June 05, 2023
Monday, June 5, 2023 - 1pm - Auditoire 51E
Biomimicking approaches to understand and direct nerve regeneration & remyelination
Sing Yian CHEW, Ph.D - School of Chemistry, Chemical Engineering and Biotechnology | Lee Kong Chian School of Medicine | School of Materials Science and Engineering | Nanyang Technological University N1.2-B2-20 Singapore
Abstract:
The microenvironment that surrounds cells plays critical roles in dictating cell fate and tissue regeneration. Biophysical signals, such as extracellular matrix architecture and compliance affect cellular response. In combination with biochemical signals from drugs, growth factors, nucleic acids and/or cells, synergistic effects on directing cell phenotypic changes and tissue regrowth are often seen. Here, we will present our approaches towards designing scaffolding constructs that recapitulate important characteristics of the extracellular microenvironment to understand and direct cell fate. We will also share our findings of combining the appropriate biophysical and biochemical signals into tissue-engineered scaffolds to promote nerve regeneration and remyelination in the central nervous system.
Related publications:
- Ong W, Marinval N, Lin J, Nai MH, Chong Y-S, Pinese C, Sajikumar S, Lim CT, Ffrench-Constant C, Bechler ME, Chew SY. Biomimicking Fiber Platform with Tunable Stiffness to Study Mechanotransduction Reveals Stiffness Enhances Oligodendrocyte Differentiation but Impedes Myelination through YAP-Dependent Regulation. Small 2020;16:2003656. https://doi.org/https://doi.org/10.1002/smll.202003656.
- Zhang N, Lin J, Lin VPH, Milbreta U, Chin JS, Chew EGY, Lian MM, Foo JN, Zhang K, Wu W, Chew SY. A 3D Fiber-Hydrogel Based Non-Viral Gene Delivery Platform Reveals that microRNAs Promote Axon Regeneration and Enhance Functional Recovery Following Spinal Cord Injury. Adv Sci 2021;8:2100805. https://doi.org/https://doi.org/10.1002/advs.202100805.
- Zhang N, Lin J, Chew SY. Neural Cell Membrane-Coated Nanoparticles for Targeted and Enhanced Uptake by Central Nervous System Cells. ACS Appl Mater Interfaces 2021;13:55840–50. https://doi.org/10.1021/acsami.1c16543.
Info : anne.desrieux@uclouvain.be