Members

IMMC

Lisa Leyssens
PhD student
Ir. at UCLouvain in 2018
Contact - Personnal web page

Main project: A microCT-based approach for high-resolution characterization of biodegradable metallic intravascular stent materials
Funding: UCLouvain Assistant
Supervisor(s): Greet Kerckhofs, Pascal Jacques

The goal of my research project is to assess different potential biodegradable metallic intravascular stent materials using high-resolution 3D microfocus X-ray computed tomography (microCT). In a first step, the optimization of microCT and contrast-enhanced microCT (CECT) for the characterization of the 3D microstructure of different blood vessels is performed (aorta, femoral artery, vena cava) in different species (rat, porcine, human). Then, this technique is applied to study the degradation behaviour of potential materials for biodegradable metallic intravascular stents. Structural properties are investigated. They are critical because they will influence the mechanical and in vivo behaviour of the stents. The materials (in the shape of wires) are screened to analyze the corrosion and surface changes, before and after immersion tests (in vitro part) and before and after implantation in rat arteries to additionally study interactions between the tissue (artery) and the metal (in vivo part).

IMMC main research direction(s):
Biomedical engineering
Processing and characterisation of materials

Keywords:
medical device
medical imaging
metallic alloys

Research group(s): MEED
Collaborations: MORF, IREC

Recent publications

See complete list of publications

Journal Articles

1. Maes, Arne; Pestiaux, Camille; Marino, Alice; Balcaen, Tim; Leyssens, Lisa; Vangrunderbeeck, Sarah; Pyka, Grzegorz; De Borggraeve, Wim M.; Bertrand, Luc; Beauloye, Christophe; Horman, Sandrine; Wevers, Martine; Kerckhofs, Greet. Cryogenic contrast-enhanced microCT enables nondestructive 3D quantitative histopathology of soft biological tissues. In: Nature Communications, Vol. 13, no.1, p. - (2022). doi:10.1038/s41467-022-34048-4. http://hdl.handle.net/2078.1/266029

2. Léger, Jean; Leyssens, Lisa; Kerckhofs, Greet; De Vleeschouwer, Christophe. Ensemble learning and test-time augmentation for the segmentation of mineralized cartilage versus bone in high-resolution microCT images. In: Computers in Biology and Medicine, Vol. 148, no.-, p. 105932 (2022). doi:10.1016/j.compbiomed.2022.105932. http://hdl.handle.net/2078.1/264450

3. Leyssens, Lisa; Pestiaux, Camille; Kerckhofs, Greet. A Review of Ex Vivo X-ray Microfocus Computed Tomography-Based Characterization of the Cardiovascular System. In: International Journal of Molecular Sciences, Vol. 22, no.6, p. 3263 (2021). doi:10.3390/ijms22063263. http://hdl.handle.net/2078.1/244890

Conference Papers

1. Leyssens, Lisa; Pétré, Maïté; Kerckhofs, Greet. Optimization of contrast-enhanced microCT for vascular applications. 2022 xxx. http://hdl.handle.net/2078.1/263186

2. Pétré, Maïté; Leyssens, Lisa; El Aazmani, Walid; Balcaen, Tim; Fehervary, Heleen; Famaey, Nele; Kerckhofs, Greet. Screening of contrast-enhancing staining agents for 4D contrast-enhanced microCT of vascular tissues. 2022 xxx. http://hdl.handle.net/2078.1/263329

3. Pestiaux, Camille; Maes, Arne; Balcaen, Tim; Leyssens, Lisa; Vangrunderbeeck, Sarah; Pyka, Grzegorz; De Borggraeve, Wim M.; Bertrand, Luc; Beauloye, Christophe; Horman, Sandrine; Wevers, Martine; Kerckhofs, Greet. Cryogenic Contrast-Enhanced MicroCT (cryo-CECT): a Novel Nondestructive Approach to 3D Quantitative Histopathology of Soft Biological Tissues. 2022 xxx. http://hdl.handle.net/2078.1/265599

4. Leyssens, Lisa; Pétré, Maïté; Kerckhofs, Greet. Optimization of MicroCT and CECT for Cardiovascular Applications. 2021 xxx. http://hdl.handle.net/2078.1/249931

5. Leyssens, Lisa; Pétré, Maïté; Kerckhofs, Greet. Optimization of microCT and CECT for cardiovascular applications. 2021 xxx. http://hdl.handle.net/2078.1/250458

6. Leyssens, Lisa; Verhaegen, Carole; Horman, Sandrine; Jacques, Pascal; Kerckhofs, Greet. Optimization of contrast-enhanced micro-CT for characterization of the in vivo behavior of biodegradable metallic intravascular stents. 2019 xxx. http://hdl.handle.net/2078.1/219156

7. Leyssens, Lisa; Bejar Ayllon, Natalia; Fehervary, Heleen; Lacroix, Valérie; Famaey, Nele; Kerckhofs, Greet. Arterial grafts: in depth characterization of structure and mechanical properties. 2019 xxx. http://hdl.handle.net/2078.1/220802

8. Léger, Jean; Leyssens, Lisa; De Vleeschouwer, Christophe; Kerckhofs, Greet. Deep learning-based segmentation of mineralized cartilage and bone in high-resolution micro-CT images. 2019 xxx. http://hdl.handle.net/2078.1/219143

9. Arne Maes; Leyssens, Lisa; Carla Geeroms; Kerckhofs, Greet. ADVANCED CHARACTERIZATION OF THE 3D MORPHOLOGY OF THE BONE-TENDON INTERFACE TOWARDS REGENERATIVE TREATMENTS. 2019 xxx. http://hdl.handle.net/2078.1/222792

10. Leyssens, Lisa; Ryelandt, Sophie; Favache, Audrey; Kerckhofs, Greet. Nanoindentation of biological tissues: opportunities and challenges for the bone-tendon interface. 2019 xxx. http://hdl.handle.net/2078.1/219241