LDRI
Avenue Mounier 73/B1.73.11
1200 Woluwe-Saint-Lambert
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- Laure Bindels
Laure Bindels
Professeure
PROFESSIONAL EXPERIENCE
Assistant Professor in Metabolomics (UCLouvain, tenured), Louvain Drug Research Institute. August 2016 – ongoing. “Harnessing the therapeutic potential of the gut microbiota for cancer and cachexia: beyond the usual suspects”
FNRS Post-doctoral Researcher (UCLouvain), Louvain Drug Research Institute, with Prof Nathalie Delzenne. July 2014 – August 2016. “Gut microbiota as a causative factor for cancer-related cachexia: involvement of the gut barrier function”
Post-doctoral Research Associate (University of Nebraska-Lincoln, NE, USA) in the Mucosal Immunology Lab, Prof Amanda Ramer-Tait and in the Gastrointestinal Microbiology Lab, Prof Jens Walter. July 2013 – June 2014. “Role of the gut microbiota in the metabolic improvements induced by resistant starches in obese mice”
Post-doctoral Researcher (UCLouvain), Louvain Drug Research Institute, with Prof Nathalie Delzenne. April 2013 - June 2013. Walloon Region-funded project (NutriGUTior) dedicated to the investigation of nutritional compounds to improve intestinal health in the elderly
FNRS fellow (UCLouvain), Louvain Drug Research Institute, with Prof Nathalie Delzenne. October 2008 - March 2013. “Gut-immunity relationship in the control of cachexia associated with tumour development: role of the gut microbiota.”
EDUCATION
- Roo programming and package development. A one-day intensive workshop. October 2019.
- MixOmics workshop (20h). A two-day intensive workshop on multi -omics data integration. November 17.
- 15.071x The Analytics Edge (MITx-edX) (90h). A course for multivariate and logistic analyses of large datasets organized by the Massachusetts Institute of Technology, Massachusetts, MA, USA. February – May 2015.
- European Nutrition Leadership Program (ENLP). April 2015.
- Intercultural Leadership skills workshop for postdocs supported by Prins Filip Fonds. September 2014.
- Perl Programming for Biological Applications (UNL, 3 credits, 75h). September-December 2013.
- Intensive one-week workshop: “Next-generation sequencing technologies and bioinformatics analyses” with Dr Ines Martinez, University of Nebraska-Lincoln, NE, USA. August 2013.
- PhD in Biomedical and Pharmaceutical Sciences (UCLouvain). Role of gut microbiota modulation in the control of cancer progression and associated cachexia. Thesis director: Prof. Nathalie Delzenne, Université catholique de Louvain (UCLouvain), Belgium. Mars 2013.
- First Nutrimetabonomics Workshop (University of Reading, UK). April 2012.
- Master in Animal Experimentation (UCLouvain). June 2009.
- Pharmacist (UCLouvain). June 2008.
PRIZES & AWARDS
- Pharmabiotics Young Investigators Award (2018), to fund future research
- Prix Docteur Maurice Godin-Maria Savelkoul (triennial prize from the Académie royale de Médecine de Belgique) (2016)
- Scholarship for the Next Gen Immunology 2016 meeting sponsored by the Weizmann Systems Biology initiative (2016)
- Award Danone Institute for the best popular article in nutrition (2015)
- Young Investigator Award from the Society on Cachexia and Wasting Disorders (2015)
- Nebraska Gateway to Nutrigenomics Research Award (2014)
- Honorary Fellowship from the B.A.E.F. (Belgian American Education Foundation) (2014)
- Early Career Investigator Travel Fellowship from the New York Academy of Sciences (2013)
- Keystone Symposium Scholarship, grant from the NIH, Colorado, USA (2012)
- Prize of Excellence for the research activities conducted as undergrad student, UCL, Belgium (2008)
- “Pharmacist & Doctor Nedeljkovitch” Award, Belgian Society of Pharmaceutical Sciences, Belgium (2008)
Last updated: February 2021.
- Diplômes
Année Label Institution 2008 Pharmacienne Université catholique de Louvain 2013 Docteur en sciences biomédicales et pharmaceutiques Université catholique de Louvain
- Les cours
Nom ID Atelier informatique et de recherche bibliographique appliquée au médicament WFARM1239 Pharmacocinétique et métabolisme des xénobiotiques WFARM1300 Génétique et biotechnologie pharmaceutiques WFARM1383 Processus de découverte, de développement et de mise sur le marché du médicament WFARM2128 Pharmacocinétique, pharmacogénomique et toxicologie WFARM2139 Analyse des médicaments issus des biotechnologies WFARM2266 Introduction à la toxicologie analytique WFARM2502 Pharmacodépendance et toxicomanie WFARM2514 Nutrition et environnement : aspects biologique et toxicologique WSBIM2137 Innovation and research in nutrition WSBIM2138 Nutrition et environnement : aspect sociétal WSBIM2237 Special issues in cancerology WSBIM2244 In-session seminar in biomedicine WSBIM2245
RESEARCH TOPIC
The gut microbiota consists of the trillions of microbes that reside in the gastrointestinal tract of mammals, and has a vast impact on host physiology and metabolism. My research program is mainly dedicated to the investigation of the role and therapeutic potential of the gut microbiota in the progression of non-gastrointestinal cancers and associated cachexia. Cancer cachexia refers to the metabolic alterations linked to cancer progression. Cachexia leads to patient weight loss; it affects up to 50% of cancer patients, causing mortality in 20% of them. Studying the gut microbiota as a therapeutic target constitutes an innovative approach to this pathology, an approach currently followed by my newly established team. Additional projects focus on the role of bacterial and microbial metabolites in various metabolic disorders and in the modulation of drug pharmacokinetics.
A summary of our key research results regarding the gut microbiota-host crosstalk in cancer cachexia can be found here. Recorded presentations can be found here (Cancer Cachexia Seminars, April 2021) and here (Académie Royale de Medecine de Belgique, Novembre 2019, in French) . You can also have a look at this talk I gave on our research at the Oslo Cancer Cluster in January 2018.
Want more information ? Do not hesitate to contact me. We are often looking for highly motivated master students to perform their thesis or project work in our group. Please reach out and let us know about your motivations.
THE 5 MOST IMPORTANT ORAL COMMUNICATIONS OF MY CAREER
- New York Academy of Sciences "Confronting Cachexia - A Disease within a Disease" webinar, online meeting, 16 APril 2021. Invited speaker.
- Keystone Symposium “Microbiome, Host Resistance and Disease”, Banff, Canada, 4-8 March 2018. Invited Speaker.
- The 6th Exploring Human Host-Microbiome Interactions in Health and Disease (Wellcome Trust Scientific Conference), Hinxton, United Kingdom, 13-15 September 2017. Invited speaker.
- ASM Microbes - Annual Meeting of the American Society for Microbiology (ASM), Boston, US, 16-20 June 2016. Invited by Lita Proctor (NIH Project Coordinator) for a plenary session.
- The 8th Cachexia Conference, Paris, France, 4-6 December 2015. Oral communication. Young Investigators Award (selected among 265 accepted abstracts).
Invited speaker in international and national events (22/9), local seminars (15) and educational seminars (9). A full list of my oral communications is available here.
CURRENT LAB MEMBERS UNDER MY SUPERVISION
- Sarah Pötgens, UCLouvain teaching assistant (Thesis director)
- Morgane Thibaut, FNRS-FRIA fellow (Thesis director)
- Alexandra Degraeve, F.R.S.-FNRS fellow (Thesis Co-director)
- Justine Gillard, F.R.S.-FNRS fellow (Thesis Co-director)
- Dr Adeline Dolly, F.R.S.-FNRS postdoctoral researcher
- Dr Camille Lefevre, UCLouvain postdoctoral researcher
- Martin Nicolas, research technician
A full list of our group with shared technical and logistical expertise can be found here.
Last updated: April 2021.
2021
Nachit, Maxime Younes ; Lanthier, Nicolas ; Rodriguez, Julie ; Neyrinck, Audrey M. ; Cani, Patrice D. ; Bindels, Laure B. ; Hiel, Sophie ; Pachikian, Barbara D. ; Trefois, Pierre ; Thissen, Jean-Paul ; Delzenne, Nathalie M.. A dynamic association between myosteatosis and liver stiffness: Results from a prospective interventional study in obese patients. In: JHEP Reports, Vol. 3, no. 4, p. 100323 [1-10] (2021). doi:10.1016/j.jhepr.2021.100323.
2021
Amadieu, Camille ; Leclercq, Sophie ; Coste, Valentin ; Thijssen, Victoria ; Neyrinck, Audrey M. ; Bindels, Laure B. ; Cani, Patrice D. ; Piessevaux, Hubert ; Starkel, Peter ; De Timary, Philippe ; Delzenne, Nathalie M.. Dietary fiber deficiency as a component of malnutrition associated with psychological alterations in alcohol use disorder.. In: Clinical nutrition, Vol. 40, no. 5, p. 2673-2682 (2021). doi:10.1016/j.clnu.2021.03.029.
2021
Le Roy, Tiphaine ; Moens De Hase, Emilie ; Van Hul, Matthias ; Paquot, Adrien ; Pelicaen, Rudy ; Régnier, Marion ; Depommier, Clara ; Druart, Céline ; Everard, Amandine ; Maiter, Dominique ; Delzenne, Nathalie M. ; Bindels, Laure B. ; de Barsy, Marie ; Loumaye, Audrey ; Hermans, Michel ; Thissen, Jean-Paul ; Vieira-Silva, Sara ; Falony, Gwen ; Raes, Jeroen ; Muccioli, Giulio ; Cani, Patrice D.. Dysosmobacter welbionis is a newly isolated human commensal bacterium preventing diet-induced obesity and metabolic disorders in mice. In: Gut, p. gutjnl-2020-323778 (2021). doi:10.1136/gutjnl-2020-323778.
2021
Breton, Jonathan ; Tirelle, Pauline ; Hasanat, Soujoud ; Pernot, Arthur ; L'Huillier, Clément ; do Rego, Jean-Claude ; Déchelotte, Pierre ; Coëffier, Moïse ; Bindels, Laure B. ; Ribet, David. Gut microbiota alteration in a mouse model of Anorexia Nervosa.. In: Clinical Nutrition, Vol. 40, no. 1, p. 181-189 (2021). doi:10.1016/j.clnu.2020.05.002.
2021
Knudsen, Christelle ; Neyrinck, Audrey M. ; Leyrolle, Quentin ; Baldin, Paméla ; Leclercq, Sophie ; Rodriguez, Julie ; Beaumont, Martin ; Cani, Patrice D. ; Bindels, Laure B. ; Lanthier, Nicolas ; Delzenne, Nathalie M.. Hepatoprotective Effects of Indole, a Gut Microbial Metabolite, in Leptin-Deficient Obese Mice.. In: The Journal of nutrition, , p. [1-10] (2021). doi:10.1093/jn/nxab032 (Accepté/Sous presse).
2021
Neyrinck, Audrey M. ; Rodriguez, Julie ; Taminiau, Bernard ; Amadieu, Camille ; Herpin, Florent ; Allaert, François-André ; Cani, Patrice D. ; Daube, Georges ; Bindels, Laure B. ; Delzenne, Nathalie M.. Improvement of gastrointestinal discomfort and inflammatory status by a synbiotic in middle-aged adults: a double-blind randomized placebo-controlled trial.. In: Scientific reports, Vol. 11, no.1, p. 2627 [1-12] (2021). doi:10.1038/s41598-020-80947-1.
2021
Thibaut, Morgane ; Sboarina, Martina ; Roumain, Martin ; Pötgens, Sarah ; Neyrinck, Audrey M. ; Destrée, Florence ; Gillard, Justine ; Leclercq, Isabelle ; Dachy, Guillaume ; Demoulin, Jean-Baptiste ; Tailleux, Anne ; Lestavel, Sophie ; Rastelli, Marialetizia ; Everard, Amandine ; Cani, Patrice D. ; Porporato, Paolo E ; Loumaye, Audrey ; Thissen, Jean-Paul ; Muccioli, Giulio ; Delzenne, Nathalie M. ; Bindels, Laure B.. Inflammation-induced cholestasis in cancer cachexia.. In: Journal of cachexia, sarcopenia and muscle, Vol. 12, no. 1, p. 70-20 (2021). doi:10.1002/jcsm.12652.
2021
Lanthier, Nicolas ; Rodriguez, Julie ; Nachit, Maxime Younes ; Hiel, Sophie ; Trefois, Pierre ; Neyrinck, Audrey M. ; Cani, Patrice D. ; Bindels, Laure B. ; Thissen, Jean-Paul ; Delzenne, Nathalie M.. Microbiota analysis and transient elastography reveal new extra-hepatic components of liver steatosis and fibrosis in obese patients.. In: Scientific reports, Vol. 11, no. 1, p. 659 [1-14] (2021). doi:10.1038/s41598-020-79718-9.
2021
Pötgens, Sarah ; Thibaut, Morgane ; Joudiou, Nicolas ; Sboarina, Martina ; Neyrinck, Audrey M. ; Cani, Patrice D. ; Claus, Sandrine P ; Delzenne, Nathalie M. ; Bindels, Laure B.. Multi-compartment metabolomics and metagenomics reveal major hepatic and intestinal disturbances in cancer cachectic mice.. In: Journal of cachexia, sarcopenia and muscle, , p. [1-20] (2021). doi:10.1002/jcsm.12684 (Accepté/Sous presse).
2021
Neyrinck, Audrey M. ; Rodriguez, Julie ; Zhang, Zhengxiao ; Seethaler, Benjamin ; Mailleux, Florence ; Vercammen, Joeri ; Bindels, Laure B. ; Cani, Patrice D. ; Nazare, Julie-Anne ; Maquet, Véronique ; Laville, Martine ; Bischoff, Stephan C ; Walter, Jens ; Delzenne, Nathalie M.. Noninvasive monitoring of fibre fermentation in healthy volunteers by analyzing breath volatile metabolites: lessons from the FiberTAG intervention study.. In: Gut microbes, Vol. 13, no.1, p. e1862028 [1-16] (2021). doi:10.1080/19490976.2020.1862028.
2021
Neyrinck, Audrey M. ; Robles Sanchez, Candido ; Rodriguez, Julie ; Cani, Patrice D. ; Bindels, Laure B. ; Delzenne, Nathalie M.. Prebiotic Effect of Berberine and Curcumin Is Associated with the Improvement of Obesity in Mice. In: Nutrients, Vol. 13, no.5, p. 1436 [1-13] (2021). doi:10.3390/nu13051436.
2021
Neyrinck, Audrey M. ; Rodriguez, Julie ; Zhang, Zhengxiao ; Seethaler, Benjamin ; Robles Sanchez, Candido ; Roumain, Martin ; Hiel, Sophie ; Bindels, Laure B. ; Cani, Patrice D. ; Paquot, Nicolas ; Cnop, Miriam ; Nazare, Julie-Anne ; Laville, Martine ; Muccioli, Giulio ; Bischoff, Stephan C ; Walter, Jens ; Thissen, Jean-Paul ; Delzenne, Nathalie M.. Prebiotic dietary fibre intervention improves fecal markers related to inflammation in obese patients: results from the Food4Gut randomized placebo-controlled trial.. In: European journal of nutrition, , p. [1-12] (2021). doi:10.1007/s00394-021-02484-5 (Accepté/Sous presse).
2021
Leyrolle, Quentin ; Cserjesi, Renata ; D.G.H. Mulders, Maria ; Zamariola, Giorgia ; Hiel, Sophie ; Gianfrancesco, Marco A. ; Portheault, Daphné ; Amadieu, Camille ; Bindels, Laure B. ; Leclercq, Sophie ; Rodriguez, Julie ; Neyrinck, Audrey M. ; Cani, Patrice D. ; Lanthier, Nicolas ; Trefois, Pierre ; Bindelle, Jérome ; Paquot, Nicolas ; Cnop, Miriam ; Thissen, Jean-Paul ; Klein, Olivier ; Luminet, Olivier ; Delzenne, Nathalie M.. Prebiotic effect on mood in obese patients is determined by the initial gut microbiota composition: a randomized, controlled trial. In: Brain, Behavior, and Immunity, p. [1-10] (2021). doi:10.1016/j.bbi.2021.01.014 (Accepté/Sous presse).
2021
La, Caroline ; de Toeuf, Bérengère ; Bindels, Laure B. ; Van Maele, Laurye ; Assabban, Assiya ; Melchior, Maxime ; Smout, Justine ; Köhler, Arnaud ; Nguyen, Muriel ; Thomas, Séverine ; Soin, Romuald ; Delacourt, Nadège ; Li, Hsüehlei ; Hu, Wenqian ; Blackshear, Perry J ; Kruys, Véronique ; Gueydan, Cyril ; Oldenhove, Guillaume ; Goriely, Stanislas. The RNA-binding protein tristetraprolin regulates RALDH2 expression by intestinal dendritic cells and controls local Treg homeostasis.. In: Mucosal immunology, Vol. 14, no. 11, p. 80-91 (2021). doi:10.1038/s41385-020-0302-x.
2020
Wyart, Elisabeth ; Bindels, Laure B. ; Mina, Erica ; Menga, Alessio ; Stanga, Serena ; Porporato, Paolo E. Cachexia, a Systemic Disease beyond Muscle Atrophy.. In: International journal of molecular sciences, Vol. 21, no.22, p. 8592 [1-18] (2020). doi:10.3390/ijms21228592.
2020
Rodriguez, Julie ; Hiel, Sophie ; Neyrinck, Audrey M. ; Le Roy, Tiphaine ; Pötgens, Sarah ; Leyrolle, Quentin ; Pachikian, Barbara D. ; Gianfrancesco, Marco A ; Cani, Patrice D. ; Paquot, Nicolas ; Cnop, Miriam ; Lanthier, Nicolas ; Thissen, Jean-Paul ; Bindels, Laure B. ; Delzenne, Nathalie M.. Discovery of the gut microbial signature driving the efficacy of prebiotic intervention in obese patients.. In: Gut, Vol. 69, no. 11, p. 1975-1987 (2020). doi:10.1136/gutjnl-2019-319726.
2020
Mbusa, Richard Kambale ; Nancy, Fransisca Isia ; Ngaboyeka, Gaylord Amani ; Kasengi, Joe Bwija ; Bindels, Laure B. ; Van der Linden, Dimitri. Effects of probiotics and synbiotics on diarrhea in undernourished children: Systematic review with meta-analysis. In: Clinical Nutrition, , p. [1-12] (2020). doi:10.1016/j.clnu.2020.12.026 (Accepté/Sous presse).
2020
Delzenne, Nathalie M. ; Bindels, Laure B.. Food for thought about manipulating gut bacteria. In: Nature, Vol. 577, no. 7788, p. 32-34 (2020). doi:10.1038/d41586-019-03704-z.
2020
Leclercq, Sophie ; Le Roy, Tiphaine ; Furgiuele, Sonia ; Coste, Valentin ; Bindels, Laure B. ; Leyrolle, Quentin ; Neyrinck, Audrey M. ; Quoilin, Caroline ; Amadieu, Camille ; Petit, Géraldine ; Dricot, Laurence ; Tagliatti, Vanessa ; Cani, Patrice D. ; Verbeke, Kristin ; Colet, Jean-Marie ; Starkel, Peter ; de Timary, Philippe ; Delzenne, Nathalie M.. Gut Microbiota-Induced Changes in β-Hydroxybutyrate Metabolism Are Linked to Altered Sociability and Depression in Alcohol Use Disorder.. In: Cell reports, Vol. 33, no.2, p. 108238 [1-24] (2020). doi:10.1016/j.celrep.2020.108238.
2020
Hiel, Sophie ; Gianfrancesco, Marco A. ; Rodriguez, Julie ; Portheault, Daphnée ; Leyrolle, Quentin ; Bindels, Laure B. ; Gomes da Silveira Cauduro, Carolina ; Mulders, Maria D.G.H. ; Zamariola, Georgia ; Azzi, Anne-Sophie ; Kalala, Gaetan ; Pachikian, Barbara D. ; Amadieu, Camille ; Neyrinck, Audrey M. ; Loumaye, Audrey ; Cani, Patrice D. ; Lanthier, Nicolas ; Trefois, Pierre ; Klein, Olivier ; Luminet, Olivier ; Bindelle, Jérôme ; Paquot, Nicolas ; Cnop, Miriam ; Thissen, Jean-Paul ; Delzenne, Nathalie M.. Link between gut microbiota and health outcomes in inulin -treated obese patients: Lessons from the Food4Gut multicenter randomized placebo-controlled trial. In: Clinical Nutrition, Vol. 39, no. 12, p. 3618-3628 (2020). doi:10.1016/j.clnu.2020.04.005.
2020
Massart, Isabelle ; Paulissen, Geneviève ; Loumaye, Audrey ; Lause, Pascale ; Pötgens, Sarah ; Thibaut, Morgane ; Balan, Estelle ; Deldicque, Louise ; Atfi, Azeddine ; Louis, Edouard ; Gruson, Damien ; Bindels, Laure B. ; Meuwis, Marie-Alice ; Thissen, Jean-Paul. Marked Increased Production of Acute Phase Reactants by Skeletal Muscle during Cancer Cachexia. In: Cancers, Vol. 12, no.11, p. 3221 [1-24] (2020). doi:10.3390/cancers12113221.
2020
Rodriguez, Julie ; Neyrinck, Audrey M. ; Zhang, Zhengxiao ; Seethaler, Benjamin ; Nazare, Julie-Anne ; Robles Sanchez, Candido ; Roumain, Martin ; Muccioli, Giulio ; Bindels, Laure B. ; Cani, Patrice D. ; Maquet, Véronique ; Laville, Martine ; Bischoff, Stephan C ; Walter, Jens ; Delzenne, Nathalie M.. Metabolite profiling reveals the interaction of chitin-glucan with the gut microbiota.. In: Gut microbes, Vol. 12, no. 1, p. 1810530 [1-15] (2020). doi:10.1080/19490976.2020.1810530.
2020
Degraeve, Alexandra ; Moudio Ebosse Timba, Moussinga Serge ; Haufroid, Vincent ; Chaib Eddour, Djamila ; Mourad, Michel ; Bindels, Laure B. ; Elens, Laure. Predictors of tacrolimus pharmacokinetic variability: current evidences and future perspectives.. In: Expert Opinion on Drug Metabolism & Toxicology, Vol. 16, no. 9, p. 769-782 (2020). doi:10.1080/17425255.2020.1803277.
2020
Leyrolle, Quentin ; Cserjesi, Renata ; Mulders, Maria D G H ; Zamariola, Giorgia ; Hiel, Sophie ; Gianfrancesco, Marco A ; Rodriguez, Julie ; Portheault, Daphnée ; Amadieu, Camille ; Leclercq, Sophie ; Bindels, Laure B. ; Neyrinck, Audrey M. ; Cani, Patrice D. ; Karkkainen, Olli ; Haninheva, Kati ; Lanthier, Nicolas ; Trefois, Pierre ; Paquot, Nicolas ; Cnop, Miriam ; Thissen, Jean-Paul ; Klein, Olivier ; Luminet, Olivier ; Delzenne, Nathalie M.. Specific gut microbial, biological, and psychiatric profiling related to binge eating disorders: A cross-sectional study in obese patients.. In: Clinical nutrition (Edinburgh, Scotland), , p. [1-10] (2020). doi:10.1016/j.clnu.2020.09.025 (Accepté/Sous presse).
2020
Segura Munoz, Rafael R ; Quach, Truyen ; Gomes-Neto, João C ; Xian, Yibo ; Pena, Pamela A ; Weier, Steven ; Pellizzon, Michael A ; Kittana, Hatem ; Cody, Liz A ; Geis, Abby L ; Heck, Kari ; Schmaltz, Robert J ; Bindels, Laure B. ; Cahoon, Edgar B ; Benson, Andrew K ; Clemente, Tom Elmo ; Ramer-Tait, Amanda E. Stearidonic-Enriched Soybean Oil Modulates Obesity, Glucose Metabolism, and Fatty Acid Profiles Independently of Akkermansia muciniphila.. In: Molecular nutrition & food research, Vol. 64, no.17, p. e2000162 [1-10] (2020). doi:10.1002/mnfr.202000162.
2020
Scorletti, Eleonora ; Afolabi, Paul R ; Miles, Elizabeth A ; Smith, Debbie E ; Almehmadi, Amal ; Alshathry, Albandri ; Childs, Caroline E ; Del Fabbro, Stefania ; Beavis, Josh ; Moyses, Helen E ; Clough, Geraldine F ; Sethi, Jaswinder K ; Patel, Janisha ; Wright, Mark ; Breen, David J ; Peebles, Charles ; Darekar, Angela ; Aspinall, Richard ; Fowell, Andrew J ; Dowman, Joanna K ; Nobili, Valerio ; Targher, Giovanni ; Delzenne, Nathalie M. ; Bindels, Laure B. ; Calder, Philip C ; Byrne, Christopher D. Synbiotics Alter Fecal Microbiomes, But Not Liver Fat or Fibrosis, in a Randomized Trial of Patients With Nonalcoholic Fatty Liver Disease. In: Gastroenterology, Vol. 158, no. 6, p. 1597-1610.e7 (2020). doi:10.1053/j.gastro.2020.01.031.
2020
Ducastel, Sarah ; Touche, Véronique ; Trabelsi, Mohamed-Sami ; Boulinguiez, Alexis ; Butruille, Laura ; Nawrot, Margaux ; Peschard, Simon ; Chávez-Talavera, Oscar ; Dorchies, Emilie ; Vallez, Emmanuelle ; Annicotte, Jean-Sébastien ; Lancel, Steve ; Briand, Olivier ; Bantubungi, Kadiombo ; Caron, Sandrine ; Bindels, Laure B. ; Delzenne, Nathalie M. ; Tailleux, Anne ; Staels, Bart ; Lestavel, Sophie. The nuclear receptor FXR inhibits Glucagon-Like Peptide-1 secretion in response to microbiota-derived Short-Chain Fatty Acids.. In: Scientific reports, Vol. 10, no.1, p. 174 [1-10] (2020). doi:10.1038/s41598-019-56743-x.
2019
Bernard, Arnaud ; Ancel, Déborah ; Neyrinck, Audrey M. ; Dastugue, Aurélie ; Bindels, Laure B. ; Delzenne, Nathalie M. ; Besnard, Philippe. A Preventive Prebiotic Supplementation Improves the Sweet Taste Perception in Diet-Induced Obese Mice.. In: Nutrients, Vol. 11, no.3, p. 549 [1-13] (2019). doi:10.3390/nu11030549.
2019
Neyrinck, Audrey M. ; Catry, Emilie ; Taminiau, Bernard ; Cani, Patrice D. ; Bindels, Laure B. ; Daube, Georges ; Dessy, Chantal ; Delzenne, Nathalie M.. Chitin-glucan and pomegranate polyphenols improve endothelial dysfunction.. In: Scientific Reports, Vol. 9, no.1, p. 14150 [1-12] (2019). doi:10.1038/s41598-019-50700-4.
2019
Delzenne, Nathalie M. ; Knudsen, Christelle ; Beaumont, Martin ; Rodriguez, Julie ; Neyrinck, Audrey M. ; Bindels, Laure B.. Contribution of the gut microbiota to the regulation of host metabolism and energy balance: a focus on the gut-liver axis.. In: The Proceedings of the Nutrition Society, Vol. 78, no. 3, p. 319-328 (2019). doi:10.1017/S0029665118002756.
2019
Hiel, Sophie ; Bindels, Laure B. ; Pachikian, Barbara D. ; Kalala, Gaetan ; Broers, Valérie ; Zamariola, Giorgia ; Chang, Betty PI ; Kambashi, Bienvenu ; Rodriguez, Julie ; Cani, Patrice D. ; Neyrinck, Audrey M. ; Thissen, Jean-Paul ; Luminet, Olivier ; Bindelle, Jérôme ; Delzenne, Nathalie M.. Effects of a diet based on inulin-rich vegetables on gut health and nutritional behavior in healthy humans. In: The American Journal of Clinical Nutrition, Vol. 109, no. 6, p. 1683-1695 (2019). doi:10.1093/ajcn/nqz001.
2019
Salazar, Nuria ; Neyrinck, Audrey M. ; Bindels, Laure B. ; Druart, Céline ; Ruas-Madiedo, Patricia ; Cani, Patrice D. ; de los Reyes-Gavilán, Clara G. ; Delzenne, Nathalie M.. Functional Effects of EPS-Producing Bifidobacterium Administration on Energy Metabolic Alterations of Diet-Induced Obese Mice. In: Frontiers in Microbiology, Vol. 10, p. 1809 [1-12] (2019). doi:10.3389/fmicb.2019.01809.
2019
Biver, Emmanuel ; Berenbaum, Francis ; Valdes, Ana M ; Araujo de Carvalho, Islene ; Bindels, Laure B. ; Brandi, Maria Luisa ; Calder, Philip C ; Castronovo, Vincenzo ; Cavalier, Etienne ; Cherubini, Antonio ; Cooper, Cyrus ; Dennison, Elaine ; Franceschi, Claudio ; Fuggle, Nicholas ; Laslop, Andrea ; Miossec, Pierre ; Thomas, Thierry ; Tuzun, Sansin ; Veronese, Nicola ; Vlaskovska, Mila ; Reginster, Jean-Yves ; Rizzoli, René. Gut microbiota and osteoarthritis management: An expert consensus of the European society for clinical and economic aspects of osteoporosis, osteoarthritis and musculoskeletal diseases (ESCEO).. In: Ageing Research Reviews, Vol. 55, p. 100946 [1-8] (2019). doi:10.1016/j.arr.2019.100946.
2019
Milard, Marine ; Laugerette, Fabienne ; Durand, Annie ; Buisson, Charline ; Meugnier, Emmanuelle ; Loizon, Emmanuelle ; Louche-Pelissier, Corinne ; Sauvinet, Valérie ; Garnier, Lorna ; Viel, Sébastien ; Bertrand, Karène ; Joffre, Florent ; Cheillan, David ; Humbert, Lydie ; Rainteau, Dominique ; Plaisancié, Pascale ; Bindels, Laure B. ; Neyrinck, Audrey M. ; Delzenne, Nathalie M. ; Michalski, Marie-Caroline. Milk Polar Lipids in a High-Fat Diet Can Prevent Body Weight Gain: Modulated Abundance of Gut Bacteria in Relation with Fecal Loss of Specific Fatty Acids.. In: Molecular Nutrition & Food Research, Vol. 63, no. 4, p. e1801078 [1-13] (2019). doi:10.1002/mnfr.201801078.
2019
Genton, Laurence ; Mareschal, Julie ; Charretier, Yannick ; Lazarevic, Vladimir ; Bindels, Laure B. ; Schrenzel, Jacques. Targeting the Gut Microbiota to Treat Cachexia.. In: Frontiers in cellular and infection microbiology, Vol. 9, p. 305 [1-8] (2019). doi:10.3389/fcimb.2019.00305.
2019
Olivares Sevilla, Marta ; Rodriguez, Julie ; Pötgens, Sarah ; Neyrinck, Audrey M. ; Cani, Patrice D. ; Bindels, Laure B. ; Delzenne, Nathalie M.. The Janus Face of Cereals: Wheat‐Derived Prebiotics Counteract the Detrimental Effect of Gluten on Metabolic Homeostasis in Mice Fed a High‐Fat/High‐Sucrose Diet. In: Molecular Nutrition & Food Research, Vol. 63, no. 24, p. 1900632 [1-12] (2019). doi:10.1002/mnfr.201900632.
2018
Kittana, Hatem ; Gomes-Neto, João Carlos ; Heck, Kari ; Geis, Abby L. ; Segura Muñoz, Rafael R. ; Cody, Liz A. ; Schmaltz, Robert J. ; Bindels, Laure B. ; Sinha, Rohita ; Hostetter, Jesse M. ; Benson, Andrew K. ; Ramer-Tait, Amanda E.. Commensal Escherichia coli Strains Can Promote Intestinal Inflammation via Differential Interleukin-6 Production. In: Frontiers in Immunology, Vol. 9, p. 2318 [1-13] (2018). doi:10.3389/fimmu.2018.02318.
2018
Scorletti, Eleonora ; Afolabi, Paul R ; Miles, Elizabeth A ; Smith, Debbie E ; Almehmadi, Amal ; Alshathry, Albandri ; Moyses, Helen E ; Clough, Geraldine F ; Wright, Mark ; Patel, Janisha ; Bindels, Laure B. ; Delzenne, Nathalie M. ; Calder, Philip C ; Byrne, Christopher D. Design and rationale of the INSYTE study: A randomised, placebo controlled study to test the efficacy of a synbiotic on liver fat, disease biomarkers and intestinal microbiota in non-alcoholic fatty liver disease.. In: Contemporary Clinical Trials, Vol. 71, p. 113-123 (2018). doi:10.1016/j.cct.2018.05.010.
2018
Kittana, Hatem ; Quintero-Villegas, Maria I ; Bindels, Laure B. ; Gomes-Neto, João Carlos ; Schmaltz, Robert J ; Segura Munoz, Rafael R ; Cody, Liz A ; Moxley, Rodney A ; Hostetter, Jesse ; Hutkins, Robert W ; Ramer-Tait, Amanda E. Galactooligosaccharide supplementation provides protection against Citrobacter rodentium-induced colitis without limiting pathogen burden.. In: Microbiology, Vol. 164, no. 2, p. 154-162 (2018). doi:10.1099/mic.0.000593.
2018
Delzenne, Nathalie M. ; Bindels, Laure B.. Gut microbiota in 2017: Contribution of gut microbiota-host cooperation to drug efficacy.. In: Nature Reviews. Gastroenterology & Hepatology, Vol. 15, no. 2, p. 69-70 (2018). doi:10.1038/nrgastro.2017.170.
2018
Pachikian, Barbara D. ; Druart, Céline ; Catry, Emilie ; Bindels, Laure B. ; Neyrinck, Audrey M. ; Larondelle, Yvan ; Cani, Patrice D. ; Delzenne, Nathalie M.. Implication of trans-11,trans-13 conjugated linoleic acid in the development of hepatic steatosis.. In: PLoS One, Vol. 13, no. 2, p. e0192447 [1-14] (2018). doi:10.1371/journal.pone.0192447.
2018
Gueugneau, Marine ; d'Hose, Donatienne ; Barbé, Caroline ; de Barsy, Marie ; Lause, Pascale ; Maiter, Dominique ; Bindels, Laure B. ; Delzenne, Nathalie M. ; Schaeffer, Laurent ; Gangloff, Yann-Gaël ; Chambon, Christophe ; Coudy-Gandilhon, Cécile ; Béchet, Daniel ; Thissen, Jean-Paul. Increased Serpina3n release into circulation during glucocorticoid-mediated muscle atrophy.. In: Journal of cachexia, sarcopenia and muscle, Vol. 9, no. 5, p. 929-946 (2018). doi:10.1002/jcsm.12315.
2018
Bindels, Laure B. ; Neyrinck, Audrey M. ; Loumaye, Audrey ; Catry, Emilie ; Walgrave, Hannah ; Cherbuy, Claire ; Leclercq, Sophie ; Van Hul, Matthias ; Plovier, Hubert ; Pachikian, Barbara D. ; Bermúdez-Humarán, Luis G ; Langella, Philippe ; Cani, Patrice D. ; Thissen, Jean-Paul ; Delzenne, Nathalie M.. Increased gut permeability in cancer cachexia: mechanisms and clinical relevance.. In: OncoTarget, Vol. 9, no.26, p. 18224-18238 (2018). doi:10.18632/oncotarget.24804.
2018
Hiel, Sophie ; Neyrinck, Audrey M. ; Rodriguez, Julie ; Pachikian, Barbara D. ; Bouzin, Caroline ; Thissen, Jean-Paul ; Cani, Patrice D. ; Bindels, Laure B. ; Delzenne, Nathalie M.. Inulin Improves Postprandial Hypertriglyceridemia by Modulating Gene Expression in the Small Intestine.. In: Nutrients, Vol. 10, no. 5, p. 532 [1-13] (2018). doi:10.3390/nu10050532.
2018
Pötgens, Sarah ; Brossel, Hélène ; Sboarina, Martina ; Catry, Emilie ; Cani, Patrice D. ; Neyrinck, Audrey M. ; Delzenne, Nathalie M. ; Bindels, Laure B.. Klebsiella oxytoca expands in cancer cachexia and acts as a gut pathobiont contributing to intestinal dysfunction.. In: Scientific Reports, Vol. 8, no.1, p. 12321 [1-12] (2018). doi:10.1038/s41598-018-30569-5.
2018
Delzenne, Nathalie M. ; Bindels, Laure B.. Microbiome metabolomics reveals new drivers of human liver steatosis.. In: Nature Medicine, Vol. 24, no.7, p. 906-907 (2018). doi:10.1038/s41591-018-0126-3.
2018
Suriano, Francesco ; Neyrinck, Audrey M. ; Verspreet, Joran ; Olivares Sevilla, Marta ; Leclercq, Sophie ; Van de Wiele, Tom ; Courtin, Christophe M. ; Cani, Patrice D. ; Bindels, Laure B. ; Delzenne, Nathalie M.. Particle size determines the anti-inflammatory effect of wheat bran in a model of fructose over-consumption: Implication of the gut microbiota. In: Journal of Functional Foods, Vol. 41, p. 155-162 (2018). doi:10.1016/j.jff.2017.12.035.
2018
Pötgens, Sarah ; Sboarina, Martina ; Bindels, Laure B.. Polyunsaturated fatty acids, polyphenols, amino acids, prebiotics: can they help to tackle cancer cachexia and related inflammation?. In: Current Opinion in Clinical Nutrition and Metabolic Care, Vol. 21, no. 6, p. 458-464 (2018). doi:10.1097/MCO.0000000000000505.
2018
Catry, Emilie ; Bindels, Laure B. ; Tailleux, Anne ; Lestavel, Sophie ; Neyrinck, Audrey M. ; Goossens, Jean-François ; Lobysheva, Irina ; Plovier, Hubert ; Essaghir, Ahmed ; Demoulin, Jean-Baptiste ; Bouzin, Caroline ; Pachikian, Barbara D. ; Cani, Patrice D. ; Staels, Bart ; Dessy, Chantal ; Delzenne, Nathalie M.. Targeting the gut microbiota with inulin-type fructans: preclinical demonstration of a novel approach in the management of endothelial dysfunction.. In: Gut, Vol. 67, no.2, p. 271-283 (2018). doi:10.1136/gutjnl-2016-313316.
2018
Olivares Sevilla, Marta ; Neyrinck, Audrey M. ; Pötgens, Sarah ; Beaumont, Martin ; Salazar, Nuria ; Cani, Patrice D. ; Bindels, Laure B. ; Delzenne, Nathalie M.. The DPP-4 inhibitor vildagliptin impacts the gut microbiota and prevents disruption of intestinal homeostasis induced by a Western diet in mice.. In: Diabetologia : clinical and experimental diabetes and metabolism, Vol. 61, no. 8, p. 1838-1848 (2018). doi:10.1007/s00125-018-4647-6.
2018
Olivares Sevilla, Marta ; Schüppel, Valentina ; Hassan, Ahmed M. ; Beaumont, Martin ; Neyrinck, Audrey M. ; Bindels, Laure B. ; Benítez-Páez, Alfonso ; Sanz, Yolanda ; Haller, Dirk ; Holzer, Peter ; Delzenne, Nathalie M.. The Potential Role of the Dipeptidyl Peptidase-4-Like Activity From the Gut Microbiota on the Host Health. In: Frontiers in Microbiology, Vol. 9, p. 1900 [1-10] (2018). doi:10.3389/fmicb.2018.01900.
2018
Beaumont, Martin ; Neyrinck, Audrey M. ; Olivares Sevilla, Marta ; Rodriguez, Julie ; de Rocca Serra, Audrey ; Roumain, Martin ; Bindels, Laure B. ; Cani, Patrice D. ; Evenepoel, Pieter ; Muccioli, Giulio ; Demoulin, Jean-Baptiste ; Delzenne, Nathalie M.. The gut microbiota metabolite indole alleviates liver inflammation in mice.. In: The FASEB Journal, Vol. 32, no. 12, p. fj201800544 [1-13] (2018). doi:10.1096/fj.201800544.
2018
Neyrinck, Audrey M. ; Hiel, Sophie ; Bouzin, Caroline ; Campayo, Vicenta Garcia ; Cani, Patrice D. ; Bindels, Laure B. ; Delzenne, Nathalie M.. Wheat-derived arabinoxylan oligosaccharides with bifidogenic properties abolishes metabolic disorders induced by western diet in mice.. In: Nutrition and Diabetes, Vol. 8, no.1, p. 15 [1-5] (2018). doi:10.1038/s41387-018-0019-z.
2017
Gomes-Neto, João Carlos ; Kittana, Hatem ; Mantz, Sara ; Segura Munoz, Rafael R ; Schmaltz, Robert J ; Bindels, Laure B. ; Clarke, Jennifer ; Hostetter, Jesse M ; Benson, Andrew K ; Walter, Jens ; Ramer-Tait, Amanda E. A gut pathobiont synergizes with the microbiota to instigate inflammatory disease marked by immunoreactivity against other symbionts but not itself.. In: Scientific Reports, Vol. 7, p. 17707 (2017). doi:10.1038/s41598-017-18014-5.
2017
Neyrinck, Audrey M. ; Bindels, Laure B. ; Geurts, Lucie ; Van Hul, Matthias ; Cani, Patrice D. ; Delzenne, Nathalie M.. A polyphenolic extract from green tea leaves activates fat browning in high-fat-diet-induced obese mice. In: The Journal of Nutritional Biochemistry, Vol. 49, p. 15-21 (2017). doi:10.1016/j.jnutbio.2017.07.008.
2017
Suriano, Francesco ; Bindels, Laure B. ; Verspreet, Joran ; Courtin, Christophe M. ; Verbeke, Kristin ; Cani, Patrice D. ; Neyrinck, Audrey M. ; Delzenne, Nathalie M.. Fat binding capacity and modulation of the gut microbiota both determine the effect of wheat bran fractions on adiposity. In: Scientific Reports, Vol. 7, no. 1, p. 5621 [1-13] (2017). doi:10.1038/s41598-017-05698-y.
2017
Bindels, Laure B. ; Porporato, Paolo ; Ducastel, Sarah ; Sboarina, Martina ; Neyrinck, Audrey M. ; Dewulf, Evelyne ; Feron, Olivier ; Lestavel, Sophie ; Cani, Patrice D. ; Staels, Bart ; Sonveaux, Pierre ; Delzenne, Nathalie M.. Ffar2 expression regulates leukaemic cell growth in vivo.. In: The British journal of cancer, Vol. 117, no. 9, p. 1336-1340 (2017). doi:10.1038/bjc.2017.307.
2017
Reid, Gregor ; Abrahamsson, Thomas Robert ; Bailey, Michael ; Bindels, Laure B. ; Bubnov, Rostyslav ; Ganguli, Kriston ; Martoni, Christopher ; O'Neill, Catherine ; Savignac, Hélène M ; Stanton, Catherine ; Ship, Noam ; Surette, Michael ; Tuohy, Kieran ; van Hemert, Saskia. How do probiotics and prebiotics function at distant sites?. In: Beneficial Microbes, Vol. 8, no.4, p. 521-533 (2017). doi:10.3920/BM2016.0222.
2017
Leclercq, Sophie ; Mian, Firoz M ; Stanisz, Andrew M ; Bindels, Laure B. ; Cambier, Emmanuel ; Ben-Amram, Hila ; Koren, Omry ; Forsythe, Paul ; Bienenstock, John. Low-dose penicillin in early life induces long-term changes in murine gut microbiota, brain cytokines and behavior. In: Nature Communications, Vol. 8, p. 15062 ^1-12] (2017). doi:10.1038/ncomms15062.
2017
Bindels, Laure B. ; Segura Munoz, Rafael R ; Gomes-Neto, João Carlos ; Mutemberezi, Valentin ; Martínez, Inés ; Salazar, Nuria ; Cody, Elizabeth A ; Quintero-Villegas, Maria I ; Kittana, Hatem ; de Los Reyes-Gavilán, Clara G ; Schmaltz, Robert J ; Muccioli, Giulio ; Walter, Jens ; Ramer-Tait, Amanda E. Resistant starch can improve insulin sensitivity independently of the gut microbiota. In: Microbiome, Vol. 5, no.1, p. 12 [1-16] (2017). doi:10.1186/s40168-017-0230-5.
2017
Neyrinck, Audrey M. ; Etxeberria, Usune ; Taminiau, Bernard ; Daube, Georges ; Van Hul, Matthias ; Everard, Amandine ; Cani, Patrice D. ; Bindels, Laure B. ; Delzenne, Nathalie M.. Rhubarb extract prevents hepatic inflammation induced by acute alcohol intake, an effect related to the modulation of the gut microbiota.. In: Molecular Nutrition & Food Research, Vol. 61, no. 1, p. 1500899 [1-12] (2017). doi:10.1002/mnfr.201500899.
2017
Neyrinck, Audrey M. ; Taminiau, Bernard ; Walgrave, Hannah ; Daube, Georges ; Cani, Patrice D. ; Bindels, Laure B. ; Delzenne, Nathalie M.. Spirulina Protects against Hepatic Inflammation in Aging: An Effect Related to the Modulation of the Gut Microbiota?. In: Nutrients, Vol. 9, no.6, p. 633 [1-13] (2017). doi:10.3390/nu9060633.
2016
Bindels, Laure B. ; Leclercq, Isabelle. Colonic acetate in obesity: location matters!. In: Clinical Science, Vol. 130, no.22, p. 2083-2086 (2016). doi:10.1042/CS20160556.
2016
Yang, Junyi ; Bindels, Laure B. ; Segura Munoz, Rafael R ; Martínez, Inés ; Walter, Jens ; Ramer-Tait, Amanda E ; Rose, Devin J. Disparate Metabolic Responses in Mice Fed a High-Fat Diet Supplemented with Maize-Derived Non-Digestible Feruloylated Oligo- and Polysaccharides Are Linked to Changes in the Gut Microbiota. In: PLoS One, Vol. 11, no.1, p. e0146144 (2016). doi:10.1371/journal.pone.0146144.
2016
Neyrinck, Audrey M. ; Pachikian, Barbara D. ; Taminiau , Bernard ; Daube , Georges ; Frédérick, Raphaël ; Cani, Patrice D. ; Bindels, Laure B. ; Delzenne, Nathalie M.. Intestinal Sucrase as a Novel Target Contributing to the Regulation of Glycemia by Prebiotics. In: PLoS One, Vol. 11, no.8, p. e0160488 [1-13] (2016). doi:10.1371/journal.pone.0160488.
2016
Bindels, Laure B. ; Thissen, Jean-Paul. Nutrition in cancer patients with cachexia: A role for the gut microbiota?. In: Clinical Nutrition Experimental, Vol. 6, no. 2016, p. 74-82 (2016). doi:10.1016/j.yclnex.2015.11.001.
2016
Hutkins, Robert W ; Krumbeck, Janina A ; Bindels, Laure B. ; Cani, Patrice D. ; Fahey, George ; Goh, Yong Jun ; Hamaker, Bruce ; Martens, Eric C ; Mills, David A ; Rastal, Robert A ; Vaughan, Elaine ; Sanders, Mary Ellen. Prebiotics: why definitions matter.. In: Current Opinion in Biotechnology, Vol. 37, p. 1-7 (2016). doi:10.1016/j.copbio.2015.09.001.
2016
Bindels, Laure B. ; Neyrinck, Audrey M. ; Claus, Sandrine P ; Le Roy, Caroline I ; Grangette, Corinne ; Pot, Bruno ; Martinez, Inés ; Walter, Jens ; Cani, Patrice D. ; Delzenne, Nathalie M.. Synbiotic approach restores intestinal homeostasis and prolongs survival in leukaemic mice with cachexia. In: The I S M E Journal : multidisciplinary journal of microbial ecology, Vol. 10, no. 6, p. 1456-70 (2016). doi:10.1038/ismej.2015.209.
2015
Druart, Céline ; Bindels, Laure B. ; Schmaltz, Robert ; Neyrinck, Audrey M. ; Cani, Patrice D. ; Walter, Jens ; Ramer-Tait, Amanda E ; Delzenne, Nathalie M.. Ability of the gut microbiota to produce PUFA-derived bacterial metabolites: Proof of concept in germ-free versus conventionalized mice.. In: Molecular Nutrition & Food Research, Vol. 59, no. 8, p. 1603–1613 (2015). doi:10.1002/mnfr.201500014.
2015
Delzenne, Nathalie M. ; Bindels, Laure B.. Gut microbiota: Ganoderma lucidum, a new prebiotic agent to treat obesity?. In: Nature Reviews. Gastroenterology & Hepatology, Vol. 12, no.10, p. 553-554 (2015). doi:10.1038/nrgastro.2015.137.
2015
Delzenne, Nathalie M. ; Cani, Patrice D. ; Everard, Amandine ; Neyrinck, Audrey M. ; Bindels, Laure B.. Gut microorganisms as promising targets for the management of type 2 diabetes.. In: Diabetologia : clinical and experimental diabetes and metabolism, Vol. 58, no.10, p. 2206-2217 (2015). doi:10.1007/s00125-015-3712-7.
2015
Simon, Marie-Christine ; Strassburger, Klaus ; Nowotny, Bettina ; Kolb, Hubert ; Nowotny, Peter ; Burkart, Volker ; Zivehe, Fariba ; Hwang, Jong-Hee ; Stehle, Peter ; Pacini, Giovanni ; Hartmann, Bolette ; Holst, Jens J ; MacKenzie, Colin ; Bindels, Laure B. ; Martinez, Ines ; Walter, Jens ; Henrich, Birgit ; Schloot, Nanette C ; Roden, Michael. Intake of Lactobacillus reuteri improves incretin and insulin secretion in glucose tolerant humans: a proof of concept. In: Diabetes Care, Vol. 38, no. 10, p. 1827-1834 (2015). doi:10.2337/dc14-2690.
2015
Salazar Garzo, Nuria ; Dewulf, Evelyne M. ; Neyrinck, Audrey M. ; Bindels, Laure B. ; Cani, Patrice D. ; Mahillon, Jacques ; de Vos, Willem M. ; Thissen, Jean-Paul ; Gueimonde, Miguel ; de los Reyes-Gavilan, Clara G. ; Delzenne, Nathalie M.. Inulin-type fructans modulate intestinal Bifidobacterium species populations and decrease fecal short-chain fatty acids in obese women. In: Clinical Nutrition, Vol. 34, no.3, p. 501–507 (2015). doi:10.1016/j.clnu.2014.06.001.
2015
Neyrinck, Audrey M. ; Catry, Emilie ; Sohet, Florence M. ; Cani, Patrice D. ; Pachikian, Barbara D. ; Bindels, Laure B. ; Delzenne, Nathalie M.. Lack of anti-inflammatory effect of coenzyme Q10 supplementation in the liver of rodents after lipopolysaccharide challenge. In: Clinical Nutrition Experimental, Vol. 1, p. 10-18 (2015). doi:10.1016/j.yclnex.2015.07.002.
2015
Bindels, Laure B. ; Neyrinck, Audrey M. ; Salazar Garzo, Nuria ; Taminiau, Bernard ; Druart, Céline ; Muccioli, Giulio ; François, Emmanuelle ; Blecker, Christophe ; Richel, Aurore ; Daube, Georges ; Mahillon, Jacques ; de Los Reyes-Gavilán, Clara G ; Cani, Patrice D. ; Delzenne, Nathalie M.. Non Digestible Oligosaccharides Modulate the Gut Microbiota to Control the Development of Leukemia and Associated Cachexia in Mice. In: PLoS One, Vol. 10, no. 6, p. e0131009 [1-16] (2015). doi:10.1371/journal.pone.0131009.
2015
Bindels, Laure B. ; Walter, Jens ; Ramer-Tait, Amanda E.. Resistant starches for the management of metabolic diseases. In: Current Opinion in Clinical Nutrition and Metabolic Care, Vol. 18, no.6, p. 559-565 (2015). doi:10.1097/MCO.0000000000000223.
2015
Bindels, Laure B. ; Delzenne, Nathalie M. ; Cani, Patrice D. ; Walter, Jens. Towards a more comprehensive concept for prebiotics. In: Nature Reviews. Gastroenterology & Hepatology, Vol. 12, no. 5, p. 303-310 (2015). doi:10.1038/nrgastro.2015.47.
2014
Sheridan, Paul O ; Bindels, Laure B. ; Saulnier, Delphine M ; Reid, Gregor ; Nova, Esther ; Holmgren, Kerstin ; O'Toole, Paul W ; Bunn, James ; Delzenne, Nathalie M. ; Scott, Karen P. Can prebiotics and probiotics improve therapeutic outcomes for undernourished individuals?. In: Gut Microbes, Vol. 5, no.1, p. 74-82 (2014). doi:10.4161/gmic.27252.
2014
Everard, Amandine ; Geurts, Lucie ; Caesar, Robert ; Van Hul, Matthias ; Matamoros, Sébastien ; Duparc, Thibaut ; Denis, Raphael G P ; Cochez, Perrine ; Pierard, Florian ; Castel, Julien ; Bindels, Laure B. ; Plovier, Hubert ; Robine, Sylvie ; Muccioli, Giulio ; Renauld, Jean-Christophe ; Dumoutier, Laure ; Delzenne, Nathalie M. ; Luquet, Serge ; Bäckhed, Fredrik ; Cani, Patrice D.. Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status. In: Nature Communications, Vol. 5, no. 1, p. 5648 [1-12] (2014). doi:10.1038/ncomms6648.
2013
Everard, Amandine ; Belzer, Clara ; Geurts, Lucie ; Ouwerkerk, Janneke P ; Druart, Céline ; Bindels, Laure B. ; Guiot, Yves ; Derrien, Muriel ; Muccioli, Giulio ; Delzenne, Nathalie M. ; de Vos, Willem M ; Cani, Patrice D.. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. In: Proceedings of the National academy of sciences of the United States of America, Vol. 110, no.22, p. 9066-9071 (2013). doi:10.1073/pnas.1219451110.
2013
Dewulf, Evelyne M. ; Ge, Qian ; Bindels, Laure B. ; Sohet, Florence M. ; Cani, Patrice D. ; Brichard, Sonia ; Delzenne, Nathalie M.. Evaluation of the relationship between GPR43 and adiposity in human. In: Nutrition & Metabolism, Vol. 10, no. 1, p. 11 [1-5] (2013). doi:10.1186/1743-7075-10-11.
2013
Bindels, Laure B. ; Dewulf, Evelyne M. ; Delzenne, Nathalie M.. GPR43/FFA2: physiopathological relevance and therapeutic prospects. In: Trends in Pharmacological Sciences, Vol. 34, no.4, p. 226-232 (2013). doi:10.1016/j.tips.2013.02.002.
2013
Dewulf, Evelyne ; Cani, Patrice D. ; Claus, Sandrine P ; Fuentes, Susana ; Puylaert, Philippe Gb ; Neyrinck, Audrey M. ; Bindels, Laure B. ; de Vos, Willem M ; Gibson, Glenn R ; Thissen, Jean-Paul ; Delzenne, Nathalie M.. Insight into the prebiotic concept: lessons from an exploratory, double blind intervention study with inulin-type fructans in obese women. In: Gut, Vol. 62, no. 8, p. 1112-1121 (2012). doi:10.1136/gutjnl-2012-303304.
2013
Bindels, Laure B. ; Delzenne, Nathalie M.. Muscle wasting: the gut microbiota as a new therapeutic target?. In: The International Journal of Biochemistry & Cell Biology, Vol. 45, no.10, p. 2186-2190 (2013). doi:10.1016/j.biocel.2013.06.021.
2013
Neyrinck, Audrey M. ; Van Hee, Vincent F ; Bindels, Laure B. ; De Backer, Fabienne ; Cani, Patrice D. ; Delzenne, Nathalie M.. Polyphenol-rich extract of pomegranate peel alleviates tissue inflammation and hypercholesterolaemia in high-fat diet-induced obese mice: potential implication of the gut microbiota. In: The British Journal of Nutrition : an international journal of nutritional science, Vol. 109, no. 5, p. 802-809 (2013). doi:10.1017/S0007114512002206.
2012
Bindels, Laure B. ; Porporato, Paolo ; Dewulf, Evelyne ; Verrax, Julien ; Neyrinck, Audrey M. ; Martin, J C ; Scott, K P ; Buc Calderon, Pedro ; Feron, Olivier ; Muccioli, Giulio ; Sonveaux, Pierre ; Cani, Patrice D. ; Delzenne, Nathalie M.. Gut microbiota-derived propionate reduces cancer cell proliferation in the liver. In: The British journal of cancer, Vol. 107, no. 8, p. 1337-1344 (2012). doi:10.1038/bjc.2012.409.
2012
Bindels, Laure B. ; Beck, Raphaël ; Schakman, Olivier ; Martin, Jennifer C ; De Backer, Fabienne ; Sohet, Florence M. ; Dewulf, Evelyne ; Pachikian, Barbara D. ; Neyrinck, Audrey M. ; Thissen, Jean-Paul ; Verrax, Julien ; Buc Calderon, Pedro ; Pot, Bruno ; Grangette, Corinne ; Cani, Patrice D. ; Scott, Karen P ; Delzenne, Nathalie M.. Restoring specific lactobacilli levels decreases inflammation and muscle atrophy markers in an acute leukemia mouse model. In: PLoS One, Vol. 7, no.6, p. e37971 [1-10] (2012). doi:10.1371/journal.pone.0037971.
2011
Dewulf, Evelyne ; Cani, Patrice D. ; Neyrinck, Audrey M. ; Possemiers, Sam ; Van Holle, Ann ; Muccioli, Giulio ; Deldicque, Louise ; Bindels, Laure B. ; Pachikian, Barbara D. ; Sohet, Florence ; Mignolet, Eric ; Francaux, Marc ; Larondelle, Yvan ; Delzenne, Nathalie M.. Inulin-type fructans with prebiotic properties counteract GPR43 overexpression and PPARγ-related adipogenesis in the white adipose tissue of high-fat diet-fed mice.. In: The Journal of Nutritional Biochemistry, Vol. 22, no. 8, p. 712-722 (2011). doi:10.1016/j.jnutbio.2010.05.009.
2010
Pachikian, Barbara D. ; Neyrinck, Audrey M. ; Deldicque, Louise ; De Backer, Fabienne ; Catry, Emilie ; Dewulf, Evelyne ; Sohet, Florence ; Bindels, Laure B. ; Everard, Amandine ; Francaux, Marc ; Guiot, Yves ; Cani, Patrice D. ; Delzenne, Nathalie M.. Changes in intestinal bifidobacteria levels are associated with the inflammatory response in magnesium-deficient mice. In: The Journal of Nutrition, Vol. 140, no. 3, p. 509-514 (2010). doi:10.3945/jn.109.117374.
2009
Sohet, Florence ; Neyrinck, Audrey M. ; Pachikian, Barbara D. ; De Backer, Fabienne ; Bindels, Laure B. ; Niklowitz, Petra ; Menke, Thomas ; Cani, Patrice D. ; Delzenne, Nathalie M.. Coenzyme Q10 supplementation lowers hepatic oxidative stress and inflammation associated with diet-induced obesity in mice.. In: Biochemical Pharmacology, Vol. 78, no. 11, p. 1391-400 (2009). doi:10.1016/j.bcp.2009.07.008.
2009
Neyrinck, Audrey M. ; Cani, Patrice D. ; Dewulf, Evelyne ; De Backer, Fabienne ; Bindels, Laure B. ; Delzenne, Nathalie M.. Critical role of Kupffer cells in the management of diet-induced diabetes and obesity. In: Biochemical and Biophysical Research Communications, Vol. 385, no. 3, p. 351-356 (2009). doi:10.1016/j.bbrc.2009.05.070.
2009
Neyrinck, Audrey M. ; Bindels, Laure B. ; De Backer, Fabienne ; Pachikian, Barbara D. ; Cani, Patrice D. ; Delzenne, Nathalie M.. Dietary supplementation with chitosan derived from mushrooms changes adipocytokine profile in diet-induced obese mice : a phenomenon linked to its lipid-lowering action. In: International Immunopharmacology, Vol. 9, no. 6, p. 767-773 (2009). doi:10.1016/j.intimp.2009.02.015.
2009
Sohet, Florence ; Neyrinck, Audrey M. ; Dewulf, Evelyne ; Bindels, Laure B. ; Portois, Laurence ; Malaisse, Willy J. ; Carpentier, Yvon A. ; Cani, Patrice D. ; Delzenne, Nathalie M.. Lipid peroxidation is not a prerequisite for the development of obesity and diabetes in high-fat-fed mice.. In: The British Journal of Nutrition : an international journal of nutritional science, Vol. 102, no. 3, p. 462-469 (2009). doi:10.1017/S0007114508191243.
2008
Pachikian, Barbara D. ; Neyrinck, Audrey M. ; Cani, Patrice D. ; Portois, L. ; Deldicque, Louise ; De Backer, Fabienne ; Bindels, Laure B. ; Sohet, Florence ; Malaisse, Willy J. ; Francaux, Marc ; Carpentier, Y. A. ; Delzenne, Nathalie M.. Hepatic steatosis in n-3 fatty acid depleted mice : focus on metabolic alterations related to tissue fatty acid composition. In: BMC physiology, Vol. 8, no. 21, p. [1-11] (2008). doi:10.1186/1472-6793-8-21.
2008
Neyrinck, Audrey M. ; De Backer, Fabienne ; Cani, Patrice D. ; Bindels, Laure B. ; Stroobants, Aurore ; Portetelle, Daniel ; Delzenne, Nathalie M.. Immunomodulatory properties of two wheat bran fractions - aleurone-enriched and crude fractions - in obese mice fed a high fat diet.. In: International Immunopharmacology, Vol. 8, no. 10, p. 1423-1432 (2008). doi:10.1016/j.intimp.2008.05.015.