THESES IN PROGRESS
Ancia Marine
Towards a better understanding of the Alternative Lengthening of Telomeres mechanism by the discovery of TSPYL5/USP7 protein-protein interaction inhibitors.
Director: Raphaël Frédérick; Co-director: Anabelle Decottignies
Brustenga Chiara
LDH disruptors for anticancer therapy
Director: Raphaël Frédérick; Co-director: Pierre Sonveaux
Dechenne Juhans
lnterrogating the self-assembly of arginase and tryptophan 2,3-dioxygenase, two proteins involved in cancer immunotherapy
Director: Raphaël Frédérick
Deskeuvre Marine
Low Insertion Peptides (pHLIP) - drug conjugates as a novel tumor targeting strategy: design, chemical synthesis, biophysical characterization and in vitro evaluation.
Director: Raphaël Frédérick; Co-director: Olivier Feron
Lacour Séraphin
Design, synthesis and evaluation of new pharmacological tools to study tryptophan-2,3-dioxygenase (TDO2) in cancer immunotherapy
Director: Raphaël Frédérick
Leone Giuditta
Inhaled vasodilator nanomedicine.
Director: Rita Vanbever; Co-director: Raphaël Frédérick
Marteau Romain
Development of ACSL4’s selective ligands: new tools to target ferrop.
Director: Raphaël Frédérick; Co-director: Séverine Ravez (Univ. lille2, France)
Mathieu Caroline
Inhibition of tryptophan 2,3-dioxygenase (TDO2) by targeting its self-assembly: from the development of analytical methodologies to the identification of new potential disrupters
Director: Raphaël Frédérick; Co-director: Marianne Fillet (ULiège)
Mazhari Darius
Deciphering the exact role of the acyl-CoA synthetase long-chain family member 4 (ACSL4) in cancer
Director: Raphaël Frédérick; Co-director: Jamal El Bakali (Univ. lille2, France)
Pierrard François
Development of new chemical tools for interrogating the lactate dehydrogenase B (LDHB) tetramerization site with stapled peptides”
Director: Olivier Riant; Co-Director: Raphaël Frédérick
Savoyen Perrine
Design and synthesis of peptide macrocycles as inhibitors of lactate dehydrogenase.
Director: Raphaël Frédérick; Co-director: Pierre Sonveaux
Tan Yonghua
Biocompatible catalysts to release prodrugs
Director: Olivier Riant; Co-director: Raphaël Frédérick
DEFENDED THESES
2022
Prévost Julien
Towards the discovery and synthesis of new Arginase1 inhibitors
Director: Raphaël Frédérick
2021
Kozlova Arina
Design, synthesis and evaluation of original 1-H-indol-3-yl heterocyclic derivatives as tryptophan 2,3-dioxygenase inhibitors.
Director: Raphaël Frédérick; Co-director: Benoit Van den Eynde
2020
Ameryckx Alice
Design and synthesis of DD-ligases inhibitors: Peptidoglycan intracellular biosynthesis as antibiotics target.
Director: Raphaël Frédérick; Co-director: Françoise Van Bambeke
Thabault Léopold
Interrogating the lactate dehydrogenase tetrameric interface using (stapled) peptides and short proteins : an original approach to protein inhibition.
Director: Raphaël Frédérick; Co-director: Pierre Sonveaux
2019
Spillier Quentin
Mechanistic study of PHGDH enzyme inhibition: towards the development of new anticancer drugs.
Director: Raphaël Frédérick; Co-director: Olivier Feron