Nuclear Magnetic Resonance & Magnetic Resonance Imaging

Nuclear Magnetic Resonance

The Bruker Ascend 600MHz NMR system equipped with a broadband cryoprobe gives the possibility to access high resolution and high signal to noise ratio.

With this system, it is possible to work on any nuclei and to perform most of the liquid state experiment (1D or 2D experiment)

The system is equipped with a sample handling system that can be thermo-regulated (from +4°C to +40°C )

Here are few example of application :

metabolomics study on biological samples (plasma, urea, etc…)
saturation transfer difference
2D homonuclear and heteronuclear correlation (such as J-RES, COSY, TOCSY, etc…)
HRMAS experiment on biopsies using the HRMAS probe

Magnetic Resonance Imaging

Equipped with a Bruker Biospec 11.7T MRI the platform can proceed to a wide range of in vivo studies. Along with this MRI comes a large set of coils that allow us to work on rats and mice on any anatomical area and different nuclei (1H, 13C, 17O, 19F and 31P).

During the past years the platform has showed skills in this following fields:

In vivo anatomical structures with high spatial resolution
Metabolism (spectroscopy and spectroscopic imaging)
Vessels architecture (micro-angiography)
Tissue perfusion (by Dynamic Contrast Enhanced MRI, DCE-MRI)
Oxygen and pH measurements
Heart physiology (ventricle function)
Cell death (Microscopic water diffusion)
Cell tracking