Regulation of skeletal muscle mass by hormones: towards new targets to mitigate muscle atrophy and new biomarkers for its diagnosis
Muscle atrophy, observed in catabolic states such as cancer cachexia, immobilization or aging is associated with muscle functional loss contributing to morbidity and mortality. Due to lack of effective treatments, new approaches have been actively investigated. Attention has been oriented towards the potential benefits of the Myostatin (Mstn) inhibition. This growth factor strongly inhibits the muscle mass development. Given its marked anabolic effect, Mstn inhibition appears as a promising way to treat muscle atrophy. The deciphering of the mechanisms by which Mstn inhibition stimulates muscle mass should provide critical information not only for understanding the control of muscle size in general but also for developing new therapeutic strategies.
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