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IMMC

Sarah Vangrunderbeeck
PhD student
MSc (Master of Science) at KU Leuven in 2017
Contact

Main project: Synthesis and development of novel contrast agents for 3D multitissue imaging using contrast-enhanced computed tomography.
Funding: FWO project
Supervisor(s): Greet Kerckhofs

The project aims to set the stage for a new era of virtual 3D histology using contrast-enhanced microfocus computed tomography (CE-CT) by developing and validating novel contrast-enhancing staining agents (CESAs). A multidisciplinary approach is applied, crossing the boundaries between biology, engineering, imaging and chemical synthesis. We will develop and synthesize novel CESAs that specifically stain different components of the extracellular matrix in whole tissues. One example within this project is the development of antigen-specific CESAs, which are comparable to immunohistochemistry. Hence, we propose ex-vivo high-resolution CE-CT imaging to become a non-invasive quantitative 3D anatomical tool that will allow unprecedented 3D characterization of the biological tissues.

IMMC main research direction(s):
Biomedical engineering

Keywords:
contrast-enhanced computed tomography
organic synthesis

Research group(s): MEED
Collaborations: I am a joint PhD student of the KU Leuven and UCLouvain. My supervisor of the KU Leuven is Wim De Borggraeve.

    

Recent publications

See complete list of publications

Journal Articles


1. Vangrunderbeeck, Sarah; Balcaen, Tim; Veryser, Cedrick; Steurs, Gert; De Borggraeve, Wim M. Carbonylation Chemistry Applied to the Synthesis of Benzimidazo[2,1‐b]quinazolin‐12‐ones. In: European Journal of Organic Chemistry, Vol. 2022, no.2, p. 6 (2022). doi:10.1002/ejoc.202101136. http://hdl.handle.net/2078/269056

2. Maes, Arne; Pestiaux, Camille; Marino, Alice; Balcaen, Tim; Leyssens, Lisa; Vangrunderbeeck, Sarah; Pyka, Grzegorz; De Borggraeve, Wim M.; Bertrand, Luc; Beauloye, Christophe; Horman, Sandrine; Wevers, Martine; Kerckhofs, Greet. Cryogenic contrast-enhanced microCT enables nondestructive 3D quantitative histopathology of soft biological tissues. In: Nature Communications, Vol. 13, no.1, p. - (2022). doi:10.1038/s41467-022-34048-4. http://hdl.handle.net/2078.1/266029

3. de Bournonville, Sébastien; Vangrunderbeeck, Sarah; Ly, Hong Giang T.; Geeroms, Carla; De Borggraeve, Wim M.; Parac-Vogt, Tatjana N.; Kerckhofs, Greet. Exploring polyoxometalates as non-destructive staining agents for contrast-enhanced microfocus computed tomography of biological tissues. In: Acta Biomaterialia, Vol. 105, p. 253-262 (2020). doi:10.1016/j.actbio.2020.01.038. http://hdl.handle.net/2078.1/228448

4. de Bournonville, Sébastien; Vangrunderbeeck, Sarah; Kerckhofs, Greet. Contrast-Enhanced MicroCT for Virtual 3D Anatomical Pathology of Biological Tissues: A Literature Review. In: Contrast Media & Molecular Imaging, Vol. 2019, no.-, p. 1-9 (2019). doi:10.1155/2019/8617406. http://hdl.handle.net/2078.1/214392

5. Gilles, Philippe; Vangrunderbeeck, Sarah. Synthesis of N-Acyl Sulfamates from Fluorosulfates and Amides. In: Synthesis of N-Acyl Sulfamates from Fluorosulfates and Amides, Vol. 84, no.2, p. 8 (2018). doi:10.1021/acs.joc.8b02785. http://hdl.handle.net/2078/255648


Conference Papers


1. Pestiaux, Camille; Maes, Arne; Balcaen, Tim; Leyssens, Lisa; Vangrunderbeeck, Sarah; Pyka, Grzegorz; De Borggraeve, Wim M.; Bertrand, Luc; Beauloye, Christophe; Horman, Sandrine; Wevers, Martine; Kerckhofs, Greet. Cryogenic Contrast-Enhanced MicroCT (cryo-CECT): a Novel Nondestructive Approach to 3D Quantitative Histopathology of Soft Biological Tissues. 2022 xxx. http://hdl.handle.net/2078.1/265599

2. Hoffmann, Delia; El Aazmani, Walid; Engelen, Lara; Balcaen, Tim; Vangrunderbeeck, Sarah; Kerckhofs, Greet. Virtual 3D histological analysis of soft tissues by contrast-enhanced microfocus computed tomography: screening contrast-enhancing staining agents. 2021 xxx. http://hdl.handle.net/2078.1/253722

3. Ly Thi, Hong Giang; Geeroms, Carla; De Borggraeve, Wim; Vogt, Tatjana; Kerckhofs, Greet; Vangrunderbeeck, Sarah; de Bournonville, Sébastien. Polyoxometalates as Non-destructive Staining Agents for ex vivo Contrast-Enhanced Microfocus Computed Tomography (CE-CT). 2021 xxx. http://hdl.handle.net/2078.1/246077

4. Vangrunderbeeck, Sarah; de Bournonville, Sébastien; Ly Thi, Hong Giang; Geeroms, Carla; De Borggraeve, Wim; Vogt, Tatjana; Kerckhofs, Greet. Exploring Polyoxometalates as Non-invasive Staining Agents for ContrastEnhanced Microfocus Computed Tomography of Biological Tissues. 2020 xxx. http://hdl.handle.net/2078.1/246079

5. Hoffmann, Delia; Vangrunderbeeck, Sarah; Maistriaux, Louis; Tohala Pulgarin, Karem Paulette; Fievé, Lies; Duisit, Jérôme; Lengelé, Benoît; Behets Wydemans, Catherine; Kerckhofs, Greet. Contrast-enhanced microfocus computed tomography of body parts and organs: screening and validation of contrast agents. 2019 xxx. http://hdl.handle.net/2078.1/222795

6. De Bournonville, Sébastien; Vangrunderbeeck, Sarah; Ly Thi, Hong G.; Geeroms, Carla; De Borggraeve, Wim; Parac-Vogt, Tatjana N.; Kerckhofs, Greet. Contrast-enhanced microCT for virtual 3D anatomical pathology of biological tissues: polyoxometalates for simultaneous imaging of soft and mineralized skeletal tissues. 2019 xxx. http://hdl.handle.net/2078.1/222799

7. Vangrunderbeeck, Sarah; Sébastien De Bournonville; Hong Giang T. Ly; Carla Geeroms; Wim Deborggraeve; Tatjana N. Parac-Vogt; Kerckhofs, Greet. Exploring Polyoxometalates as Non-invasive Contrast Agents for MicroCT of Soft Biological Tissues. 2019 xxx. http://hdl.handle.net/2078.1/222794

8. Vangrunderbeeck, Sarah; De Bournonville, Sébastien; Ly Thi, Hong G.; De Borggraeve, Wim; Parac-Vogt, Tatjana N.; Kerckhofs, Greet. Development of Novel Non-invasive Contrast Agents for Contrast-Enhanced MicroCT of Biological Tissues. 2019 xxx. http://hdl.handle.net/2078.1/222798

9. Vangrunderbeeck, Sarah; Gilles, Philippe. Synthesis of N-Acyl Sulfamates from Fluorosulfates and Amides. 2018 xxx. http://hdl.handle.net/2078/255646

10. Wim M. De Borggraeve; Vangrunderbeeck, Sarah; Gert Steurs; Cedrick Veryser. Safe and Convenient CO Generation and its Applications in Organic Chemistry. 2017 xxx. http://hdl.handle.net/2078/255645


Working Papers


1. Vangrunderbeeck, Sarah. Carbonylation Chemistry Applied to the Synthesis of Benzimidazo[2,1‐b]quinazolin‐12‐ones. 2022. xxx xxx. http://hdl.handle.net/2078/260513