May 30, 2023
Tuesday, May 30, 2023 - 11am - Auditoire Maisin
Advances in the area of Gastrointestinal Delivery Technologies
Prof. Giovanni TRAVERSO, associate professor at the Department of Mechanical Engineering at the MIT, USA
Medication non-adherence (non-compliance) represents a major barrier to effective clinical care. In developed nations, only 50% of patients take their medications as prescribed, manifesting in more than $100 billion in avoidable hospitalizations every year in the United states alone and the numbers are far worse in the developing world. In his seminar, Dr. Traverso will present a series of novel technologies being developed with the goal to enhance and facilitate medication administration.
- Oral delivery of systemic monoclonal antibodies, peptides and small molecules using gastric auto-injectors. Abramson A, Frederiksen MR, Vegge A, Jensen B, Poulsen M, Mouridsen B, Jespersen MO, Kirk RK, Windum J, Hubálek F, Water JJ, Fels J, Gunnarsson SB, Bohr A, Straarup EM, Ley MWH, Lu X, Wainer J, Collins J, Tamang S, Ishida K, Hayward A, Herskind P, Buckley ST, Roxhed N, Langer R, Rahbek U, Traverso G. Nat Biotechnol. 2022 Jan;40(1):103-109. doi: 10.1038/s41587-021-01024-0.
- An ingestible self-orienting system for oral delivery of macromolecules. Abramson A, Caffarel-Salvador E, Khang M, Dellal D, Silverstein D, Gao Y, Frederiksen MR, Vegge A, Hubálek F, Water JJ, Friderichsen AV, Fels J, Kirk RK, Cleveland C, Collins J, Tamang S, Hayward A, Landh T, Buckley ST, Roxhed N, Rahbek U, Langer R, Traverso G. Science. 2019 Feb 8;363(6427):611-615. doi: 10.1126/science.aau2277.
- A once-a-month oral contraceptive. Kirtane AR, Hua T, Hayward A, Bajpayee A, Wahane A, Lopes A, Bensel T, Ma L, Stanczyk FZ, Brooks S, Gwynne D, Wainer J, Collins J, Tamang SM, Langer R, Traverso G. Sci Transl Med. 2019 Dec 4;11(521):eaay2602. doi: 10.1126/scitranslmed.aay2602.