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![]() Professor Contact - Personnal web page Recent publications is Associate Professor at the iMMC, running the Biomechanics lab. The lab aims to apply an interdisciplinary, combinatory research approach, encompassing experiments, characterization and computational modelling, to solve different biomedical and biomechanical research questions. Her research will build further upon the expertise she has obtained during her PhD and postdoc. Prof. Greet Kerckhofs obtained her PhD in 2009 at the Dept. Materials Engineering (MTM - KU Leuven), of which the aim was to optimize and validate microfocus X-ray computed tomography (microCT) to characterize porous materials. This non-destructive 3D imaging technique allows to visualize the entire internal structure of materials without destroying them. She performed her PhD and postdoc within Prometheus, the division of Skeletal Tissue Engineering of the KU Leuven. This interdisciplinary platform aims to repair large bone defects using tissue engineering constructs (i.e. biomaterial with cells and/or growth factors). Trained as an engineer, within Prometheus she has been capable of integrating biology and engineering technology (such as imaging, biomaterials testing and production/design) into her research and as a result, she now belongs to the small group of researchers that have grown into a genuine interdisciplinary profile. During her postdoc, she has been optimizing contrast-enhanced microCT (CE-CT) for the 3D visualization and characterization of not only mineralized, but also soft biological tissues in different fields of application. As a result, she has become a pioneer and recognized expert in the field CE-CT. She has started collaborations worldwide and she is setting the stage for a new era of virtual 3D histology of soft tissues. She is currently also 10% Visiting Professor at the Dept. MTM (KU Leuven) and she is member of the scientific board of Prometheus (KU Leuven). IMMC main research direction(s): Biomedical engineering Processing and characterisation of materials Keywords: biomechanics contrast-enhanced computed tomography Research group(s): MEED ![]() PhD and Post-doc researchers under my supervision:
Recent publicationsJournal Articles1. Figeac, Florence; Tencerova, Michaela; Ali, Dalia; Andersen, Thomas L; Appadoo, Dan Rémi Christiansen; Kerckhofs, Greet; Ditzel, Nicholas; Kowal, Justyna M; Rauch, Alexander; Kassem, Moustapha. Impaired bone fracture healing in type 2 diabetes is caused by defective functions of skeletal progenitor cells. In: Stem Cells, Vol. -, no.-, p. - (2022). doi:10.1093/stmcls/sxab011. http://hdl.handle.net/2078.1/257948 2. Pascart, Tristan; Falgayrac, Guillaume; Cortet, Bernard; Paccou, Julien; Bleuse, Maverick; Coursier, Raphaël; Putman, Sophie; Quinchon, Jean-François; Bertheaume, Nicolas; Delattre, Jerome; Marchandise, Pierre; Cultot, Aurélie; Norberciak, Laurène; Kerckhofs, Greet; Budzik, Jean-François. Subchondral involvement in osteonecrosis of the femoral head: insight on local composition, microstructure and vascularization.. In: Osteoarthritis and cartilage, (2022). doi:10.1016/j.joca.2022.05.003 (Accepté/Sous presse). http://hdl.handle.net/2078.1/260877 3. de Bournonville, Sébastien; Geris, Liesbet; Kerckhofs, Greet. Micro computed tomography with and without contrast enhancement for the characterization of microcarriers in dry and wet state. In: Scientific Reports, Vol. 11, no. 1 (2021). doi:10.1038/s41598-021-81998-8. http://hdl.handle.net/2078.1/243552 4. Marin, Carlos; Tuts, Jolien; Luyten, Frank P.; Vandamme, Katleen; Kerckhofs, Greet. Impaired soft and hard callus formation during fracture healing in diet-induced obese mice as revealed by 3D contrast-enhanced computed tomography imaging. In: Bone, Vol. 150, no.-, p. 116008 (2021). doi:10.1016/j.bone.2021.116008. http://hdl.handle.net/2078.1/248508 5. Tam, Wai Long; Freitas Mendes, LuÃs; Chen, Xike; Lesage, Raphaëlle; Van Hoven, Inge; Leysen, Elke; Kerckhofs, Greet; Bosmans, Kathleen; Chai, Yoke Chin; Yamashita, Akihiro; Tsumaki, Noriyuki; Geris, Liesbet; Roberts, Scott J.; Luyten, Frank P. Human pluripotent stem cell-derived cartilaginous organoids promote scaffold-free healing of critical size long bone defects. In: Stem Cell Research & Therapy, Vol. 12, no.1 (2021). doi:10.1186/s13287-021-02580-7. http://hdl.handle.net/2078.1/251716 6. Leyssens, Lisa; Pestiaux, Camille; Kerckhofs, Greet. A Review of Ex Vivo X-ray Microfocus Computed Tomography-Based Characterization of the Cardiovascular System. In: International Journal of Molecular Sciences, Vol. 22, no.6, p. 3263 (2021). doi:10.3390/ijms22063263. http://hdl.handle.net/2078.1/244890 7. Tratwal, Josefine; Labella, Rossella; Bravenboer, Nathalie; Kerckhofs, Greet; Douni, Eleni; Scheller, Erica L.; Badr, Sammy; Karampinos, Dimitrios C.; Beck-Cormier, Sarah; Palmisano, Biagio; Poloni, Antonella; Moreno-Aliaga, Maria J.; Fretz, Jackie; Rodeheffer, Matthew S.; Boroumand, Parastoo; Rosen, Clifford J.; Horowitz, Mark C.; van der Eerden, Bram C. J.; Veldhuis-Vlug, Annegreet G.; Naveiras, Olaia. Reporting Guidelines, Review of Methodological Standards, and Challenges Toward Harmonization in Bone Marrow Adiposity Research. Report of the Methodologies Working Group of the International Bone Marrow Adiposity Society. In: Frontiers in Endocrinology, Vol. 11, no.-, p. - (2020). doi:10.3389/fendo.2020.00065. http://hdl.handle.net/2078.1/227854 8. de Bournonville, Sébastien; Vangrunderbeeck, Sarah; Ly, Hong Giang T.; Geeroms, Carla; De Borggraeve, Wim M.; Parac-Vogt, Tatjana N.; Kerckhofs, Greet. Exploring polyoxometalates as non-destructive staining agents for contrast-enhanced microfocus computed tomography of biological tissues. In: Acta Biomaterialia, Vol. 105, p. 253-262 (2020). doi:10.1016/j.actbio.2020.01.038. http://hdl.handle.net/2078.1/228448 9. Pascart, Tristan; Paccou, Julien; Colard, Thomas; Norberciak, Laurène; Girard, Julien; Delattre, Jerôme; Marchandise, Pierre; Legrand, Julie; Penel, Guillaume; Coursier, Raphaël; Putman, Sophie; Cortet, Bernard; Kerckhofs, Greet; Budzik, Jean-François. T1-weighted MRI images accurately represent the volume and surface of architectural mineral damage of osteonecrosis of the femoral head: Comparison with high-resolution computed tomography. In: Bone, Vol. 130, p. 115099 (2020). doi:10.1016/j.bone.2019.115099. http://hdl.handle.net/2078.1/222787 10. Colsoul, Nicolas; Marin, Carlos; Corbeels, Katrien; Kerckhofs, Greet; Van der Schueren, Bart; Vandamme, Katleen. Alteration of the Condylar Oral Bone in Obese and Gastric Bypass Mice. In: Calcified Tissue International, Vol. 107, no.4, p. 371-380 (2020). doi:10.1007/s00223-020-00732-0. http://hdl.handle.net/2078.1/237902 Conference Papers1. Ly Thi, Hong Giang; Geeroms, Carla; De Borggraeve, Wim; Vogt, Tatjana; Kerckhofs, Greet; Vangrunderbeeck, Sarah; de Bournonville, Sébastien. Polyoxometalates as Non-destructive Staining Agents for ex vivo Contrast-Enhanced Microfocus Computed Tomography (CE-CT). 2021 xxx. http://hdl.handle.net/2078.1/246077 2. Leyssens, Lisa; Pétré, Maïté; Kerckhofs, Greet. Optimization of microCT and CECT for cardiovascular applications. 2021 xxx. http://hdl.handle.net/2078.1/250458 3. Lang, Annemarie; Benn, Andreas; Damerau, Alexandra; Boerckel, Joel D.; Kerckhofs, Greet; Zwijsen, An. BMP-SMAD1/5 Signaling Is Required For Adequate Coupling Of Angiogenesis And Osteogenesis In Long Bones. In: Abstract book. 2021 xxx. http://hdl.handle.net/2078.1/239328 4. Rougier, G; Maistriaux, Louis; Fievé, Lies; Xhema, Daela; Manon, Julie; Evrard, Robin; de Ville de Goyet, Christine; Olszewski, Raphael; Kerckhofs, Greet; Szmytka, F; Thurieau, N; Boisson, J; Kadlub, N; Gianello, Pierre; Behets Wydemans, Catherine; Lengelé, Benoît. Perfusion-decellularization of vascularized bone matrix: Application to the porcine forelimb. In: Transplant International. Vol. 34, no.Suppl.1, p. 69 (2021). Oxford : Blackwell Pub.: England, 2021 xxx. doi:10.1111/tri.13944. http://hdl.handle.net/2078.1/258781 5. Leyssens, Lisa; Pétré, Maïté; Kerckhofs, Greet. Optimization of MicroCT and CECT for Cardiovascular Applications. 2021 xxx. http://hdl.handle.net/2078.1/249931 6. Coirbay, Alice; Pyka, Grzegorz; Kerckhofs, Greet. 4D XCT OF SYNTHETIC ARTERIAL GRAFTS: TOWARDS AN IMPROVED DESIGN. 2021 xxx. http://hdl.handle.net/2078.1/244915 7. Hoffmann, Delia; El Aazmani, Walid; Engelen, Lara; Balcaen, Tim; Vangrunderbeeck, Sarah; Kerckhofs, Greet. Virtual 3D histological analysis of soft tissues by contrast-enhanced microfocus computed tomography: screening contrast-enhancing staining agents. 2021 xxx. http://hdl.handle.net/2078.1/253722 8. Hoffmann, Delia; El Aazmani, Walid; Engelen, Lara; Kerckhofs, Greet. Virtual 3D histological analysis of soft tissues by contrast-enhanced microfocus computed tomography: screening contrast-enhancing staining agents. 2021 xxx. http://hdl.handle.net/2078.1/253721 9. Pestiaux, Camille; Kerckhofs, Greet; Beauloye, Christophe; Quirynen, Louise; Vanoverschelde, Jean-Louis. Ex vivo microfocus computed tomography and contrast-enhanced computed tomography applied to heart valves. 2021 xxx. http://hdl.handle.net/2078.1/254375 10. Pestiaux, Camille; Kerckhofs, Greet. High resolution microfocus computed tomography and POM-based contrast-enhanced computed tomography applied to the heart and its constituents. 2021 xxx. http://hdl.handle.net/2078.1/249878 Book Chapters1. Wevers, Martine; Nicolai, Bart; Verboven, Pieter; Swennen, Rudy; Roels, Staf; Verstrynge, Els; Lomov, Stepan Vladimirovitch; Kerckhofs, Greet; Van Meerbeek, Bart; Mavridou, Athina; Bergmans, Lars; Lambrechts, Paul; Soete, Jeroen; Claes, Steven; Claes, Hannes. Applications of CT for non-destructive testing and materials characterization. In: Industrial X-Ray Computed Tomography , Springer, 2018, p. 267-331. 978-3-319-59571-9. xxx xxx. http://hdl.handle.net/2078/194668 2. Verboven, P.; Ho, Q.; Herremans, E.; Mebatsion, H.; Nicolai, B.; Kerckhofs, Greet; Wevers, M.; Cloetens, P.. Fruit Microstructure Evaluation Using Synchrotron X-Ray Computed Tomography. In: Food Engineering Interfaces , Springer: New York, 2011, p. Chapter 24. 978-1-4419-7475-4. xxx xxx. http://hdl.handle.net/2078/202848 |