Bruxelles Woluwe

Selected publications

Stillemans G, Belkhir L, Vandercam B, Vincent A, Haufroid V, Elens L.
Optimal sampling strategies for darunavir and external validation of the underlying population pharmacokinetic model.
Eur J Clin Pharmacol 2020 Online ahead of Print.

Stillemans G, Belkhir L, Vandercam B, Vincent A, Haufroid V, Elens L.
Exploration of Reduced Doses and Short-Cycle Therapy for Darunavir/Cobicistat in Patients with HIV Using Population Pharmacokinetic Modeling and Simulations.
Clin Pharmacokinet. 2020 Online ahead of Print.

Jean-Baptiste Woillard, Michel Mourad, Michael Neely, Arnaud Capron, Ron H. van Schaik, Teun van Gelder, Nuria Lloberas, Dennis A. Hesselink, Pierre Marquet, Vincent Haufroid and Laure Elens.
Tacrolimus Updated Guidelines through popPK Modeling: How to Benefit More from CYP3A Pre-emptive Genotyping Prior to Kidney Transplantation”.
Front. Pharmacol., 08 June 2017  

Anne-Laure Sennesael, Nadtha Panin, Catherine Vancraeynest, Lucie Pochet, Anne Spinewine, Vincent Haufroid and Laure Elens.
“Effect of ABCB1 genetic polymorphisms on the transport of rivaroxaban in HEK293 recombinant cell lines”.
Sci Rep. 2018 Jul 12;8(1):10514.

Nuria Lloberas, Dennis A Hesselink, Ron HN van Schaik PhD, Josep M Grinyò LD, Helena Colom, Teun van Gelder and Laure Elens.
"Detection of a rare CYP3A4 variant in a transplant patient characterized by a Tacrolimus poor metabolizer phenotype".
Pharmacogenomics. 2018 Mar;19(4):305310.

de Graan A.J., Elens L., Sprowl J.A., Sparreboom A., Friberg L.E., Van der Holt B., de Raaf P.J., de Bruijn P., Engels F.K., Eskens F.A., Wiemer E.A., Verweij J., Mathijssen R.H., Van Schaik R.H.
"CYP3A4*22 genotype and systemic exposure affect paclitaxel-induced neurotoxicity".
Clin Cancer Res. (2013), 19: 3316-24.

Elens L., Bouamar R., Hesselink D.A., Haufroid V., Van der Heiden I.P., Van Gelder T., Van Schaik R.H.
"A new functional CYP3A4 intron 6 polymorphism significantly affects tacrolimus pharmacokinetics in kidney transplant recipients".
Clin Chem. (2011), 57: 1574-83.  

Elens L., Tyteca D., Panin N., Courtoy P., Lison D., Demoulin J-B., Haufroid V.
"Functional defect caused by the 4544G>A SNP in ABCC2: potential impact for drug cellular disposition".
Pharmacogenet Genomics (2011), 21: 884-93.

Elens L., Vandercam B., Yombi J-C., Lison D., Wallemacq P., Haufroid V.
"Influence of host genetic factors on efavirenz plasma and intracellular pharmacokinetics in HIV-1infected patients".
Pharmacogenomics (2010), 11: 1223-34.