Our group has been committed to characterise the immune response and the cytokine network at play primarily in Multiple Sclerosis (MS) but also in other neurological disorders. Our data originate from our expanding biobank of peripheral blood mononuclear cells (PBMC) from MS patients as well as cerebrospinal fluid (CSF) and serum from patients of the Neurology Department at the Cliniques Universitaires Saint-Luc. We have characterised the Th17/Treg balance and the involvement of their cytokines during MS relapses and remission or following MS treatments. Recently, the group has broadened its investigation of MS pathogenesis by studying microRNAs (miRNA), bioactive lipids and their putative carriers (extracellular vesicles: EVs) for their roles in MS neuroinflammation as well as on the development of oligodendrocytes producing myelin, a privileged target in MS.
MicroRNA analysis in MS patients according to disease and phenotype
Extracellular vesicles as carrier of miRNA and lipids: Involvement in MS pathogenesis
The role of EVs and their content in oligodendrocyte development, myelin integrity and myelination