Publications
Zaryouh, Hannah ; De Pauw, Ines ; Baysal, Hasan ; Melis, Jöran ; Van den Bossche, Valentin ; Hermans, Christophe ; Lau, Ho Wa ; Lambrechts, Hilde ; Merlin, Céline ; Corbet, Cyril ; Peeters, Marc ; Vermorken, Jan Baptist ; De Waele, Jorrit ; Lardon, Filip ; Wouters, An. Establishment of head and neck squamous cell carcinoma mouse models for cetuximab resistance and sensitivity.. In: Cancer drug resistance, Vol. 6, no.4, p. 709-728 (2023). doi:10.20517/cdr.2023.62.
Kerkhove, Lisa ; Geirnaert, Febe ; Rifi, Amir Laraki ; Law, Ka Lun ; Gutiérrez, Adrián ; Oudaert, Inge ; Corbet, Cyril ; Gevaert, Thierry ; Dufait, Inès ; De Ridder, Mark. Repurposing Sulfasalazine as a Radiosensitizer in Hypoxic Human Colorectal Cancer. In: Cancers, Vol. 15, no.8, p. 2363 (2023). doi:10.3390/cancers15082363.
Trouvilliez, Sarah ; Cicero, Julien ; Lévêque, Romain ; Aubert, Léo ; Corbet, Cyril ; Van Outryve, Alexandre ; Streule, Karolin ; Angrand, Pierre-Olivier ; Völkel, Pamela ; Magnez, Romain ; Brysbaert, Guillaume ; Mysiorek, Caroline ; Gosselet, Fabien ; Bourette, Roland ; Adriaenssens, Eric ; Thuru, Xavier ; Lagadec, Chann ; de Ruyck, Jérôme ; Orian-Rousseau, Véronique ; Le Bourhis, Xuefen ; Toillon, Robert-Alain. Direct interaction of TrkA/CD44v3 is essential for NGF-promoted aggressiveness of breast cancer cells. In: Journal of experimental & clinical cancer research, Vol. 41, no. 1, p. 110 [1-21] (2022). doi:10.1186/s13046-022-02314-4.
Lan, Junjie ; Cadassou, Octavia ; Corbet, Cyril ; Riant, Olivier ; Feron, Olivier. Discovery of Mitochondrial Complex I Inhibitors as Anticancer and Radiosensitizer Drugs Based on Compensatory Stimulation of Lactate Release. In: Cancers, Vol. 14, no. 21, p. 5454 [1-15] (2022). doi:10.3390/cancers14215454.
Pisapia, Pasquale ; Li, Zhi ; Corbet, Cyril. Editorial: The effect of anti-cancer drug therapies in the treatment of lung cancer. In: Frontiers in Oncology, Vol. 12, no.1, p. 1 (2022). doi:10.3389/fonc.2022.1035245.
Buyse, Chloe ; Joudiou, Nicolas ; Warscotte, Aude ; Richiardone, Elena ; Mignion, Lionel ; Corbet, Cyril ; Gallez, Bernard. Evaluation of Syrosingopine, an MCT Inhibitor, as Potential Modulator of Tumor Metabolism and Extracellular Acidification.. In: Metabolites, Vol. 12, no.6, p. 12pp (2022). doi:10.3390/metabo12060557.
Van de Gucht, Melissa ; Dufait, Inès ; Kerkhove, Lisa ; Corbet, Cyril ; de Mey, Sven ; Jiang, Heng ; Law, Ka Lun ; Gevaert, Thierry ; Feron, Olivier ; De Ridder, Mark. Inhibition of Phosphoglycerate Dehydrogenase Radiosensitizes Human Colorectal Cancer Cells under Hypoxic Conditions. In: Cancers, Vol. 14, no. 20, p. 5060 [1-17] (2022). doi:10.3390/cancers14205060.
Johanns, Manuel ; Corbet, Cyril ; Jacobs, Roxane ; Drappier, Melissa ; Bommer, Guido ; Herinckx, Gaëtan ; Vertommen, Didier ; Tajeddine, Nicolas ; Young, David ; Messens, Joris ; Feron, Olivier ; Steinberg, Gregory R ; Hue, Louis ; Rider, Mark H.. Inhibition of basal and glucagon-induced hepatic glucose production by 991 and other pharmacological AMPK activators.. In: The Biochemical journal, Vol. 479, no. 12, p. 1317-1336 (2022). doi:10.1042/BCJ20220170.
Richiardone, Elena ; Van den Bossche, Valentin ; Corbet, Cyril. Metabolic Studies in Organoids: Current Applications, Opportunities and Challenges. In: Organoids, Vol. 1, p. 85-105 (2022). doi:10.3390/ organoids1010008 (Accepté/Sous presse).
Van den Bossche, Valentin ; Zaryouh, Hannah ; Vara-Messler, Marianela ; Vignau, Julie ; Machiels, Jean-Pascal ; Wouters, An ; Schmitz, Sandra ; Corbet, Cyril. Microenvironment-driven intratumoral heterogeneity in head and neck cancers: clinical challenges and opportunities for precision medicine.. In: Drug resistance updates, Vol. 60, no. 1, p. 100806 [1-20] (2022). doi:10.1016/j.drup.2022.100806.
Derouane, Françoise ; van Marcke, Cédric ; Berlière, Martine ; Gerday, Amandine ; Fellah, Latifa ; Leconte, Isabelle ; Van Bockstal, Mieke ; Galant, Christine ; Corbet, Cyril ; Duhoux, François. Predictive Biomarkers of Response to Neoadjuvant Chemotherapy in Breast Cancer: Current and Future Perspectives for Precision Medicine.. In: Cancers, Vol. 14, no. 16, p. 3876 [1-31] (2022). doi:10.3390/cancers14163876.
Deskeuvre, Marine ; Lan, Junjie ; Dierge, Emeline ; Messens, Joris ; Riant, Olivier ; Corbet, Cyril ; Feron, Olivier ; Frédérick, Raphaël. Targeting cancer cells in acidosis with conjugates between the carnitine palmitoyltransferase 1 inhibitor etomoxir and pH (low) insertion peptides. In: International Journal of Pharmaceutics, Vol. 624, no.1, p. 122041 (2022). doi:10.1016/j.ijpharm.2022.122041.
Cappellesso, Federica ; Orban, Marie-Pauline ; Shirgaonkar, Niranjan ; Berardi, Emanuele ; Serneels, Jens ; Neveu, Marie-Aline ; di Molfetta, Daria ; Piccapane, Francesca ; Caroppo, Rosa ; Debellis, Lucantonio ; Ostyn, Tessa ; Joudiou, Nicolas ; Mignion, Lionel ; Richiardone, Elena ; Jordan, Bénédicte ; Gallez, Bernard ; Corbet, Cyril ; Roskams, Tania ; Dasgupta, Ramanuj ; Tejpar, Sabine ; Di Matteo, Mario ; Taverna, Daniela ; Reshkin, Stephan Joel ; Topal, Baki ; Virga, Federico ; Mazzone, Massimiliano. Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer. In: Nature cancer, Vol. 3, no. 12, p. 1464-1483 (2022). doi:10.1038/s43018-022-00470-2.
Yelek, Caner ; Mignion, Lionel ; Paquot, Adrien ; Bouzin, Caroline ; Corbet, Cyril ; Muccioli, Giulio ; Cani, Patrice D. ; Jordan, Bénédicte. Tumor Metabolism Is Affected by Obesity in Preclinical Models of Triple-Negative Breast Cancer. In: Cancers, Vol. 14, no. 3, p. 562 [1-16] (2022). doi:10.3390/cancers14030562.
Buyse, Chloé ; Joudiou, Nicolas ; Corbet, Cyril ; Feron, Olivier ; Mignion, Lionel ; Flament, Julien ; Gallez, Bernard. Impact of Inhibition of the Mitochondrial Pyruvate Carrier on the Tumor Extracellular pH as Measured by CEST-MRI. In: Cancers, Vol. 13, no.17, p. 4278 (2021). doi:10.3390/cancers13174278.
Gonçalves, Ana Cristina ; Richiardone, Elena ; Jorge, Joana ; Polónia, Bárbara ; Xavier, Cristina P.R. ; Salaroglio, Iris Chiara ; Riganti, Chiara ; Vasconcelos, M. Helena ; Corbet, Cyril ; Sarmento-Ribeiro, Ana Bela. Impact of cancer metabolism on therapy resistance – Clinical implications. In: Drug Resistance Updates, , p. 100797 (2021). doi:10.1016/j.drup.2021.100797 (Accepté/Sous presse).
Virga, Federico ; Cappellesso, Federica ; Stijlemans, Benoit ; Henze, Anne-Theres ; Trotta, Rosa ; Van Audenaerde, Jonas ; Mirchandani, Ananda S. ; Sanchez-Garcia, Manuel A. ; Vandewalle, Jolien ; Orso, Francesca ; Riera-Domingo, Carla ; Griffa, Alberto ; Ivan, Cristina ; Smits, Evelien ; Laoui, Damya ; Martelli, Fabio ; Langouche, Lies ; Van den Berghe, Greet ; Feron, Olivier ; Ghesquière, Bart ; Prenen, Hans ; Libert, Claude ; Walmsley, Sarah R. ; Corbet, Cyril ; Van Ginderachter, Jo A. ; Ivan, Mircea ; Taverna, Daniela ; Mazzone, Massimiliano. Macrophage miR-210 induction and metabolic reprogramming in response to pathogen interaction boost life-threatening inflammation. In: Science Advances, Vol. 7, no.19, p. eabf0466 (2021). doi:10.1126/sciadv.abf0466.
Dierge, Emeline ; Debock, Elena ; Guilbaud, Céline ; Corbet, Cyril ; Mignolet, Eric ; Mignard, Louise ; Bastien, Estelle ; Dessy, Chantal ; Larondelle, Yvan ; Feron, Olivier. Peroxidation of n-3 and n-6 polyunsaturated fatty acids in the acidic tumor environment leads to ferroptosis-mediated anticancer effects. In: Cell Metabolism, Vol. S1550-4131, no.21, p. 00233-3 (2021). doi:10.1016/j.cmet.2021.05.016.
Vander Linden, Catherine ; Corbet, Cyril ; Bastien, Estelle ; Martherus, Ruben ; Guilbaud, Céline ; Petit, Laurenne ; Wauthier, Loris ; Loriot, Axelle ; De Smet, Charles ; Feron, Olivier. Therapy-induced DNA methylation inactivates MCT1 and renders tumor cells vulnerable to MCT4 inhibition. In: Cell Reports, Vol. 35, no.9, p. 109202 (2021). doi:10.1016/j.celrep.2021.109202.
Yelek, Caner ; Mignion, Lionel ; Joudiou, Nicolas ; Terrasi, Romano ; Gourgue, Florian ; Van Hul, Matthias ; Delzenne, Nathalie M. ; Gallez, Bernard ; Corbet, Cyril ; Muccioli, Giulio ; Feron, Olivier ; Cani, Patrice D. ; Jordan, Bénédicte. Acetate: Friend or foe against breast tumour growth in the context of obesity?. In: Journal of Cellular and Molecular Medicine, Vol. 24, no. 24, p. 14195-14204 (2020). doi:10.1111/jcmm.16034.
Trempolec, Natalia ; Degavre, Charline ; Doix, Bastien ; Brusa, Davide ; Corbet, Cyril ; Feron, Olivier. Acidosis-Induced TGF-β2 Production Promotes Lipid Droplet Formation in Dendritic Cells and Alters Their Potential to Support Anti-Mesothelioma T Cell Response. In: Cancers, Vol. 12, no. 5, p. 1284 [1-17] (2020). doi:10.3390/cancers12051284.
Schoonjans, Céline ; Joudiou, Nicolas ; Brusa, Davide ; Corbet, Cyril ; Feron, Olivier ; Gallez, Bernard. Acidosis-induced metabolic reprogramming in tumor cells enhances the anti-proliferative activity of the PDK inhibitor dichloroacetate. In: Cancer Letters, Vol. 470, p. 18-28 (2020). doi:10.1016/j.canlet.2019.12.003.
de Mey, Sven ; Dufait, Inès ; Jiang, Heng ; Corbet, Cyril ; Wang, Hui ; Van De Gucht, Melissa ; Kerkhove, Lisa ; Law, Ka Lun ; Vandenplas, Hugo ; Gevaert, Thierry ; Feron, Olivier ; De Ridder, Mark. Dichloroacetate Radiosensitizes Hypoxic Breast Cancer Cells. In: International Journal of Molecular Sciences, Vol. 21, no.24, p. 9367 (2020). doi:10.3390/ijms21249367.
Corbet, Cyril ; Prieur, Alexandre. Editorial: Therapeutic Targeting of Cancer Stem-Like Cells (CSC) – The Current State of the Art. In: Frontiers in Oncology, Vol. 10, no.243, p. 1 (2020). doi:10.3389/fonc.2020.00243.
Mignion, Lionel ; Acciardo, Stefania ; Gourgue, Florian ; Joudiou, Nicolas ; Caignet, Xavier ; Goebbels, Rose-Marie ; Corbet, Cyril ; Feron, Olivier ; Bouzin, Caroline ; Cani, Patrice D. ; Machiels, Jean-Pascal ; Schmitz, Sandra ; Jordan, Bénédicte. Metabolic imaging using hyperpolarized pyruvate-lactate exchange assesses response or resistance to the EGFR inhibitor cetuximab in patient-derived HNSCC xenografts.. In: Clinical cancer research, Vol. 15, no. 26(8), p. 1932-1943 (2020). doi:10.1158/1078-0432.CCR-19-1369.
Vander Linden, Catherine ; Corbet, Cyril. Reconciling environment-mediated metabolic heterogeneity with the oncogene-driven cancer paradigm in precision oncology. In: Seminars in Cell and Developmental Biology, Vol. 98, p. 202-210 (2020). doi:10.1016/j.semcdb.2019.05.016.
Spillier, Quentin ; Ravez, Severine ; Unterlass, Judith ; Corbet, Cyril ; Degavre, Charline ; Feron, Olivier ; Frédérick, Raphaël. Structure–Activity Relationships (SARs) of α-Ketothioamides as Inhibitors of Phosphoglycerate Dehydrogenase (PHGDH). In: Pharmaceuticals, Vol. 13, no.2, p. 20 (2020). doi:10.3390/ph13020020.
Corbet, Cyril ; Bastien, Estelle ; Santiago de Jesus, Joao Pedro ; Dierge, Emeline ; Martherus, Ruben ; Vander Linden, Catherine ; Doix, Bastien ; Degavre, Charline ; Guilbaud, Céline ; Petit, Laurenne ; Michiels, Carine ; Dessy, Chantal ; Larondelle, Yvan ; Feron, Olivier. TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells. In: Nature Communications, Vol. 11, no.1, p. 1 (2020). doi:10.1038/s41467-019-14262-3.
Spillier, Quentin ; Vertommen, Didier ; Séverine Ravez ; Marteau, Romain ; THÉMANS, Quentin ; Corbet, Cyril ; Feron, Olivier ; Wouters, Johan ; Frédérick, Raphaël. Anti-alcohol abuse drug disulfiram inhibits human PHGDH via disruption of its active tetrameric form through a specific cysteine oxidation. In: Scientific Reports, Vol. 9, no. 1, p. 4737 (2019).
Wang, Hui ; Jiang, Heng ; Corbet, Cyril ; de Mey, Sven ; Law, Kalun ; Gevaert, Thierry ; Feron, Olivier ; De Ridder, Mark. Piperlongumine increases sensitivity of colorectal cancer cells to radiation: involvement of ROS production via dual inhibition of glutathione and thioredoxin systems. In: Cancer Letters, (2019). doi:10.1016/j.canlet.2019.02.034.
Aubert, Léo ; Lévêque, Romain ; Corbet, Cyril ; Guilbert, Matthieu ; Lagadec, Chann ; Adriaenssens, Eric ; Duval, Jérémy ; Finetti, Pascal ; Birnbaum, Daniel ; Magné, Nicolas ; Chopin, Valérie ; Bertucci, François ; Le Bourhis, Xuefen ; Toillon, Robert-Alain. * first authorship shared by AL, LR and CC. ProNGF increases breast tumor aggressiveness through functional association of TrkA with EphA2. In: Cancer Letters, Vol. 19, p. 30091-30096 (2019). doi:10.1016/j.canlet.2019.02.019.
Strickaert Aurélie ; Corbet, Cyril ; Spinette SA ; Craciun L ; Dom G ; Andry G ; Larsimont D ; Wattiez R ; Dumont JE ; Feron, Olivier ; Maenhaut C. Reprogramming of energetic metabolism: increased expression and roles of pyruvate carboxylase in papillary thyroid cancer.. In: Thyroid, (2019). doi:10.1089/thy.2018.0435.
Vander Linden, Catherine ; Corbet, Cyril. Therapeutic targeting of cancer stem cells: integrating and exploiting the acidic niche. In: Frontiers in Oncology, (2019). doi:10.3389/fonc.2019.00159.
Choumessi Tchewonpi, Aphrodite ; Johanns, Manuel ; Beaufay, Claire ; Herent, Marie-France ; Stroobant, Vincent ; Vertommen, Didier ; Corbet, Cyril ; Jacobs, Roxane ; Herinckx, Gaëtan ; Steinberg, Gregory R ; Feron, Olivier ; Quetin-Leclercq, Joëlle ; Rider, Mark H.. Two isoprenylated flavonoids from Dorstenia psilurus activate AMPK, stimulate glucose uptake, inhibit glucose production and lower glycemia. In: Biochemical Journal, Vol. 476, no. 24, p. 3687-3704 (2019). doi:10.1042/BCJ20190326.
Derouane, Françoise ; van Marcke, Cédric ; Berlière, Martine ; Van Bockstal, Mieke ; Mourao, Larissa ; Scheele, Colinda ; Jerusalem, Guy ; Josse, Claire ; Bours, Vincent ; Corbet, Cyril ; Duhoux, François. Identification of new biomarkers to better predict and improve response to neoadjuvant chemotherapy in triple negative breast cancers. Annual Meeting of the Belgian Society of Medical Oncology (Hasselt, Belgium, du 03/02/2023 au 04/02/2023). In: Belgian Journal of Medical Oncology, Vol. 2023, no.ORAL ABSTRACTS OF BSMO AM 2023, p. 26-27 (2023).
Mahieu, Manon ; Defour, Jean-Philippe ; Scheers, Isabelle ; Brichard, Bénédicte ; Levy, Gabriel ; Arnould, Thierry ; Heremans, Isaac ; Bommer, Guido ; Corbet, Cyril ; Decottignies, Anabelle. The mitochondrial haplotype influences oxidative stress and human telomere length . EMBO Workshop-Telomere function and evolution in health and disease (Troia, Portugal, du 26/09/2022 au 01/10/2022).
Mahieu, Manon ; Defour, Jean-Philippe ; Scheers, Isabelle ; Brichard, Bénédicte ; Levy, Gabriel ; Arnould, Thierry ; Corbet, Cyril ; Decottignies, Anabelle. The mitochondrial genome modulates oxidative stress and telomere length in human cells-A transmitochondrial cybrid approach. CSH meeting on Telomeres & Telomerase (CSH-Virtual meeting, du 14/12/2021 au 17/12/2021).
Mignion, Lionel ; Acciardo, Stefania ; Gourgue, Florian ; Joudiou, Nicolas ; Caignet, Xavier ; Goebbels Rose-Marie ; Corbet, Cyril ; Feron, Olivier ; Bouzin, Caroline ; Cani, Patrice D. ; Machiels, Jean-Pascal ; Schmitz, Sandra ; Jordan, Bénédicte. Hyperpolarized pyruvate-lactate exchange assesses metabolic shift in response to the EGFR inhibitor cetuximab in sensitive but not in resistant patient-derived HNSCC xenografts. Belgian Molecular Imaging Congress 2019.
Provided by DIAL