Riccardo LEINARDI
Background
After a M.Sc. in Industrial Biotechnology (2013), I worked at the Dept. of Public Health (University of Torino, Italy) as a Research Assistant.
In March 2018, I obtained a PhD in Pharmaceutical and Biomolecular Sciences at the “G. Scansetti” Centre, University of Torino, with a thesis focused on the investigation of the molecular mechanisms driving silica-induced toxicity, under the supervision of Prof. Bice Fubini and Dr. Francesco Turci. I carried out part of my PhD project at the Groningen Research Institute of Pharmacy (University of Groningen, The Netherlands).
Research project
I joined LTAP in November 2019 as a Postdoctoral Fellow. My work focuses on the mechanisms that trigger cell responses leading to inflammation and immunogenic cell death, upon exposure to different inorganic fibers and particles.
Publications
- Lison D, Ambrose J, Leinardi R, et al., Systemic effects and impact on the gut microbiota upon subacute oral exposure to silver acetate in rats, Arch. Toxicol., 2021 (doi:10.1007/s00204-021-02998-1)
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Pavan C, Santalucia R, Leinardi R, et al., Nearly free silanols are the critical moieties that initiate the toxicity of silica particles, PNAS, 2020, 117(45):27836-27846 (doi:10.1073/pnas.2008006117)
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Orsi M, Al Hatem C, Leinardi R, Huaux F, Carbon nanotubes under scrutinity: their toxicity and utility in mesothelioma research, Appl. Sci., 2020, 10(13), 4513 (doi:10.3390/app10134513)
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Leinardi R, Pavan C, Yedavally A, Tomatis M, Salvati A, Turci F, Cytotoxicity of fractured quartz on THP-1 human macrophages: role of the membranolytic activity of quartz and phagolysosome destabilization, Arch. Toxicol., 2020, 94, 2981-2995 (doi:10.1007/s00204-020-02819-x)
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Marucco A, Aldieri E, Leinardi R, Bergamaschi E, Riganti C, Fenoglio I, Applicability and limitations in the characterization of poly-disperses engineered nanomaterials in cell media by Dynamic Light Scattering, Materials, 2019, 12(23):3833 (doi:10.3390/ma12233833)
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Turci F, Pavan C, Leinardi R, Tomatis M, Pastero L, Garry D, Anguissola S, Lison D, Fubini B, Revisiting the paradigm of silica pathogenicity with synthetic quartz crystals: the role of crystallinity and surface disorder, Part. Fibr. Toxicol., 2016, 13(1):32 (doi:10.1186/s12989-016-0136-6)
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Pastero L, Turci F, Leinardi R, Pavan C, Monopoli M, Synthesis of α-quartz with controlled properties for the investigation of the molecular determinants in silica toxicology, Cryst. Growth Des., 2016, 16(4):2394-2403 (doi:10.1021/acs.cgd.6b00183)
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Traversi D, Gorrasi I, Bonetta S, Leinardi R, Pietrangeli B, Carraro E, Gilli G, Green job bio-aerosol exposure during anaerobic digestion for biomass energetic valorization, Environ. Res., 2015, 138:425-431 (doi:10.1016/j.envres.2015.02.035)
Serge MOUDIO
Background
MD, PhD
Dedicated, curiosity-driven, adaptable clinical research scientist, medically qualified and holder of a PhD in molecular neuroscience, with over 10 years of international research experience in biomedical sciences.
Interested in the physiopathology, pharmacology, treatment strategies, clinical trials and underlying molecular mechanisms for cellular toxicity, neurodegenerative disorders and pain.
Research project
I am currently investigating the relationship between intestinal microbiota and variabilities in the pharmacological response to immuno-suppressant therapy in renal transplant patients.
Publications
1. Alexandra L Degraeve, Serge Moudio, Vincent Haufroid, Djamila Chaib Eddour, Michel Mourad, Laure B Bindels & Laure Elens (2020) Predictors of tacrolimus pharmacokinetic variability: current evidences and future perspectives, Expert Opinion on Drug Metabolism & Toxicology, 16:9, 769-782.
2. Moudio Serge, Rodin Fredrik and Hallbeck Martin, A preclinical model to study Lewy pathology in brain organotypic slice cultures, Nature Parkinson Journal, pre-accepted, Mars 2021.
3. Moudio Serge, Bushell Trevor. Neuroprotective properties of proteinase-activated receptor 2 in the experimental autoimmune encephalomyelitis model, submitted.
4. Bushell Trevor, Cunningham Margaret Rose, McIntosh Kathryn, Moudio Serge, Plevin Robin. Proteinase-activated receptor 2: Are common functions in glial and immune cells linked to inflammation-related CNS disorders? Current drug targets 17(999) · December 2015.
Angélique MOTTAIS
Background
After a master degree in genetics and molecular biology (Université Bretagne Occidentale, Brest, France), I completed a thesis (2014-2017) on gene transfer applied to Cystic Fibrosis under the supervision of Pr Tristan Montier (MD, PhD) and Tony Le Gall (PhD) at INSERM unit 1078 in Brest (France). I developed multifunctional formulations, nebulizable with transfection and antibacterial activities.
Research project
In September 2018, I joined the "muco" team of the LTAP as a post-doctoral fellow to develop a new mouse model mimicking the pulmonary pathophysiology of Cystic Fibrosis patients and new therapeutic strategies.
Publications
Dhooghe, B.; Bouzin, C.; Mottais, A.; Hermans, E.; Delion, M.; Panin, N.; Noel, S.; Leal, T. Vardenafil Increases Intracellular Accumulation of the Most Prevalent Mutant Cystic Fibrosis Transmembrane Conductance Regulator (CTFR) in Human Bronchial Epithelial Cells. Biol. Open 2020, 9 (8). https://doi.org/10.1242/bio.053116.
Mottais, A.; Berchel, M.; Le Gall, T.; Sibiril, Y.; d’Arbonneau, F.; Laurent, V.; Jaffrès, P.-A.; Montier, T. Antibacterial and Transfection Activities of Nebulized Formulations Incorporating Long N-Alkyl Chain Silver N-Heterocyclic Carbene Complexes. Int. J. Pharm. 2019, 567, 118500. https://doi.org/10.1016/j.ijpharm.2019.118500.
Mottais, A.; Berchel, M.; Sibiril, Y.; Laurent, V.; Gill, D.; Hyde, S.; Jaffrès, P.-A.; Montier, T.; Le Gall, T. Antibacterial Effect and DNA Delivery Using a Combination of an Arsonium-Containing Lipophosphoramide with an N-Heterocyclic Carbene-Silver Complex - Potential Benefits for Cystic Fibrosis Lung Gene Therapy. Int. J. Pharm. 2018, 536 (1), 29–41. https://doi.org/10.1016/j.ijpharm.2017.11.022.
Mottais, A.; Le Gall, T.; Sibiril, Y.; Ravel, J.; Laurent, V.; d’Arbonneau, F.; Montier, T. Enhancement of Lung Gene Delivery after Aerosol: A New Strategy Using Non-Viral Complexes with Antibacterial Properties. Biosci. Rep. 2017, 37 (6). https://doi.org/10.1042/BSR20160618.
Berchel, M.; Lozach, O.; Berthe, W.; Hernot, S.; Couthon-Gourvès, H.; Mottais, A.; Gall, T. L.; Midoux, P.; Montier, T.; Jaffrès, P. A. Synthetic Phospholipids and Phospho-Bola-Amphiphiles for Nucleic Acid Delivery. Phosphorus Sulfur Silicon Relat. Elem. 2016, 191 (11–12), 1485–1487. https://doi.org/10.1080/10426507.2016.1212049.
Resnier, P.; Mottais, A.; Sibiril, Y.; Le Gall, T.; Montier, T. Challenges and Successes Using Nanomedicines for Aerosol Delivery to the Airways. Curr. Gene Ther. 2016, 16 (1), 34–46. https://doi.org/10.2174/1566523216666160104142013.
Audrey REYNAERTS