The brain has the unique ability to change its structure and function throughout life. The mechanisms of brain plasticity are typically considered adaptive in order to maximise the chance of living organisms to optimally perceive and act in their environment. Brain plasticity is a complex and dynamic process however, that tends to decrease with age and sometimes can even lead to maladaptive consequences. At the Institute of Neuroscience, researchers with multidisciplinary backgrounds use a variety of methods -from psychophysics, robotics, virtual reality, modelling to advanced neuroimaging- to better understand the mechanisms underlying the fascinating ability of the brain to reorganise itself in response to focused training, developmental disorders, sensory deprivation, strokes etc. Importantly, we are convinced that a better understanding of the mechanisms of brain plasticity may help us design better strategies to improve the quality of life of people.