Our research group proposes an approach based on integrative physiology, metabolism and nutrition, to investigate the role of the gut microbiota in the development of metabolic and behavioral disorders associated with obesity and cardiometabolic risk, alcohol dependence, cancer development and cachexia. In collaborative projects, we also evaluate the implication of the gut microbiota in xenobiotic metabolism and wound healing.
We mostly focus on nutrients targeting the gut microbiota, such as carbohydrates which escape the digestion (e.g., prebiotics) plant-derived compounds (e.g., polyphenols) or lipids. We also isolate and characterize novel bacteria considered as next-generation beneficial microbes (e.g., Akkermansia muciniphila, Dysosmobacter welbionis).
Omics and targeted approaches are used for the evaluation of gut endocrine and barrier functions and repair (wound healing), endocannabinnoid system, organ (liver, muscle, brain, adipose tissue) dysfunctions.