Seminaire du Dr. Rodrigo Fernández sur “Effects of voluntary wheel running on ATP mediated IL-6 response in skeletal muscle”
Coming from Dr. Jaimovich's laboratory, University of Chile, Rodrigo Fernández, will present the result of his research on the 7th February. As summary, "ATP released from active muscle cells can induce intracellular calcium transients in an autocrine manner. These transients lead to increases in Interleukin-6 (IL-6) mRNA, a myokine with key functions during exercise. The aim of the work was to determine the effects of voluntary wheel running on the ATP mediated IL-6 response in mice. Mice were divided in two groups: VA, with free access to wheels; and SED, without wheels. After 5 weeks, isolated muscle fibers were stimulated with exogenous ATP, and the IL-6 mRNA changes measured. ATP stimulation induced higher (p<0.01) increases of IL-6 mRNA in the VA (13.35 fold) than the SED (5.56 fold) group. The response in the VA mice was directly dependent on the level of physical activity performed (r=0.86, p<0.05). This increase in ATP sensitivity could be part of an adaptation process that improves energetic efficiency of trained muscles.”
This seminar will take place at Local A006, Faculté des Sciences de la Motricité (Place P. de Coubertin 1 à 1348 LLN) at 11:00.
For more information, contact person is marc.francaux@uclouvain.be