1. UCL Home
  2. Instituts de recherche
  3. Institut de Recherche Expérimentale et Clinique (IREC)
  4. Pharmacologie et Thérapeutique
  5. Nos groupes de recherche
  6. Axe Cancer: Groupe de recherche Pierre Sonveaux
  7. Publications

Publications

FATH

  1. Avnet S, Baldini N, Brisson L, De Milito A, Otto AM, Pastoreková S, Porporato PE, Szabadkai G, Sonveaux P. Annual meeting of the International Society of Cancer Metabolism (ISCaM): Cancer Metabolism. Front. Oncol. (in press) JCRIF2016: 4.416

  2. Vanderstraeten J, Derradji H, Sonveaux P, Colin IM, Many MC, Gérard AC. Acute iodine deficiency induces a transient VEGF dependent microvascular response in mammary glands involving HIF-1, ROS and mTOR. Am. J. Physiol. 2018; doi: 10.1152/ajpcell.00095.2017. JCRIF2016: 3.460

  3. Bettonville M, Weathery K, d’Aria S, Porporato PE, Zhang J, Bousbata S, Sonveaux P, Braun MY. Long-term antigen exposure deeply modifies metabolic requirement for T cell function. eLife 2018; 7:e30938. JCRIF2016: 7.616

  4. Payen VL, Porporato PE, Danhier P, Vazeille T, Blackman MCN, May BH, Niebes P, Sonveaux P. (+)-Catechin in a 1:2 complex with lysine inhibits cancer cell migration and metastatic take in mice. Front. Pharmacol 2017 4;8:869. JCRIF2016: 4.400

  5. Contino S, Porporato PE, Bird M, Marinangeli C, Opsomer R, Sonveaux P, Bontemps F, Dewachter I, Octave JN, Bertrand L, Stanga S, Kienlen-Campard P. Presenilin 2-dependent maintenance of mitochondrial oxidative capacity and morphology. Front. Physiol. 2017;8:796. JCRIF2016: 4.134

  6. Payen VL, Porporato PE, Danhier P, Vazeille T, Blackman MCN, May BH, Niebes P, Sonveaux P. (+)-Catechin in a 1:2 complex with lysine inhibits cancer cell migration and metastatic take in mice. Front. Pharmacol 2017 4;8:869. JCRIF2016: 4.400

  7. Milosevic T, Payen VL, Sonveaux P, Muccioli GG, Tulkens PM, Van Bambeke F. Mitochondrial alterations (inhibition of mitochondrial protein expression, oxidative metabolism, and ultrastructure) induced by Linezolid and Tedizolid at clinically relevant concentrations in cultured human HL-60 promyelocytes and THP-1 monocytes.. Antimicrob. Agents Chemother. 2018;62(3). JCRIF2016: 4.302

  8. Lemma S, Di Pompo G, Porporato PE, Sboarina M, Russel S, Sonveaux P, Avnet S, MDA-MB-231 breast cancer cells fuel osteoclast metabolism and activity: A new rationale for the pathogenesis of osteolytic bone metastases. BBA Mol. Bas. Dis.2017; 1336:1340. JCRIF2016: 5.108

  9. Gasparre G, Rossignol R, Sonveaux P. Mitochondria in cancer. BBA Bioenergetics 2017;1858:553-555. JCRIF2016: 4.280

  10. Bindels LB, Porporato PE, Ducastel S, Sboarina M, Neyrinck AM, Dewulf EM, Feron O, Levastel S, Cani PD, Staels B, Sonveaux P, Delzenne N. fFA2 expression regulates leukemic cell growth in vivo. Br. J. Cancer 2017;117:1336-1340. JCRIF2016: 6.176

  11. Payen VL, Hsu MY, Rädecke KS, Bouzin C, Porporato PE, Sonveaux P. Monocarboxylate transporter 1 promotes tumor metastasis independently of its activity as a transporter of lactate. Cancer Res. doi:10.1158/0008-5472.CAN-17-0764. JCRIF2016: 9.130

  12. Baselet B, Azimzadeh O, Erbeldinger N, Bakshi M, Dettmering T, Janssen A, Ktitareva S, Lowe D, Michaux A, Quintens R, Raj K, Durante M, Fournier C, Benotmane AM, Baatout S, Sonveaux P, Tapio S, Aerts A. Single dose Fe ion irradiation highlights the radiation quality dependent nature of the endothelial cell response to ionizing radiation exposure. Front. Pharmacol. 2017;doi: 10.3389/fphar.2017.00570. JCRIF2016: 4.400

  13. Panisova E, Kery M, Sedlakova O, Brisson L, Sboarina M, Sonveaux P, Pastorekova S, Svastova E. Lactate stimulates CA IX expression in normoxic cancer cells. Oncotarget 2017;8(44):77819-77835. JCRIF2016: 5.168

  14. Baldini N, De Milito A, Feron O, Gillies RJ, Michiels C, Otto AM, Pastoreková S, Pedersen SF, Porporato PE, Sonveaux P*, Supuran CT, Avnet S. *Corresponding author. Annual meeting of the International Society of Cancer Metabolism (ISCaM): metabolic networks in cancer. Front. Pharmacol. 2017;doi: 10.3389/fphar.2017.00411. JCRIF2016: 4.400

  15. Baselet B, Belmans N, Coninx E, Lowe D, Janssen A, Michaux A, Tabury K, Raj K, Quintens R, Benotmane MA, Baatout S, Sonveaux P, Aerts A. Functional gene analysis reveals cell cycle changes and inflammation in endothelial cells irradiated with a single X-ray dose. Front. Pharmacol. 2017;8:213. JCRIF2016: 4.400

  16. Danhier P, Deumer G, Joudiou N, Bouzin C, Leveque P, Haufroid V, Jordan BF, Feron O, Sonveaux P, Gallez B. Contribution of macrophages in the contrast loss in iron oxide-based MRI cancer cell tracking studies. Oncotarget 2017; doi: 10.18632/oncotarget.17103. JCRIF2016: 5.168

  17. Sonveaux P. ROS and radiotherapy: more we care. Oncotarget 2017; doi: 10.18632/oncotarget.16613. JCRIF2016: 5.168

  18. Danhier P, Banski P, Payen VL, Grasso D, Ippolito L, Sonveaux P, Porporato PE. Cancer metabolism in space and time: beyond the Warburg effect. BBA Bioenergetics 2017;1858:556–572. JCRIF2016: 4.932

  19. Van Hée VF, Labar D, Dehon G, Grasso D, Grégoire V, Muccioli GG, Frédérick R, Sonveaux P. Radiosynthesis and validation of (±)-[18F]-3-fluoro-2-hydroxypropionate ([18F]-FLac) as a PET tracer of lactate to monitor MCT1-dependent lactate uptake in tumors. Oncotarget 2017;8(15):24415-24428. JCRIF2016: 5.168

  20. Stickaert A, Saiselet M, Dom G, De Deken X, Dumont JE, Feron O, Sonveaux P, Maenhaut C. Cancer heterogeneity is not compatible with one unique cancer cell metabolic map. Oncogene 2017; 36(19):2637-2642. JCRIF2016: 6.854

  21. Neveu MA, De Preter G, Marchand V, Bol A, Brender JR, Saito K, Kishimoto S, Porporato PE, Sonveaux P, Grégoire V, Feron O, Jordan BF, Krishna MC, Gallez B. Multimodality imaging identifies distinct metabolic profiles in vitro and in vivo. Neoplasia 2016;18:742-752. JCRIF2016: 5.006

  22. Cacace A, Sboarina M, Vazeille T, Sonveaux P. Glutamine activates STAT3 to control cancer cell proliferation independently of glutamine metabolism. Oncogene 2017;36(15):2074-2084. JCRIF2016: 6.854

  23. Lemma S, Sboarina M, Porporato PE, Zini N, Sonveaux P, Di Pompo G, Baldini N, Avnet S. Energy metabolism in osteoclast formation and function. Int. J. Biochem. Cell. Biol. 2016;79:168-180. JCRIF2016: 3.505

  24. Brisson L, Banski, P, Sboarina M, Dethier C, Fontenille MJ, Van Hée VF, Vazeille T, Falces J, Bouzin C, Frédérick R, Michiels C, Copetti T, Sonveaux P. Lactate dehydrogenase B controls autophagy in cancer. Cancer Cell 2016;30(3):418-431. JCRIF2016: 27.407

  25. De Pauw A, Massion P, Sekkali B, Andre E, Dubroca C, Kmecova J, Bouzin C, Friart A, Sibille C, Gilon P, De Mulder D, Esfahani H, Strapart A, Matherus R, Payen V, Sonveaux P, Brouckaert P, Janssens D, Balligand JL. Paracrine nitric oxide induces expression of cardiac sarcomeric proteins in adult progenitor cells through soluble guanylyl cyclase/cyclic-GMP and Wnt/β-catenin inhibition. Cardiovasc. Res. 2016 12(1):478-490. JCRIF2016: 5.878

  26. Pérez-Escuredo J, Van Hée VF, Sboarina M, Falces J, Payen VL, Pellerin L, Sonveaux P. Monocarboxylate transporters in the brain and in cancer. BBA Mol. Cell Res. 2016;1863:2481-2497. JCRIF2016: 4.521

  27. Sonveaux P, Maechler P, Martinou JC. Channels and transporters in cell metabolism. BBA Mol. Cell Res. 2016; 1863;2359-2361. JCRIF2016: 4.521

  28. Craps J, Joris V, De Jongh B, Sonveaux P, Horman S, Lengele B, Bertrand L, Many MC, Colin IM, Gerard AC. Involvement of mTOR and regulation by AMPK in TSH-independent iodine deficiency-induced thyroid microvascular activation. Endocrinology 2016;157(6):2545-2559. JCRIF2016: 4.286

  29. Chano T, Avnet S, Kusazaki K, Salerno M, Bonuccelli G, Sonveaux P, Rotili D, Mai A, Baldini N. Tumour-specific metabolic adaptation to acidosis is coupled to epigenetic stability in osteosarcoma cells. Am. J. Cancer Res. 2016;6(4):859-875. JCRIF2016: 3.264

  30. Baldini N, Sonveaux P, De Milito A, Supuran C, Otto A, Stock C, Pedersen SF, Favicchio R, Avnet S. Metabolism and microenvironment in cancer plasticity. Cancer Metab. 2016; 4(Suppl 1):1.

  31. De Preter G, Danhier P, Porporato PE, Payen VL, Jordan BF, Sonveaux P, Gallez B. Direct evidence of the link between energetic metabolism and proliferation capacity of cancer cells in vitro. Adv. Exp. Med. Biol. 2016;876:209-214. JCRIF2016: 1.881

  32. Porporato PE, Payen VL, Baselet B, Sonveaux P. Metabolic changes associated with tumor metastasis, part 2: mitochondria, lipid and amino acid metabolism. Cell Mol. Life Sci. 2016; 73(7):1349-1363. JCRIF2016: 5.788

  33. Payen VL, Porporato PE, Baselet B, Sonveaux P. Metabolic changes associated with tumor metastasis, part 1: tumor pH, glycolysis and the pentose phosphate pathway. Cell Mol. Life Sci. 2016;73(7):1333-1348. JCRIF2016: 5.788

  34. Vanderstraeten J, Derradji H, Craps J, Sonveaux P, Colin I, Many MC, Gérard AC. Iodine deficiency induces a VEGF-dependent microvascular response in salivary glands and in the stomach. Histol. Histopathol. 2016:11727. JCRIF2016: 1.870

  35. Pérez-Escuredo J, Dadhish RK, Dhup S, Cacace A, Van Hée V, De Saedeleer CJ, Sboarina M, Rodriguez F, Fontenille MJ, Brisson L, Porporato PE, Sonveaux P. Lactate promotes glutamine uptake and metabolism in oxidative cancer cells. Cell Cycle 2016;15(1):72-83. JCRIF2016: 4.565

  36. De Preter G, Deriemaeker C, Danhier P, Brisson L, Cao Pham TT, Grégoire V, Jordan BF, Sonveaux P, Gallez B. A fast hydrogen sulfide-releasing donor increases the tumor response to radiotherapy. Mol. Cancer Ther 2016;15(1):154-161. JCRIF2016: 5.579

  37. Mignion L, Danhier P, Porporato PE, Magat J, Grégoire V, Sonveaux P, Gallez B, Jordan BF. Non-invasive in vivo imaging of early metabolic tumor responses to therapies targeting choline signaling. Int. J. Cancer, 2016;138(8):2043-2049. JCRIF2016: 5.531

  38. De Preter G, Neveu MA, Danhier P, Brisson L, Payen VL, Porporato PE, Jordan BF, Sonveaux P, Gallez B. Inhibition of the pentose phosphate pathway by dichloroacetate unravels a missing link between aerobic glycolysis and cancer cell proliferation. Oncotarget 2016;7(3):2910-2920. JCRIF2016: 5.168

  39. Desmet C, Lafosse A, Vériter S, Porporato PE, Sonveaux P, Dufrasne D, Leveque P, Gallez B. Application of electron paramagnetic resonance (EPR) oximetry to monitor oxygen in wounds in diabetic models. PloS ONE 2015;10(12):e0144914. JCRIF2015: 3.234

  40. Van Hée VF, Pérez-Escuredo J, Cacace A, Copetti T, Sonveaux P. Lactate does not activate NF-κB in oxidative tumor cells. Front. Pharmacol. 2015;6:228. JCRIF2015: 4.040

  41. Chereddy KK, Lopes A, Koussoroplis S, Payen VL, Moia C, Zhu H, Sonveaux P, Carmeliet P, des Rieux A, Vermeulen G, Preat V. Combined effects of PLGA and vascular endothelial growth factor promote the healing of non-diabetic and diabetic wounds. Nanomed. 2015;11(8):1975-1984. IFJCR2015: 5.671

  42. Payen VL, Brisson L, Dewhirst MW, Sonveaux P. Common responses of tumors and wounds to hypoxia. Cancer J. 2015;21(2):75-87. JCRIF2015: 5.649

  43. Danhier P, Magat J, Leveque P, De Preter G, Porporato PE, Bouzin C, Jordan BF, Demeur G, Haufroid V, Feron O, Sonveaux P, Gallez B. In vivo visualization and ex vivo quantification of murine cancer cells in the brain using MRI cell tracking and electron paramagnetic resonance. NMR Biomed. 2015;28(3):367-375. JCRIF2015: 2.983

  44. Danhier F, Danhier P, De Saedeleer CJ, Fruytier AC, Schleich N, des Rieux A, Sonveaux P, Gallez B, Préat V. Paclitaxel-loaded micelles enhance transvascular permeability and retention of nanomedicines in tumors. Int. J. Pharm. 2015;479(2):399-407. JCRIF2015: 3.994

  45. Craps J, Wilvers C, Joris V, Vanderstraeten J, De Jongh B, Lobysheva I, Balligand JL, Sonveaux P, Gilon P, Many MC, Gerard AC, Colin IM. Involvement of nitric oxide in iodine deficiency-induced microvascular remodeling in the thyroid gland: role of nitric oxide synthase 3 and ryanodine receptors. Endocrinology 2015;156(2):707-720. JCRIF2015: 4.159

  46. Bol V, Bol A, Bouzin C, Labar D, Lee JA, Janssens G, Porporato PE, Sonveaux P, Feron O, Grégoire V. Reprogramming of tumor metabolism by targeting mitochondria improves tumor response to irradiation. Acta Oncol. 2015;54(2)266-274. JCRIF2015: 1.530

  47. Porporato E, Sonveaux P. Paving the way for a therapeutic prevention of tumor metastasis with agents targeting mitochondrial superoxide. Mol. Cell. Oncol. 2014;2(3):e968043.

  48. Spugnini E, Sonveaux P, Stock CM, Perez-Sayans M, De Milito A, Avnet S, Garcia AG, Harguidey S, Fais S. Implication of proton channels and exchangers in cancer. BBA Biomembranes 2014;1848 (10PtB):2715-2726. JCRIF2015: 2.800

  49. Chereddy KK, Her CH, Comune M, Moia C, Lopes A, Porporato PE, Vanacker J, Lam MC, Steinstraesser L, Sonveaux P, Zhu H, Ferreira LS, Vandermeulen G, Préat V. PLGA nanoparticles loaded with host defense peptide LL37 promote wound healing. J. Control. Rel. 2014;194:138-147. JCRIF2014: 7.705

  50. Porporato PE, Payen VL, Pérez-Escuredo J, De Saedeleer CJ, Danhier P, Copetti T, Dhup S, Tardy M, Vazeille T, Bouzin C, Feron O, Michiels C, Gallez B, Sonveaux P. A mitochondrial switch promotes tumor metastasis. Cell Reports 2014;8:754-766. JCRIF2014: 8.358

  51. Draoui N, Schicke O, Seront E, Bouzin C, Sonveaux P,* Riant O,* Feron O.* *Shared authorship. Antitumor activity of 7-aminocarboxycoumarin derivatives, a new class of potent inhibitors of lactate influx but not efflux. Mol. Cancer. Ther. 2014;13(6):1410-1418. JCRIF2014: 5.683

  52. Danhier P, De Preter G, Magat J, Godechal Q, Porporato PE, Jordan BF, Feron O, Sonveaux P, Gallez B. Multimodal cell tracking of a spontaneous metastasis model: comparison between MRI, electron paramagnetic resonance and bioluminescence. Contrast Media Mol. I. 2014;9(2):143-153. JCRIF2014: 2.923

  53. Steinstraesser L, Lam MC, Jacobsen F, Porporato PE, Chereddy KK, Becerikli M, Stricker I, Hancock REW, Lehnhardt M, Sonveaux P, Préat V, Vandermeulen G. Skin electroporation of a plasmid encoding hCAP-18/LL-37 host defense peptide promotes wound healing. Mol. Ther. 2014;22(4):734-742. JCRIF2014: 6.227

  54. De Saedeleer CJ, Porporato PE, Copetti T, Pérez-Escuredo J, Payen VL, Brisson L, Feron O, Sonveaux P. Glucose deprivation increases monocarboxylate transporter 1 (MCT1) expression and MCT1-dependent tumor cell migration. Oncogene 2014;33(31);4060-4068. JCRIF2014: 8.459

  55. De Meester C, Timmermans AD, Balteau M, Ginion A, Roelants V, Noppe G, Porporato PE, Sonveaux P, Viollet B, Sakamoto K, Feron O, Horman S, Vanoverschelde JL, Beauloye C, Bertrand L. Role of AMP-activated protein kinase in regulating hypoxic survival and proliferation of mesenchymal stem cells. Cardiovas. Res. 2014;101(1):20-29. JCRIF2014: 5.940

  56. Draoui D, Schicke O, Fernandes A, Drozak X, Nahra F, Dumont A, Douxfils J, Hermans E, Dogné JM, Corbau R, Marchand A, Chaltin P, Sonveaux P,* Feron O,* Riant O.* *Shared authorship. Synthesis and pharmacological evaluation of carboxycoumarins as a new antitumor treatment targeting lactate transport in cancer cells. Bioorg. Med. Chem. 2013;21(22):7107-7117. JCRIF2013: 2.951

  57. Danhier P, De Saedeleer CJ, Karroum O, De Preter G, Jordan BF, Gallez B, Sonveaux P. Optimization of tumor radiotherapy with modulators of cell metabolism: towards clinical applications. Semin. Radiat. Oncol. 2013;23(4):262-272. JCR IF2013: 3.768

  58. Kennedy KM, Scarbrough PM, Ribeiro A, Richardson R, Yuan H, Sonveaux P, Landon CD, Chi JT, Pizzo S, Schroeder T, Dewhirst MW. Catabolism of exogenous lactate reveals it as a legitimate metabolic substrate in breast cancer. Plos ONE 2013:8(9):e75154. JCRIF2013: 3.534

  59. Hick AC, Delmarcelle AS, Bouquet M, Klotz S, Copetti T, Forez C, Van Der Smissen P, Sonveaux P, Collet JF, Feron O, Courtoy PJ, Pierreux CE. Reciprocal epithelial:endothelial paracrine interactions during thyroid development govern follicular organization and C-cells differentiation. Dev. Biol. 2013;381(1):227-240. JCRIF2013: 3.637

  60. Danhier P, Copetti T, De Preter G, Leveque P, Feron O, Jordan BF, Sonveaux P, Gallez B. Influence of cell detachment on the respiration rate of tumor and endothelial cells. Plos ONE 2013;8(1):e53324. JCRIF2013: 3.534

  61. Jordan BF, Sonveaux P. Targeting tumor perfusion and oxygenation to improve the outcome of anticancer therapy. Front. Pharmacol. 2012;3:94. JCRIF2014: 3.802

  62. Dhup S, Dadhich RK, Porporato PE, Sonveaux P. Multiple biological activities of lactic acid in cancer: influences on tumor growth, angiogenesis and metastasis. Curr. Pharm. Design 2012;18(10):1319-1330. JCR IF2012: 3.311

  63. De Saedeleer CJ, Copetti T, Porporato PE, Verrax J, Feron O, Sonveaux P. Lactate activates HIF-1 in oxidative but not in Warburg-phenotype tumor cells. Plos ONE 2012;7(10):e46571. JCRIF2012: 3.730

  64. Bindels LB, Porporato PE, Dewulf EM, Verrax J, Neyrinck AM, Martin JC, Scott KP, Buc Calderon P, Feron O, Muccioli GG, Sonveaux P,* Cani PD,* Delzenne NM. *Shared authorship. Gut microbiota-derived propionate reduces cancer cell proliferation in the liver. Brit. J. Cancer. 2012;107(8):1337-44. JCRIF2012: 5.082

  65. Karroum O, Kengen J, Danhier P, Magat J, Mignion L, Bouzin C, Verrax J, Charette N, Starkel P, Calderon BP, Sonveaux P, Feron O, Grégoire V, Gallez B, Jordan BF. Tumor reoxygenation following administration of mitogen-activated protein kinase inhibitors: a rationale for combination with radiation therapy. Radiother. Oncol. 2012;105(1):64-71. JCRIF2012: 4.520

  66. Porporato PE, Payen VL, De Saedeleer CJ, Préat V, Thissen JP, Feron O, Sonveaux P. Lactate stimulates angiogenesis and accelerates the healing of superficial and ischemic wounds in mice. Angiogenesis 2012;15:581-592. JCRIF2012: 3.972

  67. Gerard AC, Humblet K, Wilvers C, Poncin S, Derradji H, de Ville de Goyet C, Abou-el-Ardat K, Baatout S, Sonveaux P, Denef JF, Colin IM. Iodine deficiency-induced long lasting angiogenic reaction in thyroid cancers occurs via a VEGF-HIF-1, but not a ROS dependent pathway. Thyroid 2012;22(7):699-708. JCRIF2012: 3.544

  68. Danhier P, De Preter G, Boutry S, Mahieu I, Leveque P, Magat J, Haufroid V, Sonveaux P, Bouzin C, Feron O, Muller RM, Jordan BF, Gallez B. Electron paramagnetic resonance as a sensitive tool to assess the iron oxide content in cells for MRI cell labeling studies. Contrast Media Mol. I. 2012;7(3):302-307. JCRIF2012: 2.872

  69. Végran F, Seront E, Sonveaux P, Feron O. Lactate-induced IL-8 pathway in endothelial cells – Response Cancer Res. 2012;72(7):1903-1904. JCRIF2012: 8.650

  70. Sonveaux P,* Copetti T, De Saedeleer CJ, Végran F, Verrax J, Kennedy KM, Moon EJ, Dhup S, Danhier P, Frérart F, Gallez B, Ribeiro A, Michiels C, Dewhirst MW, Feron O. *Corresponding author. Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis. Plos ONE. 2012;7(3):e33418. JCRIF2012: 3.730

  71. Boidot R, Végran F, Meulle A, Sonveaux P, Lizard-Nacol S, Feron O. Regulation of monocarboxylate transporter MCT1 expression by p53 mediates inward and outward lactate fluxes in tumors. Cancer Res. 2012;72:939-948. JCRIF2012: 8.650

  72. Porporato PE, Dadhich RK, Dhup S, Copetti T, Sonveaux P. Anticancer targets in the glycolytic metabolism of tumors: a comprehensive review. Front. Pharmacol. 2011;2:49. JCRIF2014: 3.802

  73. Godechal Q, Defresne F, Danhier P, Leveque P, Porporato PE, Sonveaux P, Baurain JF, Feron O, Gallez B. Assessment of melanoma extent and melanoma metastases invasion using electron paramagnetic resonance and bioluminescence imaging. Contrast Media Mol. I. 2011;6(4):282-288. JCRIF2011: 3.328

  74. Végran F, Boidot R, Michiels C, Sonveaux P, Feron O. Lactate influx through endothelial cell monocarboxylate transporter MCT1 promotes a NFkB/IL-8 pathway driving tumor angiogenesis. Cancer Res. 2011; 71(7):2550-2560. JCRIF2011: 7.856

  75. Sonveaux P. Loss of CC3/TIP30 allows tumor cells to cope with low glucose. Cell Cycle 2011;10(3):376. JCRIF2011: 5.359

  76. Moon EJ, Sonveaux P, Nien YCC, Schroeder T, Dewhirst MW. NADPH oxidase-mediated ROS production activates HIF-1 via the ERK pathway after hyperthermia treatment. P. Natl. Acad. Sci. U.S.A. 2010;107(47):20477-20482. JCRIF2010: 9.771

  77. Jiang H, De Ridder M, Verovski VN, Sonveaux P, Jordan BF, Law K, Monsaert C, Van den Berge DL, Verellen D, Feron O, Gallez B, Storme GA. Activated macrophages as a novel determinant of tumor cell radioresponse: the role of nitric oxide-mediated inhibition of cellular respiration and oxygen sparing. Int. J. Radiat. Oncol. 2010;76(5):1520-1527. JCRIF2010: 4.503

  78. Sonveaux P, Jordan BF, Gallez B, Feron O. Nitric oxide delivery to cancer: why and how? Eur. J. Cancer 2009;45(8):1352-1369. JCR IF2009: 4.121

  79. Sonveaux P. Provascular strategy: targeting functional adaptations of mature blood vessels in tumors to selectively influence the tumor vascular reactivity and improve cancer treatment. Radiother. Oncol. 2008;86(3):300-313. JCR IF2008: 3.990

  80. Sonveaux P,* Végran F, Schroeder T, Wergin MC, Verrax J, Rabbani ZN, De Saedeleer CJ, Kennedy KM, Diepart C, Jordan BF, Kelley MJ, Gallez B, Wahl MW, Feron O, Dewhirst MW. *Corresponding authorship Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. J. Clin. Invest. 2008;118(12):3930-3942. JCR IF2008: 16.559

  81. Frérart F,* Sonveaux P,* Rath G, Smoos A, Meqor A, Charlier N, Jordan BF, Saliez J, Noël A, Dessy C, Gallez B, Feron O. *Shared first authorship. The acidic tumor microenvironment promotes the reconversion of nitrite into nitric oxide: towards a new and safe radiosensitizing strategy. Clin. Cancer Res. 2008;14(7):2768-2774. JCR IF2008: 6.488

  82. Gérard AC, Poncin S, Caetano B, Sonveaux P, Audinot JN, Feron O, Colin IM, Soncin F. Iodine deficiency induces a thyroid stimulating hormone-independent early phase of microvascular reshaping in the thyroid. Am. J. Pathol. 2008;172(3):748-760. JCR IF2008: 5.697

  83. Sonveaux P, Lobysheva II, Feron O, McMahon TJ. Transport and peripheral bioactivities of nitrogen oxides carried by red blood cell hemoglobin: role in oxygen delivery. Physiology 2007;22:97-112. JCR IF2007: 6.954

  84. DeWever J, Frérart F, Bouzin C, Baudelet C, Ansiaux R, Sonveaux P, Gallez B, Dessy C, Feron O. Caveolin-1 is critical for the maturation of tumor blood vessels through the regulation of both endothelial tube formation and mural cell recruitment. Am. J. Pathol. 2007;171(5):1619-1628. JCR IF2007: 5.487

  85. Cao Y, Sonveaux P, Liu S, Zhao Y, Mi J, Clary BM, Li CY, Kontos CD, Dewhirst MW. Systemic overexpression of angiopoietin-2 promotes tumor microvessel regression and inhibits angiogenesis and tumor growth. Cancer Res. 2007;67(8):3835-3844. JCR IF2007: 7.672

  86. Li F, Sonveaux P, Rabbani ZN, Liu S, Yan B, Huang Q, Vujaskovic Z, Dewhirst MW, Li CY. Regulation of HIF-1a stability through S-nitrosylation. Molecular Cell 2007;26(1):63-74. JCR IF2007: 13.156

  87. Sonveaux P, Frérart F, Bouzin C, Brouet A, DeWever J, Jordan BF, Gallez B, Feron O. Irradiation promotes Akt-targeting therapeutic gene delivery to the tumor vasculature. Int. J. Radiat. Oncol. 2007;67(4):1155-1162. JCR IF2007: 4.290

  88. Martinive P, DeWever J, Bouzin C, Baudelet C, Sonveaux P, Grégoire V, Gallez B, Feron O. Reversal of temporal and spatial heterogeneities in tumor perfusion identifies the tumor vascular tone as a tunable variable to improve drug delivery. Mol. Cancer Ther. 2006; 5(6):1620-1627. JCR IF2006: 5.137

  89. Jackson IL, Batinic-Haberle I, Sonveaux P, Dewhirst MW, Vujaskovic Z. ROS production and angiogenic regulation by macrophages in response to heat therapy. Int. J. Hyperther. 2006;22(4):263-273. JCR IF2006: 1.866

  90. Crokart N, Jordan BF, Baudelet C, Ansiaux R, Sonveaux P, Grégoire V, Beghein N, DeWever J, Bouzin C, Feron O, Gallez B. Early reoxygenation in tumors after irradiation: determining factors and consequences for radiotherapy regimens using daily multiple fractions. Int. J. Radiat. Oncol. 2005;63(3):901-910. JCR IF2005: 4.556

  91. Sonveaux P, Kaz AM, Snyder SA, Richardson RA, Cárdenas-Navia LI, Braun RD, Pawloski JR, Tozer GM, Bonaventura J, McMahon TJ, Stamler JS, Dewhirst MW. Oxygen regulation of tumor perfusion by S-nitrosohemoglobin reveals a pressor activity of nitric oxide. Circ. Res. 2005;96(10):1119-1126. JCR IF2005: 9.408

  92. Ansiaux R, Baudelet C, Jordan BF, Beghein N, Sonveaux P, DeWever J, Martinive P, Grégoire V, Feron O, Gallez B. Thalidomide radiosensitizes tumors through early changes in the tumor microenvironment. Clin. Cancer Res. 2005;11(2 Pt 1):743-750. JCR IF2005: 5.715

  93. Brouet A, DeWever J, Martinive P, Havaux X, Bouzin C, Sonveaux P, Feron O. Antitumor effects of in vivo caveolin gene delivery are associated with the inhibition of the proangiogenic and vasodilatory effects of nitric oxide. FASEB J. 2005;19(6): 602-604. JCR IF2005: 7.064

  94. Sonveaux P, Martinive P, DeWever J, Batova Z, Daneau G, Pelat M, Ghisdal P, Grégoire V, Dessy C, Balligand JL, Feron O. Caveolin-1 expression is critical for vascular endothelial growth factor-induced ischemic hindlimb collateralization and nitric oxide-mediated angiogenesis. Circ. Res. 2004;95(2):154-161. JCR IF2004: 9.972

  95. Jordan BF, Sonveaux P, Feron O, Grégoire V, Beghein N, Dessy C, Gallez B. Nitric oxide as a radiosensitizer: evidence for an intrinsic role in addition to its effect on oxygen delivery and consumption. Int. J. Cancer 2004;109(5):768-773. JCR IF2004: 4.416

  96. Sonveaux P, Dessy C, Martinive P, Havaux X, Jordan BF, Gallez B, Grégoire V, Balligand JL, Feron O. Endothelin-1 is a critical mediator of myogenic tone in tumor arterioles: implications for cancer treatment. Cancer Res. 2004;64(9):3209-3214. JCR IF2004: 7.690

  97. Jordan BF, Sonveaux P, Feron O, Grégoire V, Beghein N, Gallez B. Nitric oxide-mediated increase in tumor blood flow and oxygenation of tumors implanted in muscles stimulated by electric pulses. Int. J. Radiat. Oncol. 2003;55(4):1066-1073. JCR IF2003: 4.285

  98. Sonveaux P, Brouet A, Havaux X, Grégoire V, Dessy C, Balligand JL, Feron O. Irradiation-induced angiogenesis through the up-regulation of the nitric oxide pathway: implications for tumor radiotherapy. Cancer Res. 2003;63(5):1012-1019. JCR IF2003: 8.649

  99. Sonveaux P, Dessy C, Brouet A, Jordan BF, Grégoire V, Gallez B, Balligand JL, Feron O. Modulation of the tumor vasculature functionality by ionizing radiation accounts for tumor radiosensitization and promotes gene delivery. FASEB J. 2002;16(14):1979-1981. JCR IF2002: 7.252

  100. Jordan BF, Grégoire V, Demeure RJ, Sonveaux P, Feron O, O’Hara J, Vanhulle VP, Delzenne N, Gallez B. Insulin increases the sensitivity of tumors to irradiation: involvement of an increase in tumor oxygenation mediated by a nitric oxide dependent decrease of the tumor cells oxygen consumption. Cancer Res. 2002; 62(12):3555-3561. JCR IF2002: 8.318

  101. Brouet A,* Sonveaux P,* Dessy C, Moniotte S, Balligand JL, Feron O. *Shared first authorship. Hsp90 and caveolin are key targets for the proangiogenic nitric oxide-mediated effects of statins. Circ. Res. 2001;89:866-873. JCR IF2001: 9.213

  102. Brouet A, Sonveaux P, Dessy C, Balligand JL, Feron O. Hsp90 ensures the transition from the early Ca2+-dependent to the late phosphorylation-dependent activation of the endothelial nitric-oxide synthase in the vascular endothelial growth factor-exposed endothelial cells. J. Biol. Chem. 2001;276(35):32663-32669. JCR IF2001: 7.258

  103. Lambert DM, DiPaolo FG, Sonveaux P, Kanyonyo M, Govaerts SJ, Hermans E, Bueb J, Delzenne NM, Tschirhart E. Analogues and homologues of N-palmitoylethanolamide, a putative endogenous CB(2) cannabinoid agonist, as potential ligand for the cannabinoid receptors. Biochim. Biophys. Acta. 1999;1440(2-3):266-274. JCR IF1999: 2.59