Members

IMMC

Lisa Leyssens
PhD student
Ir. at UCL in 2018
Contact

Main project: A microCT-based approach for biomechanical characterization of biodegradable metallic intravascular stents
Funding: UCL Assistant
Supervisor(s): Greet Kerckhofs, Pascal Jacques

The goal of my research project is to develop a highly detailed, advanced characterization platform to assess different aspects of biodegradable metallic intravascular stents using high-resolution 3D microfocus X-ray computed tomography (microCT). This will improve the understanding of the functional behavior of biodegradable stents in order to improve their design for potential clinical use. Structural properties will be investigated. They are critical because they will influence the mechanical and in vivo behavior of the stents. The mechanical properties will be assessed through 3D local strain mapping using 4D microCT. Finally, the stents will be screened in vivo to analyze the corrosion and surface changes, before and after implantation in rat arteries, and to quantify tissue ingrowth. Contrast-enhanced microCT will be used to visualize the vascular tissue. Different metallic alloys will be compared throughout the project.

IMMC main research direction(s):
Biomedical engineering
Processing and characterisation of materials

Keywords:
biomechanics
medical device
metallic alloys

Research group(s): MEED

Recent publications

See complete list of publications

Conference Papers


1. Léger, Jean; Leyssens, Lisa; De Vleeschouwer, Christophe; Kerckhofs, Greet. Deep learning-based segmentation of mineralized cartilage and bone in high-resolution micro-CT images. http://hdl.handle.net/2078.1/219143

2. Leyssens, Lisa; Verhaegen, Carole; Horman, Sandrine; Jacques, Pascal; Kerckhofs, Greet. Optimization of contrast-enhanced micro-CT for characterization of the in vivo behavior of biodegradable metallic intravascular stents. http://hdl.handle.net/2078.1/219156

3. Leyssens, Lisa; Ryelandt, Sophie; Favache, Audrey; Kerckhofs, Greet. Advanced characterization of the 3D morphology and the mechanical properties of the enthesis: optimization study. http://hdl.handle.net/2078.1/219146

4. Leyssens, Lisa; Ryelandt, Sophie; Favache, Audrey; Kerckhofs, Greet. Nanoindentation of biological tissues: opportunities and challenges for the bone-tendon interface. http://hdl.handle.net/2078.1/219241

5. Leyssens, Lisa; Bejar Ayllon, Natalia; Fehervary, Heleen; Lacroix, Valérie; Famaey, Nele; Kerckhofs, Greet. Arterial grafts: in depth characterization of structure and mechanical properties. http://hdl.handle.net/2078.1/220802

6. Arne Maes; Leyssens, Lisa; Carla Geeroms; Kerckhofs, Greet. ADVANCED CHARACTERIZATION OF THE 3D MORPHOLOGY OF THE BONE-TENDON INTERFACE TOWARDS REGENERATIVE TREATMENTS. http://hdl.handle.net/2078.1/222792

7. Maes, Arne; Leyssens, Lisa; Kerckhofs, Greet. ADVANCED CHARACTERIZATION OF THE 3D MORPHOLOGY OF THE BONE-TENDON INTERFACE. http://hdl.handle.net/2078.1/222796

8. Leyssens, Lisa; Ryelandt, Sophie; Favache, Audrey; Kerckhofs, Greet. Nanoindentation of biological tissues: opportunities and challenges for the bone-tendon interface. http://hdl.handle.net/2078.1/213748