Publications
Alzheimer - PKC
2023
Suelves, Nuria ; Saleki, Shirine ; Ibrahim, Tasha ; Palomares, Debora ; Moonen, Sebastiaan ; Koper, Marta J ; Vrancx, Céline ; Vadukul, Devkee M ; Papadopoulos, Nicolas ; Viceconte, Nikenza ; Claude, Eloïse ; Vandenberghe, Rik ; von Arnim, Christine A F ; Constantinescu, Stefan N. ; Thal, Dietmar Rudolf ; Decottignies, Anabelle ; Kienlen-Campard, Pascal. Senescence-related impairment of autophagy induces toxic intraneuronal amyloid-β accumulation in a mouse model of amyloid pathology.. In: Acta neuropathologica communications, Vol. 11, no.1, p. 82 (2023). doi:10.1186/s40478-023-01578-x.
2023
Kyalu Ngoie Zola, Nathalie ; Balty, Clémence ; Pyr dit Ruys, Sébastien ; Vanparys, Axelle A. T. ; Huyghe, Nicolas D. G. ; Herinckx, Gaëtan ; Johanns, Manuel ; Boyer, Emilien ; Kienlen-Campard, Pascal ; Rider, Mark H. ; Vertommen, Didier ; Hanseeuw, Bernard. Specific post-translational modifications of soluble tau protein distinguishes Alzheimer’s disease and primary tauopathies. In: Nature Communications, Vol. 14, no.1 (2023). doi:10.1038/s41467-023-39328-1.
2022
Canciani, Anselmo ; Capitanio, Cristina ; Stanga, Serena ; Faravelli, Silvia ; Scietti, Luigi ; Mapelli, Lisa ; Soda, Teresa ; D’Angelo, Egidio ; Kienlen-Campard, Pascal ; Forneris, Federico. Deconstruction of Neurotrypsin Reveals a Multi-factorially Regulated Activity Affecting Myotube Formation and Neuronal Excitability. In: Molecular Neurobiology, Vol. 59, no. 12, p. 7466-7485 (2022). doi:10.1007/s12035-022-03056-2.
2022
Papadopoulos, Nicolas ; Suelves Caballol, Nuria ; Perrin, Florian ; Vadukul, Devkee M. ; Vrancx, Céline ; Constantinescu, Stefan N. ; Kienlen-Campard, Pascal. Structural Determinant of β-Amyloid Formation: From Transmembrane Protein Dimerization to β-Amyloid Aggregates. In: Biomedicines, Vol. 10, no. 11, p. 2753 [1-21] (2022). doi:10.3390/biomedicines10112753.
2021
Vadukul, Devkee Mahesh ; Vrancx, Céline ; Burguet, Pierre ; Contino, Sabrina ; Suelves Caballol, Nuria ; Serpell, Louise C ; Quinton, Loïc ; Kienlen-Campard, Pascal. An evaluation of the self-assembly enhancing properties of cell-derived hexameric amyloid-β.. In: Scientific reports, Vol. 11, no.1, p. 11570 (2021). doi:10.1038/s41598-021-90680-y.
2021
Vrancx, Céline ; Vadukul, Devkee M ; Suelves Caballol, Nuria ; Contino, Sabrina ; D'Auria, Ludovic ; Perrin, Florian ; van Pesch, Vincent ; Hanseeuw, Bernard ; Quinton, Loïc ; Kienlen-Campard, Pascal. Mechanism of Cellular Formation and In Vivo Seeding Effects of Hexameric β-Amyloid Assemblies.. In: Molecular neurobiology, (2021). doi:10.1007/s12035-021-02567-8 (Accepté/Sous presse).
2021
Kreis, Anna ; Desloovere, Jana ; Suelves Caballol, Nuria ; Pierrot, Nathalie ; Yerna, Xavier ; Issa, Farah ; Schakman, Olivier ; Gualdani, Roberta ; De Clippele, Marie ; Tajeddine, Nicolas ; Kienlen-Campard, Pascal ; Raedt, Robrecht ; Octave, Jean-Noël ; Gailly, Philippe. Overexpression of wild-type human amyloid precursor protein alters GABAergic transmission.. In: Scientific Reports, Vol. 11, no.1, p. 17600 (2021). doi:10.1038/s41598-021-97144-3.
2021
Contino, Sabrina ; Suelves Caballol, Nuria ; Vrancx, Céline ; Vadukul, Devkee Mahesh ; Payen Valery L. ; Stanga, Serena ; Bertrand, Luc ; Kienlen-Campard, Pascal. Presenilin-Deficient Neurons and Astrocytes Display Normal Mitochondrial Phenotypes. In: Frontiers in Neuroscience, Vol. 14, p. 586108 (2021).
2020
Opsomer, Remi ; Contino, Sabrina ; Perrin, Florian ; Gualdani, Roberta ; Tasiaux, Bernadette ; Doyen, Pierre ; Vergouts, Maxime ; Vrancx, Céline ; Doshina, Anna ; Pierrot, Nathalie ; Octave, Jean-Noël ; Gailly, Philippe ; Stanga, Serena ; Kienlen-Campard, Pascal. Amyloid Precursor Protein (APP) Controls the Expression of the Transcriptional Activator Neuronal PAS Domain Protein 4 (NPAS4) and Synaptic GABA Release.. In: eNeuro, Vol. 7, no. 3, p. ENEURO.0322-19.202 [1-18] (2020). doi:10.1523/ENEURO.0322-19.2020.
2020
Perrin, Florian ; Papadopoulos, Nicolas ; Suelves, Nuria ; Opsomer, Rémi ; Vadukul, Devkee M ; Vrancx, Céline ; Smith, Steven O ; Vertommen, Didier ; Kienlen-Campard, Pascal ; Constantinescu, Stefan N.. Dimeric Transmembrane Orientations of APP/C99 Regulate γ-Secretase Processing Line Impacting Signaling and Oligomerization.. In: iScience, Vol. 23, no.12, p. 101887 (2020). doi:10.1016/j.isci.2020.101887.
2020
Stanga, Serena ; Boido, Marina ; Kienlen-Campard, Pascal. How to Build and to Protect the Neuromuscular Junction: The Role of the Glial Cell Line-Derived Neurotrophic Factor. In: International Journal of Molecular Sciences (Print), Vol. 22, no.1, p. 136 (2020). doi:10.3390/ijms22010136.
2019
Tang, Tzu-Chun ; Kienlen-Campard, Pascal ; Hu, Yi ; Perrin, Florian ; Opsomer, Rémi ; Octave, Jean-Noël ; Constantinescu, Stefan N. ; Smith, Steven O. Influence of the familial Alzheimer's disease-associated T43I mutation on the transmembrane structure and γ-secretase processing of the C99 peptide.. In: The Journal of biological chemistry, Vol. 294, no. 15, p. 5854-5866 (2019). doi:10.1074/jbc.RA118.006061.
2019
Pierrot, Nathalie ; Ris, Laurence ; Stancu, Ilie-Cosmin ; Doshina, Anna ; Ribeiro, Floriane ; Tyteca, Donatienne ; Baugé, Eric ; Lalloyer, Fanny ; Malong, Liza ; Schakman, Olivier ; Leroy, Karelle ; Kienlen-Campard, Pascal ; Gailly, Philippe ; Brion, Jean-Pierre ; Dewachter, Ilse ; Staels, Bart ; Octave, Jean-Noël. Sex-regulated gene dosage effect of PPARα on synaptic plasticity.. In: Life science alliance, Vol. 2, no. 2, p. e201800262 [1-15] (2019). doi:10.26508/lsa.201800262.
2018
Stanga, Serena ; Brambilla, Liliana ; Tasiaux, Bernadette ; Dang, Hong Anh ; Ivanoiu, Adrian ; Octave, Jean-Noël ; Rossi, Daniela ; Van Pesch, Vincent ; Kienlen-Campard, Pascal. A Role for GDNF and Soluble APP as Biomarkers of Amyotrophic Lateral Sclerosis Pathophysiology.. In: Frontiers in neurology, Vol. 9, p. 384 [1-9] (2018). doi:10.3389/fneur.2018.00384.
2018
Evrard, Caroline ; Kienlen-Campard, Pascal ; Coevoet, Mathilde ; Opsomer, Rémi ; Tasiaux, Bernadette ; Melnyk, Patricia ; Octave, Jean-Noël ; Buée, Luc ; Sergeant, Nicolas ; Vingtdeux, Valérie. Contribution of the Endosomal-Lysosomal and Proteasomal Systems in Amyloid-β Precursor Protein Derived Fragments Processing.. In: Frontiers in cellular neuroscience, Vol. 12, p. 435 (2018). doi:10.3389/fncel.2018.00435.
2018
Stanga, Serena ; Vrancx, Céline ; Tasiaux, Bernadette ; Marinangeli, Claudia ; Karlström, Helena ; Kienlen-Campard, Pascal. Specificity of presenilin-1- and presenilin-2-dependent γ-secretases towards substrate processing.. In: Journal of Cellular and Molecular Medicine, Vol. 22, no. 2, p. 823-833 (2018). doi:10.1111/jcmm.13364.
2017
Doshina, Anna ; Gourgue, Florian ; Onizuka, Michiho ; Opsomer, Rémi ; Wang, Peng ; Ando, Kunie ; Tasiaux, Bernadette ; Dewachter, Ilse ; Kienlen-Campard, Pascal ; Brion, Jean-Pierre ; Gailly, Philippe ; Octave, Jean-Noël ; Pierrot, Nathalie. Cortical cells reveal APP as a new player in the regulation of GABAergic neurotransmission.. In: Scientific Reports, Vol. 7, no. 1, p. 370 [1-14] (2017). doi:10.1038/s41598-017-00325-2.
2017
Contino, Sabrina ; Porporato, Paolo ; Bird, Matthew ; Marinangeli, Claudia ; Opsomer, Rémi ; Sonveaux, Pierre ; Bontemps, Françoise ; Dewachter, Ilse ; Octave, Jean-Noël ; Bertrand, Luc ; Stanga, Serena ; Kienlen-Campard, Pascal. Presenilin 2-Dependent Maintenance of Mitochondrial Oxidative Capacity and Morphology.. In: Frontiers in Physiology, Vol. 8, p. 796 [1-11] (2017). doi:10.3389/fphys.2017.00796.
2017
Wang, Peng ; Joberty, G ; Buist, A ; Vanoosthuyse, Alexandre ; Stancu, Ilie-Cosmin ; Barbosa de Vasconcelos, Bruno ; Pierrot, Nathalie ; Faelth-Savitski, M ; Kienlen-Campard, Pascal ; Octave, Jean-Noël ; Bantscheff, M ; Drewes, G ; Moechars, D ; Dewachter, Ilse. Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo.. In: Acta Neuropathologica, . doi:10.1007/s00401-016-1663-9.
2017
Hu, Yi ; Kienlen-Campard, Pascal ; Tang, Tzu-Chun ; Perrin, Florian ; Opsomer, Rémi ; Decock, Marie ; Pan, Xiaoshu ; Octave, Jean-Noël ; Constantinescu, Stefan N. ; Smith, Steven O. β-Sheet Structure within the Extracellular Domain of C99 Regulates Amyloidogenic Processing.. In: Scientific Reports, Vol. 7, p. 17159 (2017). doi:10.1038/s41598-017-17144-0.
2016
Stanga, Serena ; Zanou, Bidossessi Nadège ; TASIAUX, Bernadette ; Contino, Sabrina ; Clotman, Frédéric ; Gailly, Philippe ; Dewachter, Ilse ; Octave, Jean-Noël ; Kienlen-Campard, Pascal. APP-dependent glial cell line-derived neurotrophic factor gene expression drives neuromuscular junction formation.. In: The FASEB Journal, Vol. 30, no. 5, p. 1696-711 (2016). doi:10.1096/fj.15-278739.
2016
Couturier, Julien ; Stancu, Ilie-Cosmin ; Schakman, Olivier ; Pierrot, Nathalie ; Huaux, François ; Kienlen-Campard, Pascal ; Dewachter, Ilse ; Octave, Jean-Noël. Activation of phagocytic activity in astrocytes by reduced expression of the inflammasome component ASC and its implication in a mouse model of Alzheimer disease. In: Journal of Neuroinflammation, Vol. 13, no.1, p. 20 (2016). doi:10.1186/s12974-016-0477-y.
2016
Decock, Marie ; Stanga, Serena ; Octave, Jean-Noël ; Dewachter, Ilse ; Smith, Steven O. ; Constantinescu, Stefan N. ; Kienlen-Campard, Pascal. Glycines from the APP GXXXG/GXXXA transmembrane motifs promote formation of pathogenic AB oligomers in cells. In: Frontiers in Aging Neuroscience, Vol. 8, p. 107 [1-15] (2016). doi:10.3389/fnagi.2016.00107.
2016
Barbosa de Vasconcelos, Bruno ; Stancu, Ilie-Cosmin ; Buist, Arjan ; Bird, Matthew ; Wang, Peng ; Vanoosthuyse, Alexandre ; Van Kolen, Kristof ; Verheyen, An ; Kienlen-Campard, Pascal ; Octave, Jean-Noël ; Baatsen, Peter ; Moechars, Diederik ; Dewachter, Ilse. Heterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo.. In: Acta Neuropathologica, Vol. 131, no. 4, p. 549-569 (April 2016). doi:10.1007/s00401-015-1525-x.
2015
Decock, Marie ; El Haylani, Laetitia ; Stanga, Serena ; Dewachter, Ilse ; Octave, Jean-Noël ; Smith, Steven O ; Constantinescu, Stefan N. ; Kienlen-Campard, Pascal. Analysis by a highly sensitive split luciferase assay of the regions involved in APP dimerization and its impact on processing.. In: F E B S Open Bio, Vol. 5, p. 763-773 (2015). doi:10.1016/j.fob.2015.09.002.
2015
Hage, Salim ; Stanga, Serena ; Marinangeli, Claudia ; Octave, Jean-Noël ; Dewachter, Ilse ; Quetin-Leclercq, Joëlle ; Kienlen-Campard, Pascal. Characterization of Pterocarpus erinaceus kino extract and its gamma-secretase inhibitory properties. In: Journal of Ethnopharmacology, Vol. 163, p. 192-202 (2015). doi:10.1016/j.jep.2015.01.028.
2015
Marinangeli, Claudia ; Tasiaux, Bernadette ; Opsomer, Rémi ; Hage, Salim ; Sodero, Alejandro ; Dewachter, Ilse ; Octave, Jean-Noël ; Smith, Steven O ; Constantinescu, Stefan N. ; Kienlen-Campard, Pascal. Presenilin Transmembrane Domain 8 conserved AxxxAxxxG Motifs Are Required for the Activity of the γ-Secretase Complex.. In: Journal of Biological Chemistry, Vol. 290, no. 11, p. 7169-7184 (2015). doi:10.1074/jbc.M114.601286.
2015
Stancu, Ilie-Cosmin ; Barbosa de Vasconcelos, Bruno ; Ris, Laurence ; Wang, Peng ; Villers, Agnès ; Peeraer, Eve ; Buist, Arjan ; Terwel, Dick ; Baatsen, Peter ; Oyelami, Tutu ; Pierrot, Nathalie ; Casteels, Cindy ; Bormans, Guy ; Kienlen-Campard, Pascal ; Octave, Jean-Noël ; Moechars, Diederik ; Dewachter, Ilse. Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice.. In: Acta Neuropathologica, Vol. 129, no.6, p. 875-894 (2015). doi:10.1007/s00401-015-1413-4.
2014
Tang, Tzu-Chun ; Hu, Yi ; Kienlen-Campard, Pascal ; El Haylani, Laetitia ; Decock, Marie ; Van Hees, Joanne ; Fu, Ziao ; Octave, Jean-Noël ; Constantinescu, Stefan N. ; Smith, Steven O. Conformational changes induced by the A21G Flemish mutation in the amyloid precursor protein lead to increased Aβ production.. In: Structure, Vol. 22, no. 3, p. 387-396 (2014). doi:10.1016/j.str.2013.12.012.
2014
Hendrickx, Aurélie ; Pierrot, Nathalie ; Tasiaux, Bernadette ; Schakman, Olivier ; Kienlen-Campard, Pascal ; De Smet, Charles ; Octave, Jean-Noël. Epigenetic regulations of immediate early genes expression involved in memory formation by the amyloid precursor protein of Alzheimer disease. In: PLoS One, Vol. 9, no. 6, p. e99467 [1-9] (2014). doi:10.1371/journal.pone.0099467.
2014
Hage, Salim ; Marinangeli, Claudia ; Stanga, Serena ; Octave, Jean-Noël ; Quetin-Leclercq, Joëlle ; Kienlen-Campard, Pascal. Gamma-Secretase Inhibitor Activity of a Pterocarpus erinaceus Extract. In: Neurodegenerative Diseases, Vol. 14, no. 1, p. 39-51 (2014). doi:10.1159/000355557.
2014
Stancu, Ilie-Cosmin ; Ris, Laurence ; Barbosa de Vasconcelos, Bruno ; Marinangeli, Claudia ; Goeminne, Léonie ; Laporte, Vincent ; El Haylani, Laetitia ; Couturier, Julien ; Schakman, Olivier ; Gailly, Philippe ; Pierrot, Nathalie ; Kienlen-Campard, Pascal ; Octave, Jean-Noël ; Dewachter, Ilse. Tauopathy contributes to synaptic and cognitive deficits in a murine model for Alzheimer's disease.. In: The FASEB Journal, Vol. 28, no.6, p. 2620-2631 (2014). doi:10.1096/fj.13-246702.
2013
Pierrot, Nathalie ; Tyteca, Donatienne ; D'auria, Ludovic ; Dewachter, Ilse ; Gailly, Philippe ; Hendrickx, Aurélie ; TASIAUX, Bernadette ; El Haylani, Laetitia ; Muls, Nathalie ; N'kuli, Francisca ; Laquerrière, Annie ; Demoulin, Jean-Baptiste ; Campion, Dominique ; Brion, Jean-Pierre ; Courtoy, Pierre J. ; Kienlen-Campard, Pascal ; Octave, Jean-Noël. Amyloid precursor protein controls cholesterol turnover needed for neuronal activity.. In: EMBO Molecular Medicine, Vol. 5, no.4, p. 608-625 (2013). doi:10.1002/emmm.201202215.
2013
Hendrickx, Aurélie ; Pierrot, Nathalie ; Tasiaux, Bernadette ; Schakman, Olivier ; Brion, Jean-Pierre ; Kienlen-Campard, Pascal ; De Smet, Charles ; Octave, Jean-Noël. Epigenetic induction of EGR-1 expression by the amyloid precursor protein during exposure to novelty.. In: PloS one, Vol. 8, no. 9, p. e74305 (2013). doi:10.1371/journal.pone.0074305.
2012
Ben Khalifa, Naouel ; Tyteca, Donatienne ; Courtoy, Pierre J. ; Renauld, Jean-Christophe ; Constantinescu, Stefan N. ; Octave, Jean-Noël ; Kienlen-Campard, Pascal. Contribution of Kunitz protease inhibitor and transmembrane domains to amyloid precursor protein homodimerization. In: Neurodegenerative Diseases, Vol. 10, no. 1-4, p. 92-95 (2012). doi:10.1159/000335225.
2012
Ben Khalifa, Naouel ; Tyteca, Donatienne ; Marinangeli, Claudia ; Depuydt, Mathieu ; Collet, Jean-François ; Courtoy, Pierre J. ; Renauld, Jean-Christophe ; Constantinescu, Stefan N. ; Octave, Jean-Noël ; Kienlen-Campard, Pascal. Structural features of the KPI domain control APP dimerization, trafficking, and processing.. In: The FASEB Journal, Vol. 26, no. 2, p. 855-867 (2012). doi:10.1096/fj.11-190207.
2010
Hage, Salim ; Kienlen-Campard, Pascal ; Octave, Jean-Noël ; Quetin-Leclercq, Joëlle. In vitro screening on beta-amyloid peptide production of plants used in traditional medicine for cognitive disorders.. In: Journal of Ethnopharmacology, Vol. 131, no. 3, p. 585-591 (2010). doi:10.1016/j.jep.2010.07.044.
2010
Khalifa, Naouel Ben ; Van Hees, Joanne ; Tasiaux, Bernadette ; Huysseune, Sandra ; Smith, Steven O. ; Constantinescu, Stefan N. ; Octave, Jean-Noël ; Kienlen-Campard, Pascal. What is the role of amyloid precursor protein dimerization?. In: Cell Adhesion and Migration, Vol. 4, no. 2, p. 268-272 (2010). doi:10.4161/cam.4.2.11476.
2009
Sato, Takeshi ; Tang, Tzu-Chun ; Reubins, Gabriella ; Fei, Jeffrey Z ; Fujimoto, Taiki ; Kienlen-Campard, Pascal ; Constantinescu, Stefan N. ; Octave, Jean-Noël ; Aimoto, Saburo ; Smith, Steven O.. A helix-to-coil transition at the epsilon-cut site in the transmembrane dimer of the amyloid precursor protein is required for proteolysis.. In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, no. 5, p. 1421-6 (2009). doi:10.1073/pnas.0812261106.
2009
Huysseune, Sandra ; Kienlen-Campard, Pascal ; Hébert, Sébastien ; Tasiaux, Bernadette ; Leroy, Karelle ; Devuyst, Olivier ; Brion, Jean-Pierre ; De Strooper, Bart ; Octave, Jean-Noël. Epigenetic control of aquaporin 1 expression by the amyloid precursor protein.. In: The FASEB Journal, Vol. 23, no. 12, p. 4158-4167 (2009). doi:10.1096/fj.09-140012.
2008
Kienlen-Campard, Pascal ; Tasiaux, Bernadette ; Van Hees, Joanne ; Li, Mingli ; Huysseune, Sandra ; Sato, Takeshi ; Fei, Jeffrey Z ; Aimoto, Saburo ; Smith, Steven O ; Constantinescu, Stefan N. ; Octave, Jean-Noël. Erratum : amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs. In: Journal of Biological Chemistry, Vol. 283, no. 12, p. 7733-7744 (2008). doi:10.1074/jbc.M707142200.
2007
Huysseune, Sandra ; Kienlen-Campard, Pascal ; Octave, Jean-Noël. Fe65 does not stabilize AICD during activation of transcription in a luciferase assay.. In: Biochemical and biophysical research communications, Vol. 361, no. 2, p. 317-22 (2007). doi:10.1016/j.bbrc.2007.06.186.
2007
Feyt, Christine ; Courtoy, Pierre J. ; Pierrot, Nathalie ; Tasiaux, Bernadette ; Van Hees, Joanne ; Kienlen-Campard, Pascal ; Octave, Jean-Noël. Phosphorylation of APP695 at Thr668 decreases gamma-cleavage and extracellular Abeta.. In: Biochemical and biophysical research communications, Vol. 357, no. 4, p. 1004-10 (2007). doi:10.1016/j.bbrc.2007.04.036.
2006
Sato, Takeshi ; Kienlen-Campard, Pascal ; Ahmed, Mahiuddin ; Liu, Wei ; Li, Huilin ; Elliott, James I ; Aimoto, Saburo ; Constantinescu, Stefan N. ; Octave, Jean-Noël ; Smith, Steven O.. Inhibitors of amyloid toxicity based on beta-sheet packing of Abeta40 and Abeta42.. In: Biochemistry, Vol. 45, no. 17, p. 5503-16 (2006). doi:10.1021/bi052485f.
2006
Kienlen-Campard, Pascal ; Courtoy, Pierre J. ; Feyt, Christine ; Huysseune, Sandra ; de Diesbach, Philippe ; N'Kuli, Francisca ; Octave, Jean-Noël. Lactacystin decreases amyloid-beta peptide production by inhibiting beta-secretase activity.. In: Journal of neuroscience research, Vol. 84, no. 6, p. 1311-1322 (2006). doi:10.1002/jnr.21025.
2005
Feyt, Christine ; Kienlen-Campard, Pascal ; Leroy, Karelle ; N'Kuli, Francisca ; Courtoy, Pierre J. ; Brion, Jean-Pierre ; Octave, Jean-Noël. Lithium chloride increases the production of amyloid-beta peptide independently from its inhibition of glycogen synthase kinase 3.. In: Journal of Biological Chemistry, Vol. 280, no. 39, p. 33220-33227 (2005). doi:10.1074/jbc.M501610200.
2004
Race, V. ; Marie, S. ; Kienlen-Campard, Pascal ; Hermans, Emmanuel ; Octave, Jean-Noël ; Van den Berghe, Georges ; Vincent, Marie-Françoise. Adenylosuccinate lyase deficiency: study of physiopathologic mechanism(s).. In: Nucleosides, Nucleotides and Nucleic Acids : an international journal for rapid communication, Vol. 23, no. 8-9, p. 1227-1229 (2004). doi:10.1081/NCN-200027491.
2002
Kienlen-Campard, Pascal ; Octave, Jean-Noël. Correlation between beta-amyloid peptide production and human APP-induced neuronal death.. In: Peptides, Vol. 23, no. 7, p. 1199-204 (2002). doi:10.1016/S0196-9781(02)00055-4.
2002
Pitsi, Didier ; Kienlen-Campard, Pascal ; Octave, Jean-Noël. Failure of the interaction between presenilin 1 and the substrate of gamma-secretase to produce Abeta in insect cells.. In: Journal of neurochemistry, Vol. 83, no. 2, p. 390-9 (2002). doi:10.1046/j.1471-4159.2002.01138.x.
2002
Kienlen-Campard, Pascal ; Miolet, Sarah ; Tasiaux, Bernadette ; Octave, Jean-Noël. Intracellular amyloid-beta 1-42, but not extracellular soluble amyloid-beta peptides, induces neuronal apoptosis.. In: The Journal of biological chemistry, Vol. 277, no. 18, p. 15666-70 (2002). doi:10.1074/jbc.M200887200.
2000
Kienlen-Campard, Pascal ; Tasiaux, Bernadette ; Octave, Jean-Noël. The processing and biological function of the human amyloid precursor protein (APP): lessons from different cellular models.. In: Experimental gerontology, Vol. 35, no. 6-7, p. 843-50 (2000). doi:10.1016/S0531-5565(00)00170-4.
Provided by DIAL
Alzheimer - JNO
2023
Kreis, Anna ; Issa, Farah ; Yerna, Xavier ; Jabbour, Caren ; Schakman, Olivier ; de Clippele, Marie ; Tajeddine, Nicolas ; Pierrot, Nathalie ; Octave, Jean-Noël ; Gualdani, Roberta ; Gailly, Philippe. Conditional deletion of KCC2 impairs synaptic plasticity and both spatial and nonspatial memory. In: Frontiers in Molecular Neuroscience, Vol. 16, no.1, p. 1081657 (2023). doi:10.3389/fnmol.2023.1081657.
2021
Lodder, Chritica ; Scheyltjens, Isabelle ; Stancu, Ilie Cosmin ; Botella Lucena, Pablo ; Gutiérrez de Ravé, Manuel ; Vanherle, Sarah ; Vanmierlo, Tim ; Cremers, Niels ; Vanrusselt, Hannah ; Brône, Bert ; Hanseeuw, Bernard ; Octave, Jean-Noël ; Bottelbergs, Astrid ; Movahedi, Kiavash ; Dewachter, Ilse. CSF1R inhibition rescues tau pathology and neurodegeneration in an A/T/N model with combined AD pathologies, while preserving plaque associated microglia.. In: Acta neuropathologica communications, Vol. 9, no. 1, p. 108 [1-21] (2021). doi:10.1186/s40478-021-01204-8.
2021
Kreis, Anna ; Desloovere, Jana ; Suelves Caballol, Nuria ; Pierrot, Nathalie ; Yerna, Xavier ; Issa, Farah ; Schakman, Olivier ; Gualdani, Roberta ; De Clippele, Marie ; Tajeddine, Nicolas ; Kienlen-Campard, Pascal ; Raedt, Robrecht ; Octave, Jean-Noël ; Gailly, Philippe. Overexpression of wild-type human amyloid precursor protein alters GABAergic transmission.. In: Scientific Reports, Vol. 11, no.1, p. 17600 (2021). doi:10.1038/s41598-021-97144-3.
2021
Saez Orellana, Francisco Javier ; LEROY, Thomas ; Ribeiro, Floriane ; Kreis, Anna ; Leroy, Karelle ; Lalloyer, Fanny ; Baugé, Eric ; Staels, Bart ; Duyckaerts, Charles ; Brion, Jean-Pierre ; Gailly, Philippe ; Octave, Jean-Noël ; Pierrot, Nathalie. Regulation of PPARα by APP in Alzheimer disease affects the pharmacological modulation of synaptic activity.. In: JCI Insight, Vol. 6, no.16 (2021). doi:10.1172/jci.insight.150099.
2020
Saez Orellana, Francisco Javier ; Octave, Jean-Noël ; Pierrot, Nathalie. Alzheimer's Disease, a Lipid Story: Involvement of Peroxisome Proliferator-Activated Receptor α.. In: Cells, Vol. 9, no.5, p. 1215 [1-27] (2020). doi:10.3390/cells9051215.
2020
Opsomer, Remi ; Contino, Sabrina ; Perrin, Florian ; Gualdani, Roberta ; Tasiaux, Bernadette ; Doyen, Pierre ; Vergouts, Maxime ; Vrancx, Céline ; Doshina, Anna ; Pierrot, Nathalie ; Octave, Jean-Noël ; Gailly, Philippe ; Stanga, Serena ; Kienlen-Campard, Pascal. Amyloid Precursor Protein (APP) Controls the Expression of the Transcriptional Activator Neuronal PAS Domain Protein 4 (NPAS4) and Synaptic GABA Release.. In: eNeuro, Vol. 7, no. 3, p. ENEURO.0322-19.202 [1-18] (2020). doi:10.1523/ENEURO.0322-19.2020.
2019
Stancu, Ilie-Cosmin ; Cremers, Niels ; Vanrusselt, Hannah ; Couturier, Julien ; Vanoosthuyse, Alexandre ; Kessels, Sofie ; Lodder, Chritica ; Brône, Bert ; Huaux, François ; Octave, Jean-Noël ; Terwel, Dick ; Dewachter, Ilse. Aggregated Tau activates NLRP3-ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo.. In: Acta neuropathologica, Vol. 137, no. 4, p. 599-617 (2019). doi:10.1007/s00401-018-01957-y.
2019
Hu, Chaur-Jong ; Octave, Jean-Noël. Editorial: Risk Factors and Outcome Predicating Biomarker of Neurodegenerative Diseases.. In: Frontiers in Neurology, Vol. 10, p. 45 (2019). doi:10.3389/fneur.2019.00045.
2019
Tang, Tzu-Chun ; Kienlen-Campard, Pascal ; Hu, Yi ; Perrin, Florian ; Opsomer, Rémi ; Octave, Jean-Noël ; Constantinescu, Stefan N. ; Smith, Steven O. Influence of the familial Alzheimer's disease-associated T43I mutation on the transmembrane structure and γ-secretase processing of the C99 peptide.. In: The Journal of biological chemistry, Vol. 294, no. 15, p. 5854-5866 (2019). doi:10.1074/jbc.RA118.006061.
2019
Pierrot, Nathalie ; Ris, Laurence ; Stancu, Ilie-Cosmin ; Doshina, Anna ; Ribeiro, Floriane ; Tyteca, Donatienne ; Baugé, Eric ; Lalloyer, Fanny ; Malong, Liza ; Schakman, Olivier ; Leroy, Karelle ; Kienlen-Campard, Pascal ; Gailly, Philippe ; Brion, Jean-Pierre ; Dewachter, Ilse ; Staels, Bart ; Octave, Jean-Noël. Sex-regulated gene dosage effect of PPARα on synaptic plasticity.. In: Life science alliance, Vol. 2, no. 2, p. e201800262 [1-15] (2019). doi:10.26508/lsa.201800262.
2018
Stanga, Serena ; Brambilla, Liliana ; Tasiaux, Bernadette ; Dang, Hong Anh ; Ivanoiu, Adrian ; Octave, Jean-Noël ; Rossi, Daniela ; Van Pesch, Vincent ; Kienlen-Campard, Pascal. A Role for GDNF and Soluble APP as Biomarkers of Amyotrophic Lateral Sclerosis Pathophysiology.. In: Frontiers in neurology, Vol. 9, p. 384 [1-9] (2018). doi:10.3389/fneur.2018.00384.
2018
Evrard, Caroline ; Kienlen-Campard, Pascal ; Coevoet, Mathilde ; Opsomer, Rémi ; Tasiaux, Bernadette ; Melnyk, Patricia ; Octave, Jean-Noël ; Buée, Luc ; Sergeant, Nicolas ; Vingtdeux, Valérie. Contribution of the Endosomal-Lysosomal and Proteasomal Systems in Amyloid-β Precursor Protein Derived Fragments Processing.. In: Frontiers in cellular neuroscience, Vol. 12, p. 435 (2018). doi:10.3389/fncel.2018.00435.
2017
Vanden Dries, Virginie ; Stygelbout, Virginie ; Pierrot, Nathalie ; Yilmaz, Zehra ; Suain, Valérie ; De Decker, Robert ; Buée, Luc ; Octave, Jean-Noël ; Brion, Jean-Pierre ; Leroy, Karelle. Amyloid precursor protein reduction enhances the formation of neurofibrillary tangles in a mutant tau transgenic mouse model.. In: Neurobiology of Aging, Vol. 55, p. 202-212 (2017). doi:10.1016/j.neurobiolaging.2017.03.031.
2017
Doshina, Anna ; Gourgue, Florian ; Onizuka, Michiho ; Opsomer, Rémi ; Wang, Peng ; Ando, Kunie ; Tasiaux, Bernadette ; Dewachter, Ilse ; Kienlen-Campard, Pascal ; Brion, Jean-Pierre ; Gailly, Philippe ; Octave, Jean-Noël ; Pierrot, Nathalie. Cortical cells reveal APP as a new player in the regulation of GABAergic neurotransmission.. In: Scientific Reports, Vol. 7, no. 1, p. 370 [1-14] (2017). doi:10.1038/s41598-017-00325-2.
2017
Contino, Sabrina ; Porporato, Paolo ; Bird, Matthew ; Marinangeli, Claudia ; Opsomer, Rémi ; Sonveaux, Pierre ; Bontemps, Françoise ; Dewachter, Ilse ; Octave, Jean-Noël ; Bertrand, Luc ; Stanga, Serena ; Kienlen-Campard, Pascal. Presenilin 2-Dependent Maintenance of Mitochondrial Oxidative Capacity and Morphology.. In: Frontiers in Physiology, Vol. 8, p. 796 [1-11] (2017). doi:10.3389/fphys.2017.00796.
2017
Wang, Peng ; Joberty, G ; Buist, A ; Vanoosthuyse, Alexandre ; Stancu, Ilie-Cosmin ; Barbosa de Vasconcelos, Bruno ; Pierrot, Nathalie ; Faelth-Savitski, M ; Kienlen-Campard, Pascal ; Octave, Jean-Noël ; Bantscheff, M ; Drewes, G ; Moechars, D ; Dewachter, Ilse. Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo.. In: Acta Neuropathologica, . doi:10.1007/s00401-016-1663-9.
2017
Hu, Yi ; Kienlen-Campard, Pascal ; Tang, Tzu-Chun ; Perrin, Florian ; Opsomer, Rémi ; Decock, Marie ; Pan, Xiaoshu ; Octave, Jean-Noël ; Constantinescu, Stefan N. ; Smith, Steven O. β-Sheet Structure within the Extracellular Domain of C99 Regulates Amyloidogenic Processing.. In: Scientific Reports, Vol. 7, p. 17159 (2017). doi:10.1038/s41598-017-17144-0.
2016
Stanga, Serena ; Zanou, Bidossessi Nadège ; TASIAUX, Bernadette ; Contino, Sabrina ; Clotman, Frédéric ; Gailly, Philippe ; Dewachter, Ilse ; Octave, Jean-Noël ; Kienlen-Campard, Pascal. APP-dependent glial cell line-derived neurotrophic factor gene expression drives neuromuscular junction formation.. In: The FASEB Journal, Vol. 30, no. 5, p. 1696-711 (2016). doi:10.1096/fj.15-278739.
2016
Couturier, Julien ; Stancu, Ilie-Cosmin ; Schakman, Olivier ; Pierrot, Nathalie ; Huaux, François ; Kienlen-Campard, Pascal ; Dewachter, Ilse ; Octave, Jean-Noël. Activation of phagocytic activity in astrocytes by reduced expression of the inflammasome component ASC and its implication in a mouse model of Alzheimer disease. In: Journal of Neuroinflammation, Vol. 13, no.1, p. 20 (2016). doi:10.1186/s12974-016-0477-y.
2016
Decock, Marie ; Stanga, Serena ; Octave, Jean-Noël ; Dewachter, Ilse ; Smith, Steven O. ; Constantinescu, Stefan N. ; Kienlen-Campard, Pascal. Glycines from the APP GXXXG/GXXXA transmembrane motifs promote formation of pathogenic AB oligomers in cells. In: Frontiers in Aging Neuroscience, Vol. 8, p. 107 [1-15] (2016). doi:10.3389/fnagi.2016.00107.
2016
Barbosa de Vasconcelos, Bruno ; Stancu, Ilie-Cosmin ; Buist, Arjan ; Bird, Matthew ; Wang, Peng ; Vanoosthuyse, Alexandre ; Van Kolen, Kristof ; Verheyen, An ; Kienlen-Campard, Pascal ; Octave, Jean-Noël ; Baatsen, Peter ; Moechars, Diederik ; Dewachter, Ilse. Heterotypic seeding of Tau fibrillization by pre-aggregated Abeta provides potent seeds for prion-like seeding and propagation of Tau-pathology in vivo.. In: Acta Neuropathologica, Vol. 131, no. 4, p. 549-569 (April 2016). doi:10.1007/s00401-015-1525-x.
2016
Pierrot, Nathalie ; Lhommel, Renaud ; Quenon, Lisa ; Hanseeuw, Bernard ; Dricot, Laurence ; Sindic, Christian ; Maloteaux, Jean-Marie ; Octave, Jean-Noël ; Ivanoiu, Adrian. Targretin Improves Cognitive and Biological Markers in a Patient with Alzheimer's Disease.. In: Journal of Alzheimer's Disease, Vol. 49, no. 2, p. 271-276 (2016). doi:10.3233/JAD-150405.
2015
Decock, Marie ; El Haylani, Laetitia ; Stanga, Serena ; Dewachter, Ilse ; Octave, Jean-Noël ; Smith, Steven O ; Constantinescu, Stefan N. ; Kienlen-Campard, Pascal. Analysis by a highly sensitive split luciferase assay of the regions involved in APP dimerization and its impact on processing.. In: F E B S Open Bio, Vol. 5, p. 763-773 (2015). doi:10.1016/j.fob.2015.09.002.
2015
Hage, Salim ; Stanga, Serena ; Marinangeli, Claudia ; Octave, Jean-Noël ; Dewachter, Ilse ; Quetin-Leclercq, Joëlle ; Kienlen-Campard, Pascal. Characterization of Pterocarpus erinaceus kino extract and its gamma-secretase inhibitory properties. In: Journal of Ethnopharmacology, Vol. 163, p. 192-202 (2015). doi:10.1016/j.jep.2015.01.028.
2015
Marinangeli, Claudia ; Tasiaux, Bernadette ; Opsomer, Rémi ; Hage, Salim ; Sodero, Alejandro ; Dewachter, Ilse ; Octave, Jean-Noël ; Smith, Steven O ; Constantinescu, Stefan N. ; Kienlen-Campard, Pascal. Presenilin Transmembrane Domain 8 conserved AxxxAxxxG Motifs Are Required for the Activity of the γ-Secretase Complex.. In: Journal of Biological Chemistry, Vol. 290, no. 11, p. 7169-7184 (2015). doi:10.1074/jbc.M114.601286.
2015
Stancu, Ilie-Cosmin ; Barbosa de Vasconcelos, Bruno ; Ris, Laurence ; Wang, Peng ; Villers, Agnès ; Peeraer, Eve ; Buist, Arjan ; Terwel, Dick ; Baatsen, Peter ; Oyelami, Tutu ; Pierrot, Nathalie ; Casteels, Cindy ; Bormans, Guy ; Kienlen-Campard, Pascal ; Octave, Jean-Noël ; Moechars, Diederik ; Dewachter, Ilse. Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice.. In: Acta Neuropathologica, Vol. 129, no.6, p. 875-894 (2015). doi:10.1007/s00401-015-1413-4.
2014
Pierrot, Nathalie ; Octave, Jean-Noël. Cholestérol, activité neuronale et maladie d’Alzheimer. In: M/S : médecine sciences, Vol. 30, no.3, p. 244-246 (2014). doi:10.1051/medsci/20143003008.
2014
Tang, Tzu-Chun ; Hu, Yi ; Kienlen-Campard, Pascal ; El Haylani, Laetitia ; Decock, Marie ; Van Hees, Joanne ; Fu, Ziao ; Octave, Jean-Noël ; Constantinescu, Stefan N. ; Smith, Steven O. Conformational changes induced by the A21G Flemish mutation in the amyloid precursor protein lead to increased Aβ production.. In: Structure, Vol. 22, no. 3, p. 387-396 (2014). doi:10.1016/j.str.2013.12.012.
2014
Rabolli, Virginie ; Wallemme, Laurent ; Lo Re, Sandra ; Uwambayinema, Francine ; Palmai-Pallag, Mihaly ; Thomassen, Leen ; Tyteca, Donatienne ; Octave, Jean-Noël ; Marbaix, Etienne ; Lison, Dominique ; Devuyst, Olivier ; Huaux, François. Critical role of aquaporins in IL-1β-mediated inflammation. In: Journal of Biological Chemistry, Vol. 289, no. 20, p. 13937-13947 (2014). doi:10.1074/jbc.M113.534594.
2014
Hendrickx, Aurélie ; Pierrot, Nathalie ; Tasiaux, Bernadette ; Schakman, Olivier ; Kienlen-Campard, Pascal ; De Smet, Charles ; Octave, Jean-Noël. Epigenetic regulations of immediate early genes expression involved in memory formation by the amyloid precursor protein of Alzheimer disease. In: PLoS One, Vol. 9, no. 6, p. e99467 [1-9] (2014). doi:10.1371/journal.pone.0099467.
2014
Hage, Salim ; Marinangeli, Claudia ; Stanga, Serena ; Octave, Jean-Noël ; Quetin-Leclercq, Joëlle ; Kienlen-Campard, Pascal. Gamma-Secretase Inhibitor Activity of a Pterocarpus erinaceus Extract. In: Neurodegenerative Diseases, Vol. 14, no. 1, p. 39-51 (2014). doi:10.1159/000355557.
2014
Héraud, Céline ; Goufak, Doris ; Ando, Kunie ; Leroy, Karelle ; Suain, Valérie ; Yilmaz, Zehra ; De Decker, Robert ; Authelet, Michèle ; Laporte, Vincent ; Octave, Jean-Noël ; Brion, Jean-Pierre. Increased misfolding and truncation of tau in APP/PS1/tau transgenic mice compared to mutant tau mice. In: Neurobiology of Disease, Vol. 62, p. 100-112 (2014). doi:10.1016/j.nbd.2013.09.010.
2014
Marquer, Catherine ; Laine, Jeanne ; Dauphinot, Luce ; Hanbouch, Linda ; Lemercier-Neuillet, Camille ; Pierrot, Nathalie ; Bossers, Koen ; Le, Mickael ; Corlier, Fabian ; Benstaali, Caroline ; Saudou, Frédéric ; Thinakaran, Gopal ; Cartier, Nathalie ; Octave, Jean-Noël ; Duyckaerts, Charles ; Potier, Marie-Claude. Increasing membrane cholesterol of neurons in culture recapitulates Alzheimer's disease early phenotypes.. In: Molecular Neurodegeneration, Vol. 9, no.1, p. 60 (2014). doi:10.1186/1750-1326-9-60.
2014
Stancu, Ilie-Cosmin ; Ris, Laurence ; Barbosa de Vasconcelos, Bruno ; Marinangeli, Claudia ; Goeminne, Léonie ; Laporte, Vincent ; El Haylani, Laetitia ; Couturier, Julien ; Schakman, Olivier ; Gailly, Philippe ; Pierrot, Nathalie ; Kienlen-Campard, Pascal ; Octave, Jean-Noël ; Dewachter, Ilse. Tauopathy contributes to synaptic and cognitive deficits in a murine model for Alzheimer's disease.. In: The FASEB Journal, Vol. 28, no.6, p. 2620-2631 (2014). doi:10.1096/fj.13-246702.
2013
Pierrot, Nathalie ; Tyteca, Donatienne ; D'auria, Ludovic ; Dewachter, Ilse ; Gailly, Philippe ; Hendrickx, Aurélie ; TASIAUX, Bernadette ; El Haylani, Laetitia ; Muls, Nathalie ; N'kuli, Francisca ; Laquerrière, Annie ; Demoulin, Jean-Baptiste ; Campion, Dominique ; Brion, Jean-Pierre ; Courtoy, Pierre J. ; Kienlen-Campard, Pascal ; Octave, Jean-Noël. Amyloid precursor protein controls cholesterol turnover needed for neuronal activity.. In: EMBO Molecular Medicine, Vol. 5, no.4, p. 608-625 (2013). doi:10.1002/emmm.201202215.
2013
Hendrickx, Aurélie ; Pierrot, Nathalie ; Tasiaux, Bernadette ; Schakman, Olivier ; Brion, Jean-Pierre ; Kienlen-Campard, Pascal ; De Smet, Charles ; Octave, Jean-Noël. Epigenetic induction of EGR-1 expression by the amyloid precursor protein during exposure to novelty.. In: PloS one, Vol. 8, no. 9, p. e74305 (2013). doi:10.1371/journal.pone.0074305.
2013
Octave, Jean-Noël ; Pierrot, Nathalie ; Ferao Santos, Susana ; Nalivaeva, Natalia N ; Turner, Anthony J. From synaptic spines to nuclear signaling: nuclear and synaptic actions of the amyloid precursor protein.. In: Journal of Neurochemistry, Vol. Online First (2013). doi:10.1111/jnc.12239.
2013
Chapuis, J ; Hansmannel, F ; Gistelinck, M ; Mounier, A ; Van Cauwenberghe, C ; Kolen, K V ; Geller, F ; Sottejeau, Y ; Harold, D ; Dourlen, P ; Grenier-Boley, B ; Kamatani, Y ; Delepine, B ; Demiautte, F ; Zelenika, D ; Zommer, N ; Hamdane, M ; Bellenguez, C ; Dartigues, J-F ; Hauw, J-J ; Letronne, F ; Ayral, A-M ; Sleegers, K ; Schellens, A ; Broeck, L V ; Engelborghs, S ; De Deyn, P P ; Vandenberghe, R ; O'Donovan, M ; Owen, M ; Epelbaum, J ; Mercken, M ; Karran, E ; Bantscheff, M ; Drewes, G ; Joberty, G ; Campion, D ; Octave, Jean-Noël ; Berr, C ; Lathrop, M ; Callaerts, P ; Mann, D ; Williams, J ; Buée, L ; Dewachter, Ilse ; Van Broeckhoven, C ; Amouyel, P ; Moechars, D ; Dermaut, B ; Lambert, J-C ; GERAD consortium. Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology.. In: Molecular Psychiatry, Vol. 18, no.11, p. 1225-34 (2013). doi:10.1038/mp.2013.1.
2012
Ben Khalifa, Naouel ; Tyteca, Donatienne ; Courtoy, Pierre J. ; Renauld, Jean-Christophe ; Constantinescu, Stefan N. ; Octave, Jean-Noël ; Kienlen-Campard, Pascal. Contribution of Kunitz protease inhibitor and transmembrane domains to amyloid precursor protein homodimerization. In: Neurodegenerative Diseases, Vol. 10, no. 1-4, p. 92-95 (2012). doi:10.1159/000335225.
2012
Leroy, Karelle ; Ando, Kunie ; Laporte, Vincent ; Dedecker, Robert ; Suain, Valérie ; Authelet, Michèle ; Héraud, Céline ; Pierrot, Nathalie ; Yilmaz, Zehra ; Octave, Jean-Noël ; Brion, Jean-Pierre ; Octave, Jean-Noël. Lack of Tau Proteins Rescues Neuronal Cell Death and Decreases Amyloidogenic Processing of APP in APP/PS1 Mice.. In: The American Journal of Pathology : cellular and molecular biology of disease, Vol. 181, no. 6, p. 1928-1940 (28 septembre 2012). doi:10.1016/j.ajpath.2012.08.012.
2012
Ben Khalifa, Naouel ; Tyteca, Donatienne ; Marinangeli, Claudia ; Depuydt, Mathieu ; Collet, Jean-François ; Courtoy, Pierre J. ; Renauld, Jean-Christophe ; Constantinescu, Stefan N. ; Octave, Jean-Noël ; Kienlen-Campard, Pascal. Structural features of the KPI domain control APP dimerization, trafficking, and processing.. In: The FASEB Journal, Vol. 26, no. 2, p. 855-867 (2012). doi:10.1096/fj.11-190207.
2010
Hage, Salim ; Kienlen-Campard, Pascal ; Octave, Jean-Noël ; Quetin-Leclercq, Joëlle. In vitro screening on beta-amyloid peptide production of plants used in traditional medicine for cognitive disorders.. In: Journal of Ethnopharmacology, Vol. 131, no. 3, p. 585-591 (2010). doi:10.1016/j.jep.2010.07.044.
2010
Santos, Susana Ferrao ; Sindic, Christian ; Tasiaux, Bernadette ; Octave, Jean-Noël. Inhibition of neuronal calcium oscillations by cell surface APP phosphorylated on T668.. In: Neurobiology of Aging, Vol. 32, no. 12, p. 2308-2313 (2011). doi:10.1016/j.neurobiolaging.2010.01.006.
2010
Wiame, Elsa ; Tyteca, Donatienne ; Pierrot, Nathalie ; Collard, François ; Amyere, Mustapha ; Noël, Gaëtane ; Desmedt, Jonathan ; Nassogne, Marie-Cécile ; Vikkula, Miikka ; Octave, Jean-Noël ; Vincent, Marie-Françoise ; Courtoy, Pierre J. ; Boltshauser, Eugen ; Van Schaftingen, Emile. Molecular identification of aspartate N-acetyltransferase and its mutation in hypoacetylaspartia. In: Biochemical Journal, Vol. 425, no. 1, p. 127-136 (2010). doi:10.1042/BJ20091024.
2010
Santos, Susana Ferrao ; Pierrot, Nathalie ; Octave, Jean-Noël. Network excitability dysfunction in Alzheimer's disease: insights from in vitro and in vivo models.. In: Reviews in the Neurosciences, Vol. 21, no. 3, p. 153-171 (2010).
2010
Khalifa, Naouel Ben ; Van Hees, Joanne ; Tasiaux, Bernadette ; Huysseune, Sandra ; Smith, Steven O. ; Constantinescu, Stefan N. ; Octave, Jean-Noël ; Kienlen-Campard, Pascal. What is the role of amyloid precursor protein dimerization?. In: Cell Adhesion and Migration, Vol. 4, no. 2, p. 268-272 (2010). doi:10.4161/cam.4.2.11476.
2009
Sato, Takeshi ; Tang, Tzu-Chun ; Reubins, Gabriella ; Fei, Jeffrey Z ; Fujimoto, Taiki ; Kienlen-Campard, Pascal ; Constantinescu, Stefan N. ; Octave, Jean-Noël ; Aimoto, Saburo ; Smith, Steven O.. A helix-to-coil transition at the epsilon-cut site in the transmembrane dimer of the amyloid precursor protein is required for proteolysis.. In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, no. 5, p. 1421-6 (2009). doi:10.1073/pnas.0812261106.
2009
Huysseune, Sandra ; Kienlen-Campard, Pascal ; Hébert, Sébastien ; Tasiaux, Bernadette ; Leroy, Karelle ; Devuyst, Olivier ; Brion, Jean-Pierre ; De Strooper, Bart ; Octave, Jean-Noël. Epigenetic control of aquaporin 1 expression by the amyloid precursor protein.. In: The FASEB Journal, Vol. 23, no. 12, p. 4158-4167 (2009). doi:10.1096/fj.09-140012.
2009
Santos, Susana Ferrao ; Pierrot, Nathalie ; Morel, Nicole ; Gailly, Philippe ; Sindic, Christian ; Octave, Jean-Noël. Expression of human amyloid precursor protein in rat cortical neurons inhibits calcium oscillations.. In: The Journal of Neuroscience, Vol. 29, no. 15, p. 4708-4718 (2009). doi:10.1523/JNEUROSCI.4917-08.2009.
2009
Octave, Jean-Noël. [The precursor of amyloid peptide in Alzheimer disease : a protein with multiple functions].. In: Bulletin et mémoires de l'Académie royale de médecine de Belgique, Vol. 164, no. 7-9, p. 181-6; discussion 187-8 (2009).
2008
Kienlen-Campard, Pascal ; Tasiaux, Bernadette ; Van Hees, Joanne ; Li, Mingli ; Huysseune, Sandra ; Sato, Takeshi ; Fei, Jeffrey Z ; Aimoto, Saburo ; Smith, Steven O ; Constantinescu, Stefan N. ; Octave, Jean-Noël. Erratum : amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs. In: Journal of Biological Chemistry, Vol. 283, no. 12, p. 7733-7744 (2008). doi:10.1074/jbc.M707142200.
2008
Octave, Jean-Noël ; Pierrot, Nathalie. La maladie d'Alzheimer: aspects cellulaires et moléculaires.. In: Bulletin de l'Académie nationale de médecine, Vol. 192, no. 2, p. 323-331; discussion 331-332 (2008).
2008
Pierrot, Nathalie ; Octave, Jean-Noël. Processing of amyloid precursor protein and amyloid Peptide neurotoxicity.. In: Current Alzheimer research, Vol. 5, no. 2, p. 92-9 (2008). doi:10.2174/156720508783954721.
2007
Huysseune, Sandra ; Kienlen-Campard, Pascal ; Octave, Jean-Noël. Fe65 does not stabilize AICD during activation of transcription in a luciferase assay.. In: Biochemical and biophysical research communications, Vol. 361, no. 2, p. 317-22 (2007). doi:10.1016/j.bbrc.2007.06.186.
2007
Feyt, Christine ; Courtoy, Pierre J. ; Pierrot, Nathalie ; Tasiaux, Bernadette ; Van Hees, Joanne ; Kienlen-Campard, Pascal ; Octave, Jean-Noël. Phosphorylation of APP695 at Thr668 decreases gamma-cleavage and extracellular Abeta.. In: Biochemical and biophysical research communications, Vol. 357, no. 4, p. 1004-10 (2007). doi:10.1016/j.bbrc.2007.04.036.
2006
Caumont, Anne-Sophie ; Octave, Jean-Noël ; Hermans, Emmanuel. Amantadine and memantine induce the expression of the glial cell line-derived neurotrophic factor in C6 glioma cells.. In: Neuroscience Letters, Vol. 394, no. 3, p. 196-201 (2006). doi:10.1016/j.neulet.2005.10.027.
2006
Pierrot, Nathalie ; Santos, Susana Ferrao ; Feyt, Christine ; Morel, Marina ; Brion, Jean-Pierre ; Octave, Jean-Noël. Calcium-mediated transient phosphorylation of tau and amyloid precursor protein followed by intraneuronal amyloid-beta accumulation.. In: The Journal of biological chemistry, Vol. 281, no. 52, p. 39907-14 (2006). doi:10.1074/jbc.M606015200.
2006
Sato, Takeshi ; Kienlen-Campard, Pascal ; Ahmed, Mahiuddin ; Liu, Wei ; Li, Huilin ; Elliott, James I ; Aimoto, Saburo ; Constantinescu, Stefan N. ; Octave, Jean-Noël ; Smith, Steven O.. Inhibitors of amyloid toxicity based on beta-sheet packing of Abeta40 and Abeta42.. In: Biochemistry, Vol. 45, no. 17, p. 5503-16 (2006). doi:10.1021/bi052485f.
2006
Kienlen-Campard, Pascal ; Courtoy, Pierre J. ; Feyt, Christine ; Huysseune, Sandra ; de Diesbach, Philippe ; N'Kuli, Francisca ; Octave, Jean-Noël. Lactacystin decreases amyloid-beta peptide production by inhibiting beta-secretase activity.. In: Journal of neuroscience research, Vol. 84, no. 6, p. 1311-1322 (2006). doi:10.1002/jnr.21025.
2006
Caumont, Anne-Sophie ; Octave, Jean-Noël ; Hermans, Emmanuel. Specific regulation of rat glial cell line-derived neurotrophic factor gene expression by riluzole in C6 glioma cells.. In: Journal of neurochemistry, Vol. 97, no. 1, p. 128-39 (2006). doi:10.1111/j.1471-4159.2006.03711.x.
2005
Feyt, Christine ; Kienlen-Campard, Pascal ; Leroy, Karelle ; N'Kuli, Francisca ; Courtoy, Pierre J. ; Brion, Jean-Pierre ; Octave, Jean-Noël. Lithium chloride increases the production of amyloid-beta peptide independently from its inhibition of glycogen synthase kinase 3.. In: Journal of Biological Chemistry, Vol. 280, no. 39, p. 33220-33227 (2005). doi:10.1074/jbc.M501610200.
2005
Octave, Jean-Noël. Maladie d'Alzheimer: aspects cellulaires et moléculaires.. In: Bulletin et mémoires de l'Académie royale de médecine de Belgique, Vol. 160, no. 10-12, p. 445-9; discussion 450-1 (2005).
2004
Race, V. ; Marie, S. ; Kienlen-Campard, Pascal ; Hermans, Emmanuel ; Octave, Jean-Noël ; Van den Berghe, Georges ; Vincent, Marie-Françoise. Adenylosuccinate lyase deficiency: study of physiopathologic mechanism(s).. In: Nucleosides, Nucleotides and Nucleic Acids : an international journal for rapid communication, Vol. 23, no. 8-9, p. 1227-1229 (2004). doi:10.1081/NCN-200027491.
2004
Pierrot, Nathalie ; Ghisdal, Philippe ; Caumont, Anne-Sophie ; Octave, Jean-Noël. Intraneuronal amyloid-beta1-42 production triggered by sustained increase of cytosolic calcium concentration induces neuronal death.. In: Journal of Neurochemistry, Vol. 88, no. 5, p. 1140-1150 (2004). doi:10.1046/j.1471-4159.2003.02227.x.
2004
Pitsi, Didier ; Octave, Jean-Noël. Presenilin 1 stabilizes the C-terminal fragment of the amyloid precursor protein independently of gamma-secretase activity.. In: Journal of Biological Chemistry, Vol. 279, no. 24, p. 25333-25338 (2004). doi:10.1074/jbc.M312710200.
2003
Leroy, K ; Boutajangout, A ; Richardson, J ; Octave, Jean-Noël ; Lovestone, S ; Anderton, B H ; Brion, J P. Mutant presenilin 1 proteins induce cell death and reduce tau-dependent processes outgrowth.. In: Neuroscience letters, Vol. 353, no. 3, p. 226-30 (2003). doi:10.1016/j.neulet.2003.09.051.
2002
Kienlen-Campard, Pascal ; Octave, Jean-Noël. Correlation between beta-amyloid peptide production and human APP-induced neuronal death.. In: Peptides, Vol. 23, no. 7, p. 1199-204 (2002). doi:10.1016/S0196-9781(02)00055-4.
2002
Pitsi, Didier ; Kienlen-Campard, Pascal ; Octave, Jean-Noël. Failure of the interaction between presenilin 1 and the substrate of gamma-secretase to produce Abeta in insect cells.. In: Journal of neurochemistry, Vol. 83, no. 2, p. 390-9 (2002). doi:10.1046/j.1471-4159.2002.01138.x.
2002
Kienlen-Campard, Pascal ; Miolet, Sarah ; Tasiaux, Bernadette ; Octave, Jean-Noël. Intracellular amyloid-beta 1-42, but not extracellular soluble amyloid-beta peptides, induces neuronal apoptosis.. In: The Journal of biological chemistry, Vol. 277, no. 18, p. 15666-70 (2002). doi:10.1074/jbc.M200887200.
2001
Festy, Franck ; Lins, Laurent ; Péranzi, Gabriel ; Octave, Jean-Noël ; Brasseur, Robert ; Thomas, Annick. Is aggregation of beta-amyloid peptides a mis-functioning of a current interaction process?. In: Biochimica et Biophysica Acta : international journal of biochemistry and biophysics, Vol. 1546, no. 2, p. 356-664 (2001). doi:10.1016/s0167-4838(01)00158-3.
2001
Brion, J P ; Anderton, B H ; Authelet, M ; Dayanandan, R ; Leroy, K ; Lovestone, S ; Octave, Jean-Noël ; Pradier, L. ; Touchet, N ; Tremp, G.. Neurofibrillary tangles and tau phosphorylation.. In: Biochemical Society symposium, , no. 67, p. 81-8 (2001).
2000
Mbella, E G ; Bertrand, S ; Huez, G. ; Octave, Jean-Noël. A GG nucleotide sequence of the 3' untranslated region of amyloid precursor protein mRNA plays a key role in the regulation of translation and the binding of proteins.. In: Molecular and cellular biology, Vol. 20, no. 13, p. 4572-9 (2000). doi:10.1128/MCB.20.13.4572-4579.2000.
2000
Kienlen-Campard, Pascal ; Tasiaux, Bernadette ; Octave, Jean-Noël. The processing and biological function of the human amyloid precursor protein (APP): lessons from different cellular models.. In: Experimental gerontology, Vol. 35, no. 6-7, p. 843-50 (2000). doi:10.1016/S0531-5565(00)00170-4.
2000
Octave, Jean-Noël ; Essalmani, R ; Tasiaux, Bernadette ; Menager, J ; Czech, C. ; Mercken, L.. The role of presenilin-1 in the gamma-secretase cleavage of the amyloid precursor protein of Alzheimer's disease.. In: The Journal of biological chemistry, Vol. 275, no. 3, p. 1525-8 (2000). doi:10.1074/jbc.275.3.1525.
2000
Boyd, A P ; Grosdent, N ; Tötemeyer, S ; Geuijen, C ; Bleves, S ; Iriarte, M. ; Lambermont, Isabelle ; Octave, Jean-Noël ; Cornelis, G R. Yersinia enterocolitica can deliver Yop proteins into a wide range of cell types: development of a delivery system for heterologous proteins.. In: European journal of cell biology, Vol. 79, no. 10, p. 659-71 (2000). doi:10.1078/0171-9335-00098.
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