Members
IMMC





Close

Thinking ahead

Team building at institute level
GCE team
IMAP team

iMMC logo

MEED team
MEMA team

TFL team
![]() Professor Contact - Personnal web page Recent publications is Associate Professor at the iMMC, running the Biomechanics lab. The lab aims to apply an interdisciplinary, combinatory research approach, encompassing experiments, characterization and computational modelling, to solve different biomedical and biomechanical research questions. Her research will build further upon the expertise she has obtained during her PhD and postdoc. Prof. Greet Kerckhofs obtained her PhD in 2009 at the Dept. Materials Engineering (MTM - KU Leuven), of which the aim was to optimize and validate microfocus X-ray computed tomography (microCT) to characterize porous materials. This non-destructive 3D imaging technique allows to visualize the entire internal structure of materials without destroying them. She performed her PhD and postdoc within Prometheus, the division of Skeletal Tissue Engineering of the KU Leuven. This interdisciplinary platform aims to repair large bone defects using tissue engineering constructs (i.e. biomaterial with cells and/or growth factors). Trained as an engineer, within Prometheus she has been capable of integrating biology and engineering technology (such as imaging, biomaterials testing and production/design) into her research and as a result, she now belongs to the small group of researchers that have grown into a genuine interdisciplinary profile. During her postdoc, she has been optimizing contrast-enhanced microCT (CE-CT) for the 3D visualization and characterization of not only mineralized, but also soft biological tissues in different fields of application. As a result, she has become a pioneer and recognized expert in the field CE-CT. She has started collaborations worldwide and she is setting the stage for a new era of virtual 3D histology of soft tissues. She is currently also 10% Visiting Professor at the Dept. MTM (KU Leuven) and she is member of the scientific board of Prometheus (KU Leuven). IMMC main research direction(s): Biomedical engineering Processing and characterisation of materials Keywords: biomechanics contrast-enhanced computed tomography Research group(s): MEED ![]() PhD and Post-doc researchers under my supervision:
Recent publicationsJournal Articles1. Starovoyt, Anastasiya; Shaheen, Eman; Putzeys, Tristan; Kerckhofs, Greet; Politis, Constantinus; Wouters, Jan; Verhaert, Nicolas. Anatomically and mechanically accurate scala tympani model for electrode insertion studies. In: Hearing Research, Vol. 430, no.-, p. 108707 (2023). doi:10.1016/j.heares.2023.108707. http://hdl.handle.net/2078.1/272437 2. Figeac, Florence; Tencerova, Michaela; Ali, Dalia; Andersen, Thomas L; Appadoo, Dan Rémi Christiansen; Kerckhofs, Greet; Ditzel, Nicholas; Kowal, Justyna M; Rauch, Alexander; Kassem, Moustapha. Impaired bone fracture healing in type 2 diabetes is caused by defective functions of skeletal progenitor cells. In: Stem Cells, Vol. -, no.-, p. - (2022). doi:10.1093/stmcls/sxab011. http://hdl.handle.net/2078.1/257948 3. Pascart, Tristan; Falgayrac, Guillaume; Cortet, Bernard; Paccou, Julien; Bleuse, Maverick; Coursier, Raphaël; Putman, Sophie; Quinchon, Jean-François; Bertheaume, Nicolas; Delattre, Jerome; Marchandise, Pierre; Cultot, Aurélie; Norberciak, Laurène; Kerckhofs, Greet; Budzik, Jean-François. Subchondral involvement in osteonecrosis of the femoral head: insight on local composition, microstructure and vascularization.. In: Osteoarthritis and cartilage, (2022). doi:10.1016/j.joca.2022.05.003 (Accepté/Sous presse). http://hdl.handle.net/2078.1/260877 4. Ali, Dalia; Figeac, Florence; Caci, Atenisa; Ditzel, Nicholas; Schmal, Clarissa; Kerckhofs, Greet; Havelund, Jesper; Færgeman, Nils; Rauch, Alexander; Tencerova, Michaela; Kassem, Moustapha. Highâfat dietâinduced obesity augments the deleterious effects of estrogen deficiency on bone: Evidence from ovariectomized mice. In: Aging Cell, Vol. -, no.-, p. - (2022). doi:10.1111/acel.13726. http://hdl.handle.net/2078.1/266031 5. Benova, Andrea; Ferencakova, Michaela; Bardova, Kristina; Funda, Jiri; Prochazka, Jan; Spoutil, Frantisek; Cajka, Tomas; Dzubanova, Martina; Balcaen, Tim; Kerckhofs, Greet; Willekens, Wouter; van Lenthe, G. Harry; Alquicer, Glenda; Pecinova, Alena; Mracek, Tomas; Horakova, Olga; Rossmeisl, Martin; Kopecky, Jan; Tencerova, Michaela. Novel thiazolidinedione analog reduces a negative impact on bone and mesenchymal stem cell properties in obese mice compared to classical thiazolidinediones. In: Molecular Metabolism, Vol. 65, no.-, p. 101598 (2022). doi:10.1016/j.molmet.2022.101598 (Accepté/Sous presse). http://hdl.handle.net/2078.1/265281 6. Maes, Arne; Pestiaux, Camille; Marino, Alice; Balcaen, Tim; Leyssens, Lisa; Vangrunderbeeck, Sarah; Pyka, Grzegorz; De Borggraeve, Wim M.; Bertrand, Luc; Beauloye, Christophe; Horman, Sandrine; Wevers, Martine; Kerckhofs, Greet. Cryogenic contrast-enhanced microCT enables nondestructive 3D quantitative histopathology of soft biological tissues. In: Nature Communications, Vol. 13, no.1, p. - (2022). doi:10.1038/s41467-022-34048-4. http://hdl.handle.net/2078.1/266029 7. Frangi, Giulia; Guicheteau, Marie; Jacquot, Frederic; Pyka, Grzegorz; Kerckhofs, Greet; Feyeux, Magalie; Veziers, Joëlle; Guihard, Pierre; Halgand, Boris; Sourice, Sophie; Guicheux, Jérôme; Prieur, Xavier; Beck, Laurent; Beck-Cormier, Sarah. PiT2 deficiency prevents increase of bone marrow adipose tissue during skeletal maturation but not in OVX-induced osteoporosis. In: Frontiers in Endocrinology, Vol. 13, p. 1-11 (2022). doi:10.3389/fendo.2022.921073 (Soumis). http://hdl.handle.net/2078.1/267201 8. Starovoyt, Anastasiya; Quirk, Bryden C.; Putzeys, Tristan; Kerckhofs, Greet; Nuyts, Johan; Wouters, Jan; McLaughlin, Robert A.; Verhaert, Nicolas. An optically-guided cochlear implant sheath for real-time monitoring of electrode insertion into the human cochlea. In: Scientific Reports, Vol. 12, no.1, p. 19234 (2022). doi:10.1038/s41598-022-23653-4. http://hdl.handle.net/2078.1/267197 9. Léger, Jean; Leyssens, Lisa; Kerckhofs, Greet; De Vleeschouwer, Christophe. Ensemble learning and test-time augmentation for the segmentation of mineralized cartilage versus bone in high-resolution microCT images. In: Computers in Biology and Medicine, Vol. 148, no.-, p. 105932 (2022). doi:10.1016/j.compbiomed.2022.105932. http://hdl.handle.net/2078.1/264450 10. de Bournonville, Sébastien; Geris, Liesbet; Kerckhofs, Greet. Micro computed tomography with and without contrast enhancement for the characterization of microcarriers in dry and wet state. In: Scientific Reports, Vol. 11, no. 1 (2021). doi:10.1038/s41598-021-81998-8. http://hdl.handle.net/2078.1/243552 Conference Papers1. Leyssens, Lisa; Pétré, Maïté; Kerckhofs, Greet. Optimization of contrast-enhanced microCT for vascular applications. 2022 xxx. http://hdl.handle.net/2078.1/263186 2. Pétré, Maïté; Balcaen, Tim; El Aazmani, Walid; Pyka, Grzegorz; Fehervary, Heleen; Famaey, Nele; Kerckhofs, Greet. Effect of X-ray contrast-enhancing staining agents on the mechanical properties of blood vessels.. 2022 xxx. http://hdl.handle.net/2078.1/263328 3. Pétré, Maïté; Ghasemi, Milad; Vervenne, Thibault; Pyka, Grzegorz; Kerckhofs, Greet; Cox, Martijn; Fehervary, Heleen; Fameay, Nele. Image-based mechanical modeling of an electrospun scaffold. 2022 xxx. http://hdl.handle.net/2078.1/263327 4. Pétré, Maïté; Leyssens, Lisa; El Aazmani, Walid; Balcaen, Tim; Fehervary, Heleen; Famaey, Nele; Kerckhofs, Greet. Screening of contrast-enhancing staining agents for 4D contrast-enhanced microCT of vascular tissues. 2022 xxx. http://hdl.handle.net/2078.1/263329 5. Pestiaux, Camille; Quirynen, Louise; Beauloye, Christophe; Vanoverschelde, Jean-Louis; Pyka, Grzegorz; Kerckhofs, Greet. X-ray based 3D histology of heart valves using microfocus computed tomography and contrast-enhanced computed tomography. 2022 xxx. http://hdl.handle.net/2078.1/264497 6. Pestiaux, Camille; Quirynen, Louise; Beauloye, Christophe; Vanoverschelde, Jean-Louis; Kerckhofs, Greet. X-ray-based 3D histology and quantitative microstructural analysis of heart valves using ex vivo microCT and contrast-enhanced microCT. 2022 xxx. http://hdl.handle.net/2078.1/264498 7. Tim Balcaen; Catherine Piens; Hoffmann, Delia; Fabien Chauveau; Wim De Borggraeve; Kerckhofs, Greet. Revealing the murine brain anatomy by contrast-enhanced computed tomography â a screening study. 2022 xxx. http://hdl.handle.net/2078.1/267781 8. Laurenz Schröer; Tim De Kock; Balcaen, Tim; Kerckhofs, Greet; Nico Boon; Veerle Cnudde. Distinguishing biofilms from water using X-ray micro-computed tomography. 2022 xxx. http://hdl.handle.net/2078.1/267783 9. Pestiaux, Camille; Maes, Arne; Balcaen, Tim; Leyssens, Lisa; Vangrunderbeeck, Sarah; Pyka, Grzegorz; De Borggraeve, Wim M.; Bertrand, Luc; Beauloye, Christophe; Horman, Sandrine; Wevers, Martine; Kerckhofs, Greet. Cryogenic Contrast-Enhanced MicroCT (cryo-CECT): a Novel Nondestructive Approach to 3D Quantitative Histopathology of Soft Biological Tissues. 2022 xxx. http://hdl.handle.net/2078.1/265599 10. Rougier, G; Maistriaux, Louis; Fievé, Lies; Xhema, Daela; Manon, Julie; Evrard, Robin; de Ville de Goyet, Christine; Olszewski, Raphael; Kerckhofs, Greet; Szmytka, F; Thurieau, N; Boisson, J; Kadlub, N; Gianello, Pierre; Behets Wydemans, Catherine; Lengelé, Benoît. Perfusion-decellularization of vascularized bone matrix: Application to the porcine forelimb. In: Transplant International. Vol. 34, no.Suppl.1, p. 69 (2021). Oxford : Blackwell Pub.: England, 2021 xxx. http://hdl.handle.net/2078.1/258781 Book Chapters1. Wevers, Martine; Nicolai, Bart; Verboven, Pieter; Swennen, Rudy; Roels, Staf; Verstrynge, Els; Lomov, Stepan Vladimirovitch; Kerckhofs, Greet; Van Meerbeek, Bart; Mavridou, Athina; Bergmans, Lars; Lambrechts, Paul; Soete, Jeroen; Claes, Steven; Claes, Hannes. Applications of CT for non-destructive testing and materials characterization. In: Industrial X-Ray Computed Tomography , Springer, 2018, p. 267-331. 978-3-319-59571-9. xxx xxx. http://hdl.handle.net/2078/194668 2. Verboven, P.; Ho, Q.; Herremans, E.; Mebatsion, H.; Nicolai, B.; Kerckhofs, Greet; Wevers, M.; Cloetens, P.. Fruit Microstructure Evaluation Using Synchrotron X-Ray Computed Tomography. In: Food Engineering Interfaces , Springer: New York, 2011, p. Chapter 24. 978-1-4419-7475-4. xxx xxx. http://hdl.handle.net/2078/202848 |