; Elens, Laure. Optimal sampling strategies for darunavir and external validation of the underlying population pharmacokinetic model. In: European Journal of Clinical Pharmacology, Vol. 77, no. 4, p. 607-616 (2021). doi:10.1007/s00228-020-03036-2.

http://hdl.handle.net/2078.1/240937

Bergan, Stein ; Brunet, Mercè ; Hesselink, Dennis A. ; Johnson-Davis, Kamisha L. ; Kunicki, Paweł K. ; Lemaitre, Florian ; Marquet, Pierre ; Molinaro, Mariadelfina ; Noceti, Ofelia ; Pattanaik, Smita ; Pawinski, Tomasz ; Seger, Christoph ; Shipkova, Maria ; Swen, Jesse J. ; van Gelder, Teun ; Venkataramanan, Raman ; Wieland, Eberhard ; Woillard, Jean-Baptiste ; Zwart, Tom C. ; Barten, Markus J. ; Budde, Klemens ; Dieterlen, Maja-Theresa ; Elens, Laure ; Haufroid, Vincent ; Masuda, Satohiro ; Millan, Olga ; Mizuno, Tomoyuki ; Moes, Dirk J. A. R. ; Oellerich, Michael ; Picard, Nicolas ; Salzmann, Linda ; Tönshoff, Burkhard ; van Schaik, Ron H. N. ; Vethe, Nils Tore ; Vinks, Alexander A. ; Wallemacq, Pierre ; Åsberg, Anders ; Langman, Loralie J.. Personalized Therapy for Mycophenolate: Consensus Report by the International Association of Therapeutic Drug Monitoring and Clinical Toxicology. In: Therapeutic drug monitoring, Vol. 43, no. 2, p. 150-200 (2021). doi:10.1097/ftd.0000000000000871.

http://hdl.handle.net/2078.1/249100

Elens, Laure ; Langman, Loralie J. ; Hesselink, Dennis A. ; Bergan, Stein ; Moes, Dirk Jan A.R. ; Molinaro, Mariadelfina ; Venkataramanan, Raman ; Lemaitre, Florian. Pharmacologic Treatment of Transplant Recipients Infected With SARS-CoV-2 : Considerations Regarding Therapeutic Drug Monitoring and Drug–Drug Interactions. In: Therapeutic Drug Monitoring, Vol. 42, no. 3, p. 360-368 (2020). doi:10.1097/ftd.0000000000000761.

http://hdl.handle.net/2078.1/230869

Lemaitre, Florian ; Solas, Caroline ; Grégoire, Matthieu ; Lagarce, Laurence ; Elens, Laure ; Polard, Elisabeth ; Saint‐Salvi, Béatrice ; Sommet, Agnès ; Tod, Michel ; Barin‐Le Guellec, Chantal. Potential drug‐drug interactions associated with drugs currently proposed for COVID‐19 treatment in patients receiving other treatments. In: Fundamental & Clinical Pharmacology, Vol. 34, no. 5, p. 530-547 (2020). doi:10.1111/fcp.12586.

http://hdl.handle.net/2078.1/231287

Degraeve, Alexandra ; Moudio Ebosse Timba, Moussinga Serge ; Haufroid, Vincent ; Chaib Eddour, Djamila ; Mourad, Michel ; Bindels, Laure B. ; Elens, Laure. Predictors of tacrolimus pharmacokinetic variability: current evidences and future perspectives.. In: Expert Opinion on Drug Metabolism & Toxicology, Vol. 16, no. 9, p. 769-782 (2020). doi:10.1080/17425255.2020.1803277.

http://hdl.handle.net/2078.1/232126

De Greef, Julien ; Doyen, Louise ; Henrard, Séverine ; Elens, Laure ; Vandercam, Bernard ; Belkhir, Leïla. Should we treat bacteremic prostatitis for 7 days?. In: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Vol. 70, no. 2, p. 351 (2020). doi:10.1093/cid/ciz392.

http://hdl.handle.net/2078.1/215889

Francke, Marith I. ; de Winter, Brenda C.M. ; Elens, Laure ; Lloberas, Nuria ; Hesselink, Dennis A.. The pharmacogenetics of tacrolimus and its implications for personalized therapy in kidney transplant recipients. In: Expert Review of Precision Medicine and Drug Development, Vol. 5, no.5, p. 313-316 (2020). doi:10.1080/23808993.2020.1776107.

http://hdl.handle.net/2078.1/249102

Andrews, L.M. ; Hesselink, D.A. ; Schaik, R.H.N. ; Gelder, T. ; Fijter, J.W. ; Lloberas, N. ; Elens, Laure ; Moes, D.J.A.R. ; Winter, B.C.M.. A population pharmacokinetic model to predict the individual starting dose of tacrolimus in adult renal transplant recipients. In: British Journal of Clinical Pharmacology, (2018). doi:10.1111/bcp.13838.

http://hdl.handle.net/2078.1/210398

Brunet, Mercè ; van Gelder, Teun ; Åsberg, Anders ; Haufroid, Vincent ; Hesselink, Dennis A ; Langman, Loralie ; Lemaitre, Florian ; Marquet, Pierre ; Seger, Christoph ; Shipkova, Maria ; Vinks, Alexander ; Wallemacq, Pierre ; Wieland, Eberhard ; Woillard, Jean Baptiste ; Barten, Markus J ; Budde, Klemens ; Colom, Helena ; Dieterlen, Maja-Theresa ; Elens, Laure ; Johnson-Davis, Kamisha L ; Kunicki, Paweł K ; MacPhee, Iain ; Masuda, Satohiro ; Mathew, Binu S ; Millán, Olga ; Mizuno, Tomoyuki ; Moes, Dirk-Jan A R ; Monchaud, Caroline ; Noceti, Ofelia ; Pawinski, Tomasz ; Picard, Nicolas ; van Schaik, Ron ; Sommerer, Claudia ; Vethe, Nils Tore ; de Winter, Brenda ; Christians, Uwe ; Bergan, Stein. Therapeutic Drug Monitoring of Tacrolimus-Personalized Therapy: Second Consensus Report.. In: Therapeutic drug monitoring, Vol. 41, no.3, p. 261-307 (2019). doi:10.1097/FTD.0000000000000640.

http://hdl.handle.net/2078.1/216688

Ekhart, Corine ; Matic, Maja ; Kant, Agnes ; Elens, Laure ; Puijenbroek, Eugène van ; Schaik, Ron van. Cytochrome P450 genotype and aggressive behavior on selective serotonin reuptake inhibitors. In: Pharmacogenomics, Vol. 19, no. 14, p. 1097-1099 (2018). doi:10.2217/pgs-2018-0122.

http://hdl.handle.net/2078.1/240932

Lloberas, Nuria ; Hesselink, Dennis A ; van Schaik, Ron Hn ; Grinyò, Josep M ; Colom, Helena ; Gelder, Teun van ; Elens, Laure. Detection of a rare CYP3A4 variant in a transplant patient characterized by a tacrolimus poor metabolizer phenotype.. In: Pharmacogenomics, Vol. 19, no.4, p. 305-310 (2018). doi:10.2217/pgs-2017-0301.

http://hdl.handle.net/2078.1/200207

Sennesael, Anne-Laure ; Panin, Nadtha ; Vancraeynest, Christelle ; Pochet, Lionel ; Spinewine, Anne ; Haufroid, Vincent ; Elens, Laure. Effect of ABCB1 genetic polymorphisms on the transport of rivaroxaban in HEK293 recombinant cell lines. In: Scientific Reports, Vol. 8, no. 1, p. 10514 [1-6] (2018). doi:10.1038/s41598-018-28622-4.

http://hdl.handle.net/2078.1/220089

Belkhir, Leïla ; Seguin-Devaux, Carole ; Elens, Laure ; Pauly, Caroline ; Gengler, Nicolas ; Schneider, Serge ; Ruelle, Jean ; Haufroid, Vincent ; Vandercam, Bernard. Impact of UGT1A1 polymorphisms on Raltegravir and its glucuronide plasma concentrations in a cohort of HIV-1 infected patients.. In: Scientific Reports, Vol. 8, no.1, p. 7359 [1-8] (2018). doi:10.1038/s41598-018-25803-z.

http://hdl.handle.net/2078.1/199051

Stillemans, Gabriel ; Belkhir, Leïla ; Hesselink, Dennis A ; Haufroid, Vincent ; Elens, Laure. Pharmacogenetic associations with cytochrome P450 in antiretroviral therapy: what does the future hold?. In: Expert opinion on drug metabolism & toxicology, Vol. 14, no. 6, p. 601-611 (2018). doi:10.1080/17425255.2018.1478964.

http://hdl.handle.net/2078.1/210415

Sennesael, Anne-Laure ; Larock, Anne-Sophie ; Douxfils Jonathan ; Elens, Laure ; Stillemans, Gabriel ; Wiesen, Martin ; Taubert, Max ; Dogné, Jean-Michel ; Spinewine, Anne ; Mullier, François. Rivaroxaban plasma levels in patients admitted for bleeding events: insights from a prospective study.. In: Thrombosis journal, Vol. 16, p. 28 (2018). doi:10.1186/s12959-018-0183-3.

http://hdl.handle.net/2078.1/208106

Andreu, Franc ; Colom, Helena ; Elens, Laure ; van Gelder, Teun ; van Schaik, Ronald H N ; Hesselink, Dennis A ; Bestard, Oriol ; Torras, Joan ; Cruzado, Josep M ; Grinyó, Josep M ; Lloberas, Nuria. A New CYP3A5*3 and CYP3A4*22 Cluster Influencing Tacrolimus Target Concentrations: A Population Approach.. In: Clinical Pharmacokinetics, Vol. 56, p. 963-975 (2017). doi:10.1007/s40262-016-0491-3.

http://hdl.handle.net/2078.1/191541

Matic, Maja ; Jongen, Joost Lm ; Elens, Laure ; de Wildt, Saskia N ; Tibboel, Dick ; Sillevis Smitt, Peter Ae ; van Schaik, Ron Hn. Advanced cancer pain: the search for genetic factors correlated with interindividual variability in opioid requirement.. In: Pharmacogenomics, Vol. 18, no.12, p. 1133-1142 (2017). doi:10.2217/pgs-2017-0060.

http://hdl.handle.net/2078.1/249104

Elens, Laure ; Haufroid, Vincent. Genotype-based tacrolimus dosing guidelines: with or without CYP3A4*22?. In: Pharmacogenomics, Vol. 18, p. 1473-1480 (2017). doi:10.2217/pgs-2017-0131.

http://hdl.handle.net/2078.1/191546

Woillard, Jean-Baptiste ; Mourad, Michel ; Neely, Michael ; Capron, Arnaud ; van Schaik, Ron H ; van Gelder, Teun ; Lloberas, Nuria ; Hesselink, Dennis A ; Marquet, Pierre ; Haufroid, Vincent ; Elens, Laure. Tacrolimus Updated Guidelines through popPK Modeling: How to Benefit More from CYP3A Pre-emptive Genotyping Prior to Kidney Transplantation.. In: Frontiers in Pharmacology, Vol. 8, p. 358 [1-14] (2017). doi:10.3389/fphar.2017.00358.

http://hdl.handle.net/2078.1/185793

Lloberas, Nuria ; Elens, Laure ; Llaudó, Ines ; Padullés, Ariadna ; van Gelder, Teun ; Hesselink, Dennis A ; Colom, Helena ; Andreu, Franc ; Torras, Joan ; Bestard, Oriol ; Cruzado, Josep M ; Gil-Vernet, Salvador ; van Schaik, Ron ; Grinyó, Josep M. The combination of CYP3A4*22 and CYP3A5*3 single-nucleotide polymorphisms determines tacrolimus dose requirement after kidney transplantation.. In: Pharmacogenetics and Genomics, Vol. 27, p. 313-322 (2017). doi:10.1097/FPC.0000000000000296.

http://hdl.handle.net/2078.1/191543

Dessilly, Géraldine ; Elens, Laure ; Panin, Nadtha ; Karmani, Linda ; Demoulin, Jean-Baptiste ; Haufroid, Vincent. ABCB1 1199G>A polymorphism (rs2229109) affects the transport of imatinib, nilotinib and dasatinib.. In: Pharmacogenomics, Vol. 17, no. 8, p. 883-890 (2016). doi:10.2217/pgs-2016-0012.

http://hdl.handle.net/2078.1/174889

Elens, Laure ; Elisabeth, Norman ; Maja, Matic ; Rane, Anders ; Fellman, Vineta ; van Schaik, Ron Hn. Genetic predisposition to poor opioid response in preterm infants: Impact of KCNJ6 and COMT polymorphisms on pain relief after endotracheal intubation.. In: Therapeutic Drug Monitoring, Vol. 38, no. 4, p. 525-33 (2016). doi:10.1097/FTD.0000000000000301.

http://hdl.handle.net/2078.1/174485

Dessilly, Géraldine ; Panin, Nadtha ; Elens, Laure ; Haufroid, Vincent ; Demoulin, Jean-Baptiste. Impact of ABCB1 1236C > T-2677G > T-3435C > T polymorphisms on the anti-proliferative activity of imatinib, nilotinib, dasatinib and ponatinib.. In: Scientific Reports, Vol. 6, p. 29559 [1-9] (2016). doi:10.1038/srep29559.

http://hdl.handle.net/2078.1/183376

Belkhir, Leïla ; Elens, Laure ; Zech, Francis ; Panin, Nadtha ; Vincent, Anne ; Yombi, Jean Cyr ; Vandercam, Bernard ; Haufroid, Vincent. Interaction between Darunavir and Etravirine Is Partly Mediated by CYP3A5 Polymorphism.. In: PLoS One, Vol. 11, no. 10, p. e0165631 [1-13] (2016). doi:10.1371/journal.pone.0165631.

http://hdl.handle.net/2078.1/179341

Belkhir, Leïla ; de Laveleye, Morgane ; Vandercam, Bernard ; Zech, Francis ; Delongie, Kévin-Alexandre ; Capron, Arnaud ; Yombi, Jean Cyr ; Vincent, Anne ; Elens, Laure ; Haufroid, Vincent. Quantification of darunavir and etravirine in human peripheral blood mononuclear cells using high performance liquid chromatography tandem mass spectrometry (LC-MS/MS), clinical application in a cohort of 110 HIV-1 infected patients and evidence of a potential drug-drug interaction. In: Clinical Biochemistry, Vol. 49, no. 7-8, p. 580-586 (2016). doi:10.1016/j.clinbiochem.2015.12.011.

http://hdl.handle.net/2078.1/172077

Matic, Maja ; de Wildt, Saskia N ; Elens, Laure ; de Hoon, Jan N ; Annaert, Pieter ; Tibboel, Dick ; van Schaik, Ron Hn ; Allegaert, Karel. SLC22A1 /OCT1 genotype affects O-desmethyltramadol exposure in new-born infants.. In: Therapeutic Drug Monitoring, Vol. EPub, no.AOP, p. 1 (2016). doi:10.1097/FTD.0000000000000307.

http://hdl.handle.net/2078.1/174484

Traynor, Carol ; Conlon, Peter ; Phelan, Paul J ; O'Kelly, Patrick ; Elens, Laure ; McCormack, Mark ; Cavalleri, Gianpiero ; Comber, Harry ; van Schaik, R H N ; Conlon, Peter J. Association of CYP3A variants with kidney transplant outcomes.. In: Renal Failure, Vol. 37, no. 4, p. 562-566 (2015). doi:10.3109/0886022X.2015.1007013.

http://hdl.handle.net/2078.1/161644

De Berdt, Pauline ; Vanacker, Julie ; Ucakar, Bernard ; Elens, Laure ; Diogenes, Anibal ; Leprince, Julian ; Deumens, Ronald ; des Rieux, Anne. Dental Apical Papilla as Therapy for Spinal Cord Injury. In: Journal of Dental Research, Vol. 94, no.11, p. 1575-1581 (2015). doi:10.1177/0022034515604612.

http://hdl.handle.net/2078.1/167569

Ragia, Georgia ; Kolovou, Vana ; Tavridou, Anna ; Elens, Laure ; Tselepis, Alexandros D ; Elisaf, Moses ; Van Schaik, Ron H N ; Kolovou, Genovefa ; Manolopoulos, Vangelis G. No effect of CYP3A4 intron 6 C>T polymorphism (CYP3A4*22) on lipid-lowering response to statins in Greek patients with primary hypercholesterolemia. In: Drug metabolism and personalized therapy, Vol. 30, no. 1, p. 43-48 (2015). doi:10.1515/dmdi-2014-0021.

http://hdl.handle.net/2078.1/161649

de Jonge, H. ; Elens, Laure ; de Loor, H. ; van Schaik, R. H. ; Kuypers, D. R. J.. The CYP3A4*22 C>T single nucleotide polymorphism is associated with reduced midazolam and tacrolimus clearance in stable renal allograft recipients.. In: The Pharmacogenomics Journal, Vol. 15, no. 2, p. 144-152 (2015).

http://hdl.handle.net/2078.1/157810

Dessilly, Géraldine ; Elens, Laure ; Panin, Nadtha ; Capron, Arnaud ; Decottignies, Anabelle ; Demoulin, Jean-Baptiste ; Haufroid, Vincent. ABCB1 1199G>A genetic polymorphism (Rs2229109) influences the intracellular accumulation of tacrolimus in HEK293 and K562 recombinant cell lines. In: PLoS One, Vol. 9, no. 3, p. e91555 [1-11] (2014). doi:10.1371/journal.pone.0091555.

http://hdl.handle.net/2078.1/144862

Ragia, Georgia ; Tavridou, Anna ; Elens, Laure ; Van Schaik, Ron H. N. ; Manolopoulos, Vangelis G.. CYP2C9*2 allele increases risk for hypoglycemia in POR*1/*1 type 2 diabetic patients treated with sulfonylureas. In: Experimental and Clinical Endocrinology and Diabetes, Vol. 122, no. 1, p. 60-63 (2014). doi:10.1055/s-0033-1361097.

http://hdl.handle.net/2078.1/159739

Elens, Laure ; Bouamar, Rachida ; Shuker, Nauras ; Hesselink, Dennis A. ; Van Gelder, Teun ; Van Schaik, Ron H. N.. Clinical implementation of pharmacogenetics in kidney transplantation: Calcineurin inhibitors in the starting blocks. In: British Journal of Clinical Pharmacology, Vol. 77, no. 4, p. 715-728 (2014). doi:10.1111/bcp.12253.

http://hdl.handle.net/2078.1/159832

Matic, Maja ; Norman, Elisabeth ; Rane, Anders ; Beck, Olof ; Andersson, Maria ; Elens, Laure ; Tibboel, Dick ; Fellman, Vineta ; van Schaik, Ron H N. Effect of UGT2B7 -900G>A (-842G>A; rs7438135) on morphine glucuronidation in preterm newborns: results from a pilot cohort.. In: Pharmacogenomics, Vol. 15, no. 12, p. 1589-1597 (2014).

http://hdl.handle.net/2078.1/161652

Matic, Maja ; Norman, Elisabeth ; Rane, Anders ; Beck, Olof ; Andersson, Maria ; Elens, Laure ; Tibboel, Dick ; Fellman, Vineta ; Van Schaik, Ron H.N.. Effect of UGT2B7-900G>A (-842G>A; rs7438135) on morphine glucuronidation in preterm newborns: Results from a pilot cohort. In: Pharmacogenomics, Vol. 15, no. 12, p. 1589-1597 (2014). doi:10.2217/pgs.14.115.

http://hdl.handle.net/2078.1/159852

Elens, Laure ; Hesselink, Dennis A ; Bouamar, Rachida ; Budde, Klemens ; de Fijter, Johannes W ; De Meyer, Martine ; Mourad, Michel ; Kuypers, Dirk R J ; Haufroid, Vincent ; van Gelder, Teun ; van Schaik, Ron H N. Impact of POR*28 on the pharmacokinetics of tacrolimus and cyclosporine A in renal transplant patients. In: Therapeutic Drug Monitoring, Vol. 36, no. 1, p. 71-79 (2014). doi:10.1097/FTD.0b013e31829da6dd.

http://hdl.handle.net/2078.1/139014

Guy-Viterbo, Vanessa ; Baudet, Henry ; Elens, Laure ; Haufroid, Vincent ; Lacaille, Florence ; Girard, Muriel ; Debray, Dominique ; Chardot, Christophe ; Reding, Raymond ; Wallemacq, Pierre ; Musuamba, Flora. Influence of donor-recipient CYP3A4/5 genotypes, age and fluconazole on tacrolimus pharmacokinetics in pediatric liver transplantation: a population approach. In: Pharmacogenomics, Vol. 15, no. 9, p. 1207-1221 (2014). doi:10.2217/pgs.14.75.

http://hdl.handle.net/2078.1/150321

Ragia, Georgia ; Kolovou, Vana ; Tavridou, Anna ; Elens, Laure ; Tselepis, Alexandros D. ; Elisaf, Moses ; Van Schaik, Ron H. N. ; Kolovou, Genovefa ; Manolopoulos, Vangelis G.. Lack of association of the P450 oxidoreductase *28 single nucleotide polymorphism with the lipid-lowering effect of statins in hypercholesterolemic patients. In: Molecular Diagnosis and Therapy, Vol. 18, no. 3, p. 323-331 (2014). doi:10.1007/s40291-013-0082-z.

http://hdl.handle.net/2078.1/159787

Drogari, Euridiki ; Ragia, Georgia ; Mollaki, Vasiliki ; Elens, Laure ; Van Schaik, Ron H N ; Manolopoulos, Vangelis G. POR*28 SNP is associated with lipid response to atorvastatin in children and adolescents with familial hypercholesterolemia. In: Pharmacogenomics, Vol. 15, no. 16, p. 1963-1972 (2014). doi:10.2217/pgs.14.138.

http://hdl.handle.net/2078.1/161646

Matic, Maja ; Simons, Sinno H.P. ; Van Lingen, Richard A. ; Van Rosmalen, Joost ; Elens, Laure ; De Wildt, Saskia N. ; Tibboel, Dick ; Van Schaik, Ron H.N.. Rescue morphine in mechanically ventilated newborns associated with combined OPRM1 and COMT genotype. In: Pharmacogenomics, Vol. 15, no. 10, p. 1287-1295 (2014). doi:10.2217/pgs.14.100.

http://hdl.handle.net/2078.1/159836

Hesselink, Dennis A. ; Bouamar, Rachida ; Elens, Laure ; Van Schaik, Ron H. N. ; Van Gelder, Teun. The role of pharmacogenetics in the disposition of and response to tacrolimus in solid organ transplantation. In: Clinical Pharmacokinetics, Vol. 53, no. 2, p. 123-139 (2014). doi:10.1007/s40262-013-0120-3.

http://hdl.handle.net/2078.1/160495

de Graan, Anne-Joy M ; Elens, Laure ; Smid, Marcel ; Martens, John W ; Sparreboom, Alex ; Nieuweboer, Annemieke J M ; Friberg, Lena E ; Elbouazzaoui, Samira ; Wiemer, Erik A C ; van der Holt, Bronno ; Verweij, Jaap ; van Schaik, Ron H N ; Mathijssen, Ron H J. A pharmacogenetic predictive model for paclitaxel clearance based on the DMET platform.. In: Clinical Cancer Research, Vol. 19, no.18, p. 5210-5217 (2013). doi:10.1158/1078-0432.CCR-13-0487.

http://hdl.handle.net/2078.1/161647

Elens, Laure ; Nieuweboer, Annemieke ; Clarke, Stephen J ; Charles, Kellie A ; de Graan, Anne-Joy ; Haufroid, Vincent ; Mathijssen, Ron H J ; van Schaik, Ron H N. CYP3A4 intron 6 C>T SNP (CYP3A4*22) encodes lower CYP3A4 activity in cancer patients, as measured with probes midazolam and erythromycin.. In: Pharmacogenomics, Vol. 14, no.2, p. 137-149 (2013). doi:10.2217/pgs.12.202.

http://hdl.handle.net/2078.1/161648

Gijsen, Violette Mgj ; Van Schaik, Ron Hn ; Elens, Laure ; Soldin, Offie P ; Soldin, Steven J ; Koren, Gideon ; De Wildt, Saskia N. CYP3A4*22 and CYP3A combined genotypes both correlate with tacrolimus disposition in pediatric heart transplant recipients. In: Pharmacogenomics, Vol. 14, no. 9, p. 1027-1036 (2013). doi:10.2217/pgs.13.80.

http://hdl.handle.net/2078.1/160706

de Graan, Anne-Joy M ; Elens, Laure ; Sprowl, Jason A ; Sparreboom, Alex ; Friberg, Lena E ; van der Holt, Bronno ; de Raaf, Pleun J ; de Bruijn, Peter ; Engels, Frederike K ; Eskens, Ferry A L M ; Wiemer, Erik A C ; Verweij, Jaap ; Mathijssen, Ron H J ; van Schaik, Ron H N. CYP3A4*22 genotype and systemic exposure affect paclitaxel-induced neurotoxicity.. In: Clinical Cancer Research, Vol. 19, no.12, p. 3316-3324 (2013). doi:10.1158/1078-0432.CCR-12-3786.

http://hdl.handle.net/2078.1/161653

Elens, Laure ; van Gelder, Teun ; Hesselink, Dennis A ; Haufroid, Vincent ; van Schaik, Ron H N. CYP3A4*22: promising newly identified CYP3A4 variant allele for personalizing pharmacotherapy. In: Pharmacogenomics, Vol. 14, no. 1, p. 47-62 (2013). doi:10.2217/pgs.12.187.

http://hdl.handle.net/2078.1/125649

Becker, M L ; Elens, Laure ; Visser, L E ; Hofman, A ; Uitterlinden, A G ; van Schaik, R H N ; Stricker, B H. Genetic variation in the ABCC2 gene is associated with dose decreases or switches to other cholesterol-lowering drugs during simvastatin and atorvastatin therapy.. In: The Pharmacogenomics Journal, Vol. 13, no.3, p. 251-256 (2011). doi:10.1038/tpj.2011.59.

http://hdl.handle.net/2078.1/161651

De Keyser, Catherine E ; Becker, Matthijs L ; Uitterlinden, André G ; Hofman, Albert ; Lous, Jan J ; Elens, Laure ; Visser, Loes E ; Van Schaik, Ron Hn ; Stricker, Bruno H. Genetic variation in the PPARA gene is associated with simvastatin-mediated cholesterol reduction in the Rotterdam Study. In: Pharmacogenomics, Vol. 14, no. 11, p. 1295-1304 (2013). doi:10.2217/pgs.13.112.

http://hdl.handle.net/2078.1/160705

Elens, Laure ; Capron, Arnaud ; van Schaik, Ron H N ; De Meyer, Martine ; De Pauw, Luc ; Eddour, Djamila C ; Latinne, Dominique ; Wallemacq, Pierre ; Mourad, Michel ; Haufroid, Vincent. Impact of CYP3A4*22 allele on tacrolimus pharmacokinetics in early period after renal transplantation: toward updated genotype-based dosage guidelines. In: Therapeutic Drug Monitoring, Vol. 35, no. 5, p. 608-616 (2013). doi:10.1097/FTD.0b013e318296045b.

http://hdl.handle.net/2078.1/134918

Elens, Laure ; Nieuweboer, Annemieke J M ; Clarke, Stephen J ; Charles, Kellie A ; de Graan, Anne-Joy M ; Haufroid, Vincent ; van Gelder, Teun ; Mathijssen, Ron H J ; van Schaik, Ron H N. Impact of POR*28 on the clinical pharmacokinetics of CYP3A phenotyping probes midazolam and erythromycin.. In: Pharmacogenetics and Genomics, Vol. 23, no.3, p. 148-155 (2013). doi:10.1097/FPC.0b013e32835dc113.

http://hdl.handle.net/2078.1/146515

Elens, Laure ; Sombogaard, Ferdi ; Hesselink, Dennis A ; van Schaik, Ron H N ; van Gelder, Teun. Single-nucleotide polymorphisms in P450 oxidoreductase and peroxisome proliferator-activated receptor-α are associated with the development of new-onset diabetes after transplantation in kidney transplant recipients treated with tacrolimus.. In: Pharmacogenetics and Genomics, Vol. 23, no.12, p. 649-657 (2013). doi:10.1097/FPC.0000000000000001.

http://hdl.handle.net/2078.1/161645

Elens, Laure ; Hesselink, Dennis A ; van Schaik, Ron H N ; van Gelder, Teun. The CYP3A4*22 allele affects the predictive value of a pharmacogenetic algorithm predicting tacrolimus predose concentrations. In: British Journal of Clinical Pharmacology, Vol. 75, no. 6, p. 1545-1547 (2013). doi:10.1111/bcp.12038.

http://hdl.handle.net/2078/117980

Ahlers, Sabine J G M ; Elens, Laure ; van Gulik, Laura ; van Schaik, Ron H ; van Dongen, Eric P A ; Bruins, Peter ; Tibboel, Dick ; Knibbe, Catherijne A J. The Val158Met polymorphism of the COMT gene is associated with increased pain sensitivity in morphine-treated patients undergoing a painful procedure after cardiac surgery.. In: British Journal of Clinical Pharmacology, Vol. 75, no.6, p. 1506-1515 (2013). doi:10.1111/bcp.12052.

http://hdl.handle.net/2078.1/161650

De Meyer, Martine ; Haufroid, Vincent ; Elens, Laure ; Fusaro, Fabio ; Patrono , Damiano ; De Pauw, Luc ; Kanaan, Nada ; Goffin, Eric ; Mourad, Michel. Donor age and ABCB1 1199G>A genetic polymorphism are independent factors affecting long-term renal function after kidney transplantation.. In: Journal of Surgical Research, Vol. 178, no.2, p. 988-95 (2012). doi:10.1016/j.jss.2012.06.070.

http://hdl.handle.net/2078.1/118125

de Graan, Anne-Joy M ; Lancaster, Cynthia S ; Obaidat, Amanda ; Hagenbuch, Bruno ; Elens, Laure ; Friberg, Lena E ; de Bruijn, Peter ; Hu, Shuiying ; Gibson, Alice A ; Bruun, Gitte H ; Corydon, Thomas J ; Mikkelsen, Torben S ; Walker, Aisha L ; Du, Guoqing ; Loos, Walter J ; van Schaik, Ron H N ; Baker, Sharyn D ; Mathijssen, Ron H J ; Sparreboom, Alex. Influence of polymorphic OATP1B-type carriers on the disposition of docetaxel.. In: Clinical Cancer Research, Vol. 18, no. 16, p. 4433-4440 (2012). doi:10.1158/1078-0432.CCR-12-0761.

http://hdl.handle.net/2078.1/125645

Bouamar, Rachida ; Elens, Laure ; Shuker, Nauras ; van Schaik, Ron H N ; Weimar, Willem ; Hesselink, Dennis A ; van Gelder, Teun. Mycophenolic acid-related anemia and leucopenia in renal transplant recipients are related to genetic polymorphisms in CYP2C8.. In: Transplantation, Vol. 93, no.10, p. e39-40; author reply e41-2 (2012). doi:10.1097/TP.0b013e3182488bb4.

http://hdl.handle.net/2078.1/125610

Elens, Laure ; Hesselink, Dennis A ; van Schaik, Ron H N ; van Gelder, Teun. Pharmacogenetics in kidney transplantation: recent updates and potential clinical applications. In: Molecular Diagnosis and Therapy, Vol. 16, no. 6, p. 331-345 (2012). doi:10.1007/s40291-012-0012-5.

http://hdl.handle.net/2078.1/125651

Elens, Laure ; Bouamar, Rachida ; Hesselink, Dennis A ; Haufroid, Vincent ; van Gelder, Teun ; van Schaik, Ron H N. The new CYP3A4 intron 6 C>T polymorphism (CYP3A4*22) is associated with an increased risk of delayed graft function and worse renal function in cyclosporine-treated kidney transplant patients.. In: Pharmacogenetics and genomics, Vol. 22, no.5, p. 373-80 (2012). doi:10.1097/FPC.0b013e328351f3c1.

http://hdl.handle.net/2078.1/144882

Elens, Laure ; Bouamar, Rachida ; Hesselink, Dennis A ; Haufroid, Vincent ; van der Heiden, Ilse P ; van Gelder, Teun ; van Schaik, Ron H N. A new functional CYP3A4 intron 6 polymorphism significantly affects tacrolimus pharmacokinetics in kidney transplant recipients.. In: Clinical Chemistry : international journal of molecular diagnostics and laboratory medicine, Vol. 57, no. 11, p. 1574-83 (2011). doi:10.1373/clinchem.2011.165613.

http://hdl.handle.net/2078.1/106381

Elens, Laure ; van Schaik, Ron H. ; Panin, Nadtha ; De Meyer, Martine ; Wallemacq, Pierre ; Lison, Dominique ; Mourad, Michel ; Haufroid, Vincent. Effect of a new functional CYP3A4 polymorphism on calcineurin inhibitors' dose requirements and trough blood levels in stable renal transplant patients. In: Pharmacogenomics, Vol. 12, no. 10, p. 1383-1396 (2011). doi:10.2217/pgs.11.90.

http://hdl.handle.net/2078.1/88292

Elens, Laure ; Tyteca, Donatienne ; Panin, Nadtha ; Courtoy, Pierre J. ; Lison, Dominique ; Demoulin, Jean-Baptiste ; Haufroid, Vincent. Functional defect caused by the 4544G>A SNP in ABCC2 : potential impact for drug cellular disposition.. In: Pharmacogenetics and Genomics, Vol. 21, no. 12, p. 884-893 (2011). doi:10.1097/FPC.0b013e32834d672b.

http://hdl.handle.net/2078.1/96945

Elens, Laure ; Vandercam, Bernard ; Yombi, Jean Cyr ; Lison, Dominique ; Wallemacq, Pierre ; Haufroid, Vincent. Influence of host genetic factors on efavirenz plasma and intracellular pharmacokinetics in HIV-1-infected patients.. In: Pharmacogenomics, Vol. 11, no. 9, p. 1223-1234 (2010). doi:10.2217/pgs.10.94.

http://hdl.handle.net/2078.1/105869

Elens, Laure ; Becker, Matthijs L ; Haufroid, Vincent ; Hofman, Albert ; Visser, Loes E ; Uitterlinden, André G ; Stricker, Bruno Ch ; van Schaik, Ron H N. Novel CYP3A4 intron 6 single nucleotide polymorphism is associated with simvastatin-mediated cholesterol reduction in The Rotterdam Study.. In: Pharmacogenetics and Genomics, Vol. 21, no. 12, p. 861-6 (2011). doi:10.1097/FPC.0b013e32834c6edb.

http://hdl.handle.net/2078.1/106380

Capron, Arnaud ; Mourad, Michel ; De Meyer, Martine ; De Pauw, Luc ; Eddour, Djamila Chaib ; Latinne, Dominique ; Elens, Laure ; Haufroid, Vincent ; Wallemacq, Pierre. CYP3A5 and ABCB1 polymorphisms influence tacrolimus concentrations in peripheral blood mononuclear cells after renal transplantation.. In: Pharmacogenomics, Vol. 11, no. 5, p. 703-714 (2010). doi:10.2217/pgs.10.43.

http://hdl.handle.net/2078.1/32182

Elens, Laure ; Haufroid, Vincent ; Doyen, Chantal ; Vandercam, Bernard ; Yombi, Jean Cyr. Acute intoxication with nevirapine in an HIV-1-infected patient : clinical and pharmacokinetic follow up.. In: AIDS (London, England), Vol. 23, no. 10, p. 1291-1293 (2009). doi:10.1097/QAD.0b013e328325d61f.

http://hdl.handle.net/2078.1/26604

Elens, Laure ; Yombi, Jean Cyr ; Lison, Dominique ; Wallemacq, Pierre ; Vandercam, Bernard ; Haufroid, Vincent. Association between ABCC2 polymorphism and lopinavir accumulation in peripheral blood mononuclear cells of HIV-infected patients. In: Pharmacogenomics, Vol. 10, no. 10, p. 1589-1597 (2009). doi:10.2217/PGS.09.88.

http://hdl.handle.net/2078.1/105883

Elens, Laure ; Yombi, Jean-Cyr ; Lison, Dominique ; Wallemacq, Pierre ; Vandercam, Bernard ; Haufroid, Vincent. Association between ABCC2 polymorphism and lopinavir accumulation in peripheral blood mononuclear cells of HIV-infected patients.. In: Pharmacogenomics, Vol. 10, no.10, p. 1589-1597 (2009). doi:10.2217/pgs.09.88.

http://hdl.handle.net/2078.1/161654

Elens, Laure ; Veriter, Sophie ; Yombi, Jean Cyr ; Di Fazio, V ; Vanbinst, R ; Lison, Dominique ; Wallemacq, Pierre ; Vandercam, B ; Haufroid, Vincent. Validation and Clinical Application of a High Performance Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) Method for the Quantitative Determination of 10 Antiretrovirals in Human Peripheral Blood Mononuclear Cells. In: Therapeutic drug monitoring, Vol. 31, no. 5, p. 19 - (2009).

http://hdl.handle.net/2078.1/105885

Elens, Laure ; Veriter, Sophie ; Yombi, Jean Cyr ; Di Fazio, V. ; Vanbinst, R. ; Lison, Dominique ; Wallemacq, Pierre ; Vandercam, Bernard ; Haufroid, Vincent. Validation and clinical application of a high performance liquid chromatography tandem mass spectrometry (LC-MS/MS) method for the quantitative determination of 10 anti-retrovirals in human peripheral blood mononuclear cells.. In: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, Vol. 877, no. 20-21, p. 1805-14 (2009). doi:10.1016/j.jchromb.2009.04.046.

http://hdl.handle.net/2078.1/22495

Elens, Laure ; Veriter, Sophie ; Di Fazio, Vincent ; Vanbinst, Roger ; Boesmans, Daniel ; Wallemacq, Pierre ; Haufroid, Vincent. Quantification of 8 HIV-Protease Inhibitors and 2 Nonnucleoside Reverse Transcriptase Inhibitors by Ultra-Performance Liquid Chromatography with Diode Array Detection.. In: Clinical chemistry, Vol. 55, no. 1, p. 170-174 (2009). doi:10.1373/clinchem.2008.108647.

http://hdl.handle.net/2078.1/20027

Elens, Laure ; Capron, Arnaud ; Kerckhove, Valérie Van ; Lerut, Jan ; Mourad, Michel ; Lison, Dominique ; Wallemacq, Pierre ; Haufroid, Vincent. 1199G>A and 2677G>T/A polymorphisms of ABCB1 independently affect tacrolimus concentration in hepatic tissue after liver transplantation.. In: Pharmacogenetics and Genomics, Vol. 17, no. 10, p. 873-883 (2007). doi:10.1097/FPC.0b013e3282e9a533.

http://hdl.handle.net/2078.1/11119