Clinical trials are essential to evaluate the translational potential of our findings issued from preclinical models. For this reason, several clinical trials have been launched by the MNUT team in close collaboration with clinicians. Three of them are described below: the MicroAML study, the FOOD4GUT study and the Microbes4U study.
The MicroAML study aims to evaluate the composition and activity of the gut microbiota in patients with acute myeloid leukemia. Information related to appetite, food habits, body composition and muscle strength as well as biological samples are collected before any chemotherapy and after chemotherapy. More information on this multi-center interdisciplinary project can be found here .
FOOD4GUT is a multidisciplinary and inter-university project that aims to demonstrate that changing the microbiota via supplementation with inulin-type fructans accompanied by dietary advice promoting the consumption of vegetables rich in these colonic nutrients, may modulate feeding behavior, body composition, inflammation and metabolic disorders associated with obesity. A simple-blind placebo-controlled randomized trial is ongoing to highlight the interest for the health of vegetables in inulin-type fructans in obese adults. More information is available on the website of the FOOD4GUT project.
The Microbes4U study investigates the effects of an oral administration of Akkermansia muciniphila on metabolic disorders associated with overweight and obesity. After the inclusion according to specific criteria, the volunteers are randomly assigned into 4 different groups: one placebo group, two others groups receiving live Akkermansia muciniphila 109 cells/day or 1010 cells/day and the last group receiving pasteurized Akkermansia muciniphila. The supplementation lasts for 3 months. Different parameters are recorded such as anthropometric parameters, lipid and glucose metabolic markers, and inflammation. For more information, you can visit our website. Please find here our data access agreement.